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David A. Foster

TitleRosalyn Yalow Professor
Faculty RankProfessor
InstitutionHunter College, CUNY
DepartmentBiological Sciences
AddressRoom 432 Belfer Research building
413 East 69th Street
New York NY 10021
Phone(212) 896-0441
Fax(212) 772-5227
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Frias MA, Hatipoglu A, Foster DA. Regulation of mTOR by phosphatidic acid. Trends Endocrinol Metab. 2023 03; 34(3):170-180. PMID: 36732094.
      Citations: 2     Fields:    Translation:Humans
    2. Hatipoglu A, Menon D, Levy T, Frias MA, Foster DA. Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells. PLoS One. 2022; 17(10):e0276579. PMID: 36269753.
      Citations: 2     Fields:    Translation:Humans
    3. Chakraborty S, Utter MB, Frias MA, Foster DA. Cancer cells with defective RB and CDKN2A are resistant to the apoptotic effects of rapamycin. Cancer Lett. 2021 12 01; 522:164-170. PMID: 34563639.
      Citations: 3     Fields:    Translation:HumansCells
    4. Uddin S, Melnyk N, Foster DA. Albumin promotes the progression of fibroblasts through late G1 into S-phase in the absence of growth factors. Cell Cycle. 2020 09; 19(17):2158-2167. PMID: 32715871.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Frias MA, Mukhopadhyay S, Lehman E, Walasek A, Utter M, Menon D, Foster DA. Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids. J Biol Chem. 2020 01 03; 295(1):263-274. PMID: 31767684.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    6. Goren L, Zhang G, Kaushik S, Breslin PAS, Du YN, Foster DA. (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells. PLoS One. 2019; 14(8):e0216024. PMID: 31412041.
      Citations: 10     Fields:    Translation:AnimalsCells
    7. Bernfeld E, Foster DA. Glutamine as an Essential Amino Acid for KRas-Driven Cancer Cells. Trends Endocrinol Metab. 2019 06; 30(6):357-368. PMID: 31040047.
      Citations: 38     Fields:    Translation:HumansAnimals
    8. Bernfeld E, Menon D, Vaghela V, Zerin I, Faruque P, Frias MA, Foster DA. Phospholipase D-dependent mTOR complex 1 (mTORC1) activation by glutamine. J Biol Chem. 2018 10 19; 293(42):16390-16401. PMID: 30194281.
      Citations: 19     Fields:    Translation:HumansCells
    9. Utter M, Chakraborty S, Goren L, Feuser L, Zhu YS, Foster DA. Elevated phospholipase D activity in androgen-insensitive prostate cancer cells promotes both survival and metastatic phenotypes. Cancer Lett. 2018 06 01; 423:28-35. PMID: 29524555.
      Citations: 6     Fields:    Translation:HumansCells
    10. Menon D, Salloum D, Bernfeld E, Gorodetsky E, Akselrod A, Frias MA, Sudderth J, Chen PH, DeBerardinis R, Foster DA. Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid. J Biol Chem. 2017 04 14; 292(15):6303-6311. PMID: 28223357.
      Citations: 59     Fields:    Translation:HumansCells
    11. Patel D, Salloum D, Saqcena M, Chatterjee A, Mroz V, Ohh M, Foster DA. A Late G1 Lipid Checkpoint That Is Dysregulated in Clear Cell Renal Carcinoma Cells. J Biol Chem. 2017 01 20; 292(3):936-944. PMID: 27956548.
      Citations: 9     Fields:    Translation:HumansCells
    12. Patel D, Menon D, Bernfeld E, Mroz V, Kalan S, Loayza D, Foster DA. Aspartate Rescues S-phase Arrest Caused by Suppression of Glutamine Utilization in KRas-driven Cancer Cells. J Biol Chem. 2016 Apr 22; 291(17):9322-9. PMID: 26921316.
      Citations: 38     Fields:    Translation:HumansCells
    13. Mukhopadhyay S, Frias MA, Chatterjee A, Yellen P, Foster DA. The Enigma of Rapamycin Dosage. Mol Cancer Ther. 2016 Mar; 15(3):347-53. PMID: 26916116.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    14. Mukhopadhyay S, Saqcena M, Foster DA. Synthetic lethality in KRas-driven cancer cells created by glutamine deprivation. Oncoscience. 2015; 2(10):807-8. PMID: 26682255.
    15. Saqcena M, Patel D, Menon D, Mukhopadhyay S, Foster DA. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Cell Cycle. 2015; 14(14):2285-92. PMID: 25945415.
      Citations: 18     Fields:    Translation:HumansCells
    16. Chatterjee A, Mukhopadhyay S, Tung K, Patel D, Foster DA. Rapamycin-induced G1 cell cycle arrest employs both TGF-? and Rb pathways. Cancer Lett. 2015 May 01; 360(2):134-40. PMID: 25659819.
      Citations: 28     Fields:    Translation:HumansCells
    17. Mukhopadhyay S, Saqcena M, Chatterjee A, Garcia A, Frias MA, Foster DA. Reciprocal regulation of AMP-activated protein kinase and phospholipase D. J Biol Chem. 2015 Mar 13; 290(11):6986-93. PMID: 25632961.
      Citations: 46     Fields:    Translation:HumansCells
    18. Mukhopadhyay S, Chatterjee A, Kogan D, Patel D, Foster DA. 5-Aminoimidazole-4-carboxamide-1-?-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell Cycle. 2015; 14(20):3331-9. PMID: 26323019.
      Citations: 37     Fields:    Translation:HumansCells
    19. LeGendre O, Breslin PA, Foster DA. (-)-Oleocanthal rapidly and selectively induces cancer cell death via lysosomal membrane permeabilization. Mol Cell Oncol. 2015; 2(4):e1006077. PMID: 26380379.
    20. Foster DA. Metabolic vulnerability of KRAS-driven cancer cells. Mol Cell Oncol. 2014; 1(3). PMID: 26609545.
    21. Foster DA. In memoriam: Geoffrey Louis Zubay, 1931-2014. Pioneer in cell-free gene expression studies and molecular genetics. Trends Biochem Sci. 2014 Nov; 39(11):505-6. PMID: 25131814.
      Citations: 1     Fields:    Translation:Cells
    22. Yellen P, Foster DA. Inhibition of fatty acid synthase induces pro-survival Akt and ERK signaling in K-Ras-driven cancer cells. Cancer Lett. 2014 Oct 28; 353(2):258-63. PMID: 25086185.
      Citations: 5     Fields:    Translation:HumansCells
    23. Foster DA, Salloum D, Menon D, Frias MA. Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR). J Biol Chem. 2014 Aug 15; 289(33):22583-22588. PMID: 24990952.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    24. Legendre O, Sookdeo A, Foster DA. BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition. Oncol Lett. 2014 Apr; 7(4):1165-1168. PMID: 24944686.
    25. Salloum D, Mukhopadhyay S, Tung K, Polonetskaya A, Foster DA. Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin. Mol Cancer Ther. 2014 Mar; 13(3):733-41. PMID: 24435447.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    26. Einbond LS, Mighty J, Kashiwazaki R, Figueroa M, Jalees F, Acuna UM, Le Gendre O, Foster DA, Kennelly EJ. Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anticancer Agents Med Chem. 2013 Dec; 13(10):1540-50. PMID: 23848206.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    27. Saqcena M, Menon D, Patel D, Mukhopadhyay S, Chow V, Foster DA. Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycle. PLoS One. 2013; 8(8):e74157. PMID: 23977397.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    28. Foster DA. Phosphatidic acid and lipid-sensing by mTOR. Trends Endocrinol Metab. 2013 Jun; 24(6):272-8. PMID: 23507202.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    29. Le Gendre O, Sookdeo A, Duliepre SA, Utter M, Frias M, Foster DA. Suppression of AKT phosphorylation restores rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells. Mol Cancer Res. 2013 May; 11(5):474-81. PMID: 23443316.
      Citations: 12     Fields:    Translation:HumansCells
    30. Yellen P, Chatterjee A, Preda A, Foster DA. Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-?-dependent G1 cell cycle arrest. Cancer Lett. 2013 Jun 10; 333(2):239-43. PMID: 23376634.
      Citations: 10     Fields:    Translation:HumansCells
    31. Yellen P, Saqcena M, Salloum D, Feng J, Preda A, Xu L, Rodrik-Outmezguine V, Foster DA. High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle. 2011 Nov 15; 10(22):3948-56. PMID: 22071574.
      Citations: 60     Fields:    Translation:HumansCells
    32. Xu L, Salloum D, Medlin PS, Saqcena M, Yellen P, Perrella B, Foster DA. Phospholipase D mediates nutrient input to mammalian target of rapamycin complex 1 (mTORC1). J Biol Chem. 2011 Jul 22; 286(29):25477-86. PMID: 21622984.
      Citations: 55     Fields:    Translation:HumansCells
    33. Toschi A, Lee E, Thompson S, Gadir N, Yellen P, Drain CM, Ohh M, Foster DA. Phospholipase D-mTOR requirement for the Warburg effect in human cancer cells. Cancer Lett. 2010 Dec 18; 299(1):72-9. PMID: 20805015.
      Citations: 24     Fields:    Translation:HumansCells
    34. Foster DA, Yellen P, Xu L, Saqcena M. Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s). Genes Cancer. 2010 Nov; 1(11):1124-31. PMID: 21779436.
    35. Lyo D, Xu L, Foster DA. Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway. Biochem Biophys Res Commun. 2010 May 28; 396(2):562-5. PMID: 20438709.
      Citations: 7     Fields:    Translation:HumansCells
    36. Foster DA. Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection. Cell Cycle. 2010 Apr 01; 9(7):1291-4. PMID: 20372065.
      Citations: 6     Fields:    Translation:Humans
    37. Roberts AM, Watson IR, Evans AJ, Foster DA, Irwin MS, Ohh M. Suppression of hypoxia-inducible factor 2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Res. 2009 Dec 01; 69(23):9056-64. PMID: 19920202.
      Citations: 33     Fields:    Translation:HumansCells
    38. Foster DA, Darnell JE. Obituary: Hidesaburo Hanafusa (1929-2009). Nature. 2009 Apr 09; 458(7239):718. PMID: 19360078.
      Citations:    Fields:    Translation:Cells
    39. Foster DA, Toschi A. Targeting mTOR with rapamycin: one dose does not fit all. Cell Cycle. 2009 Apr 01; 8(7):1026-9. PMID: 19270529.
      Citations: 70     Fields:    Translation:Humans
    40. Foster DA. Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells. Biochim Biophys Acta. 2009 Sep; 1791(9):949-55. PMID: 19264150.
      Citations: 110     Fields:    Translation:HumansCells
    41. Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin. Mol Cell Biol. 2009 Mar; 29(6):1411-20. PMID: 19114562.
      Citations: 183     Fields:    Translation:HumansCells
    42. Toschi A, Lee E, Gadir N, Ohh M, Foster DA. Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem. 2008 Dec 12; 283(50):34495-9. PMID: 18945681.
      Citations: 155     Fields:    Translation:HumansCells
    43. Thompson S, Chen X, Hui L, Toschi A, Foster DA, Drain CM. Low concentrations of a non-hydrolysable tetra-S-glycosylated porphyrin and low light induces apoptosis in human breast cancer cells via stress of the endoplasmic reticulum. Photochem Photobiol Sci. 2008 Nov; 7(11):1415-21. PMID: 18958330.
      Citations: 7     Fields:    Translation:AnimalsCells
    44. Foster DA, Gadir N. [Can defective TGF-Beta signaling be an Achilles heel in human cancer?]. Ai Zheng. 2008 Aug; 27(8):882-4. PMID: 18710627.
      Citations: 4     Fields:    Translation:HumansCells
    45. Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res. 2008 Jul 01; 14(13):4267-74. PMID: 18594009.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    46. Bonis PA, Pickens GT, Rind DM, Foster DA. Association of a clinical knowledge support system with improved patient safety, reduced complications and shorter length of stay among Medicare beneficiaries in acute care hospitals in the United States. Int J Med Inform. 2008 Nov; 77(11):745-53. PMID: 18565788.
      Citations: 21     Fields:    Translation:Humans
    47. Shi M, Zheng Y, Garcia A, Xu L, Foster DA. Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras. Cancer Lett. 2007 Dec 18; 258(2):268-75. PMID: 17949898.
      Citations: 39     Fields:    Translation:HumansCells
    48. Gadir N, Lee E, Garcia A, Toschi A, Foster DA. Suppression of TGF-beta signaling by phospholipase D. Cell Cycle. 2007 Nov 15; 6(22):2840-5. PMID: 18032924.
      Citations: 10     Fields:    Translation:HumansCells
    49. Mor A, Campi G, Du G, Zheng Y, Foster DA, Dustin ML, Philips MR. The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol. 2007 Jun; 9(6):713-9. PMID: 17486117.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    50. Foster DA. Regulation of mTOR by phosphatidic acid? Cancer Res. 2007 Jan 01; 67(1):1-4. PMID: 17210675.
      Citations: 90     Fields:    Translation:HumansAnimals
    51. Rodrik V, Gomes E, Hui L, Rockwell P, Foster DA. Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells. FEBS Lett. 2006 Oct 16; 580(24):5647-52. PMID: 16996503.
      Citations: 18     Fields:    Translation:HumansCells
    52. Zheng Y, Rodrik V, Toschi A, Shi M, Hui L, Shen Y, Foster DA. Phospholipase D couples survival and migration signals in stress response of human cancer cells. J Biol Chem. 2006 Jun 09; 281(23):15862-8. PMID: 16595654.
      Citations: 74     Fields:    Translation:HumansCells
    53. Cai D, Netzer WJ, Zhong M, Lin Y, Du G, Frohman M, Foster DA, Sisodia SS, Xu H, Gorelick FS, Greengard P. Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1941-6. PMID: 16449386.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    54. Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1936-40. PMID: 16449385.
      Citations: 56     Fields:    Translation:AnimalsCells
    55. Rodrik V, Zheng Y, Harrow F, Chen Y, Foster DA. Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc. Mol Cell Biol. 2005 Sep; 25(17):7917-25. PMID: 16107734.
      Citations: 29     Fields:    Translation:HumansCells
    56. Hui L, Rodrik V, Pielak RM, Knirr S, Zheng Y, Foster DA. mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells. J Biol Chem. 2005 Oct 28; 280(43):35829-35. PMID: 16109716.
      Citations: 29     Fields:    Translation:HumansCells
    57. Jackson D, Zheng Y, Lyo D, Shen Y, Nakayama K, Nakayama KI, Humphries MJ, Reyland ME, Foster DA. Suppression of cell migration by protein kinase Cdelta. Oncogene. 2005 Apr 21; 24(18):3067-72. PMID: 15735725.
      Citations: 23     Fields:    Translation:Animals
    58. Chen Y, Rodrik V, Foster DA. Alternative phospholipase D/mTOR survival signal in human breast cancer cells. Oncogene. 2005 Jan 20; 24(4):672-9. PMID: 15580312.
      Citations: 51     Fields:    Translation:HumansCells
    59. Chen X, Hui L, Foster DA, Drain CM. Efficient synthesis and photodynamic activity of porphyrin-saccharide conjugates: targeting and incapacitating cancer cells. Biochemistry. 2004 Aug 31; 43(34):10918-29. PMID: 15323552.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    60. Foster DA. Targeting mTOR-mediated survival signals in anticancer therapeutic strategies. Expert Rev Anticancer Ther. 2004 Aug; 4(4):691-701. PMID: 15270672.
      Citations: 15     Fields:    Translation:HumansCells
    61. Hui L, Abbas T, Pielak RM, Joseph T, Bargonetti J, Foster DA. Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol Cell Biol. 2004 Jul; 24(13):5677-86. PMID: 15199126.
      Citations: 21     Fields:    Translation:AnimalsCells
    62. Jackson DN, Foster DA. The enigmatic protein kinase Cdelta: complex roles in cell proliferation and survival. FASEB J. 2004 Apr; 18(6):627-36. PMID: 15054085.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    63. Abbas T, White D, Hui L, Yoshida K, Foster DA, Bargonetti J. Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta. J Biol Chem. 2004 Mar 12; 279(11):9970-7. PMID: 14699137.
      Citations: 16     Fields:    Translation:HumansCells
    64. Foster DA, Xu L. Phospholipase D in cell proliferation and cancer. Mol Cancer Res. 2003 Sep; 1(11):789-800. PMID: 14517341.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    65. Chen Y, Zheng Y, Foster DA. Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene. 2003 Jun 19; 22(25):3937-42. PMID: 12813467.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    66. Zhong M, Shen Y, Zheng Y, Joseph T, Jackson D, Foster DA. Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun. 2003 Mar 14; 302(3):615-9. PMID: 12615079.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    67. Xu L, Frankel P, Jackson D, Rotunda T, Boshans RL, D'Souza-Schorey C, Foster DA. Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6. Mol Cell Biol. 2003 Jan; 23(2):645-54. PMID: 12509462.
      Citations: 23     Fields:    Translation:AnimalsCells
    68. Joseph T, Bryant A, Frankel P, Wooden R, Kerkhoff E, Rapp UR, Foster DA. Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling. Oncogene. 2002 May 16; 21(22):3651-8. PMID: 12032867.
      Citations: 17     Fields:    Translation:AnimalsCells
    69. Jiang Y, Lu Z, Zang Q, Foster DA. Regulation of phosphatidic acid phosphohydrolase by epidermal growth factor. Reduced association with the EGF receptor followed by increased association with protein kinase Cepsilon. J Biol Chem. 1996 Nov 22; 271(47):29529-32. PMID: 8939878.
      Citations: 5     Fields:    Translation:HumansCells
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