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Derrick Brazill

TitleProfessor of Biology
Faculty RankProfessor
InstitutionHunter College, CUNY
DepartmentBiological Sciences
AddressHunter College, CUNY
695 Park Avenue
New York NY 10021
Phone(212) 650-3144
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    Collapse Biography 
    Collapse awards and honors
    2005Presidential Early Career Award for Scientists and Engineers, USA
    2013Inaugural Dr. Milton J. Hernandez Lecture in Mentoring Excellence, NIH-NIAID

    Collapse Overview 
    Collapse overview
    Cancer is a major health issue in the United States. It is characterized by uncontrolled cell replication, leading to the formation of a tumor. If detected early, such a primary tumor remains localized and is easily removed by surgery. However, if left untreated, cells detach from the primary tumor, migrate into a blood vessel at one point in the body, and out at another, forming secondary tumors. These metastatic tumors can be much harder to identify and remove, as they often form at great distances from the original tumor. Thus, understanding and controlling how cells remain attached to each other and how they migrate is integral to treating cancer. To these ends, we have been studying how secreted factors regulate cell adhesion and motility. Regulation of adhesion and motility involves integrating signaling molecules and actin binding proteins. Phospholipase D (PLD) and paxillin are two such molecules which link signaling to the cytoskeleton. We hypothesize that these proteins form a complex, and work together to regulate cytoskeletal function. Unfortunately, studying human cells is difficult due to their immense complexity. Therefore, we study adhesion and motility in Dictyostelium discoideum, a simpler organism that displays many of the characteristics of human cells. We then apply what we have learned to breast cancer cells to better understand why they detach and migrate away from a primary tumor. This work is expected to identify novel targets for the development of pharmacological strategies designed to prevent the motility and invasiveness associated with cancer during metastasis, leading to more effective treatments and better health outcomes.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Santiago Z, Loustau J, Meretzky D, Rawal D, Brazill D. Advances in geometric techniques for analyzing blebbing in chemotaxing Dictyostelium cells. PLoS One. 2019; 14(2):e0211975. PMID: 30763409.
      Citations:    Fields:    Translation:AnimalsCells
    2. Singh S, Mohamed W, Aguessy A, Dyett E, Shah S, Khan M, Baskar R, Brazill D. Functional interaction of PkcA and PldB regulate aggregation and development in Dictyostelium discoideum. Cell Signal. 2017 06; 34:47-54. PMID: 28257811.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Brazill D. Chemotaxis: Under Agarose Assay. Methods Mol Biol. 2016; 1365:339-46. PMID: 26498795.
      Citations:    Fields:    Translation:Animals
    4. Mohamed W, Ray S, Brazill D, Baskar R. Absence of catalytic domain in a putative protein kinase C (PkcA) suppresses tip dominance in Dictyostelium discoideum. Dev Biol. 2015 Sep 01; 405(1):10-20. PMID: 26183108.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Garcia M, Ray S, Brown I, Irom J, Brazill D. PakD, a putative p21-activated protein kinase in Dictyostelium discoideum, regulates actin. Eukaryot Cell. 2014 Jan; 13(1):119-26. PMID: 24243792.
      Citations: 6     Fields:    Translation:AnimalsCells
    6. Garcia R, Nguyen L, Brazill D. Dictyostelium discoideum SecG interprets cAMP-mediated chemotactic signals to influence actin organization. Cytoskeleton (Hoboken). 2013 May; 70(5):269-80. PMID: 23564751.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Maharjan AS, Roife D, Brazill D, Gomer RH. Serum amyloid P inhibits granulocyte adhesion. Fibrogenesis Tissue Repair. 2013 Jan 17; 6(1):2. PMID: 23324174.
    8. Pribic J, Brazill D. Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells. Cell Signal. 2012 Aug; 24(8):1531-40. PMID: 22481092.
      Citations: 3     Fields:    Translation:HumansCells
    9. Pribic J, Garcia R, Kong M, Brazill D. Paxillin and phospholipase D interact to regulate actin-based processes in Dictyostelium discoideum. Eukaryot Cell. 2011 Jul; 10(7):977-84. PMID: 21531871.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Gomer RH, Jang W, Brazill D. Cell density sensing and size determination. Dev Growth Differ. 2011 May; 53(4):482-94. PMID: 21521184.
      Citations: 18     Fields:    Translation:AnimalsCells
    11. Ray S, Chen Y, Ayoung J, Hanna R, Brazill D. Phospholipase D controls Dictyostelium development by regulating G protein signaling. Cell Signal. 2011 Feb; 23(2):335-43. PMID: 20950684.
      Citations: 9     Fields:    Translation:AnimalsCells
    12. Duran MB, Rahman A, Colten M, Brazill D. Dictyostelium discoideum paxillin regulates actin-based processes. Protist. 2009 May; 160(2):221-32. PMID: 19213599.
      Citations: 7     Fields:    Translation:AnimalsCells
    13. Bakthavatsalam D, Brazill D, Gomer RH, Eichinger L, Rivero F, Noegel AA. A G protein-coupled receptor with a lipid kinase domain is involved in cell-density sensing. Curr Biol. 2007 May 15; 17(10):892-7. PMID: 17481898.
      Citations: 13     Fields:    Translation:AnimalsCells
    14. Thomason PA, Brazill DT, Cox EC. A series of Dictyostelium expression vectors for recombination cloning. Plasmid. 2006 Nov; 56(3):145-52. PMID: 16765443.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Chen Y, Rodrick V, Yan Y, Brazill D. PldB, a putative phospholipase D homologue in Dictyostelium discoideum mediates quorum sensing during development. Eukaryot Cell. 2005 Apr; 4(4):694-702. PMID: 15821129.
      Citations: 12     Fields:    Translation:AnimalsCells
    16. Gomer R, Brazill D. The versatile Dictyostelium discoideum. Meeting report: International Dictyostelium Conference 2002. Protist. 2003 Apr; 154(1):5-10. PMID: 12812366.
      Citations:    Fields:    Translation:AnimalsCells
    17. Bishop JD, Moon BC, Harrow F, Ratner D, Gomer RH, Dottin RP, Brazill DT. A second UDP-glucose pyrophosphorylase is required for differentiation and development in Dictyostelium discoideum. J Biol Chem. 2002 Sep 06; 277(36):32430-7. PMID: 12060658.
      Citations: 13     Fields:    Translation:AnimalsCells
    18. Brazill DT, Meyer LR, Hatton RD, Brock DA, Gomer RH. ABC transporters required for endocytosis and endosomal pH regulation in Dictyostelium. J Cell Sci. 2001 Nov; 114(Pt 21):3923-32. PMID: 11719559.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Azhar M, Kennady PK, Pande G, Espiritu M, Holloman W, Brazill D, Gomer RH, Nanjundiah V. Cell cycle phase, cellular Ca2+ and development in Dictyostelium discoideum. Int J Dev Biol. 2001 Apr; 45(2):405-14. PMID: 11330860.
      Citations: 11     Fields:    Translation:AnimalsCells
    20. Brazill DT, Caprette DR, Myler HA, Hatton RD, Ammann RR, Lindsey DF, Brock DA, Gomer RH. A protein containing a serine-rich domain with vesicle fusing properties mediates cell cycle-dependent cytosolic pH regulation. J Biol Chem. 2000 Jun 23; 275(25):19231-40. PMID: 10747962.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Brazill DT, Lindsey DF, Bishop JD, Gomer RH. Cell density sensing mediated by a G protein-coupled receptor activating phospholipase C. J Biol Chem. 1998 Apr 03; 273(14):8161-8. PMID: 9525920.
      Citations: 15     Fields:    Translation:AnimalsCells
    22. Brazill DT, Gundersen R, Gomer RH. A cell-density sensing factor regulates the lifetime of a chemoattractant-induced G alpha-GTP conformation. FEBS Lett. 1997 Mar 03; 404(1):100-4. PMID: 9074646.
      Citations: 6     Fields:    Translation:AnimalsCells
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