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Reza Khayat

Faculty RankAssistant
InstitutionCity College, CUNY
Address160 Convent Ave
Dept of Chemistry MR-1024
New York NY 10031
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    My research groups uses X-ray crystallography, cryo-electron microscopy, biochemistry, biophysics and cellular biology to detail the atomic resolution mechanism by which a number of human and non-human pathogens replicate within their host.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tarasova E, Dhindwal S, Popp M, Hussain S, Khayat R. Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus. mBio. 2021 08 31; 12(4):e0076321. PMID: 34311576.
      Citations:    Fields:    
    2. Khayat R, Russell RS. It is all about the Structure. Viral Immunol. 2021 Jan-Feb; 34(1):1-2. PMID: 33507134.
      Citations:    Fields:    
    3. Murphy EL, Singh KV, Avila B, Kleffmann T, Gregory ST, Murray BE, Krause KL, Khayat R, Jogl G. Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis. Sci Rep. 2020 10 01; 10(1):16301. PMID: 33004869.
      Citations: 1     Fields:    Translation:Cells
    4. Khayat R, Wen K, Alimova A, Gavrilov B, Katz A, Galarza JM, Gottlieb P. Structural characterization of the PCV2d virus-like particle at 3.3?Å resolution reveals differences to PCV2a and PCV2b capsids, a tetranucleotide, and an N-terminus near the icosahedral 3-fold axes. Virology. 2019 11; 537:186-197. PMID: 31505320.
      Citations: 1     Fields:    Translation:Cells
    5. Dhindwal S, Feng S, Khayat R. The Arginines in the N-Terminus of the Porcine Circovirus 2 Virus-like Particles Are Responsible for Disrupting the Membranes at Neutral and Acidic pH. J Mol Biol. 2019 08 09; 431(17):3261-3274. PMID: 31173778.
      Citations: 1     Fields:    Translation:Cells
    6. Dhindwal S, Avila B, Feng S, Khayat R. Porcine Circovirus 2 Uses a Multitude of Weak Binding Sites To Interact with Heparan Sulfate, and the Interactions Do Not Follow the Symmetry of the Capsid. J Virol. 2019 03 15; 93(6). PMID: 30602608.
      Citations: 12     Fields:    Translation:AnimalsCells
    7. Alphonse S, Itin B, Khayat R, Ghose R. Sequential Protein Expression and Capsid Assembly in Cell: Toward the Study of Multiprotein Viral Capsids Using Solid-State Nuclear Magnetic Resonance Techniques. Biochemistry. 2018 03 13; 57(10):1568-1571. PMID: 29465229.
      Citations:    Fields:    Translation:Cells
    8. Tarasova E, Farafonov V, Khayat R, Okimoto N, Komatsu TS, Taiji M, Nerukh D. All-Atom Molecular Dynamics Simulations of Entire Virus Capsid Reveal the Role of Ion Distribution in Capsid's Stability. J Phys Chem Lett. 2017 Feb 16; 8(4):779-784. PMID: 28129688.
      Citations: 12     Fields:    
    9. Wang N, Zhan Y, Wang A, Zhang L, Khayat R, Yang Y. In silico analysis of surface structure variation of PCV2 capsid resulting from loop mutations of its capsid protein (Cap). J Gen Virol. 2016 Dec; 97(12):3331-3344. PMID: 27902320.
      Citations: 9     Fields:    Translation:AnimalsCells
    10. Murin CD, Julien JP, Sok D, Stanfield RL, Khayat R, Cupo A, Moore JP, Burton DR, Wilson IA, Ward AB. Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy. J Virol. 2014 Sep 01; 88(17):10177-88. PMID: 24965454.
      Citations: 42     Fields:    Translation:Cells
    11. Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Architecture of a dsDNA viral capsid in complex with its maturation protease. Structure. 2014 Feb 04; 22(2):230-7. PMID: 24361271.
      Citations: 15     Fields:    Translation:Cells
    12. Khayat R, Lee JH, Julien JP, Cupo A, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers. J Virol. 2013 Sep; 87(17):9865-72. PMID: 23824817.
      Citations: 55     Fields:    Translation:HumansCells
    13. Klasse PJ, Depetris RS, Pejchal R, Julien JP, Khayat R, Lee JH, Marozsan AJ, Cupo A, Cocco N, Korzun J, Yasmeen A, Ward AB, Wilson IA, Sanders RW, Moore JP. Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein. J Virol. 2013 Sep; 87(17):9873-85. PMID: 23824824.
      Citations: 61     Fields:    Translation:HumansCells
    14. Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat Struct Mol Biol. 2013 Jul; 20(7):796-803. PMID: 23708606.
      Citations: 210     Fields:    Translation:HumansCells
    15. Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, Paulson JC, Sanders RW, Moore JP, Burton DR, Poignard P, Ward AB, Wilson IA. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathog. 2013; 9(5):e1003342. PMID: 23658524.
      Citations: 174     Fields:    Translation:HumansCells
    16. Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature. 2012 Sep 27; 489(7417):526-32. PMID: 22982990.
      Citations: 236     Fields:    Translation:AnimalsCells
    17. Schneemann A, Speir JA, Tan GS, Khayat R, Ekiert DC, Matsuoka Y, Wilson IA. A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin. J Virol. 2012 Nov; 86(21):11686-97. PMID: 22896619.
      Citations: 29     Fields:    Translation:AnimalsCells
    18. Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin Ö, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH. Highly conserved protective epitopes on influenza B viruses. Science. 2012 Sep 14; 337(6100):1343-8. PMID: 22878502.
      Citations: 368     Fields:    Translation:HumansAnimalsCells
    19. Depetris RS, Julien JP, Khayat R, Lee JH, Pejchal R, Katpally U, Cocco N, Kachare M, Massi E, David KB, Cupo A, Marozsan AJ, Olson WC, Ward AB, Wilson IA, Sanders RW, Moore JP. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers. J Biol Chem. 2012 Jul 13; 287(29):24239-54. PMID: 22645128.
      Citations: 40     Fields:    Translation:HumansCells
    20. McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Kwon YD, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature. 2011 Nov 23; 480(7377):336-43. PMID: 22113616.
      Citations: 513     Fields:    Translation:Cells
    21. Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science. 2011 Nov 25; 334(6059):1097-103. PMID: 21998254.
      Citations: 422     Fields:    Translation:HumansCells
    22. Khayat R, Johnson JE. Pass the jelly rolls. Structure. 2011 Jul 13; 19(7):904-6. PMID: 21742257.
      Citations: 7     Fields:    
    23. Khayat R, Brunn N, Speir JA, Hardham JM, Ankenbauer RG, Schneemann A, Johnson JE. The 2.3-angstrom structure of porcine circovirus 2. J Virol. 2011 Aug; 85(15):7856-62. PMID: 21632760.
      Citations: 50     Fields:    Translation:Cells
    24. Wang K, Fu CY, Khayat R, Doerschuk PC, Johnson JE. In vivo virus structures: simultaneous classification, resolution enhancement, and noise reduction in whole-cell electron tomography. J Struct Biol. 2011 Jun; 174(3):425-33. PMID: 21396453.
      Citations: 1     Fields:    Translation:Cells
    25. Huang RK, Khayat R, Lee KK, Gertsman I, Duda RL, Hendrix RW, Johnson JE. The Prohead-I structure of bacteriophage HK97: implications for scaffold-mediated control of particle assembly and maturation. J Mol Biol. 2011 May 06; 408(3):541-54. PMID: 21276801.
      Citations: 32     Fields:    Translation:AnimalsCells
    26. Fu CY, Wang K, Gan L, Lanman J, Khayat R, Young MJ, Jensen GJ, Doerschuk PC, Johnson JE. In vivo assembly of an archaeal virus studied with whole-cell electron cryotomography. Structure. 2010 Dec 08; 18(12):1579-86. PMID: 21134637.
      Citations: 31     Fields:    Translation:Cells
    27. Matsui T, Lander GC, Khayat R, Johnson JE. Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14111-5. PMID: 20660783.
      Citations: 11     Fields:    Translation:AnimalsCells
    28. Khayat R, Fu CY, Ortmann AC, Young MJ, Johnson JE. The architecture and chemical stability of the archaeal Sulfolobus turreted icosahedral virus. J Virol. 2010 Sep; 84(18):9575-83. PMID: 20592081.
      Citations: 15     Fields:    Translation:Cells
    29. Parent KN, Khayat R, Tu LH, Suhanovsky MM, Cortines JR, Teschke CM, Johnson JE, Baker TS. P22 coat protein structures reveal a novel mechanism for capsid maturation: stability without auxiliary proteins or chemical crosslinks. Structure. 2010 Mar 10; 18(3):390-401. PMID: 20223221.
      Citations: 67     Fields:    Translation:Cells
    30. Khayat R, Lander GC, Johnson JE. An automated procedure for detecting protein folds from sub-nanometer resolution electron density. J Struct Biol. 2010 Jun; 170(3):513-21. PMID: 20026407.
      Citations: 6     Fields:    Translation:AnimalsCells
    31. Lander GC, Khayat R, Li R, Prevelige PE, Potter CS, Carragher B, Johnson JE. The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit. Structure. 2009 Jun 10; 17(6):789-99. PMID: 19523897.
      Citations: 34     Fields:    Translation:Cells
    32. Banerjee M, Khayat R, Walukiewicz HE, Odegard AL, Schneemann A, Johnson JE. Dissecting the functional domains of a nonenveloped virus membrane penetration peptide. J Virol. 2009 Jul; 83(13):6929-33. PMID: 19369344.
      Citations: 16     Fields:    Translation:Cells
    33. Lawrence CM, Menon S, Eilers BJ, Bothner B, Khayat R, Douglas T, Young MJ. Structural and functional studies of archaeal viruses. J Biol Chem. 2009 May 08; 284(19):12599-603. PMID: 19158076.
      Citations: 40     Fields:    Translation:Cells
    34. Maaty WS, Ortmann AC, Dlakic M, Schulstad K, Hilmer JK, Liepold L, Weidenheft B, Khayat R, Douglas T, Young MJ, Bothner B. Characterization of the archaeal thermophile Sulfolobus turreted icosahedral virus validates an evolutionary link among double-stranded DNA viruses from all domains of life. J Virol. 2006 Aug; 80(15):7625-35. PMID: 16840341.
      Citations: 46     Fields:    Translation:Cells
    35. Khayat R, Tang L, Larson ET, Lawrence CM, Young M, Johnson JE. Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18944-9. PMID: 16357204.
      Citations: 86     Fields:    Translation:Cells
    36. Annedi SC, Biabani F, Poduch E, Mannargudi BM, Majumder K, Wei L, Khayat R, Tong L, Kotra LP. Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture. Bioorg Med Chem. 2006 Jan 01; 14(1):214-36. PMID: 16198572.
      Citations: 3     Fields:    Translation:Cells
    37. Khayat R, Batra R, Bebernitz GA, Olson MW, Tong L. Characterization of the monomer-dimer equilibrium of human cytomegalovirus protease by kinetic methods. Biochemistry. 2004 Jan 20; 43(2):316-22. PMID: 14717585.
      Citations: 5     Fields:    Translation:HumansCells
    38. Tao X, Khayat R, Christendat D, Savchenko A, Xu X, Goldsmith-Fischman S, Honig B, Edwards A, Arrowsmith CH, Tong L. Crystal structures of MTH1187 and its yeast ortholog YBL001c. Proteins. 2003 Aug 15; 52(3):478-80. PMID: 12866058.
      Citations: 4     Fields:    Translation:AnimalsCells
    39. Khayat R, Batra R, Qian C, Halmos T, Bailey M, Tong L. Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease. Biochemistry. 2003 Feb 04; 42(4):885-91. PMID: 12549906.
      Citations: 4     Fields:    Translation:HumansCells
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