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David Jeruzalmi, PhD

TitleProfessor
Faculty RankProfessor
InstitutionCity College, CUNY
DepartmentChemistry and Biochemistry
Address160 Convent Ave
85 St. Nicholas Terrace
New York NY 10031
Phone22-650-6062
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gao N, Mazzoletti D, Peng A, Olinares PDB, Morrone C, Garavaglia A, Gouda N, Tsoy S, Mendoza A, Chowdhury A, Cerullo A, Bhavsar H, Rossi F, Rizzi M, Chait BT, Miggiano R, Jeruzalmi D. DnaB and DciA: mechanisms of helicase loading and translocation on ssDNA. Nucleic Acids Res. 2025 Jun 20; 53(12). PMID: 40598899.
      Citations:    Fields:    Translation:Cells
    2. Shatarupa A, Brown D, Olinares PDB, Chase J, Isiorho E, Chait BT, Jeruzalmi D. Distinct Quaternary States, Intermediates, and Autoinhibition During Loading of the DnaB-Replicative Helicase by the Phage ?P Helicase Loader. bioRxiv. 2025 Jun 02. PMID: 40501539.
      Citations:    
    3. Gemeinhardt TM, Regy RM, Phan TM, Pal N, Sharma J, Senkovich O, Mendiola AJ, Ledterman HJ, Henrickson A, Lopes D, Kapoor U, Bihani A, Sihou D, Kim YC, Jeruzalmi D, Demeler B, Kim CA, Mittal J, Francis NJ. A disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization. Mol Cell. 2025 Jun 05; 85(11):2128-2146.e15. PMID: 40441156.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Gao N, Mazzoletti D, Peng A, Olinares PDB, Morrone C, Garavaglia A, Gouda N, Tsoy S, Mendoza A, Chowdhury A, Cerullo A, Bhavsar H, Rossi F, Rizzi M, Chait BT, Miggiano R, Jeruzalmi D. DnaB and DciA: Mechanisms of Helicase Loading and Translocation on ssDNA. bioRxiv. 2025 May 14. PMID: 39574654.
      Citations:    
    5. Genta M, Ferrara G, Capelli R, Rondelli D, Sertic S, Bolognesi M, Rizzi M, Rossi F, Jeruzalmi D, Chaves-Sanjuan A, Miggiano R. Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair. Nat Commun. 2025 Apr 10; 16(1):3416. PMID: 40210888.
      Citations:    Fields:    Translation:Cells
    6. Gemeinhardt TM, Regy RM, Phan TM, Pal N, Sharma J, Senkovich O, Mendiola AJ, Ledterman HJ, Henrickson A, Lopes D, Kapoor U, Bihani A, Sihou D, Kim YC, Jeruzalmi D, Demeler B, Kim CA, Mittal J, Francis NJ. How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization. bioRxiv. 2025 Feb 26. PMID: 37961422.
      Citations:    
    7. Piserchio A, Isiorho EA, Long K, Bohanon AL, Kumar EA, Will N, Jeruzalmi D, Dalby KN, Ghose R. Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase. Sci Adv. 2022 Jul 08; 8(27):eabo2039. PMID: 35857468.
      Citations: 7     Fields:    
    8. Jeruzalmi D. The partner-swapping sliding clamp loader exposed. Nat Struct Mol Biol. 2022 04; 29(4):283-286. PMID: 35410371.
      Citations:    Fields:    Translation:Cells
    9. Chase J, Berger J, Jeruzalmi D. Convergent evolution in two bacterial replicative helicase loaders. Trends Biochem Sci. 2022 07; 47(7):620-630. PMID: 35351361.
      Citations: 7     Fields:    Translation:Cells
    10. Kraithong T, Hartley S, Jeruzalmi D, Pakotiprapha D. A Peek Inside the Machines of Bacterial Nucleotide Excision Repair. Int J Mol Sci. 2021 Jan 19; 22(2). PMID: 33477956.
      Citations: 17     Fields:    Translation:Cells
    11. Kraithong T, Sucharitakul J, Buranachai C, Jeruzalmi D, Chaiyen P, Pakotiprapha D. Real-time investigation of the roles of ATP hydrolysis by UvrA and UvrB during DNA damage recognition in nucleotide excision repair. DNA Repair (Amst). 2021 01; 97:103024. PMID: 33302090.
      Citations: 6     Fields:    Translation:Cells
    12. Homchan A, Sukted J, Mongkolsuk S, Jeruzalmi D, Matangkasombut O, Pakotiprapha D. Wss1 homolog from Candida albicans and its role in DNA-protein crosslink tolerance. Mol Microbiol. 2020 09; 114(3):409-422. PMID: 32302440.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Case BC, Hartley S, Osuga M, Jeruzalmi D, Hingorani MM. The ATPase mechanism of UvrA2 reveals the distinct roles of proximal and distal ATPase sites in nucleotide excision repair. Nucleic Acids Res. 2019 05 07; 47(8):4136-4152. PMID: 30892613.
      Citations: 11     Fields:    Translation:Cells
    14. Chase J, Catalano A, Noble AJ, Eng ET, Olinares PD, Molloy K, Pakotiprapha D, Samuels M, Chait B, des Georges A, Jeruzalmi D. Mechanisms of opening and closing of the bacterial replicative helicase. Elife. 2018 12 24; 7. PMID: 30582519.
      Citations: 15     Fields:    Translation:Cells
    15. Noble AJ, Dandey VP, Wei H, Brasch J, Chase J, Acharya P, Tan YZ, Zhang Z, Kim LY, Scapin G, Rapp M, Eng ET, Rice WJ, Cheng A, Negro CJ, Shapiro L, Kwong PD, Jeruzalmi D, des Georges A, Potter CS, Carragher B. Routine single particle CryoEM sample and grid characterization by tomography. Elife. 2018 05 29; 7. PMID: 29809143.
      Citations: 158     Fields:    Translation:AnimalsCells
    16. Orlova N, Gerding M, Ivashkiv O, Olinares PDB, Chait BT, Waldor MK, Jeruzalmi D. The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators. Nucleic Acids Res. 2017 04 20; 45(7):3724-3737. PMID: 28031373.
      Citations: 20     Fields:    Translation:Cells
    17. Kraithong T, Channgam K, Itsathitphaisarn O, Tiensuwan M, Jeruzalmi D, Pakotiprapha D. Movement of the ?-hairpin in the third zinc-binding module of UvrA is required for DNA damage recognition. DNA Repair (Amst). 2017 03; 51:60-69. PMID: 28209516.
      Citations: 6     Fields:    Translation:Cells
    18. Pakotiprapha D, Jeruzalmi D. Small-angle X-ray scattering reveals architecture and A2B2 stoichiometry of the UvrA-UvrB DNA damage sensor. Proteins. 2013 Jan; 81(1):132-9. PMID: 22933319.
      Citations: 11     Fields:    Translation:Cells
    19. Pakotiprapha D, Samuels M, Shen K, Hu JH, Jeruzalmi D. Structure and mechanism of the UvrA-UvrB DNA damage sensor. Nat Struct Mol Biol. 2012 Feb 05; 19(3):291-8. PMID: 22307053.
      Citations: 50     Fields:    Translation:Cells
    20. Muecke M, Samuels M, Davey M, Jeruzalmi D. Preparation of Multimilligram Quantities of Large, Linear DNA Molecules for Structural Studies. Structure. 2009 Dec 09; 17(12):1679. PMID: 28903019.
      Citations:    Fields:    
    21. Lu M, Yang J, Ren Z, Sabui S, Espejo A, Bedford MT, Jacobson RH, Jeruzalmi D, McMurray JS, Chen X. Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. J Mol Biol. 2009 Oct 23; 393(2):397-408. PMID: 19660470.
      Citations: 5     Fields:    Translation:HumansCells
    22. Samuels M, Gulati G, Shin JH, Opara R, McSweeney E, Sekedat M, Long S, Kelman Z, Jeruzalmi D. A biochemically active MCM-like helicase in Bacillus cereus. Nucleic Acids Res. 2009 Jul; 37(13):4441-52. PMID: 19474351.
      Citations: 6     Fields:    Translation:Cells
    23. Jeruzalmi D. Enzymatic synthesis of multi-milligram quantities of large, linear DNA molecules for structural studies. Cold Spring Harb Protoc. 2009 Apr; 2009(4):pdb.prot5197. PMID: 20147140.
      Citations:    Fields:    
    24. Pakotiprapha D, Liu Y, Verdine GL, Jeruzalmi D. A structural model for the damage-sensing complex in bacterial nucleotide excision repair. J Biol Chem. 2009 May 08; 284(19):12837-44. PMID: 19287003.
      Citations: 32     Fields:    Translation:Cells
    25. Muecke M, Samuels M, Davey M, Jeruzalmi D. Preparation of multimilligram quantities of large, linear DNA molecules for structural studies. Structure. 2008 Jun; 16(6):837-41. PMID: 18547516.
      Citations: 4     Fields:    
    26. Pakotiprapha D, Inuzuka Y, Bowman BR, Moolenaar GF, Goosen N, Jeruzalmi D, Verdine GL. Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding. Mol Cell. 2008 Jan 18; 29(1):122-33. PMID: 18158267.
      Citations: 51     Fields:    Translation:Cells
    27. Jeruzalmi D. First analysis of macromolecular crystals: biochemistry and x-ray diffraction. Methods Mol Biol. 2007; 364:43-62. PMID: 17172760.
      Citations: 2     Fields:    Translation:Cells
    28. O'Donnell M, Jeruzalmi D. Helical proteins initiate replication of DNA helices. Nat Struct Mol Biol. 2006 Aug; 13(8):665-7. PMID: 16886004.
      Citations: 6     Fields:    Translation:Cells
    29. Jeruzalmi D. The opened processivity clamp slides into view. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):14939-40. PMID: 16217036.
      Citations:    Fields:    Translation:Cells
    30. Jeruzalmi D. Chromosomal DNA replication on a protein "chip". Structure. 2004 Dec; 12(12):2100-2. PMID: 15576024.
      Citations:    Fields:    Translation:Cells
    31. Davey MJ, Jeruzalmi D, Kuriyan J, O'Donnell M. Motors and switches: AAA+ machines within the replisome. Nat Rev Mol Cell Biol. 2002 Nov; 3(11):826-35. PMID: 12415300.
      Citations: 76     Fields:    Translation:HumansCells
    32. Jeruzalmi D, O'Donnell M, Kuriyan J. Clamp loaders and sliding clamps. Curr Opin Struct Biol. 2002 Apr; 12(2):217-24. PMID: 11959500.
      Citations: 67     Fields:    Translation:HumansCells
    33. Bruck I, Yuzhakov A, Yurieva O, Jeruzalmi D, Skangalis M, Kuriyan J, O'Donnell M. Analysis of a multicomponent thermostable DNA polymerase III replicase from an extreme thermophile. J Biol Chem. 2002 May 10; 277(19):17334-48. PMID: 11859073.
      Citations: 10     Fields:    Translation:AnimalsCells
    34. O'Donnell M, Jeruzalmi D, Kuriyan J. Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC. Curr Biol. 2001 Nov 13; 11(22):R935-46. PMID: 11719243.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    35. Jeruzalmi D, Yurieva O, Zhao Y, Young M, Stewart J, Hingorani M, O'Donnell M, Kuriyan J. Mechanism of processivity clamp opening by the delta subunit wrench of the clamp loader complex of E. coli DNA polymerase III. Cell. 2001 Aug 24; 106(4):417-28. PMID: 11525728.
      Citations: 115     Fields:    Translation:Cells
    36. Jeruzalmi D, O'Donnell M, Kuriyan J. Crystal structure of the processivity clamp loader gamma (gamma) complex of E. coli DNA polymerase III. Cell. 2001 Aug 24; 106(4):429-41. PMID: 11525729.
      Citations: 144     Fields:    Translation:Cells
    37. Jeruzalmi D, Kuriyan J, Doudna J. Paul Sigler (1934-2000). Trends Biochem Sci. 2000 May; 25(5):221-2. PMID: 10782089.
      Citations:    Fields:    Translation:Cells
    38. Moarefi I, Jeruzalmi D, Turner J, O'Donnell M, Kuriyan J. Crystal structure of the DNA polymerase processivity factor of T4 bacteriophage. J Mol Biol. 2000 Mar 10; 296(5):1215-23. PMID: 10698628.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    39. Zhao Y, Jeruzalmi D, Moarefi I, Leighton L, Lasken R, Kuriyan J. Crystal structure of an archaebacterial DNA polymerase. Structure. 1999 Oct 15; 7(10):1189-99. PMID: 10545321.
      Citations: 33     Fields:    Translation:HumansCells
    40. Cheetham GM, Jeruzalmi D, Steitz TA. Structural basis for initiation of transcription from an RNA polymerase-promoter complex. Nature. 1999 May 06; 399(6731):80-3. PMID: 10331394.
      Citations: 125     Fields:    Translation:Cells
    41. Jeruzalmi D, Steitz TA. Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme. EMBO J. 1998 Jul 15; 17(14):4101-13. PMID: 9670025.
      Citations: 59     Fields:    Translation:Cells
    42. Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE, Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. 1998 May 29; 93(5):827-39. PMID: 9630226.
      Citations: 232     Fields:    Translation:HumansCells
    43. Cheetham GM, Jeruzalmi D, Steitz TA. Transcription regulation, initiation, and "DNA scrunching" by T7 RNA polymerase. Cold Spring Harb Symp Quant Biol. 1998; 63:263-7. PMID: 10384290.
      Citations: 12     Fields:    Translation:Cells
    44. Jeruzalmi D, Steitz TA. Use of organic cosmotropic solutes to crystallize flexible proteins: application to T7 RNA polymerase and its complex with the inhibitor T7 lysozyme. J Mol Biol. 1997 Dec 19; 274(5):748-56. PMID: 9405156.
      Citations: 11     Fields:    Translation:Cells
    45. Abdel-Meguid SS, Jeruzalmi D, Sanderson MR. Preliminary characterization of crystals. Methods Mol Biol. 1996; 56:55-86. PMID: 8781242.
      Citations: 1     Fields:    Translation:Cells
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