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Zhenbang Chen

Faculty RankAssociate Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr. D B Todd Jr. Blvd
Nashville TN 37208
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    Other Positions
    TitleMember of Vanderbilt-Ingram Cancer Center
    InstitutionVanderbilt University

    Collapse Biography 
    Collapse awards and honors
    2005Member, American Association for the Advancement of Science
    2008Member, American Association for Cancer Research
    2009Member, Society for Basic Urological Research
    2010 - 2012Faculty Scholar Award in Cancer Research, AACR Minority-Serving Institution
    2011 - 2024Ad hoc reviewer, NIH study section
    2012Ad hoc reviewer, Tumor Cell Biology (TCB) study section of NIH
    2012 - 2013Ad hoc reviewer, NIHMD SEP/IAM study section of NIH
    2010Ad hoc reviewer, DOD study section
    2013 - 2024Ad hoc reviewer, DOD study section

    Collapse Overview 
    Collapse overview
    Prostate cancer is the leading life-threatening malignancy in American men, and novel mechanisms and therapeutic approaches can lead to reduce the morbidity and the mortality of prostate cancer. I have obtained extensive and intensive training on molecular biology and prostate cancer research using both cultured cells and animal models in Dr. Pier Paolo Pandolfi’s laboratory at Memorial Sloan-Kettering Cancer Center and Beth Israel Deaconess Medical Center/Harvard University. My research focuses on dysregulated signaling pathways in prostate cancer. My expertise and contributions to cancer research are demonstrated by my publications in several high-impact journals including Nature, Nature Genetics, Cell and Science Signaling etc. I laid the groundwork on PTEN-loss induced cellular senescence in vivo and its implication as a novel anticancer mechanism to suppress cancer progression. As PI and Co-investigator on several projects funded by my university, DoD and NIH, I have made very important discoveries on Pten-loss dysregulated pathways in prostate cancer including Castration Resistant Prostate Cancer, and projects have produced several peer-reviewed publications. In addition, I have successfully administered these research projects from training people, budget plan, and progress reports to publications. More importantly, I am fully aware of the challenges and importance of generating a realistic plan and keeping frequent communication among project members. I have established strong collaborations with investigators from other institutions in the US and other countries on prostate cancer research.

    Collapse Research 
    Collapse research activities and funding
    R01MD004038     (CHEN, ZHENBANG)Sep 25, 2009 - Apr 30, 2015
    Pten-loss Dysregulated Pathways in Prostate Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondr?cek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engstr?m W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142.
      Citations: 85     Fields:    Translation:HumansAnimalsPHPublic Health
    2. Ochieng J, Nangami GN, Ogunkua O, Miousse IR, Koturbash I, Odero-Marah V, McCawley LJ, Nangia-Makker P, Ahmed N, Luqmani Y, Chen Z, Papagerakis S, Wolf GT, Dong C, Zhou BP, Brown DG, Colacci AM, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Al-Temaimi R, Al-Mulla F, Bisson WH, Eltom SE. The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis. 2015 Jun; 36 Suppl 1:S128-59. PMID: 26106135.
      Citations: 18     Fields:    Translation:HumansAnimalsPHPublic Health
    3. Chen Z, Lu W. Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications. Int J Mol Sci. 2015 Feb 27; 16(3):4560-80. PMID: 25734985.
      Citations: 23     Fields:    Translation:HumansCells
    4. Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, Ballard BR, Nakayama KI, Matusik RJ, Chen Z. SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Oncotarget. 2015 Jan 20; 6(2):771-88. PMID: 25596733.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    5. Grabowska MM, DeGraff DJ, Yu X, Jin RJ, Chen Z, Borowsky AD, Matusik RJ. Mouse models of prostate cancer: picking the best model for the question. Cancer Metastasis Rev. 2014 Sep; 33(2-3):377-97. PMID: 24452759.
      Citations: 59     Fields:    Translation:HumansAnimals
    6. Xie Y, Lu W, Liu S, Yang Q, Carver BS, Li E, Wang Y, Fazli L, Gleave M, Chen Z. Crosstalk between nuclear MET and SOX9/?-catenin correlates with castration-resistant prostate cancer. Mol Endocrinol. 2014 Oct; 28(10):1629-39. PMID: 25099011.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    7. Xie Y, Liu S, Lu W, Yang Q, Williams KD, Binhazim AA, Carver BS, Matusik RJ, Chen Z. Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis. Mol Oncol. 2014 Oct; 8(7):1355-64. PMID: 24910389.
      Citations: 33     Fields:    Translation:HumansAnimals
    8. Li B, Lu W, Chen Z. Regulation of Androgen Receptor by E3 Ubiquitin Ligases: for More or Less. Receptors Clin Investig. 2014; 1(5). PMID: 25152898.
    9. Li B, Lu W, Yang Q, Yu X, Matusik RJ, Chen Z. Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer. Prostate. 2014 Apr; 74(4):421-32. PMID: 24347472.
      Citations: 32     Fields:    Translation:HumansCells
    10. Wang G, Lunardi A, Zhang J, Chen Z, Ala U, Webster KA, Tay Y, Gonzalez-Billalabeitia E, Egia A, Shaffer DR, Carver B, Liu XS, Taulli R, Kuo WP, Nardella C, Signoretti S, Cordon-Cardo C, Gerald WL, Pandolfi PP. Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion. Nat Genet. 2013 Jul; 45(7):739-746. PMID: 23727861.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    11. Lu W, Xie Y, Ma Y, Matusik RJ, Chen Z. ARF represses androgen receptor transactivation in prostate cancer. Mol Endocrinol. 2013 Apr; 27(4):635-48. PMID: 23449888.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    12. Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD. Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus. Sci Signal. 2012 Oct 23; 5(247):ra77. PMID: 23092893.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    13. Zhang Q, Liu S, Ge D, Zhang Q, Xue Y, Xiong Z, Abdel-Mageed AB, Myers L, Hill SM, Rowan BG, Sartor O, Melamed J, Chen Z, You Z. Interleukin-17 promotes formation and growth of prostate adenocarcinoma in mouse models. Cancer Res. 2012 May 15; 72(10):2589-99. PMID: 22461511.
      Citations: 61     Fields:    Translation:Animals
    14. Pandhare-Dash J, Mantri CK, Gong Y, Chen Z, Dash C. XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1). Prostate. 2012 Jun 01; 72(8):886-97. PMID: 21932423.
      Citations: 10     Fields:    Translation:HumansCells
    15. Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature. 2010 Mar 18; 464(7287):374-9. PMID: 20237562.
      Citations: 224     Fields:    Translation:AnimalsCells
    16. Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest. 2010 Mar; 120(3):681-93. PMID: 20197621.
      Citations: 188     Fields:    Translation:HumansAnimalsCells
    17. Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal. 2009 Aug 18; 2(84):ra44. PMID: 19690330.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    18. Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP. Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet. 2009 May; 41(5):619-24. PMID: 19396168.
      Citations: 344     Fields:    Translation:HumansAnimalsCells
    19. Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol. 2009 Apr; 11(4):420-32. PMID: 19270694.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    20. Carver BS, Tran J, Chen Z, Carracedo-Perez A, Alimonti A, Nardella C, Gopalan A, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP. ETS rearrangements and prostate cancer initiation. Nature. 2009 Feb 12; 457(7231):E1; discussion E2-3. PMID: 19212347.
      Citations: 59     Fields:    Translation:Animals
    21. Nardella C, Carracedo A, Alimonti A, Hobbs RM, Clohessy JG, Chen Z, Egia A, Fornari A, Fiorentino M, Loda M, Kozma SC, Thomas G, Cordon-Cardo C, Pandolfi PP. Differential requirement of mTOR in postmitotic tissues and tumorigenesis. Sci Signal. 2009 Jan 27; 2(55):ra2. PMID: 19176516.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    22. Nardella C, Chen Z, Salmena L, Carracedo A, Alimonti A, Egia A, Carver B, Gerald W, Cordon-Cardo C, Pandolfi PP. Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev. 2008 Aug 15; 22(16):2172-7. PMID: 18708577.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    23. Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 2007 Jan 12; 128(1):141-56. PMID: 17218261.
      Citations: 383     Fields:    Translation:HumansAnimalsCells
    24. Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN. Cell. 2007 Jan 12; 128(1):129-39. PMID: 17218260.
      Citations: 358     Fields:    Translation:HumansAnimalsCells
    25. Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M, Koutcher JA, Scher HI, Ludwig T, Gerald W, Cordon-Cardo C, Pandolfi PP. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005 Aug 04; 436(7051):725-30. PMID: 16079851.
      Citations: 978     Fields:    Translation:AnimalsCells
    26. Ma L, Teruya-Feldstein J, Behrendt N, Chen Z, Noda T, Hino O, Cordon-Cardo C, Pandolfi PP. Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev. 2005 Aug 01; 19(15):1779-86. PMID: 16027168.
      Citations: 52     Fields:    Translation:AnimalsCells
    27. Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell. 2005 Apr 22; 121(2):179-93. PMID: 15851026.
      Citations: 607     Fields:    Translation:HumansAnimalsCells
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