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Waldemar Popik

Faculty RankAssociate Professor
InstitutionMeharry Medical College
DepartmentInternal Medicine Center for AIDS Health Disparities Research
AddressMeharry Medical College
1005 D. B. Todd Blvd
Nashville TN 37208
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    Collapse Research 
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    R21DK089980     (POPIK, WALDEMAR)Aug 1, 2010 - Jul 31, 2013
    Mechanism of HIV-1 infection of urinary podocytes in HIVAN
    Role: Principal Investigator

    R21DK094735     (POPIK, WALDEMAR)Sep 24, 2012 - Aug 31, 2015
    Role of APOL1 in HIVAN pathogenesis
    Role: Principal Investigator

    R21DA052832     (POPIK, WALDEMAR)Apr 1, 2021 - Mar 31, 2023
    Mitochondrial DNA content in blood extracellular vesicles as a biomarker of neuronal mitochondrial DNA damage induced by cigarette smoking in virally suppressed, HIV-positive African Americans
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Davis SE, Khatua AK, Popik W. Nucleosomal dsDNA Stimulates APOL1 Expression in Human Cultured Podocytes by Activating the cGAS/IFI16-STING Signaling Pathway. Sci Rep. 2019 10 29; 9(1):15485. PMID: 31664093.
      Citations: 4     Fields:    Translation:HumansCells
    2. Popik W, Khatua AK, Fabre NF, Hildreth JEK, Alcendor DJ. BK Virus Replication in the Glomerular Vascular Unit: Implications for BK Virus Associated Nephropathy. Viruses. 2019 06 27; 11(7). PMID: 31252545.
      Citations: 4     Fields:    Translation:HumansCells
    3. Kumar V, Vashistha H, Lan X, Chandel N, Ayasolla K, Shoshtari SSM, Aslam R, Paliwal N, Abbruscato F, Mikulak J, Popik W, Atta MG, Chander PN, Malhotra A, Meyer-Schwesinger C, Skorecki K, Singhal PC. Role of Apolipoprotein L1 in Human Parietal Epithelial Cell Transition. Am J Pathol. 2018 11; 188(11):2508-2528. PMID: 30201495.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    4. Cheatham AM, Davis SE, Khatua AK, Popik W. Blocking the 5' splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch. Sci Rep. 2018 06 07; 8(1):8739. PMID: 29880816.
      Citations: 4     Fields:    Translation:HumansCells
    5. Popik W, Correa H, Khatua A, Aronoff DM, Alcendor DJ. Mesangial cells, specialized renal pericytes and cytomegalovirus infectivity: Implications for HCMV pathology in the glomerular vascular unit and post-transplant renal disease. J Transl Sci. 2019 Feb; 5(1). PMID: 29977613.
    6. Popik W, Khatua A, Hildreth JEK, Lee B, Alcendor DJ. Phosphorodiamidate morpholino targeting the 5' untranslated region of the ZIKV RNA inhibits virus replication. Virology. 2018 06; 519:77-85. PMID: 29679791.
      Citations: 1     Fields:    Translation:HumansCells
    7. Mishra A, Ayasolla K, Kumar V, Lan X, Vashistha H, Aslam R, Hussain A, Chowdhary S, Marashi Shoshtari S, Paliwal N, Popik W, Saleem MA, Malhotra A, Meggs LG, Skorecki K, Singhal PC. Modulation of apolipoprotein L1-microRNA-193a axis prevents podocyte dedifferentiation in high-glucose milieu. Am J Physiol Renal Physiol. 2018 05 01; 314(5):F832-F843. PMID: 29357419.
      Citations: 10     Fields:    Translation:HumansCells
    8. Haque S, Patil G, Mishra A, Lan X, Popik W, Malhotra A, Skorecki K, Singhal PC. Effect of APOL1 disease risk variants on APOL1 gene product. Biosci Rep. 2017 04 30; 37(2). PMID: 28385815.
      Citations: 6     Fields:    Translation:HumansCells
    9. Haque S, Lan X, Wen H, Lederman R, Chawla A, Attia M, Bongu RP, Husain M, Mikulak J, Saleem MA, Popik W, Malhotra A, Chander PN, Singhal PC. HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy. Am J Pathol. 2016 Feb; 186(2):347-58. PMID: 26683666.
      Citations: 27     Fields:    Translation:AnimalsCells
    10. Lan X, Wen H, Lederman R, Malhotra A, Mikulak J, Popik W, Skorecki K, Singhal PC. Protein domains of APOL1 and its risk variants. Exp Mol Pathol. 2015 Aug; 99(1):139-44. PMID: 26091559.
      Citations: 19     Fields:    Translation:HumansCells
    11. Taylor HE, Simmons GE, Mathews TP, Khatua AK, Popik W, Lindsley CW, D'Aquila RT, Brown HA. Phospholipase D1 Couples CD4+ T Cell Activation to c-Myc-Dependent Deoxyribonucleotide Pool Expansion and HIV-1 Replication. PLoS Pathog. 2015 May; 11(5):e1004864. PMID: 26020637.
      Citations: 16     Fields:    Translation:HumansCells
    12. Khatua AK, Cheatham AM, Kruzel ED, Singhal PC, Skorecki K, Popik W. Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1. Am J Physiol Cell Physiol. 2015 Jul 01; 309(1):C22-37. PMID: 25924622.
      Citations: 32     Fields:    Translation:HumansCells
    13. Rana T, Hasan RJ, Nowicki S, Venkatarajan MS, Singh R, Urvil PT, Popov V, Braun WA, Popik W, Goodwin JS, Nowicki BJ. Complement protective epitopes and CD55-microtubule complexes facilitate the invasion and intracellular persistence of uropathogenic Escherichia coli. J Infect Dis. 2014 Apr 01; 209(7):1066-76. PMID: 24259524.
      Citations: 7     Fields:    Translation:AnimalsCells
    14. Taylor HE, Khatua AK, Popik W. The innate immune factor apolipoprotein L1 restricts HIV-1 infection. J Virol. 2014 Jan; 88(1):592-603. PMID: 24173214.
      Citations: 47     Fields:    Translation:HumansCells
    15. Taylor HE, Linde ME, Khatua AK, Popik W, Hildreth JE. Sterol regulatory element-binding protein 2 couples HIV-1 transcription to cholesterol homeostasis and T cell activation. J Virol. 2011 Aug; 85(15):7699-709. PMID: 21613400.
      Citations: 17     Fields:    Translation:HumansCells
    16. Khatua AK, Taylor HE, Hildreth JE, Popik W. Non-productive HIV-1 infection of human glomerular and urinary podocytes. Virology. 2010 Dec 05; 408(1):119-27. PMID: 20937511.
      Citations: 17     Fields:    Translation:HumansCells
    17. Khatua AK, Taylor HE, Hildreth JE, Popik W. Inhibition of LINE-1 and Alu retrotransposition by exosomes encapsidating APOBEC3G and APOBEC3F. Virology. 2010 Apr 25; 400(1):68-75. PMID: 20153011.
      Citations: 16     Fields:    Translation:HumansCells
    18. Khatua AK, Taylor HE, Hildreth JE, Popik W. Exosomes packaging APOBEC3G confer human immunodeficiency virus resistance to recipient cells. J Virol. 2009 Jan; 83(2):512-21. PMID: 18987139.
      Citations: 75     Fields:    Translation:HumansCells
    19. Fiala M, Eshleman AJ, Cashman J, Lin J, Lossinsky AS, Suarez V, Yang W, Zhang J, Popik W, Singer E, Chiappelli F, Carro E, Weinand M, Witte M, Arthos J. Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells. J Neurovirol. 2005 Jul; 11(3):281-91. PMID: 16036808.
      Citations: 43     Fields:    Translation:HumansCells
    20. Alce TM, Popik W. APOBEC3G is incorporated into virus-like particles by a direct interaction with HIV-1 Gag nucleocapsid protein. J Biol Chem. 2004 Aug 13; 279(33):34083-6. PMID: 15215254.
      Citations: 134     Fields:    Translation:HumansCells
    21. Fiala M, Popik W, Qiao JH, Lossinsky AS, Alce T, Tran K, Yang W, Roos KP, Arthos J. HIV-1 induces cardiomyopathyby cardiomyocyte invasion and gp120, Tat, and cytokine apoptotic signaling. Cardiovasc Toxicol. 2004; 4(2):97-107. PMID: 15371627.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    22. Popik W, Alce TM. CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4. J Biol Chem. 2004 Jan 02; 279(1):704-12. PMID: 14570906.
      Citations: 43     Fields:    Translation:HumansCells
    23. Twu C, Liu NQ, Popik W, Bukrinsky M, Sayre J, Roberts J, Rania S, Bramhandam V, Roos KP, MacLellan WR, Fiala M. Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14386-91. PMID: 12379743.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    24. Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M. Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol. 2002 Jul; 76(13):6689-700. PMID: 12050382.
      Citations: 98     Fields:    Translation:HumansCells
    25. Popik W, Alce TM, Au WC. Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4(+) T cells. J Virol. 2002 May; 76(10):4709-22. PMID: 11967288.
      Citations: 124     Fields:    Translation:HumansCells
    26. Gujuluva C, Burns AR, Pushkarsky T, Popik W, Berger O, Bukrinsky M, Graves MC, Fiala M. HIV-1 penetrates coronary artery endothelial cells by transcytosis. Mol Med. 2001 Mar; 7(3):169-76. PMID: 11471553.
      Citations: 12     Fields:    Translation:Cells
    27. Popik W, Pitha PM. Exploitation of cellular signaling by HIV-1: unwelcome guests with master keys that signal their entry. Virology. 2000 Oct 10; 276(1):1-6. PMID: 11021988.
      Citations: 34     Fields:    Translation:HumansCells
    28. Popik W, Pitha PM. Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes. J Virol. 2000 Mar; 74(6):2558-66. PMID: 10684270.
      Citations: 19     Fields:    Translation:HumansCells
    29. Popik W, Pitha PM. Early activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 receptor. Virology. 1998 Dec 05; 252(1):210-7. PMID: 9875330.
      Citations: 29     Fields:    Translation:HumansCells
    30. Popik W, Hesselgesser JE, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J Virol. 1998 Aug; 72(8):6406-13. PMID: 9658081.
      Citations: 70     Fields:    Translation:HumansCells
    31. Popik W, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol. 1996 Nov; 16(11):6532-41. PMID: 8887682.
      Citations: 27     Fields:    Translation:HumansCells
    32. Su Y, Popik W, Pitha PM. Inhibition of human immunodeficiency virus type 1 replication by a Tat-activated, transduced interferon gene: targeted expression to human immunodeficiency virus type 1-infected cells. J Virol. 1995 Jan; 69(1):110-21. PMID: 7983701.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    33. Shirazi Y, Popik W, Pitha PM. Modulation of interferon-mediated inhibition of human immunodeficiency virus type 1 by Tat. J Interferon Res. 1994 Oct; 14(5):259-63. PMID: 7532202.
      Citations: 4     Fields:    Translation:HumansCells
    34. Zhong F, Swendeman SL, Popik W, Pitha PM, Sheffery M. Evidence that levels of the dimeric cellular transcription factor CP2 play little role in the activation of the HIV-1 long terminal repeat in vivo or following superinfection with herpes simplex virus type 1. J Biol Chem. 1994 Aug 19; 269(33):21269-76. PMID: 8063751.
      Citations: 13     Fields:    Translation:Cells
    35. Popik W, Pitha PM. Differential effect of tumor necrosis factor-alpha and herpes simplex virus type 1 on the Tat-targeted inhibition of human immunodeficiency virus type 1 replication. Virology. 1994 Aug 01; 202(2):521-9. PMID: 8030218.
      Citations: 1     Fields:    Translation:HumansCells
    36. Popik W, Pitha PM. The presence of tat protein or tumor necrosis factor alpha is critical for herpes simplex virus type 1-induced expression of human immunodeficiency virus type 1. J Virol. 1994 Mar; 68(3):1324-33. PMID: 8107197.
      Citations: 1     Fields:    Translation:Cells
    37. Popik W, Pitha PM. Role of tumor necrosis factor alpha in activation and replication of the tat-defective human immunodeficiency virus type 1. J Virol. 1993 Feb; 67(2):1094-9. PMID: 8419639.
      Citations: 15     Fields:    Translation:Cells
    38. Popik W, Pitha PM. Transcriptional activation of the tat-defective human immunodeficiency virus type-1 provirus: effect of interferon. Virology. 1992 Aug; 189(2):435-47. PMID: 1641975.
      Citations: 10     Fields:    Translation:HumansCells
    39. Popik W, Pitha PM. Inhibition by interferon of herpes simplex virus type 1-activated transcription of tat-defective provirus. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9573-7. PMID: 1719535.
      Citations: 6     Fields:    Translation:HumansCells
    40. Zielinska-Jenczylik J, Inglot AD, Inglot O, Popik W. Transforming growth factor-beta inhibits the antiviral action of interferons in human embryonic fibroblasts. J Interferon Res. 1991 Apr; 11(2):87-9. PMID: 1714487.
      Citations:    Fields:    Translation:HumansCells
    41. Popik W, Inglot AD. Combined action of interferons and transforming growth factor beta on the proliferation of human fibroblasts. Arch Immunol Ther Exp (Warsz). 1991; 39(1-2):19-26. PMID: 1725103.
      Citations:    Fields:    Translation:HumansCells
    42. Popik W, Inglot O. Bovine transforming growth factor beta. Purification and characterization. Arch Immunol Ther Exp (Warsz). 1989; 37(5-6):715-24. PMID: 2487381.
      Citations:    Fields:    Translation:AnimalsCells
    43. Popik W. [Transforming growth factors--molecular structure and biological role]. Postepy Hig Med Dosw. 1988 Sep-Oct; 42(5):523-42. PMID: 3076237.
      Citations:    Fields:    Translation:HumansAnimalsCells
    44. Popik W, Inglot AD, Wilusz T, Polanowski A. Participation of polypeptide proteinase inhibitors in proliferation of fibroblasts. Arch Immunol Ther Exp (Warsz). 1988; 36(5):645-53. PMID: 3268073.
      Citations:    Fields:    Translation:HumansAnimalsCells
    45. Popik W, Inglot AD. Interactions of interferons and transforming growth factors during clonal growth of mouse or human cells in soft agar and in mice. Int J Cancer. 1987 Jul 15; 40(1):108-13. PMID: 2439465.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    46. Popik W. [Transforming growth factors]. Postepy Biochem. 1987; 33(2-3):165-81. PMID: 3330224.
      Citations:    Fields:    Translation:HumansAnimals
    47. Popik W. Separation of transforming growth factors TGF alpha and TGF beta during chromatographic purification of extracts from mouse C-234 tumors. Arch Immunol Ther Exp (Warsz). 1987; 35(6):839-51. PMID: 3508041.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    48. Inglot AD, Popik W, Piasecki E, Czyrski J. A few distinct 'molecular sandwiches' are basis for structural and functional similarities of subspecies of interferon alpha and of families of growth-promoting hormones. Mol Biol Rep. 1986; 11(1):37-42. PMID: 3511360.
      Citations:    Fields:    Translation:HumansAnimalsCells
    49. Piasecki E, Popik W, Inglot AD, Konieczny M, Charytonowicz D. New derivatives of blue dextran binding and stabilizing human or mouse interferons. Arch Immunol Ther Exp (Warsz). 1984; 32(2):231-8. PMID: 6207796.
      Citations:    Fields:    Translation:HumansAnimalsCells
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