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Pandu Gangula

Faculty RankAssociate Professor
InstitutionMeharry Medical College
DepartmentOral Biology & Research, Microbiology, Immunology, & Physiology, CWHR
Address1005 Dr. D.B. Todd Jr. BLVD
WBSB 3132
Meharry Medical College
Nashville TN 37208
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    Other Positions
    TitleAssociate Professor
    InstitutionMeharry Medical College School of Dentistry
    DepartmentOral Biology and Research

    InstitutionMeharry Medical College School of Dentistry
    DepartmentOral Biology and Research

    Collapse Biography 
    Collapse awards and honors
    2011 - 2015Health Policy Associate RWJF, Meharry Medical College
    1991 - 1993Senior Research Fellow, Council of Scientific and Industrial Research (CSIR)
    1993 - 1996Research Associate, Council of Scientific and Industrial Research (CSIR)
    1996President''s Presenters Award, Society for Gynecological Investigation

    Collapse Overview 
    Collapse overview
    As background, my earlier training was as a post-doctoral fellow and Assistant Professor (non T-T) in the Department of Ob/Gyn (1994-2004) and Assistant Professor (T-T) in the Division of Gastroenterology (2004-2008) at UTMB in Galveston, TX. When I arrived in Nashville (2008), my appointment was as an Associate Professor (T-T) in the Department of Ob/Gyn at Meharry; I was also a member of the center for women’s health research (CWHR). In 2012, I was given an appointment in the School of Dentistry and the title of Chair, Oral Biology and Research (70% time/effort). Since then, I organized a SOD course on “Introduction to Clinical Research” and continue to foster collaborative faculty and student research projects. Recently, in Fall 2013 we have introduced “Biomedical Integration Seminar Course” to Freshman Dental Students. This course will allow the students not only to learn how to integrate basic sciences into their dental clinical approach and patient care but also will help them to understand on how poor oral health can cause systemic diseases. For the past several years, I have been providing research training to post-doctoral fellows, research technicians, and junior faculty, and residents, medical and dental students.

    Dr. Gangula’s research efforts and published work over the years have focused on understanding the role and regulation of nitric oxide, vascular neuropeptides by sex steroid hormones as well as vitamin D in regulating gut motility and vascular functions in both diabetes mellitus and hypertension rodent(s) models as well as in clinical setting. Dr. Gangula have several years of research experience in the field of cardiovascular biology, gastroenterology, endocrinology, fetal programming and female hormone research as evidenced by number of publications (review in PubMed, author name: Gangula P). Recently, Dr. Gangula established research in the area of oral pathogens and its impact on systemic health (cardiovascular and gastrointestinal function). Dr. Gangula was specifically recruited in the division of gastroenterology when he was in UTMB, Galveston, Texas (2004-2008) to investigate the gender bias in gastroparesis and examine the role of female sex steroid hormones, estradiol-17ß (E2) and progesterone (P4) on gut motility functions in both health and disease state.

    As an Assistant Professor (Non-Tenure-Track; 2000-2004) in UTMB, Galveston, TX, Dr. Gangula served as an active collaborator (co-investigator) for two independent RO1 grants with the collaboration of two separate investigators in the field of endocrinology/physiology. During the past few years, he has been working in the field of gastrointestinal motility disorders associated with diabetic & idiopathic gastroparesis [(delayed gastric emptying) which is a disorder that predominantly affects women)] and IBD. As a primary and corresponding author, he has published several articles in the field of “fetal programming, hypertension and gastroparesis”. Also, As a PI, Dr. Gangula had a grant support from NIIDDK (R21) and Diabetic Research Training Center (DRTC) pilot grant (NIDDK) to investigate the role of oxidative stress and nitric oxide in diabetic gastroparesis. He is a member of the American Gastroenterological Association (AGA), American Neurogastroenterology & Motility Society (ANMS) and the Society for Gynecological Investigations (SG1). Dr. Gangula has trained several post-doctoral fellows, graduate students, technicians, medical and dental students since 2001. He is a member of editorial board for several peer reviewed journals. In addition, he has been serving as a reviewer for several journals including but not limited to American Journal of Physiology and Neurogastroenterology and Motility.

    Collapse Research 
    Collapse research activities and funding
    R03AG018999     (GANGULA, PANDU R)Sep 30, 2000 - Aug 31, 2002
    Role: Principal Investigator

    R21DK076704     (GANGULA, PANDU R)Apr 1, 2008 - Dec 31, 2012
    Nitric Oxide and gastric motility in female diabetics
    Role: Principal Investigator

    SC1GM121282     (GANGULA, PANDU R)Sep 12, 2017 - Aug 31, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dontsop M, Nwankwo K, Walker R, Potter C, Chen CK, Bol R, Sherden L, Gangula PR, Farmer-Dixon C. Investigating the relationship between dental cavities and protective factors among children aged 0-5 years. J Clin Pediatr Dent. 2024 Jan; 48(1):60-68. PMID: 38239157.
      Citations:    Fields:    Translation:HumansAnimals
    2. Rahad K, Martin K, Amugo I, Ferguson S, Curtis A, Davis A, Gangula P, Wang Q. ChatGPT to enhance learning in dental education at a historically black medical college. Res Sq. 2023 Dec 29. PMID: 37986988.
    3. Sprouse J, Sampath C, Gangula P. 17?-Estradiol Suppresses Gastric Inflammatory and Apoptotic Stress Responses and Restores nNOS-Mediated Gastric Emptying in Streptozotocin (STZ)-Induced Diabetic Female Mice. Antioxidants (Basel). 2023 Mar 20; 12(3). PMID: 36979006.
    4. Ramesh A, Halpern LR, Southerland JH, Adunyah SE, Gangula PR. Saliva as a diagnostic tool to measure polycyclic aromatic hydrocarbon exposure in dental patients exposed to intimate partner violence (IPV). Biomed J. 2023 Dec; 46(6):100586. PMID: 36804615.
      Citations: 1     Fields:    Translation:Humans
    5. Sampath C, Raju AV, Freeman ML, Srinivasan S, Gangula PR. Nrf2 attenuates hyperglycemia-induced nNOS impairment in adult mouse primary enteric neuronal crest cells and normalizes stomach function. Am J Physiol Gastrointest Liver Physiol. 2022 03 01; 322(3):G368-G382. PMID: 35084215.
      Citations: 1     Fields:    Translation:Animals
    6. Sampath C, Wilus D, Tabatabai M, Freeman M, Gangula P. Biomedicine & Pharmacotherapy. Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice. 2021; 137: 111370. View Publication.
    7. Sampath C, Wilus D, Tabatabai M, Freeman ML, Gangula PR. Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice. Biomed Pharmacother. 2021 May; 137:111370. PMID: 33761597.
      Citations: 6     Fields:    Translation:AnimalsCells
    8. Coke CJ, Davison B, Fields N, Fletcher J, Rollings J, Roberson L, Challagundla KB, Sampath C, Cade J, Farmer-Dixon C, Gangula PR. SARS-CoV-2 Infection and Oral Health: Therapeutic Opportunities and Challenges. J Clin Med. 2021 Jan 05; 10(1). PMID: 33466289.
    9. Anup S. Pathania1, Philip Prathipati2, Bakrudeen AA. Abdul3, Srinivas Chava1, Santharam S. Katta4, Subash C. Gupta5, Pandu R. Gangula6, Manoj K. Pandey7, Donald L. Durden8,9,10, Siddappa N. Byrareddy1,11, and Kishore B. Challagundla1,12?. Theranostics. COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges. 2021; 11(2):731-753.
    10. Sampath C, Okoro EU, Gipson MJ, Chukkapalli SS, Farmer-Dixon CM, Gangula PR. Porphyromonas gingivalis infection alters Nrf2-phase II enzymes and nitric oxide in primary human aortic endothelial cells. J Periodontol. 2021 07; 92(7):54-65. PMID: 33128253.
      Citations: 4     Fields:    Translation:HumansCells
    11. Sprouse J, Sampath C, Gangula PR. Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model. BMC Gastroenterol. 2020 Sep 23; 20(1):313. PMID: 32967621.
      Citations: 4     Fields:    Translation:Animals
    12. Sampath C, Srinivasan S, Freeman ML, Gangula PR. Inhibition of GSK-3? restores delayed gastric emptying in obesity-induced diabetic female mice. Am J Physiol Gastrointest Liver Physiol. 2020 10 01; 319(4):G481-G493. PMID: 32812777.
      Citations: 4     Fields:    Translation:Animals
    13. Sprouse JC, Sampath C, Gangula PR. Supplementation of 17?-Estradiol Normalizes Rapid Gastric Emptying by Restoring Impaired Nrf2 and nNOS Function in Obesity-Induced Diabetic Ovariectomized Mice. Antioxidants (Basel). 2020 Jul 03; 9(7). PMID: 32635208.
    14. Sampath C, Sprouse JC, Freeman ML, Gangula PR. Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice. Free Radic Biol Med. 2019 05 01; 135:132-143. PMID: 30831189.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    15. Dinakaran V, Mandape SN, Shuba K, Pratap S, Sakhare SS, Tabatabai MA, Smoot DT, Farmer-Dixon CM, Kesavalu LN, Adunyah SE, Southerland JH, Gangula PR. Identification of Specific Oral and Gut Pathogens in Full Thickness Colon of Colitis Patients: Implications for Colon Motility. Front Microbiol. 2018; 9:3220. PMID: 30666239.
    16. Gangula PR, Challagundla KB, Ravella K, Mukhopadhyay S, Chinnathambi V, Mittal MK, Sekhar KR, Sampath C. Sepiapterin alleviates impaired gastric nNOS function in spontaneous diabetic female rodents through NRF2 mRNA turnover and miRNA biogenesis pathway. Am J Physiol Gastrointest Liver Physiol. 2018 12 01; 315(6):G980-G990. PMID: 30285465.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Halpern LR, Shealer ML, Cho R, McMichael EB, Rogers J, Ferguson-Young D, Mouton CP, Tabatabai M, Southerland J, Gangula P. Influence of Intimate Partner Violence (IPV) Exposure on Cardiovascular and Salivary Biosensors: Is There a Relationship? J Natl Med Assoc. 2017 Winter; 109(4):252-261. PMID: 29173932.
      Citations: 3     Fields:    Translation:Humans
    18. Walker MY, Pratap S, Southerland JH, Farmer-Dixon CM, Lakshmyya K, Gangula PR. Role of oral and gut microbiome in nitric oxide-mediated colon motility. Nitric Oxide. 2018 02 28; 73:81-88. PMID: 28602746.
      Citations: 33     Fields:    Translation:Humans
    19. Southerland JH, Gill DG, Gangula PR, Halpern LR, Cardona CY, Mouton CP. Dental management in patients with hypertension: challenges and solutions. Clin Cosmet Investig Dent. 2016; 8:111-120. PMID: 27799823.
    20. Stewart CR, Obi N, Epane EC, Akbari AA, Halpern L, Southerland JH, Gangula PR. Effects of Diabetes on Salivary Gland Protein Expression of Tetrahydrobiopterin and Nitric Oxide Synthesis and Function. J Periodontol. 2016 Jun; 87(6):735-41. PMID: 26777763.
      Citations: 13     Fields:    Translation:HumansAnimals
    21. Gangula P, Ravella K, Chukkapalli S, Rivera M, Srinivasan S, Hale A, Channon K, Southerland J, Kesavalu L. Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/nNOS/NRF2-Phase II Enzyme Expression. PLoS One. 2015; 10(6):e0129885. PMID: 26111153.
      Citations: 14     Fields:    Translation:AnimalsCells
    22. Velsko IM, Chukkapalli SS, Rivera-Kweh MF, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoE(null) Mice. PLoS One. 2015; 10(6):e0129795. PMID: 26079509.
      Citations: 27     Fields:    Translation:AnimalsCells
    23. Chukkapalli SS, Rivera-Kweh MF, Velsko IM, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers. Pathog Dis. 2015 Apr; 73(3). PMID: 25663343.
      Citations: 30     Fields:    Translation:AnimalsCells
    24. Myers JN, Sch?ffer MW, Korolkova OY, Williams AD, Gangula PR, M'Koma AE. Implications of the colonic deposition of free hemoglobin-a chain: a previously unknown tissue by-product in inflammatory bowel disease. Inflamm Bowel Dis. 2014 09; 20(9):1530-47. PMID: 25078150.
      Citations: 13     Fields:    Translation:Humans
    25. Velsko IM, Chukkapalli SS, Rivera MF, Lee JY, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis. PLoS One. 2014; 9(5):e97811. PMID: 24836175.
      Citations: 90     Fields:    Translation:AnimalsCells
    26. Chukkapalli SS, Rivera MF, Velsko IM, Lee JY, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis. Infect Immun. 2014 May; 82(5):1959-67. PMID: 24566627.
      Citations: 35     Fields:    Translation:AnimalsCells
    27. Umoh NA, Walker RK, Millis RM, Al-Rubaiee M, Gangula PR, Haddad GE. Calcitonin Gene-Related Peptide Regulates Cardiomyocyte Survival through Regulation of Oxidative Stress by PI3K/Akt and MAPK Signaling Pathways. Ann Clin Exp Hypertens. 2014 Jan; 2(1):1007. PMID: 25478604.
    28. Al-Rubaiee M, Gangula PR, Millis RM, Walker RK, Umoh NA, Cousins VM, Jeffress MA, Haddad GE. Inotropic and lusitropic effects of calcitonin gene-related peptide in the heart. Am J Physiol Heart Circ Physiol. 2013 Jun 01; 304(11):H1525-37. PMID: 23585136.
      Citations: 14     Fields:    Translation:AnimalsCells
    29. Ravella K, Al-Hendy A, Sharan C, Hale AB, Channon KM, Srinivasan S, Gangula PR. Chronic estrogen deficiency causes gastroparesis by altering neuronal nitric oxide synthase function. Dig Dis Sci. 2013 Jun; 58(6):1507-15. PMID: 23504347.
      Citations: 17     Fields:    Translation:AnimalsCells
    30. Gangula PR, Dong YL, Al-Hendy A, Richard-Davis G, Montgomery-Rice V, Haddad G, Millis R, Nicholas SB, Moseberry D. Protective cardiovascular and renal actions of vitamin D and estrogen. Front Biosci (Schol Ed). 2013 01 01; 5(1):134-48. PMID: 23277041.
      Citations: 8     Fields:    Translation:HumansAnimals
    31. Ravella K, Yang H, Gangula PR. Impairment of gastric nitrergic and NRF2 system in apolipoprotein E knockout mice. Dig Dis Sci. 2012 Jun; 57(6):1504-9. PMID: 22302246.
      Citations: 11     Fields:    Translation:AnimalsCells
    32. Southerland JH, Moss K, Taylor GW, Beck JD, Pankow J, Gangula PR, Offenbacher S. Periodontitis and diabetes associations with measures of atherosclerosis and CHD. Atherosclerosis. 2012 May; 222(1):196-201. PMID: 22440543.
      Citations: 36     Fields:    Translation:Humans
    33. Gangula PR, Sekhar KR, Mukhopadhyay S. Gender bias in gastroparesis: is nitric oxide the answer? Dig Dis Sci. 2011 Sep; 56(9):2520-7. PMID: 21559738.
      Citations: 24     Fields:    Translation:HumansAnimals
    34. Mukhopadhyay S, Sekhar KR, Hale AB, Channon KM, Farrugia G, Freeman ML, Gangula PR. Loss of NRF2 impairs gastric nitrergic stimulation and function. Free Radic Biol Med. 2011 Aug 01; 51(3):619-25. PMID: 21605664.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    35. Gangula PR, Chinnathambi V, Hale AB, Mukhopadhyay S, Channon KM, Ravella K. Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice. Neurogastroenterol Motil. 2011 Aug; 23(8):773-e335. PMID: 21414103.
      Citations: 12     Fields:    Translation:Animals
    36. Gangula PR, Mukhopadhyay S, Pasricha PJ, Ravella K. Sepiapterin reverses the changes in gastric nNOS dimerization and function in diabetic gastroparesis. Neurogastroenterol Motil. 2010 Dec; 22(12):1325-31, e351-2. PMID: 20731778.
      Citations: 14     Fields:    Translation:AnimalsCells
    37. Ross GR, Yallampalli U, Gangula PR, Reed L, Sathishkumar K, Gao H, Chauhan M, Yallampalli C. Adrenomedullin relaxes rat uterine artery: mechanisms and influence of pregnancy and estradiol. Endocrinology. 2010 Sep; 151(9):4485-93. PMID: 20631002.
      Citations: 22     Fields:    Translation:Animals
    38. Gangula PR, Mukhopadhyay S, Ravella K, Cai S, Channon KM, Garfield RE, Pasricha PJ. Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats. Am J Physiol Gastrointest Liver Physiol. 2010 May; 298(5):G692-9. PMID: 20185690.
      Citations: 28     Fields:    Translation:Animals
    39. Gangula PR, Chauhan M, Reed L, Yallampalli C. Age-related changes in dorsal root ganglia, circulating and vascular calcitonin gene-related peptide (CGRP) concentrations in female rats: effect of female sex steroid hormones. Neurosci Lett. 2009 Apr 24; 454(2):118-23. PMID: 19429067.
      Citations: 16     Fields:    Translation:AnimalsCells
    40. Gangula PR, Maner WL, Micci MA, Garfield RE, Pasricha PJ. Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. Am J Physiol Gastrointest Liver Physiol. 2007 Mar; 292(3):G725-33. PMID: 17347455.
      Citations: 56     Fields:    Translation:AnimalsCells
    41. Ambalavanar R, Dessem D, Moutanni A, Yallampalli C, Yallampalli U, Gangula P, Bai G. Muscle inflammation induces a rapid increase in calcitonin gene-related peptide (CGRP) mRNA that temporally relates to CGRP immunoreactivity and nociceptive behavior. Neuroscience. 2006 Dec; 143(3):875-84. PMID: 17027165.
      Citations: 21     Fields:    Translation:Animals
    42. Gangula PR, Pasricha PJ. Women and irritable bowel syndrome: is the gain in pain mainly in the brain? J Gastroenterol Hepatol. 2006 Feb; 21(2):343-4. PMID: 16509856.
      Citations:    Fields:    Translation:Humans
    43. Ambalavanar R, Moritani M, Moutanni A, Gangula P, Yallampalli C, Dessem D. Deep tissue inflammation upregulates neuropeptides and evokes nociceptive behaviors which are modulated by a neuropeptide antagonist. Pain. 2006 Jan; 120(1-2):53-68. PMID: 16359792.
      Citations: 33     Fields:    Translation:AnimalsCells
    44. Ross GR, Chauhan M, Gangula PR, Reed L, Thota C, Yallampalli C. Female sex steroids increase adrenomedullin-induced vasodilation by increasing the expression of adrenomedullin2 receptor components in rat mesenteric artery. Endocrinology. 2006 Jan; 147(1):389-96. PMID: 16210373.
      Citations: 14     Fields:    Translation:Animals
    45. Gangula PR, Reed L, Yallampalli C. Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero. Am J Obstet Gynecol. 2005 Mar; 192(3):952-60. PMID: 15746697.
      Citations: 21     Fields:    Translation:Animals
    46. Dong YL, Vegiraju S, Chauhan M, Gangula PR, Hankins GD, Goodrum L, Yallampalli C. Involvement of calcitonin gene-related peptide in control of human fetoplacental vascular tone. Am J Physiol Heart Circ Physiol. 2004 Jan; 286(1):H230-9. PMID: 14684361.
      Citations: 19     Fields:    Translation:HumansCells
    47. Witlin AG, Gangula PR, Wimalawansa SJ, Grafe M, Grady JJ, Yallampalli C. Adrenomedullin requires an intact nitric oxide system to function as an endogenous vasodilator in rat gestation. Hypertens Pregnancy. 2003; 22(1):9-24. PMID: 12648439.
      Citations: 7     Fields:    Translation:Animals
    48. Witlin AG, Gangula PR, Thompson ML, Yallampalli C. Growth and fertility rates in the offspring of pregnant rats treated with L-omega nitro-L-arginine methyl ester (L-NAME), a nitric oxide inhibitor. Am J Obstet Gynecol. 2002 Jan; 186(1):89-93. PMID: 11810091.
      Citations: 4     Fields:    Translation:Animals
    49. Wimalawansa SJ, De Marco G, Gangula P, Yallampalli C. Nitric oxide donor alleviates ovariectomy-induced bone loss. Bone. 1996 Apr; 18(4):301-4. PMID: 8726385.
      Citations: 48     Fields:    Translation:HumansAnimals
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