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Hong Yang

Faculty RankProfessor
InstitutionMeharry Medical College
DepartmentMicrobiology, Immunology, & Physiology
Address1005 Dr. D.B. Todd
Nashville TN 37208
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    Collapse Biography 
    Collapse awards and honors
    2003 - 2005Recipient AFAR A03109 award to study the age-related increase in the sensitivity of endothelial cell, AFAR
    2004 - 2009Recipient K01HL0076623 award to study the role of oxidative stress in endothelial aging., NIH
    2010 - 2011Recipient U54RR026140 pilot award to study the role of suppression of unfolded protein response in f
    2012Travel award for oral presentation, SERLC
    2010 - 2019NIH SC1 HL101431: Defective isoforms of apoE induce atherogenesis via unfolded protein responses, NIH

    Collapse Overview 
    Collapse overview
    I am an enthusiastic researcher with specific training and expertise in atherosclerosis pathology, lipid metabolism and molecular biology. Since being appointed as a faculty member in Meharry Medical College 12 years ago, I have been successful in acquiring research funding from the National Institutes of Health and the American Federation for Aging Research (AFAR). Our laboratory has developed a number of techniques in studying the pathogenesis of atherosclerosis in vitro and in vivo. Specifically: a) we have developed methods to assess the histology and immunohistochemistry changes in mouse tissues; b) refined molecular tools for quantifying the steady-state levels of proteins in these target cells and tissues; c) refined methods for assessing not only the steady state levels of mRNAs but also the efficiency mRNA transcription and translation in tissues and cells; and d) developed a proteomics laboratory, which is equipped with 2-D electrophoresis systems, protein spot picker, Typhoon laser scanner and MALDI-TOF-mass spectrometry. With this system, we examined the changes induced by apoE-deficient lipoproteins, atherosclerosis and hypertension in protein profile in cultured cells, animal tissues and human blood. To test many hypotheses at the cellular level, our laboratory has developed protocols for the successful culturing of mouse endothelial cells, smooth muscle cells and peritoneal macrophages that overexpress or underexpress various genes. To study the impact of various interventions on atherosclerosis in vivo, we developed mouse models by crossbreeding existing transgenic and knockout mice. An example is the mouse model that lacks apoE and overexpresses antioxidant enzyme GPx4. Therefore we expect the studies in this proposal to proceed without any technical difficulties.
    More than this, I have established working relationships with several faculties at Vanderbilt (which is ~ 2 miles from Meharry). As background, in spring, 1999, Meharry and Vanderbilt co-signed an MOU forming the Meharry-Vanderbilt Alliance. Since that time, we have worked together in areas of mutual interest including research, patient care and education. As part of this agreement, our libraries and research cores are open for use by faculty, students on both campuses and a number of faculty hold adjunct appts at the other institution. Thus since ~2005, I have enjoyed a cordial working relationship with faculty at Vanderbilt U Medical Ctr such as L.Jackson Roberts, MD (discoverer of isoprostanes who studies free-radical damage/oxidative stress) and Sergio Fazio, MD, PhD and MacRae Linton, MD, experts in dyslipidemia and atherosclerosis. Although Dr. Fazio recently moved to the West Coast, I frequently contact Drs. Roberts and Linton advice. I also collaborated with several cardiovascular research and other experts, including Drs. Shawn Goodwin and ZhongMao Guo at Meharry and Arlan Richardson at UT-San Antonio. Finally, the research core facilities at Meharry are superb in supporting our proposed research, including the molecular biology core, the confocal morphology core, and the tissue preparation for histology/ immunohistochemistry core. Thus, all of the essential equipment and expertise needed for our proposed work is readily available in this research environment.

    Collapse Research 
    Collapse research activities and funding
    K01HL076623     (YANG, HONG)May 1, 2004 - Mar 31, 2009
    The Role of Oxidative Stress in Endothelial Aging
    Role: Principal Investigator

    SC1HL101431     (YANG, HONG)Sep 1, 2009 - Feb 28, 2021
    Defective isoforms of ApoE induce atherogenesis via unfolded protein responses
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Guo Z, Zhang N, Yang H. Apolipoprotein A-I Inhibits Transendothelial Transport of Apolipoprotein B-Carrying Lipoproteins and Enhances Its Associated High-Density Lipoprotein Formation. J Vasc Res. 2022; 59(5):275-287. PMID: 35760057.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Foley KE, Yang HS, Graham LC, Howell GR. Transcriptional profiling predicts running promotes cerebrovascular remodeling in young but not midlife mice. BMC Genomics. 2019 Nov 14; 20(1):860. PMID: 31726991.
      Citations: 3     Fields:    Translation:AnimalsCells
    3. Yang H, Zhang N, Okoro EU, Guo Z. Transport of Apolipoprotein B-Containing Lipoproteins through Endothelial Cells Is Associated with Apolipoprotein E-Carrying HDL-Like Particle Formation. Int J Mol Sci. 2018 Nov 14; 19(11). PMID: 30441770.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Yang F, Yang H, Ramesh A, Goodwin JS, Okoro EU, Guo Z. Overexpression of Catalase Enhances Benzo(a)pyrene Detoxification in Endothelial Microsomes. PLoS One. 2016; 11(9):e0162561. PMID: 27607467.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Okoro EU, Guo Z, Yang H. Akt isoform-dependent regulation of ATP-Binding cassette A1 expression by apolipoprotein E. Biochem Biophys Res Commun. 2016 08 12; 477(1):123-128. PMID: 27297104.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    6. Okoro EU, Zhang H, Guo Z, Yang F, Smith C, Yang H. A Subregion of Reelin Suppresses Lipoprotein-Induced Cholesterol Accumulation in Macrophages. PLoS One. 2015; 10(8):e0136895. PMID: 26317415.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Miao L, Okoro EU, Cao Z, Yang H, Motley-Johnson E, Guo Z. High-density lipoprotein-mediated transcellular cholesterol transport in mouse aortic endothelial cells. Biochem Biophys Res Commun. 2015 Sep 18; 465(2):256-61. PMID: 26255968.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Shan G, Yang F, Zhou L, Tang T, Okoro EU, Yang H, Guo Z. Increase in Blood Glutathione and Erythrocyte Proteins Related to Glutathione Generation, Reduction and Utilization in African-American Old Women with Diabetes. J Sci Technol Environ. 2015; 5(1). PMID: 26770888.
    9. Zhou L, Yang H, Okoro EU, Guo Z. Up-regulation of cholesterol absorption is a mechanism for cholecystokinin-induced hypercholesterolemia. J Biol Chem. 2014 May 09; 289(19):12989-99. PMID: 24692543.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Wu J, Xiao Y, Liu J, Yang H, Dong X, Hu S, Jin S, Wu D. Potential role of ATM in hepatocyte endocytosis of ApoE-deficient, ApoB48-containing lipoprotein in ApoE-deficient mice. Int J Mol Med. 2014 Feb; 33(2):462-8. PMID: 24276232.
      Citations: 1     Fields:    Translation:AnimalsCells
    11. Zhou L, Yang D, Wu DF, Guo ZM, Okoro E, Yang H. Inhibition of endoplasmic reticulum stress and atherosclerosis by 2-aminopurine in apolipoprotein e-deficient mice. ISRN Pharmacol. 2013; 2013:847310. PMID: 23984090.
    12. Lin X, Yang H, Zhang H, Zhou L, Guo Z. A novel transcription mechanism activated by ethanol: induction of Slc7a11 gene expression via inhibition of the DNA-binding activity of transcriptional repressor octamer-binding transcription factor 1 (OCT-1). J Biol Chem. 2013 May 24; 288(21):14815-23. PMID: 23592778.
      Citations: 16     Fields:    Translation:AnimalsCells
    13. Zhou L, Yang H, Lin X, Okoro EU, Guo Z. Cholecystokinin elevates mouse plasma lipids. PLoS One. 2012; 7(12):e51011. PMID: 23300532.
      Citations: 3     Fields:    Translation:Animals
    14. Okoro EU, Zhao Y, Guo Z, Zhou L, Lin X, Yang H. Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway. PLoS One. 2012; 7(9):e44430. PMID: 22984509.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    15. Ravella K, Yang H, Gangula PR. Impairment of gastric nitrergic and NRF2 system in apolipoprotein E knockout mice. Dig Dis Sci. 2012 Jun; 57(6):1504-9. PMID: 22302246.
      Citations: 11     Fields:    Translation:AnimalsCells
    16. Zhang HF, Lin XH, Yang H, Zhou LC, Guo YL, Barnett JV, Guo ZM. Regulation of the activity and expression of aryl hydrocarbon receptor by ethanol in mouse hepatic stellate cells. Alcohol Clin Exp Res. 2012 Nov; 36(11):1873-81. PMID: 22486318.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Chen X, Guo Z, Okoro EU, Zhang H, Zhou L, Lin X, Rollins AT, Yang H. Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2. J Biol Chem. 2012 Feb 03; 287(6):3751-9. PMID: 22170052.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    18. Lin X, Yang H, Zhou L, Guo Z. Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase. Free Radic Biol Med. 2011 Jul 01; 51(1):97-106. PMID: 21569840.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    19. Chen X, Zhao Y, Guo Z, Zhou L, Okoro EU, Yang H. Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway. J Biol Chem. 2011 Mar 18; 286(11):8917-23. PMID: 21257755.
      Citations: 19     Fields:    Translation:AnimalsCells
    20. Zhao Y, Guo Z, Lin X, Zhou L, Okoro EU, Fan G, Ramaswamy R, Yang H. Apolipoprotein E-Deficient Lipoproteins Induce Foam Cell Formation by Activation of PERK-EIF-2a Signaling Cascade. J Bioanal Biomed. 2010 Oct 06; 2:113-120. PMID: 21552349.
    21. Chen A, Guo Z, Zhou L, Yang H. Hepatic Endosome Protein Profiling in Apolipoprotein E Deficient Mice Expressing Apolipoprotein B48 but not B100. J Bioanal Biomed. 2010 Sep 23; 2(5):100-106. PMID: 21837265.
    22. Tang T, Lin X, Yang H, Zhou L, Wang Z, Shan G, Guo Z. Overexpression of antioxidant enzymes upregulates aryl hydrocarbon receptor expression via increased Sp1 DNA-binding activity. Free Radic Biol Med. 2010 Aug 01; 49(3):487-92. PMID: 20478378.
      Citations: 8     Fields:    Translation:AnimalsCells
    23. Wang Z, Yang H, Ramesh A, Roberts LJ, Zhou L, Lin X, Zhao Y, Guo Z. Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. Free Radic Biol Med. 2009 Oct 15; 47(8):1221-9. PMID: 19666105.
      Citations: 19     Fields:    Translation:AnimalsCells
    24. Yang H, Zhou L, Wang Z, Roberts LJ, Lin X, Zhao Y, Guo Z. Overexpression of antioxidant enzymes in ApoE-deficient mice suppresses benzo(a)pyrene-accelerated atherosclerosis. Atherosclerosis. 2009 Nov; 207(1):51-8. PMID: 19409565.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    25. Onumah OE, Jules GE, Zhao Y, Zhou L, Yang H, Guo Z. Overexpression of catalase delays G0/G1- to S-phase transition during cell cycle progression in mouse aortic endothelial cells. Free Radic Biol Med. 2009 Jun 15; 46(12):1658-67. PMID: 19341793.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    26. Mukherjee S, Stone WL, Yang H, Smith MG, Das SK. Protection of half sulfur mustard gas-induced lung injury in guinea pigs by antioxidant liposomes. J Biochem Mol Toxicol. 2009 Mar-Apr; 23(2):143-53. PMID: 19367648.
      Citations: 15     Fields:    Translation:Animals
    27. Wu D, Yang H, Zhao Y, Sharan C, Goodwin JS, Zhou L, Guo Y, Guo Z. 2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eukaryotic initiation factor-2alpha phosphorylation in foam cell formation. J Pharmacol Exp Ther. 2008 Aug; 326(2):395-405. PMID: 18463320.
      Citations: 2     Fields:    Translation:AnimalsCells
    28. Guo Z, Ran Q, Roberts LJ, Zhou L, Richardson A, Sharan C, Wu D, Yang H. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med. 2008 Feb 01; 44(3):343-52. PMID: 18215741.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    29. Wu D, Sharan C, Yang H, Goodwin JS, Zhou L, Grabowski GA, Du H, Guo Z. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res. 2007 Dec; 48(12):2571-8. PMID: 17720994.
      Citations: 15     Fields:    Translation:AnimalsCells
    30. Hou R, Chen F, Yang Y, Cheng X, Gao Z, Yang HO, Wu W, Mao T. Comparative study between coral-mesenchymal stem cells-rhBMP-2 composite and auto-bone-graft in rabbit critical-sized cranial defect model. J Biomed Mater Res A. 2007 Jan; 80(1):85-93. PMID: 16960828.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    31. Zhou L, Xiang W, Potts J, Floyd M, Sharan C, Yang H, Ross J, Nyanda AM, Guo Z. Reduction in extracellular superoxide dismutase activity in African-American patients with hypertension. Free Radic Biol Med. 2006 Nov 01; 41(9):1384-91. PMID: 17023265.
      Citations: 22     Fields:    Translation:Humans
    32. Zhou L, Shi M, Guo Z, Brisbon W, Hoover R, Yang H. Different cytotoxic injuries induced by lysophosphatidylcholine and 7-ketocholesterol in mouse endothelial cells. Endothelium. 2006 May-Jun; 13(3):213-26. PMID: 16840177.
      Citations: 13     Fields:    Translation:AnimalsCells
    33. Wu D, Yang H, Xiang W, Zhou L, Shi M, Julies G, Laplante JM, Ballard BR, Guo Z. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res. 2005 Jul; 46(7):1380-7. PMID: 15863839.
      Citations: 24     Fields:    Translation:Animals
    34. Yang H, Roberts LJ, Shi MJ, Zhou LC, Ballard BR, Richardson A, Guo ZM. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res. 2004 Nov 26; 95(11):1075-81. PMID: 15528470.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    35. Van Remmen H, Qi W, Sabia M, Freeman G, Estlack L, Yang H, Mao Guo Z, Huang TT, Strong R, Lee S, Epstein CJ, Richardson A. Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic Biol Med. 2004 Jun 15; 36(12):1625-34. PMID: 15182862.
      Citations: 49     Fields:    Translation:AnimalsCells
    36. Shi M, Yang H, Motley ED, Guo Z. Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation. Am J Hypertens. 2004 May; 17(5 Pt 1):450-6. PMID: 15110906.
      Citations: 16     Fields:    Translation:AnimalsCells
    37. Yang H, Shi M, Story J, Richardson A, Guo Z. Food restriction attenuates age-related increase in the sensitivity of endothelial cells to oxidized lipids. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59(4):316-23. PMID: 15071074.
      Citations: 8     Fields:    Translation:AnimalsCells
    38. Yang H, Shi M, Richardson A, Vijg J, Guo Z. Attenuation of leukocyte-endothelium interaction by antioxidant enzymes. Free Radic Biol Med. 2003 Aug 01; 35(3):266-76. PMID: 12885588.
      Citations: 13     Fields:    Translation:AnimalsCells
    39. Uddin M, Yang H, Shi M, Polley-Mandal M, Guo Z. Elevation of oxidative stress in the aorta of genetically hypertensive mice. Mech Ageing Dev. 2003 Jul; 124(7):811-7. PMID: 12875744.
      Citations: 11     Fields:    Translation:Animals
    40. Yang H, Shi M, VanRemmen H, Chen X, Vijg J, Richardson A, Guo Z. Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice. Am J Hypertens. 2003 Jan; 16(1):1-5. PMID: 12517675.
      Citations: 9     Fields:    Translation:Animals
    41. Guo Z, Mitchell-Raymundo F, Yang H, Ikeno Y, Nelson J, Diaz V, Richardson A, Reddick R. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev. 2002 Apr 30; 123(8):1121-31. PMID: 12044962.
      Citations: 50     Fields:    Translation:AnimalsCells
    42. Guo ZM, Yang H, Hamilton ML, VanRemmen H, Richardson A. Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta. Mech Ageing Dev. 2001 Oct; 122(15):1771-86. PMID: 11557279.
      Citations: 17     Fields:    Translation:AnimalsCells
    43. Van Remmen H, Williams MD, Guo Z, Estlack L, Yang H, Carlson EJ, Epstein CJ, Huang TT, Richardson A. Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1422-32. PMID: 11514315.
      Citations: 89     Fields:    Translation:AnimalsCells
    44. Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, Richardson A. Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10469-74. PMID: 11517304.
      Citations: 219     Fields:    Translation:AnimalsCells
    45. Guo Z, Van Remmen H, Yang H, Chen X, Mele J, Vijg J, Epstein CJ, Ho YS, Richardson A. Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells. Arterioscler Thromb Vasc Biol. 2001 Jul; 21(7):1131-8. PMID: 11451741.
      Citations: 25     Fields:    Translation:AnimalsCells
    46. Van Remmen H, Salvador C, Yang H, Huang TT, Epstein CJ, Richardson A. Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse. Arch Biochem Biophys. 1999 Mar 01; 363(1):91-7. PMID: 10049502.
      Citations: 60     Fields:    Translation:Animals
    47. Guo Z, Heydari AR, Wu W, Yang H, Sabia MR, Richardson A. Characterization of gene-specific DNA repair by primary cultures of rat hepatocytes. J Cell Physiol. 1998 Aug; 176(2):314-22. PMID: 9648918.
      Citations: 4     Fields:    Translation:AnimalsCells
    48. Van Remmen H, Williams MD, Yang H, Walter CA, Richardson A. Analysis of the transcriptional activity of the 5'-flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice. J Cell Physiol. 1998 Jan; 174(1):18-26. PMID: 9397152.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    49. Guo ZM, Hang DH, Yang H. [Measurement for instantaneous acceleration of ventricular pressure and its significant]. Sheng Li Xue Bao. 1989 Feb; 41(1):102-10. PMID: 2762828.
      Citations:    Fields:    Translation:Animals
    50. Yang H, Guo ZM, Zhang SH . An application of the first and second derivative impedance cardiogram for evaluating myocardial ischemia. J. Chinese Physics in Medicine. 1986; (7):242-248.
    51. Yang H, Zhang SH . Analysis of the first and second derivative impedance cardiogram of human. Wuhan Medical Journal. 1984; (8):260-264.
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