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Zhigang Xiong

Faculty RankProfessor
InstitutionMorehouse School of Medicine
Address720 Westveiw Drive, SW
Atlanta GA 30310
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    R01NS042926     (XIONG, ZHIGANG)Jun 1, 2002 - May 31, 2008
    Ion channel role-glutamate-independent neuronal injury
    Role: Principal Investigator

    R56NS047506     (XIONG, ZHIGANG)Oct 1, 2003 - Jul 31, 2010
    Acid-sensing channels as novel target for brain ischemia
    Role: Principal Investigator

    R01NS047506     (XIONG, ZHIGANG)Oct 1, 2003 - May 31, 2012
    Acid-sensing channels as novel target for brain ischemia
    Role: Principal Investigator

    R01NS049470     (XIONG, ZHIGANG)Apr 1, 2005 - Mar 31, 2009
    A novel cation channel in excitatory neuronal injury
    Role: Principal Investigator

    R01NS066027     (XIONG, ZHIGANG)Jun 15, 2011 - Apr 30, 2017
    ASICs and increased ischemic brain injury in diabetic condition
    Role: Principal Investigator

    R01NS104349     (XIONG, ZHIGANG)Dec 15, 2017 - Mar 31, 2024
    Mechanisms of ASIC-mediated neuronal injury
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Luo Y, Xue Y, Lin Q, Mao L, Tang G, Song H, Liu W, Wu S, Liu W, Zhou Y, Xu L, Xiong Z, Wang T, Yuan X, Gan Y, Sun Z, Wang F. Diagnostic Model for Discrimination Between Tuberculous Meningitis and Bacterial Meningitis. Front Immunol. 2021; 12:731876. PMID: 34867952.
      Citations:    Fields:    
    2. Tang G, Huang M, Luo Y, Liu W, Lin Q, Mao L, Wu S, Xiong Z, Hou H, Sun Z, Wang F. The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes. Front Immunol. 2021; 12:697622. PMID: 34777333.
      Citations:    Fields:    Translation:HumansCells
    3. Hu N, Wang D, Lin Y, Zou J, Liu Y, Xiong Z, Guo J, Zeng L, Li J. Molecular Analysis and Antimicrobial Resistance Pattern of Tigecycline-Non-Susceptible K. pneumoniae Isolated from a Tertiary Care Hospital of East Asia. Infect Drug Resist. 2021; 14:4147-4155. PMID: 34675559.
    4. Hou H, Zhang Y, Tang G, Luo Y, Liu W, Cheng C, Jiang Y, Xiong Z, Wu S, Sun Z, Xu S, Fan X, Wang F. Immunologic memory to SARS-CoV-2 in convalescent COVID-19 patients at 1 year postinfection. J Allergy Clin Immunol. 2021 12; 148(6):1481-1492.e2. PMID: 34536418.
      Citations:    Fields:    
    5. Sheng Y, Wu B, Leng T, Zhu L, Xiong Z. Acid-sensing ion channel 1 (ASIC1) mediates weak acid-induced migration of human malignant glioma cells. Am J Cancer Res. 2021; 11(3):997-1008. PMID: 33791169.
    6. Wu BM, Bargaineer J, Zhang L, Yang T, Xiong ZG, Leng TD. Upregulation of acid sensing ion channel 1a (ASIC1a) by hydrogen peroxide through the JNK pathway. Acta Pharmacol Sin. 2021 Aug; 42(8):1248-1255. PMID: 33184449.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Wang T, Zhou G, He M, Xu Y, Rusyniak WG, Xu Y, Ji Y, Simon RP, Xiong ZG, Zha XM. GPR68 Is a Neuroprotective Proton Receptor in Brain Ischemia. Stroke. 2020 12; 51(12):3690-3700. PMID: 33059544.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Zhang L, Leng TD, Yang T, Li J, Xiong ZG. Protein Kinase C Regulates ASIC1a Protein Expression and Channel Function via NF-kB Signaling Pathway. Mol Neurobiol. 2020 Nov; 57(11):4754-4766. PMID: 32783140.
      Citations:    Fields:    Translation:AnimalsCells
    9. Cheng L, Wu B, Zhang L, Bian E, An R, Yu S, Liu W, Xiong Z. Gankyrin promotes osteosarcoma tumorigenesis by forming a positive feedback loop with YAP. Cell Signal. 2020 01; 65:109460. PMID: 31678253.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Du X, Yu L, Xiong Z, Chen G, Zou J, Wu X, Xiong B, Wang B. Percutaneous leverage reduction with two Kirschner wires combined with the Métaizeau technique versus open reduction plus internal fixation with a single Kirschner-wire for treating Judet IV radial neck fractures in children. J Int Med Res. 2019 Nov; 47(11):5497-5507. PMID: 31422720.
      Citations: 1     Fields:    Translation:Humans
    11. Zhou R, Leng T, Yang T, Chen F, Hu W, Xiong ZG. ß-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation. Stroke. 2019 10; 50(10):2902-2911. PMID: 31412757.
      Citations: 11     Fields:    Translation:AnimalsCells
    12. Leng T, Xiong ZG. Treatment for ischemic stroke: From thrombolysis to thrombectomy and remaining challenges. Brain Circ. 2019 Jan-Mar; 5(1):8-11. PMID: 31001594.
    13. Xu X, Zhong W, Zhang X, Dou J, Xiong Z, Sun Y, Wang T, Du Y. Flexible symmetric supercapacitor with ultrahigh energy density based on NiS/MoS2@N-rGO hybrids electrode. J Colloid Interface Sci. 2019 May 01; 543:147-155. PMID: 30797998.
      Citations:    Fields:    
    14. Zhou RP, Leng TD, Yang T, Chen FH, Xiong ZG. Acute Ethanol Exposure Promotes Autophagy-Lysosome Pathway-Dependent ASIC1a Protein Degradation and Protects Against Acidosis-Induced Neurotoxicity. Mol Neurobiol. 2019 May; 56(5):3326-3340. PMID: 30120732.
      Citations: 8     Fields:    Translation:AnimalsCells
    15. Huang Y, Leng TD, Inoue K, Yang T, Liu M, Horgen FD, Fleig A, Li J, Xiong ZG. TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis. J Biol Chem. 2018 09 14; 293(37):14393-14406. PMID: 30076216.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. Deng L, Xiong Z, Li H, Lei X, Cheng L. Analytical validation and investigation on reference intervals of aldosterone and renin in Chinese Han population by using fully automated chemiluminescence immunoassays. Clin Biochem. 2018 Jun; 56:89-94. PMID: 29684370.
      Citations: 2     Fields:    Translation:Humans
    17. Vann KT, Xiong ZG. Acid-sensing ion channel 1 contributes to normal olfactory function. Behav Brain Res. 2018 Jan 30; 337:246-251. PMID: 28912013.
      Citations: 4     Fields:    Translation:Animals
    18. Leng T, Lin S, Xiong Z, Lin J. Lidocaine suppresses glioma cell proliferation by inhibiting TRPM7 channels. Int J Physiol Pathophysiol Pharmacol. 2017; 9(2):8-15. PMID: 28533887.
    19. Xiao L, Chang SY, Xiong ZG, Selveraj P, Peng Loh Y. Absence of Carboxypeptidase E/Neurotrophic Factor-?1 in Knock-Out Mice Leads to Dysfunction of BDNF-TRKB Signaling in Hippocampus. J Mol Neurosci. 2017 May; 62(1):79-87. PMID: 28386642.
      Citations: 3     Fields:    Translation:AnimalsCells
    20. Liu M, Inoue K, Leng T, Zhou A, Guo S, Xiong ZG. ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway. Oncotarget. 2017 Jan 31; 8(5):8283-8293. PMID: 28030818.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. Wu BM, Leng TD, Inoue K, Li J, Xiong ZG. Effect of Redox-Modifying Agents on the Activity of Channelrhodopsin-2. CNS Neurosci Ther. 2017 Mar; 23(3):216-221. PMID: 27917616.
      Citations: 1     Fields:    Translation:AnimalsCells
    22. Jiang N, Wu J, Leng T, Yang T, Zhou Y, Jiang Q, Wang B, Hu Y, Ji YH, Simon RP, Chu XP, Xiong ZG, Zha XM. Region specific contribution of ASIC2 to acidosis-and ischemia-induced neuronal injury. J Cereb Blood Flow Metab. 2017 Feb; 37(2):528-540. PMID: 26861816.
      Citations: 16     Fields:    Translation:AnimalsCells
    23. Li MH, Leng TD, Feng XC, Yang T, Simon RP, Xiong ZG. Modulation of Acid-sensing Ion Channel 1a by Intracellular pH and Its Role in Ischemic Stroke. J Biol Chem. 2016 08 26; 291(35):18370-83. PMID: 27402850.
      Citations: 15     Fields:    Translation:Animals
    24. O'Bryant Z, Leng T, Liu M, Inoue K, Vann KT, Xiong ZG. Acid Sensing Ion Channels (ASICs) in NS20Y cells - potential role in neuronal differentiation. Mol Brain. 2016 06 24; 9(1):68. PMID: 27342076.
      Citations: 5     Fields:    Translation:AnimalsCells
    25. Inoue K, Leng T, Yang T, Zeng Z, Ueki T, Xiong ZG. Role of serum- and glucocorticoid-inducible kinases in stroke. J Neurochem. 2016 07; 138(2):354-61. PMID: 27123541.
      Citations: 13     Fields:    Translation:Animals
    26. Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG. Amiloride Analogs as ASIC1a Inhibitors. CNS Neurosci Ther. 2016 06; 22(6):468-76. PMID: 26890278.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Wu J, Leng T, Jing L, Jiang N, Chen D, Hu Y, Xiong ZG, Zha XM. Two di-leucine motifs regulate trafficking and function of mouse ASIC2a. Mol Brain. 2016 Jan 27; 9:9. PMID: 26819004.
      Citations: 8     Fields:    Translation:AnimalsCells
    28. Leng T, Liu A, Wang Y, Chen X, Zhou S, Li Q, Zhu W, Zhou Y, Su X, Huang Y, Yin W, Qiu P, Hu H, Xiong ZG, Zhang J, Yan G. Naturally occurring marine steroid 24-methylenecholestane-3ß,5a,6ß,19-tetraol functions as a novel neuroprotectant. Steroids. 2016 Jan; 105:96-105. PMID: 26631550.
      Citations: 2     Fields:    Translation:AnimalsCells
    29. Wang YZ, Wang JJ, Huang Y, Liu F, Zeng WZ, Li Y, Xiong ZG, Zhu MX, Xu TL. Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. Elife. 2015 Nov 02; 4. PMID: 26523449.
      Citations: 51     Fields:    Translation:AnimalsCells
    30. Zeng Z, Leng T, Feng X, Sun H, Inoue K, Zhu L, Xiong ZG. Silencing TRPM7 in mouse cortical astrocytes impairs cell proliferation and migration via ERK and JNK signaling pathways. PLoS One. 2015; 10(3):e0119912. PMID: 25799367.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    31. Huang Y, Jiang N, Li J, Ji YH, Xiong ZG, Zha XM. Two aspects of ASIC function: Synaptic plasticity and neuronal injury. Neuropharmacology. 2015 Jul; 94:42-8. PMID: 25582290.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    32. Inoue K, O'Bryant Z, Xiong ZG. Zinc-permeable ion channels: effects on intracellular zinc dynamics and potential physiological/pathophysiological significance. Curr Med Chem. 2015; 22(10):1248-57. PMID: 25666796.
      Citations: 14     Fields:    Translation:HumansAnimals
    33. Zeng Z, Inoue K, Sun H, Leng T, Feng X, Zhu L, Xiong ZG. TRPM7 regulates vascular endothelial cell adhesion and tube formation. . 2015 Feb 15; 308(4):C308-18. PMID: 25472964.
    34. Leng TD, Li MH, Shen JF, Liu ML, Li XB, Sun HW, Branigan D, Zeng Z, Si HF, Li J, Chen J, Xiong ZG. Suppression of TRPM7 inhibits proliferation, migration, and invasion of malignant human glioma cells. CNS Neurosci Ther. 2015 Mar; 21(3):252-61. PMID: 25438992.
      Citations: 23     Fields:    Translation:HumansCells
    35. Liu M, Inoue K, Leng T, Guo S, Xiong ZG. TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal. 2014 Dec; 26(12):2773-81. PMID: 25192910.
      Citations: 38     Fields:    Translation:HumansCells
    36. Leng TD, Lin J, Sun HW, Zeng Z, O'Bryant Z, Inoue K, Xiong ZG. Local anesthetic lidocaine inhibits TRPM7 current and TRPM7-mediated zinc toxicity. CNS Neurosci Ther. 2015 Jan; 21(1):32-9. PMID: 25169754.
      Citations: 14     Fields:    Translation:HumansCells
    37. Zhou W, Guo S, Xiong Z, Liu M. Oncogenic role and therapeutic target of transient receptor potential melastatin 7 channel in malignancy. Expert Opin Ther Targets. 2014 Oct; 18(10):1177-96. PMID: 25069584.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    38. Li MH, Liu SQ, Inoue K, Lan J, Simon RP, Xiong ZG. Acid-sensing ion channels in mouse olfactory bulb M/T neurons. J Gen Physiol. 2014 Jun; 143(6):719-31. PMID: 24821964.
      Citations: 7     Fields:    Translation:AnimalsCells
    39. Leng T, Shi Y, Xiong ZG, Sun D. Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? Prog Neurobiol. 2014 Apr; 115:189-209. PMID: 24467911.
      Citations: 45     Fields:    Translation:HumansAnimals
    40. Wang B, Xu B, Liu T, Liu P, Guo C, Wang S, Wang Q, Xiong Z, Wang D, Zhao XS. Mesoporous carbon-coated LiFePO4 nanocrystals co-modified with graphene and Mg2+ doping as superior cathode materials for lithium ion batteries. Nanoscale. 2014 Jan 21; 6(2):986-95. PMID: 24287590.
      Citations:    Fields:    
    41. O'Bryant Z, Vann KT, Xiong ZG. Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a. Transl Stroke Res. 2014 Feb; 5(1):59-68. PMID: 24390970.
      Citations: 14     Fields:    Translation:HumansAnimals
    42. Sun H, Leng T, Zeng Z, Gao X, Inoue K, Xiong ZG. Role of TRPM7 channels in hyperglycemia-mediated injury of vascular endothelial cells. PLoS One. 2013; 8(11):e79540. PMID: 24223965.
      Citations: 16     Fields:    Translation:HumansCells
    43. Lu X, Ke J, Luo X, Zhu Y, Zou L, Li H, Zhu B, Xiong Z, Chen W, Deng L, Lou J, Wang X, Zhang Y, Wang Z, Miao X, Cheng L. The SNP rs402710 in 5p15.33 is associated with lung cancer risk: a replication study in Chinese population and a meta-analysis. PLoS One. 2013; 8(10):e76252. PMID: 24194831.
      Citations: 7     Fields:    Translation:HumansCells
    44. Leng T, Lin J, Cottrell JE, Xiong ZG. Subunit and frequency-dependent inhibition of acid sensing ion channels by local anesthetic tetracaine. Mol Pain. 2013 Jun 10; 9:27. PMID: 23758830.
      Citations: 19     Fields:    Translation:AnimalsCells
    45. Liu AJ, Zang P, Guo JM, Wang W, Dong WZ, Guo W, Xiong ZG, Wang WZ, Su DF. Involvement of acetylcholine-a7nAChR in the protective effects of arterial baroreflex against ischemic stroke. CNS Neurosci Ther. 2012 Nov; 18(11):918-26. PMID: 23106973.
      Citations: 18     Fields:    Translation:AnimalsCells
    46. Leng TD, Xiong ZG. The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke intervention. Acta Pharmacol Sin. 2013 Jan; 34(1):33-8. PMID: 22820909.
      Citations: 9     Fields:    Translation:HumansAnimals
    47. Zheng X, Wang L, Zhu Y, Guan Q, Li H, Xiong Z, Deng L, Lu J, Miao X, Cheng L. The SNP rs961253 in 20p12.3 is associated with colorectal cancer risk: a case-control study and a meta-analysis of the published literature. PLoS One. 2012; 7(4):e34625. PMID: 22509336.
      Citations: 7     Fields:    Translation:HumansCells
    48. Chu XP, Xiong ZG. Physiological and pathological functions of acid-sensing ion channels in the central nervous system. Curr Drug Targets. 2012 Feb; 13(2):263-71. PMID: 22204324.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    49. Jiang Q, Inoue K, Wu X, Papasian CJ, Wang JQ, Xiong ZG, Chu XP. Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition. Neuroscience. 2011 Oct 13; 193:89-99. PMID: 21767613.
      Citations: 15     Fields:    Translation:AnimalsCells
    50. Li MH, Inoue K, Si HF, Xiong ZG. Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury. Acta Pharmacol Sin. 2011 Jun; 32(6):734-40. PMID: 21552295.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    51. Lin J, Chu X, Maysami S, Li M, Si H, Cottrell JE, Simon RP, Xiong Z. Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg. 2011 Apr; 112(4):977-81. PMID: 21385979.
      Citations: 11     Fields:    Translation:AnimalsCells
    52. Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, Zhu MX, Xiong ZG, Xu TL. Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci. 2011 Feb 09; 31(6):2101-12. PMID: 21307247.
      Citations: 63     Fields:    Translation:AnimalsCells
    53. Coombes E, Jiang J, Chu XP, Inoue K, Seeds J, Branigan D, Simon RP, Xiong ZG. Pathophysiologically relevant levels of hydrogen peroxide induce glutamate-independent neurodegeneration that involves activation of transient receptor potential melastatin 7 channels. Antioxid Redox Signal. 2011 May 15; 14(10):1815-27. PMID: 20812867.
      Citations: 23     Fields:    Translation:AnimalsCells
    54. Chen X, Numata T, Li M, Mori Y, Orser BA, Jackson MF, Xiong ZG, MacDonald JF. The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations. Mol Brain. 2010 Dec 01; 3:38. PMID: 21122141.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    55. Li M, Kratzer E, Inoue K, Simon RP, Xiong ZG. Developmental change in the electrophysiological and pharmacological properties of acid-sensing ion channels in CNS neurons. J Physiol. 2010 Oct 15; 588(Pt 20):3883-900. PMID: 20724366.
      Citations: 17     Fields:    Translation:AnimalsCells
    56. Jiang Q, Papasian CJ, Wang JQ, Xiong ZG, Chu XP. Inhibitory regulation of acid-sensing ion channel 3 by zinc. Neuroscience. 2010 Aug 25; 169(2):574-83. PMID: 20580786.
      Citations: 16     Fields:    Translation:AnimalsCells
    57. Li M, Inoue K, Branigan D, Kratzer E, Hansen JC, Chen JW, Simon RP, Xiong ZG. Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1247-60. PMID: 20216553.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    58. Stapels M, Piper C, Yang T, Li M, Stowell C, Xiong ZG, Saugstad J, Simon RP, Geromanos S, Langridge J, Lan JQ, Zhou A. Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance. Sci Signal. 2010 Mar 02; 3(111):ra15. PMID: 20197544.
      Citations: 53     Fields:    Translation:AnimalsCells
    59. Chai S, Li M, Branigan D, Xiong ZG, Simon RP. Activation of acid-sensing ion channel 1a (ASIC1a) by surface trafficking. J Biol Chem. 2010 Apr 23; 285(17):13002-11. PMID: 20185828.
      Citations: 29     Fields:    Translation:AnimalsCells
    60. Chen X, Qiu L, Li M, Dürrnagel S, Orser BA, Xiong ZG, MacDonald JF. Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology. 2010 Jun; 58(7):1045-53. PMID: 20114056.
      Citations: 43     Fields:    Translation:AnimalsCells
    61. Inoue K, Branigan D, Xiong ZG. Zinc-induced neurotoxicity mediated by transient receptor potential melastatin 7 channels. J Biol Chem. 2010 Mar 05; 285(10):7430-9. PMID: 20048154.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    62. Woronowicz A, Cawley NX, Chang SY, Koshimizu H, Phillips AW, Xiong ZG, Loh YP. Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons. J Neurosci Res. 2010 Jan; 88(1):64-72. PMID: 19598241.
      Citations: 17     Fields:    Translation:AnimalsCells
    63. Ying W, Xiong ZG. Oxidative stress and NAD+ in ischemic brain injury: current advances and future perspectives. Curr Med Chem. 2010; 17(20):2152-8. PMID: 20423305.
      Citations: 21     Fields:    Translation:HumansAnimals
    64. Inoue K, Xiong ZG. Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway. Cardiovasc Res. 2009 Aug 01; 83(3):547-57. PMID: 19454490.
      Citations: 47     Fields:    Translation:HumansCells
    65. Jiang Q, Li MH, Papasian CJ, Branigan D, Xiong ZG, Wang JQ, Chu XP. Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum. Neuroscience. 2009 Aug 04; 162(1):55-66. PMID: 19376200.
      Citations: 30     Fields:    Translation:AnimalsCells
    66. Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, Zhu X, Lan J, Xiong Z, Steiner DF, Simon RP, Zhou A. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab. 2009 Apr; 29(4):698-706. PMID: 19142196.
      Citations: 4     Fields:    Translation:AnimalsCells
    67. Meller R, Thompson SJ, Lusardi TA, Ordonez AN, Ashley MD, Jessick V, Wang W, Torrey DJ, Henshall DC, Gafken PR, Saugstad JA, Xiong ZG, Simon RP. Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance. J Neurosci. 2008 Jan 02; 28(1):50-9. PMID: 18171922.
      Citations: 44     Fields:    Translation:AnimalsCells
    68. Woronowicz A, Koshimizu H, Chang SY, Cawley NX, Hill JM, Rodriguiz RM, Abebe D, Dorfman C, Senatorov V, Zhou A, Xiong ZG, Wetsel WC, Loh YP. Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. Hippocampus. 2008; 18(10):1051-63. PMID: 18570185.
      Citations: 30     Fields:    Translation:AnimalsCells
    69. Jiang J, Li MH, Inoue K, Chu XP, Seeds J, Xiong ZG. Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells: role in cell proliferation. Cancer Res. 2007 Nov 15; 67(22):10929-38. PMID: 18006838.
      Citations: 64     Fields:    Translation:HumansCells
    70. Xiong ZG, Pignataro G, Li M, Chang SY, Simon RP. Acid-sensing ion channels (ASICs) as pharmacological targets for neurodegenerative diseases. Curr Opin Pharmacol. 2008 Feb; 8(1):25-32. PMID: 17945532.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    71. Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, MacDonald JF. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16323-8. PMID: 17913893.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    72. Pignataro G, Meller R, Inoue K, Ordonez AN, Ashley MD, Xiong Z, Gala R, Simon RP. In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab. 2008 Feb; 28(2):232-41. PMID: 17882162.
      Citations: 90     Fields:    Translation:Animals
    73. Murphy B, Dunleavy M, Shinoda S, Schindler C, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Chu X, Wang W, Xiong Z, Prehn J, Simon R, Henshall D. Bcl-w protects hippocampus during experimental status epilepticus. Am J Pathol. 2007 Oct; 171(4):1258-68. PMID: 17702891.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    74. Sun A, Xiong Z, Xu Y. Removal of malodorous organic sulfides with molecular oxygen and visible light over metal phthalocyanine. J Hazard Mater. 2008 Mar 21; 152(1):191-5. PMID: 17707582.
      Citations: 1     Fields:    Translation:Cells
    75. Chai S, Li M, Lan J, Xiong ZG, Saugstad JA, Simon RP. A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem. 2007 Aug 03; 282(31):22668-77. PMID: 17548344.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    76. Bottlang M, Sommers MB, Lusardi TA, Miesch JJ, Simon RP, Xiong ZG. Modeling neural injury in organotypic cultures by application of inertia-driven shear strain. J Neurotrauma. 2007 Jun; 24(6):1068-77. PMID: 17600521.
      Citations: 5     Fields:    Translation:Animals
    77. Hey JG, Chu XP, Seeds J, Simon RP, Xiong ZG. Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels. Stroke. 2007 Feb; 38(2 Suppl):670-3. PMID: 17261712.
      Citations: 10     Fields:    Translation:HumansCells
    78. Xu TL, Xiong ZG. Dynamic regulation of acid-sensing ion channels by extracellular and intracellular modulators. Curr Med Chem. 2007; 14(16):1753-63. PMID: 17627513.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    79. Xiong ZG, Chu XP, Simon RP. Acid sensing ion channels--novel therapeutic targets for ischemic brain injury. Front Biosci. 2007 Jan 01; 12:1376-86. PMID: 17127388.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    80. Liu XY, Chu XP, Mao LM, Wang M, Lan HX, Li MH, Zhang GC, Parelkar NK, Fibuch EE, Haines M, Neve KA, Liu F, Xiong ZG, Wang JQ. Modulation of D2R-NR2B interactions in response to cocaine. Neuron. 2006 Dec 07; 52(5):897-909. PMID: 17145509.
      Citations: 104     Fields:    Translation:AnimalsCells
    81. Pignataro G, Simon RP, Xiong ZG. Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain. 2007 Jan; 130(Pt 1):151-8. PMID: 17114797.
      Citations: 109     Fields:    Translation:Animals
    82. Xiong Z, Wei Q, Chen H, Chen S, Xu W, Qiu G, Liang S, Hu X. Microbial transformation of androst-4-ene-3,17-dione by Beauveria bassiana. Steroids. 2006 Nov; 71(11-12):979-83. PMID: 16973198.
      Citations: 3     Fields:    Translation:AnimalsCells
    83. Wang WZ, Chu XP, Li MH, Seeds J, Simon RP, Xiong ZG. Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH. J Biol Chem. 2006 Sep 29; 281(39):29369-78. PMID: 16882660.
      Citations: 30     Fields:    Translation:AnimalsCells
    84. Chu XP, Close N, Saugstad JA, Xiong ZG. ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. J Neurosci. 2006 May 17; 26(20):5329-39. PMID: 16707785.
      Citations: 46     Fields:    Translation:AnimalsCells
    85. Xiong ZG, Chu XP, Simon RP. Ca2+ -permeable acid-sensing ion channels and ischemic brain injury. J Membr Biol. 2006 Jan; 209(1):59-68. PMID: 16685601.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    86. MacDonald JF, Xiong ZG, Jackson MF. Paradox of Ca2+ signaling, cell death and stroke. Trends Neurosci. 2006 Feb; 29(2):75-81. PMID: 16376999.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    87. Xiong Z, Xu Y, Zhu L, Zhao J. Enhanced photodegradation of 2,4,6-trichlorophenol over palladium phthalocyaninesulfonate modified organobentonite. Langmuir. 2005 Nov 08; 21(23):10602-7. PMID: 16262326.
      Citations: 1     Fields:    
    88. Xiong Z, Xu Y, Zhu L, Zhao J. Photosensitized oxidation of substituted phenols on aluminum phthalocyanine-intercalated organoclay. Environ Sci Technol. 2005 Jan 15; 39(2):651-7. PMID: 15707068.
      Citations: 2     Fields:    Translation:CellsPHPublic Health
    89. Ye JH, Wang F, Krnjevic K, Wang W, Xiong ZG, Zhang J. Presynaptic glycine receptors on GABAergic terminals facilitate discharge of dopaminergic neurons in ventral tegmental area. J Neurosci. 2004 Oct 13; 24(41):8961-74. PMID: 15483115.
      Citations: 39     Fields:    Translation:AnimalsCells
    90. Chu XP, Wemmie JA, Wang WZ, Zhu XM, Saugstad JA, Price MP, Simon RP, Xiong ZG. Subunit-dependent high-affinity zinc inhibition of acid-sensing ion channels. J Neurosci. 2004 Oct 06; 24(40):8678-89. PMID: 15470133.
      Citations: 73     Fields:    Translation:AnimalsCells
    91. Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, Wei WL, MacDonald JF, Wemmie JA, Price MP, Welsh MJ, Simon RP. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell. 2004 Sep 17; 118(6):687-98. PMID: 15369669.
      Citations: 432     Fields:    Translation:AnimalsCells
    92. Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, Xiong ZG, Simon RP. Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication. J Cereb Blood Flow Metab. 2004 Jun; 24(6):612-22. PMID: 15181368.
      Citations: 13     Fields:    Translation:AnimalsCells
    93. Aarts M, Iihara K, Wei WL, Xiong ZG, Arundine M, Cerwinski W, MacDonald JF, Tymianski M. A key role for TRPM7 channels in anoxic neuronal death. Cell. 2003 Dec 26; 115(7):863-77. PMID: 14697204.
      Citations: 304     Fields:    Translation:HumansAnimalsCells
    94. Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, Meller R, Rosenzweig HL, Tobar E, Shaw TE, Chu X, Simon RP. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet. 2003 Sep 27; 362(9389):1028-37. PMID: 14522533.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    95. Chu XP, Zhu XM, Wei WL, Li GH, Simon RP, MacDonald JF, Xiong ZG. Acidosis decreases low Ca(2+)-induced neuronal excitation by inhibiting the activity of calcium-sensing cation channels in cultured mouse hippocampal neurons. J Physiol. 2003 Jul 15; 550(Pt 2):385-99. PMID: 12777448.
      Citations: 13     Fields:    Translation:AnimalsCells
    96. Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham SH, Simon RP. Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem. 2003 May; 85(3):670-9. PMID: 12694393.
      Citations: 3     Fields:    Translation:AnimalsCells
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