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Martine Behra

TitlePhD
Faculty RankAssistant Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus
San Juan PR 936
Phone17875227793
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    Martine L. Behra is an Assistant Professor in the Department of Anatomy and Neurobiology, School of Medicine, University of Puerto Rico Medical Sciences Campus.

    Dr. Behra earned her Ph.D. in Molecular and Cellular Biology from the University Louis Pasteur in Strasbourg, France. She completed her graduate work at the Institut de Génétique et de Biologie Moléculaire et Cellulaire, IGBMC.

    Dr. Behra’s research focuses on regeneration of sensory neuroepithelia. In the inner ear, the hair cells are mechanoreceptors which respond to sound waves (in the cochlea) and to head movements (in the vestibule). Capitalizing on the genetic power of zebrafish, her short-term objectives are to elucidate the molecular
    events underlying the multi-step process of regeneration of hair cells in the lateral line in zebrafish larvae. As an entry point, she is using a zebrafish mutant line (phoenix), which she has previously characterized. The mutated gene is novel and homozygote larvae have a clear reduction in regenerated hair cells
    in the lateral line. Her laboratory is currently pursuing several approaches to elucidate the function of this new gene, including work in fish and human cell lines.

    Dr. Behra’s research is supported by grants from the National Institutes of Health 4R00DC009443-02.

    Research Areas: Genetics of regeneration in the context of whole organisms, using the zebrafish as an animal model.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vicente-Rodr?guez LC, Torres-Arroyo AC, Hern?ndez-V?zquez A, Rosa-Casillas M, Bracho-Rinc?n DP, de Jes?s PM, Behra ML, Habib MR, Zhou XN, Rosenthal JJC, Miller MW. The FMRF-NH2 gated sodium channel of Biomphalaria glabrata: Localization and expression following infection by Schistosoma mansoni. PLoS Negl Trop Dis. 2023 06; 17(6):e0011249. PMID: 37352363.
      Citations:    Fields:    Translation:HumansAnimals
    2. Lin SJ, Vona B, Barbalho PG, Kaiyrzhanov R, Maroofian R, Petree C, Severino M, Stanley V, Varshney P, Bahena P, Alzahrani F, Alhashem A, Pagnamenta AT, Aubertin G, Estrada-Veras JI, Hern?ndez HAD, Mazaheri N, Oza A, Thies J, Renaud DL, Dugad S, McEvoy J, Sultan T, Pais LS, Tabarki B, Villalobos-Ramirez D, Rad A, Galehdari H, Ashrafzadeh F, Sahebzamani A, Saeidi K, Torti E, Elloumi HZ, Mora S, Palculict TB, Yang H, Wren JD, Joshi M, Behra M, Burgess SM, Nath SK, Hanna MG, Kenna M, Merritt JL, Houlden H, Karimiani EG, Zaki MS, Haaf T, Alkuraya FS, Gleeson JG, Varshney GK. Biallelic variants in KARS1 are associated with neurodevelopmental disorders and hearing loss recapitulated by the knockout zebrafish. Genet Med. 2021 10; 23(10):1933-1943. PMID: 34172899.
      Citations: 7     Fields:    Translation:HumansAnimals
    3. Col?n-Cruz L, Rodriguez-Morales R, Santana-Cruz A, Cantres-Velez J, Torrado-Tapias A, Lin SJ, Yudowski G, Kensler R, Marie B, Burgess SM, Renaud O, Varshney GK, Behra M. Cnr2 Is Important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors. Front Mol Neurosci. 2021; 14:624265. PMID: 33958989.
      Citations:    
    4. Rodr?guez-Morales R, V?lez-Negr?n V, Torrado-Tapias A, Varshney G, Behra M. Expression patterns of activating transcription factor 5 (atf5a and atf5b) in zebrafish. Gene Expr Patterns. 2020 09; 37:119126. PMID: 32663618.
      Citations:    Fields:    Translation:HumansAnimals
    5. Acevedo-Canabal A, Col?n-Cruz L, Rodriguez-Morales R, Varshney GK, Burgess S, Gonz?lez-Sep?lveda L, Yudowski G, Behra M. Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2. Cannabis Cannabinoid Res. 2019; 4(2):88-101. PMID: 31236475.
      Citations: 8     Fields:    
    6. Col?n-Cruz L, Kristofco L, Crooke-Rosado J, Acevedo A, Torrado A, Brooks BW, Sosa MA, Behra M. Alterations of larval photo-dependent swimming responses (PDR): New endpoints for rapid and diagnostic screening of aquatic contamination. Ecotoxicol Environ Saf. 2018 Jan; 147:670-680. PMID: 28934711.
      Citations: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    7. Torres-Hern?ndez BA, Col?n LR, Rosa-Falero C, Torrado A, Miscalichi N, Ort?z JG, Gonz?lez-Sep?lveda L, P?rez-R?os N, Su?rez-P?rez E, Bradsher JN, Behra M. Reversal of pentylenetetrazole-altered swimming and neural activity-regulated gene expression in zebrafish larvae by valproic acid and valerian extract. Psychopharmacology (Berl). 2016 07; 233(13):2533-47. PMID: 27165438.
      Citations: 11     Fields:    Translation:Animals
    8. Kristofco LA, Cruz LC, Haddad SP, Behra ML, Chambliss CK, Brooks BW. Age matters: Developmental stage of Danio rerio larvae influences photomotor response thresholds to diazinion or diphenhydramine. Aquat Toxicol. 2016 Jan; 170:344-354. PMID: 26431593.
      Citations: 24     Fields:    Translation:Animals
    9. Gonz?lez-Sol? M, Al-Khayat HA, Behra M, Kensler RW. Zebrafish cardiac muscle thick filaments: isolation technique and three-dimensional structure. Biophys J. 2014 Apr 15; 106(8):1671-80. PMID: 24739166.
      Citations: 21     Fields:    Translation:Animals
    10. Xu H, Ye D, Behra M, Burgess S, Chen S, Lin F. G?1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Dev Biol. 2014 Jan 15; 385(2):316-27. PMID: 24201188.
      Citations: 17     Fields:    Translation:AnimalsCells
    11. Gallardo VE, Behra M. Fluorescent activated cell sorting (FACS) combined with gene expression microarrays for transcription enrichment profiling of zebrafish lateral line cells. Methods. 2013 Aug 15; 62(3):226-31. PMID: 23791746.
      Citations: 12     Fields:    Translation:AnimalsCells
    12. Behra M, Gallardo VE, Bradsher J, Torrado A, Elkahloun A, Idol J, Sheehy J, Zonies S, Xu L, Shaw KM, Satou C, Higashijima S, Weinstein BM, Burgess SM. Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. BMC Dev Biol. 2012 Jan 24; 12:6. PMID: 22273551.
      Citations: 15     Fields:    Translation:AnimalsCells
    13. Gallardo VE, Liang J, Behra M, Elkahloun A, Villablanca EJ, Russo V, Allende ML, Burgess SM. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. BMC Dev Biol. 2010 Dec 13; 10:120. PMID: 21144052.
      Citations: 20     Fields:    Translation:AnimalsCells
    14. Behra M, Bradsher J, Sougrat R, Gallardo V, Allende ML, Burgess SM. Phoenix is required for mechanosensory hair cell regeneration in the zebrafish lateral line. PLoS Genet. 2009 Apr; 5(4):e1000455. PMID: 19381250.
      Citations: 41     Fields:    Translation:AnimalsCells
    15. Hawkins TA, Haramis AP, Etard C, Prodromou C, Vaughan CK, Ashworth R, Ray S, Behra M, Holder N, Talbot WS, Pearl LH, Str?hle U, Wilson SW. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development. 2008 Mar; 135(6):1147-56. PMID: 18256191.
      Citations: 54     Fields:    Translation:AnimalsCells
    16. Etard C, Behra M, Fischer N, Hutcheson D, Geisler R, Str?hle U. The UCS factor Steif/Unc-45b interacts with the heat shock protein Hsp90a during myofibrillogenesis. Dev Biol. 2007 Aug 01; 308(1):133-43. PMID: 17586488.
      Citations: 66     Fields:    Translation:AnimalsCells
    17. Ahmed ZM, Goodyear R, Riazuddin S, Lagziel A, Legan PK, Behra M, Burgess SM, Lilley KS, Wilcox ER, Riazuddin S, Griffith AJ, Frolenkov GI, Belyantseva IA, Richardson GP, Friedman TB. The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15. J Neurosci. 2006 Jun 28; 26(26):7022-34. PMID: 16807332.
      Citations: 167     Fields:    Translation:AnimalsCells
    18. Etard C, Behra M, Ertzer R, Fischer N, Jesuthasan S, Blader P, Geisler R, Str?hle U. Mutation in the delta-subunit of the nAChR suppresses the muscle defects caused by lack of Dystrophin. Dev Dyn. 2005 Dec; 234(4):1016-25. PMID: 16245342.
      Citations: 15     Fields:    Translation:AnimalsCells
    19. Behra M, Etard C, Cousin X, Str?hle U. The use of zebrafish mutants to identify secondary target effects of acetylcholine esterase inhibitors. Toxicol Sci. 2004 Feb; 77(2):325-33. PMID: 14657522.
      Citations: 20     Fields:    Translation:Animals
    20. Behra M, Cousin X, Bertrand C, Vonesch JL, Biellmann D, Chatonnet A, Str?hle U. Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo. Nat Neurosci. 2002 Feb; 5(2):111-8. PMID: 11753420.
      Citations: 86     Fields:    Translation:AnimalsCells
    21. Bola?os-Jim?nez F, Bordais A, Behra M, Str?hle U, Mornet D, Sahel J, Rend?n A. Molecular cloning and characterization of dystrophin and Dp71, two products of the Duchenne Muscular Dystrophy gene, in zebrafish. Gene. 2001 Aug 22; 274(1-2):217-26. PMID: 11675014.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Bola?os-Jim?nez F, Bordais A, Behra M, Str?hle U, Sahel J, Rend?n A. Dystrophin and Dp71, two products of the DMD gene, show a different pattern of expression during embryonic development in zebrafish. Mech Dev. 2001 Apr; 102(1-2):239-41. PMID: 11287201.
      Citations: 8     Fields:    Translation:AnimalsCells
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