RCMI Coordinating Center (RCMI CC) Header Logo

Antonio Martins

Faculty RankAssistant Professor
InstitutionUniversity of Puerto Rico
DepartmentSchool of Medicine
AddressUPR-Medical Sciences Campus
San Juan PR 935
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Ischemic stroke is the disruption of blood flow to a part of the brain. Without oxygen, some neurons die by apoptosis and other neurons experiencing energy failure are not able to complete apoptosis, therefore end up in necrosis and give rise to inflammatory conditions. However, during the first few hours after the first signs of symptoms, the neurons present in an region called penumbra, which commence to die by apoptosis, could be saved by either allowing the blood flow to restart or using antiapoptotic drugs, therefore promoting neuroprotection. In this regard, our group developed a new antiapoptotic and anti-inflammatory drug derived from tobacco leaves named 4R. Strong in vitro and in vivo evidences suggests two possible mechanisms of neuroprotection by 4R after brain ischemia, one is due to Akt activation, a well known antiapoptotic and anti-inflammatory protein and the second one is by decrease of cytokine release. We are currently evaluating these possible mechanism of action of 4R. In the same umbrella of neuroprotection our group is also verifying the action of cholinergic system and renin-angiotensin system using transient middle cerebral artery occlusion as in vivo model of stroke in rats.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rivera-Pagán AF, Rivera-Aponte DE, Melnik-Martínez KV, Zayas-Santiago A, Kucheryavykh LY, Martins AH, Cubano LA, Skatchkov SN, Eaton MJ. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. PLoS One. 2015; 10(4):e0125195. PMID: 25886567.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    2. Berríos VO, Boukli NM, Rodriguez JW, Negraes PD, Schwindt TT, Trujillo CA, Oliveira SL, Cubano LA, Ferchmin PA, Eterovic VA, Ulrich H, Martins AH. Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation. Neurochem Res. 2015 Oct; 40(10):2091-101. PMID: 25758980.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Martins AH, Hu J, Xu Z, Mu C, Alvarez P, Ford BD, El Sayed K, Eterovic VA, Ferchmin PA, Hao J. Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia. Neuroscience. 2015 Apr 16; 291:250-259. PMID: 25677097.
      Citations: 10     Fields:    Translation:AnimalsCells
    4. Ferchmin PA, Andino M, Reyes Salaman R, Alves J, Velez-Roman J, Cuadrado B, Carrasco M, Torres-Rivera W, Segarra A, Martins AH, Lee JE, Eterovic VA. 4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration. Neurotoxicology. 2014 Sep; 44:80-90. PMID: 24928201.
      Citations: 18     Fields:    Translation:Animals
    5. Torres-Rivera W, Pérez D, Park KY, Carrasco M, Platt MO, Eterovic VA, Ferchmin PA, Ulrich H, Martins AH. Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage. Neuroscience. 2013 Sep 05; 247:273-9. PMID: 23735753.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Martins AH, Alves JM, Perez D, Carrasco M, Torres-Rivera W, Eterovic VA, Ferchmin PA, Ulrich H. Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. PLoS One. 2012; 7(2):e30755. PMID: 22348022.
      Citations: 15     Fields:    Translation:Animals
    7. Eterovic VA, Pérez D, Martins AH, Cuadrado BL, Carrasco M, Ferchmin PA. A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity. Toxicol In Vitro. 2011 Oct; 25(7):1468-74. PMID: 21569834.
      Citations: 8     Fields:    Translation:Animals
    8. Nery AA, Resende RR, Martins AH, Trujillo CA, Eterovic VA, Ulrich H. Alpha 7 nicotinic acetylcholine receptor expression and activity during neuronal differentiation of PC12 pheochromocytoma cells. J Mol Neurosci. 2010 Jul; 41(3):329-39. PMID: 20461497.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Oliveira CR, Paredes-Gamero EJ, Barbosa CM, Nascimento FD, Batista EC, Reis FC, Martins AH, Ferreira AT, Carmona AK, Pesquero JB, Tersariol IL, Araújo RC, Bincoletto C. Myelopoiesis modulation by ACE hyperfunction in kinin B(1) receptor knockout mice: relationship with AcSDKP levels. Chem Biol Interact. 2010 Mar 30; 184(3):388-95. PMID: 20096676.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Trujillo CA, Schwindt TT, Martins AH, Alves JM, Mello LE, Ulrich H. Novel perspectives of neural stem cell differentiation: from neurotransmitters to therapeutics. Cytometry A. 2009 Jan; 75(1):38-53. PMID: 18988295.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    11. Martins AH, Alves JM, Trujillo CA, Schwindt TT, Barnabé GF, Motta FL, Guimaraes AO, Casarini DE, Mello LE, Pesquero JB, Ulrich H. Kinin-B2 receptor expression and activity during differentiation of embryonic rat neurospheres. Cytometry A. 2008 Apr; 73(4):361-8. PMID: 18302192.
      Citations: 15     Fields:    Translation:AnimalsCells
    12. Trujillo CA, Nery AA, Alves JM, Martins AH, Ulrich H. Development of the anti-VEGF aptamer to a therapeutic agent for clinical ophthalmology. Clin Ophthalmol. 2007 Dec; 1(4):393-402. PMID: 19668516.
    13. Ulrich H, Trujillo CA, Nery AA, Alves JM, Majumder P, Resende RR, Martins AH. DNA and RNA aptamers: from tools for basic research towards therapeutic applications. Comb Chem High Throughput Screen. 2006 Sep; 9(8):619-32. PMID: 17017882.
      Citations: 22     Fields:    Translation:Humans
    14. Trujillo CA, Nery AA, Martins AH, Majumder P, Gonzalez FA, Ulrich H. Inhibition mechanism of the recombinant rat P2X(2) receptor in glial cells by suramin and TNP-ATP. Biochemistry. 2006 Jan 10; 45(1):224-33. PMID: 16388598.
      Citations: 14     Fields:    Translation:AnimalsCells
    15. Ulrich H, Martins AH, Pesquero JB. RNA and DNA aptamers in cytomics analysis. Curr Protoc Cytom. 2005 Aug; Chapter 7:Unit 7.28. PMID: 18770826.
      Citations: 2     Fields:    
    16. Magdesian MH, Nery AA, Martins AH, Juliano MA, Juliano L, Ulrich H, Ferreira ST. Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid beta. J Biol Chem. 2005 Sep 02; 280(35):31085-90. PMID: 15987688.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    17. Martins AH, Resende RR, Majumder P, Faria M, Casarini DE, Tárnok A, Colli W, Pesquero JB, Ulrich H. Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function. J Biol Chem. 2005 May 20; 280(20):19576-86. PMID: 15767251.
      Citations: 16     Fields:    Translation:AnimalsCells
    18. Ulrich H, Martins AH, Pesquero JB. RNA and DNA aptamers in cytomics analysis. Cytometry A. 2004 Jun; 59(2):220-31. PMID: 15170601.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    Martins's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (122)
    Co-Authors (9)
    Similar People (60)
    Same Department Expand Description
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support