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Chiung-Yu Hung

TitleAssociate Professor
InstitutionUniversity of Texas at San Antonio
Address1 UTSA Cir
San Antonio TX 78249
Phone(210) 458-7018
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    TitleImmune Defense Core (Flow)
    InstitutionUniversity of Texas at San Antonio

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    My research is focused on studies of virulence factors of Coccidioides spp. which are causative agents of coccidioidomycosis. Coccidioides can cause a respiratory disease in healthy individuals as well as immunocompromised patients. In the United States there is an estimated 150,000 yearly cases of coccidioidal infection and it is considered to be a reemerging infectious disease. My research interest is in the identification and characterization of dominant antigens of Coccidioides spp. which elicit innate inflammatory response or stimulate acquired immunity to infection with the fungal pathogen. Studies of the interaction between the host and these antigens may lead to a better understanding of the course of disease, and to the identification of vaccine candidates or novel therapeutic drug targets. I am also interested in the application of biochemical, molecular, genetic, and bioinformatic techniques to the characterization of proteins involved in cell wall synthesis and degradation. Coccidioides spp. is a diphasic fungus characterized by a parasitic cycle (Fig.1) which is unique amongst medically important fungal pathogens. Cell wall synthases, hydrolases and their regulatory proteins have been proposed to play key roles in morphogenesis and, therefore, represent potential molecular targets for novel antifungal drugs.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mendoza Barker M, Saeger S, Campuzano A, Yu JJ, Hung CY. Galleria mellonella Model of Coccidioidomycosis for Drug Susceptibility Tests and Virulence Factor Identification. J Fungi (Basel). 2024 Feb 05; 10(2). PMID: 38392803.
    2. Campuzano A, Pentakota KD, Liao YR, Zhang H, Wiederhold NP, Ostroff GR, Hung CY. A Recombinant Multivalent Vaccine (rCpa1) Induces Protection for C57BL/6 and HLA Transgenic Mice against Pulmonary Infection with Both Species of Coccidioides. Vaccines (Basel). 2024 Jan 09; 12(1). PMID: 38250880.
    3. Xie J, Kittur FS, Hung CY, Ding TT. Regulation of one-carbon metabolism may open new avenues to slow down the initiation and progression of Huntington's disease. Neural Regen Res. 2023 Nov; 18(11):2401-2402. PMID: 37282468.
    4. McMahon CL, Esqueda M, Yu JJ, Wall G, Romo JA, Vila T, Chaturvedi A, Lopez-Ribot JL, Wormley F, Hung CY. Development of an Imaging Flow Cytometry Method for Fungal Cytological Profiling and Its Potential Application in Antifungal Drug Development. J Fungi (Basel). 2023 Jun 30; 9(7). PMID: 37504711.
    5. Hung CY, Kittur FS, Wharton KN, Umstead ML, Burwell DB, Thomas M, Qi Q, Zhang J, Oldham CE, Burkey KO, Chen J, Xie J. A Rapid Alkalinization Factor-like Peptide EaF82 Impairs Tapetum Degeneration during Pollen Development through Induced ATP Deficiency. Cells. 2023 06 04; 12(11). PMID: 37296662.
      Citations:    Fields:    Translation:Animals
    6. Kittur FS, Hung CY, Li PA, Sane DC, Xie J. Asialo-rhuEPO as a Potential Neuroprotectant for Ischemic Stroke Treatment. Pharmaceuticals (Basel). 2023 Apr 18; 16(4). PMID: 37111367.
    7. Gorris ME, Ardon-Dryer K, Campuzano A, Casta??n-Olivares LR, Gill TE, Greene A, Hung CY, Kaufeld KA, Lacy M, S?nchez-Paredes E. Advocating for Coccidioidomycosis to Be a Reportable Disease Nationwide in the United States and Encouraging Disease Surveillance across North and South America. J Fungi (Basel). 2023 Jan 05; 9(1). PMID: 36675904.
    8. Jeffreys S, Chambers JP, Yu JJ, Hung CY, Forsthuber T, Arulanandam BP. Insights into Acinetobacter baumannii protective immunity. Front Immunol. 2022; 13:1070424. PMID: 36466845.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    9. Hung CY, Zhu C, Kittur FS, He M, Arning E, Zhang J, Johnson AJ, Jawa GS, Thomas MD, Ding TT, Xie J. A plant-based mutant huntingtin model-driven discovery of impaired expression of GTPCH and DHFR. Cell Mol Life Sci. 2022 Oct 17; 79(11):553. PMID: 36251090.
      Citations: 2     Fields:    Translation:Animals
    10. Kirkland TN, Stevens DA, Hung CY, Beyhan S, Taylor JW, Shubitz LF, Duttke SH, Heidari A, Johnson RH, Deresinski SC, Lauer A, Fierer J. Coccidioides Species: A Review of Basic Research: 2022. J Fungi (Basel). 2022 Aug 16; 8(8). PMID: 36012847.
    11. Xie J, Kittur FS, Li PA, Hung CY. Rethinking the necessity of low glucose intervention for cerebral ischemia/reperfusion injury. Neural Regen Res. 2022 Jul; 17(7):1397-1403. PMID: 34916409.
    12. He M, Kittur FS, Hung CY, Zhang J, Jing L, Sane DC, Li PA, Xie J. A Novel Plant-Produced Asialo-rhuEPO Protects Brain from Ischemic Damage Without Erythropoietic Action. Transl Stroke Res. 2022 04; 13(2):338-354. PMID: 34553324.
      Citations: 5     Fields:    Translation:Animals
    13. Pel?ez-Jaramillo CA, Jim?nez-Alzate MDP, Araque-Marin P, Hung CY, Castro-Lopez N, Cole GT. Lipid Secretion by Parasitic Cells of Coccidioides Contributes to Disseminated Disease. Front Cell Infect Microbiol. 2021; 11:592826. PMID: 34055661.
      Citations: 2     Fields:    Translation:Animals
    14. Hung CY, Zhang J, Bhattacharya C, Li H, Kittur FS, Oldham CE, Wei X, Burkey KO, Chen J, Xie J. Transformation of Long-Lived Albino Epipremnum aureum 'Golden Pothos' and Restoring Chloroplast Development. Front Plant Sci. 2021; 12:647507. PMID: 34054894.
    15. Shrestha B, Wang L, Zhang H, Hung CY, Tang L. Gold Nanoparticles Mediated Drug-Gene Combinational Therapy for Breast Cancer Treatment. Int J Nanomedicine. 2020; 15:8109-8119. PMID: 33116521.
      Citations: 10     Fields:    Translation:Humans
    16. Li H, Kittur FS, Hung CY, Li PA, Ge X, Sane DC, Xie J. Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model. Front Cell Neurosci. 2020; 14:272. PMID: 33033473.
    17. Campuzano A, Zhang H, Ostroff GR, Dos Santos Dias L, W?thrich M, Klein BS, Yu JJ, Lara HH, Lopez-Ribot JL, Hung CY. CARD9-Associated Dectin-1 and Dectin-2 Are Required for Protective Immunity of a Multivalent Vaccine against Coccidioides posadasii Infection. J Immunol. 2020 06 15; 204(12):3296-3306. PMID: 32358020.
      Citations: 15     Fields:    Translation:AnimalsCells
    18. Kittur FS, Hung CY, Zhu C, Shajahan A, Azadi P, Thomas MD, Pearce JL, Gruber C, Kallolimath S, Xie J. Glycoengineering tobacco plants to stably express recombinant human erythropoietin with different N-glycan profiles. Int J Biol Macromol. 2020 Aug 15; 157:158-169. PMID: 32348856.
      Citations: 5     Fields:    Translation:HumansCells
    19. Hayden CA, Landrock D, Hung CY, Ostroff G, Fake GM, Walker JH, Kier A, Howard JA. Co-Administration of Injected and Oral Vaccine Candidates Elicits Improved Immune Responses over Either Route Alone. Vaccines (Basel). 2020 Jan 21; 8(1). PMID: 31973150.
    20. Campuzano A, Castro-Lopez N, Martinez AJ, Olszewski MA, Ganguly A, Leopold Wager C, Hung CY, Wormley FL. CARD9 Is Required for Classical Macrophage Activation and the Induction of Protective Immunity against Pulmonary Cryptococcosis. mBio. 2020 01 07; 11(1). PMID: 31911495.
      Citations: 12     Fields:    Translation:AnimalsCells
    21. Yu JJ, Holbrook E, Liao YR, Zarnowski R, Andes DR, Wheat LJ, Malo J, Hung CY. Characterization of an Uncinocarpus reesii-expressed recombinant tube precipitin antigen of Coccidioides posadasii for serodiagnosis. PLoS One. 2019; 14(8):e0221228. PMID: 31412087.
      Citations: 3     Fields:    Translation:HumansAnimals
    22. Hayden CA, Hung CY, Zhang H, Negron A, Esquerra R, Ostroff G, Abraham A, Lopez AG, Gonzales JE, Howard JA. Maize-Produced Ag2 as a Subunit Vaccine for Valley Fever. J Infect Dis. 2019 07 19; 220(4):615-623. PMID: 31184702.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    23. Hung CY, Hsu AP, Holland SM, Fierer J. A review of innate and adaptive immunity to coccidioidomycosis. Med Mycol. 2019 Feb 01; 57(Supplement_1):S85-S92. PMID: 30690602.
      Citations: 20     Fields:    Translation:HumansAnimals
    24. Kittur FS, Lin Y, Arthur E, Hung CY, Li PA, Sane DC, Xie J. Recombinant asialoerythropoetin protects HL-1 cardiomyocytes from injury via suppression of Mst1 activation. Biochem Biophys Rep. 2019 Mar; 17:157-168. PMID: 30671548.
    25. Hung CY, Zhang H, Castro-Lopez N, Ostroff GR, Khoshlenar P, Abraham A, Cole GT, Negron A, Forsthuber T, Peng T, Galgiani JN, Ampel NM, Yu JJ. Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection. Infect Immun. 2018 11; 86(11). PMID: 30104216.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    26. Lin Y, Hung CY, Bhattacharya C, Nichols S, Rahimuddin H, Kittur FS, Leung T, Xie J. An Effective Way of Producing Fully Assembled Antibody in Transgenic Tobacco Plants by Linking Heavy and Light Chains via a Self-Cleaving 2A Peptide. Front Plant Sci. 2018; 9:1379. PMID: 30283486.
    27. Romo JA, Pierce CG, Esqueda M, Hung CY, Saville SP, Lopez-Ribot JL. In Vitro Characterization of a Biaryl Amide Anti-virulence Compound Targeting Candida albicans Filamentation and Biofilm Formation. Front Cell Infect Microbiol. 2018; 8:227. PMID: 30042929.
      Citations: 8     Fields:    Translation:HumansAnimals
    28. Glazier VE, Murante T, Koselny K, Murante D, Esqueda M, Wall GA, Wellington M, Hung CY, Kumar A, Krysan DJ. Systematic Complex Haploinsufficiency-Based Genetic Analysis of Candida albicans Transcription Factors: Tools and Applications to Virulence-Associated Phenotypes. G3 (Bethesda). 2018 03 28; 8(4):1299-1314. PMID: 29472308.
      Citations: 14     Fields:    Translation:Animals
    29. Trivedi NH, Yu JJ, Hung CY, Doelger RP, Navara CS, Armitige LY, Seshu J, Sinai AP, Chambers JP, Guentzel MN, Arulanandam BP. Microbial co-infection alters macrophage polarization, phagosomal escape, and microbial killing. Innate Immun. 2018 04; 24(3):152-162. PMID: 29482417.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    30. Arthur E, Kittur FS, Lin Y, Hung CY, Sane DC, Xie J. Plant-Produced Asialo-Erythropoietin Restores Pancreatic Beta-Cell Function by Suppressing Mammalian Sterile-20-like Kinase (MST1) and Caspase-3 Activation. Front Pharmacol. 2017; 8:208. PMID: 28469576.
    31. Castro-Lopez N, Hung CY. Immune Response to Coccidioidomycosis and the Development of a Vaccine. Microorganisms. 2017 Mar 16; 5(1). PMID: 28300772.
    32. Sun YH, Hung CY, Qiu J, Chen J, Kittur FS, Oldham CE, Henny RJ, Burkey KO, Fan L, Xie J. Accumulation of high OPDA level correlates with reduced ROS and elevated GSH benefiting white cell survival in variegated leaves. Sci Rep. 2017 03 09; 7:44158. PMID: 28276518.
      Citations: 6     Fields:    Translation:Animals
    33. Hurtgen BJ, Hung CY. Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection. Methods Mol Biol. 2017; 1625:45-64. PMID: 28584982.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    34. Hurtgen BJ, Castro-Lopez N, Jim?nez-Alzate MDP, Cole GT, Hung CY. Preclinical identification of vaccine induced protective correlates in human leukocyte antigen expressing transgenic mice infected with Coccidioides posadasii. Vaccine. 2016 10 17; 34(44):5336-5343. PMID: 27622300.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    35. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, W?thrich M. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 08; 12(8):e1005787. PMID: 27542117.
      Citations: 6     Fields:    Translation:AnimalsCells
    36. Hung CY, Qiu J, Sun YH, Chen J, Kittur FS, Henny RJ, Jin G, Fan L, Xie J. Gibberellin deficiency is responsible for shy-flowering nature of Epipremnum aureum. Sci Rep. 2016 06 27; 6:28598. PMID: 27345283.
      Citations: 9     Fields:    Translation:AnimalsCells
    37. Cunningham AL, Guentzel MN, Yu JJ, Hung CY, Forsthuber TG, Navara CS, Yagita H, Williams IR, Klose KE, Eaves-Pyles TD, Arulanandam BP. M-Cells Contribute to the Entry of an Oral Vaccine but Are Not Essential for the Subsequent Induction of Protective Immunity against Francisella tularensis. PLoS One. 2016; 11(4):e0153402. PMID: 27100824.
      Citations: 2     Fields:    Translation:AnimalsCells
    38. Hung CY, Castro-Lopez N, Cole GT. Card9- and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection. Infect Immun. 2016 Apr; 84(4):1166-75. PMID: 26857574.
      Citations: 24     Fields:    Translation:AnimalsCells
    39. W?thrich M, Gern B, Hung CY, Ersland K, Rocco N, Pick-Jacobs J, Galles K, Filutowicz H, Warner T, Evans M, Cole G, Klein B. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest. 2016 Feb; 126(2):795. PMID: 26829626.
      Citations: 3     Fields:    
    40. Hung CY, Wozniak KL, Cole GT. Flow Cytometric Analysis of Protective T-Cell Response Against Pulmonary Coccidioides Infection. Methods Mol Biol. 2016; 1403:551-66. PMID: 27076153.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    41. W?thrich M, Brandhorst TT, Sullivan TD, Filutowicz H, Sterkel A, Stewart D, Li M, Lerksuthirat T, LeBert V, Shen ZT, Ostroff G, Deepe GS, Hung CY, Cole G, Walter JA, Jenkins MK, Klein B. Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes. Cell Host Microbe. 2015 Apr 08; 17(4):452-65. PMID: 25800545.
      Citations: 38     Fields:    Translation:AnimalsCells
    42. Kittur FS, Lalgondar M, Hung CY, Sane DC, Xie J. C-Terminally fused affinity Strep-tag II is removed by proteolysis from recombinant human erythropoietin expressed in transgenic tobacco plants. Plant Cell Rep. 2015 Mar; 34(3):507-16. PMID: 25504272.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    43. Kittur FS, Arthur E, Nguyen M, Hung CY, Sane DC, Xie J. Two-step purification procedure for recombinant human asialoerythropoietin expressed in transgenic plants. Int J Biol Macromol. 2015 Jan; 72:1111-6. PMID: 25450830.
      Citations: 5     Fields:    Translation:HumansAnimals
    44. Vallentine P, Hung CY, Xie J, Van Hoewyk D. The ubiquitin-proteasome pathway protects Chlamydomonas reinhardtii against selenite toxicity, but is impaired as reactive oxygen species accumulate. AoB Plants. 2014 Oct 08; 6. PMID: 25301821.
    45. Hung CY, Aspesi P, Hunter MR, Lomax AW, Perera IY. Phosphoinositide-signaling is one component of a robust plant defense response. Front Plant Sci. 2014; 5:267. PMID: 24966862.
    46. Hung CY, Umstead ML, Chen J, Holliday BM, Kittur FS, Henny RJ, Burkey KO, Xie J. Differential expression of a novel gene EaF82a in green and yellow sectors of variegated Epipremnum aureum leaves is related to uneven distribution of auxin. Physiol Plant. 2014 Dec; 152(4):749-62. PMID: 24796240.
      Citations: 2     Fields:    Translation:AnimalsCells
    47. Tetteh AY, Sun KH, Hung CY, Kittur FS, Ibeanu GC, Williams D, Xie J. Transcriptional Response of Selenopolypeptide Genes and Selenocysteine Biosynthesis Machinery Genes in Escherichia coli during Selenite Reduction. Int J Microbiol. 2014; 2014:394835. PMID: 24839442.
    48. Hung CY, Jim?nez-Alzate Mdel P, Gonzalez A, W?thrich M, Klein BS, Cole GT. Interleukin-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection. Infect Immun. 2014 May; 82(5):2106-14. PMID: 24614655.
      Citations: 26     Fields:    Translation:AnimalsCells
    49. Wang H, LeBert V, Hung CY, Galles K, Saijo S, Lin X, Cole GT, Klein BS, W?thrich M. C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol. 2014 Feb 01; 192(3):1107-1119. PMID: 24391211.
      Citations: 59     Fields:    Translation:AnimalsCellsPHPublic Health
    50. Cole GT, Hung CY, Sanderson SD, Hurtgen BJ, W?thrich M, Klein BS, Deepe GS, Ostroff GR, Levitz SM. Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS Pathog. 2013; 9(12):e1003768. PMID: 24367252.
      Citations: 20     Fields:    Translation:HumansAnimalsPHPublic Health
    51. Hung CY, Castro-Lopez N, Cole GT. Vaccinated C57BL/6 mice develop protective and memory T cell responses to Coccidioides posadasii infection in the absence of interleukin-10. Infect Immun. 2014 Feb; 82(2):903-13. PMID: 24478103.
      Citations: 15     Fields:    Translation:AnimalsCells
    52. Kittur FS, Bah M, Archer-Hartmann S, Hung CY, Azadi P, Ishihara M, Sane DC, Xie J. Cytoprotective effect of recombinant human erythropoietin produced in transgenic tobacco plants. PLoS One. 2013; 8(10):e76468. PMID: 24124563.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    53. Wise HZ, Hung CY, Whiston E, Taylor JW, Cole GT. Extracellular ammonia at sites of pulmonary infection with Coccidioides posadasii contributes to severity of the respiratory disease. Microb Pathog. 2013 Jun-Jul; 59-60:19-28. PMID: 23583291.
      Citations: 24     Fields:    Translation:HumansAnimals
    54. Hung CY, Fan L, Kittur FS, Sun K, Qiu J, Tang S, Holliday BM, Xiao B, Burkey KO, Bush LP, Conkling MA, Roje S, Xie J. Alteration of the alkaloid profile in genetically modified tobacco reveals a role of methylenetetrahydrofolate reductase in nicotine N-demethylation. Plant Physiol. 2013 Feb; 161(2):1049-60. PMID: 23221678.
      Citations: 7     Fields:    Translation:AnimalsCells
    55. Cole GT, Hurtgen BJ, Hung CY. Progress Toward a Human Vaccine Against Coccidioidomycosis. Curr Fungal Infect Rep. 2012 Dec 01; 6(4):235-244. PMID: 23585916.
    56. Hurtgen BJ, Hung CY, Ostroff GR, Levitz SM, Cole GT. Construction and evaluation of a novel recombinant T cell epitope-based vaccine against Coccidioidomycosis. Infect Immun. 2012 Nov; 80(11):3960-74. PMID: 22949556.
      Citations: 41     Fields:    Translation:HumansAnimals
    57. Mgbemena V, Segovia JA, Chang TH, Tsai SY, Cole GT, Hung CY, Bose S. Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection. J Immunol. 2012 Jul 15; 189(2):606-15. PMID: 22711891.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    58. Hung CY, Hurtgen BJ, Bellecourt M, Sanderson SD, Morgan EL, Cole GT. An agonist of human complement fragment C5a enhances vaccine immunity against Coccidioides infection. Vaccine. 2012 Jun 29; 30(31):4681-90. PMID: 22575167.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    59. Kittur FS, Hung CY, Darlington DE, Sane DC, Xie J. N-Glycosylation engineering of tobacco plants to produce asialoerythropoietin. Plant Cell Rep. 2012 Jul; 31(7):1233-43. PMID: 22371257.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    60. Hung CY, Holliday BM, Kaur H, Yadav R, Kittur FS, Xie J. Identification and characterization of selenate- and selenite-responsive genes in a Se-hyperaccumulator Astragalus racemosus. Mol Biol Rep. 2012 Jul; 39(7):7635-46. PMID: 22362314.
      Citations: 5     Fields:    Translation:Animals
    61. Hung CY, Wise HZ, Cole GT. Gene disruption in Coccidioides using hygromycin or phleomycin resistance markers. Methods Mol Biol. 2012; 845:131-47. PMID: 22328372.
      Citations: 6     Fields:    Translation:Animals
    62. Gonzalez A, Hung CY, Cole GT. Absence of phagocyte NADPH oxidase 2 leads to severe inflammatory response in lungs of mice infected with Coccidioides. Microb Pathog. 2011 Dec; 51(6):432-41. PMID: 21896326.
      Citations: 13     Fields:    Translation:AnimalsCells
    63. Hung CY, Gonzalez A, W?thrich M, Klein BS, Cole GT. Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17). Infect Immun. 2011 Nov; 79(11):4511-22. PMID: 21859851.
      Citations: 57     Fields:    Translation:AnimalsCells
    64. W?thrich M, Hung CY, Gern BH, Pick-Jacobs JC, Galles KJ, Filutowicz HI, Cole GT, Klein BS. A TCR transgenic mouse reactive with multiple systemic dimorphic fungi. J Immunol. 2011 Aug 01; 187(3):1421-31. PMID: 21705621.
      Citations: 28     Fields:    Translation:Animals
    65. Gonzalez A, Hung CY, Cole GT. Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice. Microb Pathog. 2011 Sep; 51(3):161-8. PMID: 21513788.
      Citations: 18     Fields:    Translation:AnimalsCells
    66. W?thrich M, Gern B, Hung CY, Ersland K, Rocco N, Pick-Jacobs J, Galles K, Filutowicz H, Warner T, Evans M, Cole G, Klein B. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest. 2011 Feb; 121(2):554-68. PMID: 21206087.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    67. Gonzalez A, Hung CY, Cole GT. Coccidioides releases a soluble factor that suppresses nitric oxide production by murine primary macrophages. Microb Pathog. 2011 Feb; 50(2):100-8. PMID: 21129481.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    68. Neafsey DE, Barker BM, Sharpton TJ, Stajich JE, Park DJ, Whiston E, Hung CY, McMahan C, White J, Sykes S, Heiman D, Young S, Zeng Q, Abouelleil A, Aftuck L, Bessette D, Brown A, FitzGerald M, Lui A, Macdonald JP, Priest M, Orbach MJ, Galgiani JN, Kirkland TN, Cole GT, Birren BW, Henn MR, Taylor JW, Rounsley SD. Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control. Genome Res. 2010 Jul; 20(7):938-46. PMID: 20516208.
      Citations: 91     Fields:    Translation:AnimalsCells
    69. Hung CY, Sun YH, Chen J, Darlington DE, Williams AL, Burkey KO, Xie J. Identification of a Mg-protoporphyrin IX monomethyl ester cyclase homologue, EaZIP, differentially expressed in variegated Epipremnum aureum 'Golden Pothos' is achieved through a unique method of comparative study using tissue regenerated plants. J Exp Bot. 2010 Mar; 61(5):1483-93. PMID: 20167611.
      Citations: 15     Fields:    Translation:AnimalsCells
    70. Phillips JA, Morgan EL, Dong Y, Cole GT, McMahan C, Hung CY, Sanderson SD. Single-step conjugation of bioactive peptides to proteins via a self-contained succinimidyl bis-arylhydrazone. Bioconjug Chem. 2009 Oct 21; 20(10):1950-7. PMID: 19788175.
      Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    71. Sharpton TJ, Stajich JE, Rounsley SD, Gardner MJ, Wortman JR, Jordar VS, Maiti R, Kodira CD, Neafsey DE, Zeng Q, Hung CY, McMahan C, Muszewska A, Grynberg M, Mandel MA, Kellner EM, Barker BM, Galgiani JN, Orbach MJ, Kirkland TN, Cole GT, Henn MR, Birren BW, Taylor JW. Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives. Genome Res. 2009 Oct; 19(10):1722-31. PMID: 19717792.
      Citations: 163     Fields:    Translation:HumansAnimals
    72. Xue J, Chen X, Selby D, Hung CY, Yu JJ, Cole GT. A genetically engineered live attenuated vaccine of Coccidioides posadasii protects BALB/c mice against coccidioidomycosis. Infect Immun. 2009 Aug; 77(8):3196-208. PMID: 19487479.
      Citations: 66     Fields:    Translation:HumansAnimals
    73. Perera IY, Hung CY, Moore CD, Stevenson-Paulik J, Boss WF. Transgenic Arabidopsis plants expressing the type 1 inositol 5-phosphatase exhibit increased drought tolerance and altered abscisic acid signaling. Plant Cell. 2008 Oct; 20(10):2876-93. PMID: 18849493.
      Citations: 61     Fields:    Translation:AnimalsCells
    74. Herr RA, Hung CY, Cole GT. Evaluation of two homologous proline-rich proteins of Coccidioides posadasii as candidate vaccines against coccidioidomycosis. Infect Immun. 2007 Dec; 75(12):5777-87. PMID: 17875631.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    75. Hung CY, Xue J, Cole GT. Virulence mechanisms of coccidioides. Ann N Y Acad Sci. 2007 Sep; 1111:225-35. PMID: 17513466.
      Citations: 25     Fields:    Translation:HumansAnimals
    76. Nosanchuk JD, Yu JJ, Hung CY, Casadevall A, Cole GT. Coccidioides posadasii produces melanin in vitro and during infection. Fungal Genet Biol. 2007 Jun; 44(6):517-20. PMID: 17074521.
      Citations: 16     Fields:    Translation:Animals
    77. Tarcha EJ, Basrur V, Hung CY, Gardner MJ, Cole GT. Multivalent recombinant protein vaccine against coccidioidomycosis. Infect Immun. 2006 Oct; 74(10):5802-13. PMID: 16988258.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    78. Shubitz LF, Yu JJ, Hung CY, Kirkland TN, Peng T, Perrill R, Simons J, Xue J, Herr RA, Cole GT, Galgiani JN. Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein. Vaccine. 2006 Jul 26; 24(31-32):5904-11. PMID: 16759762.
      Citations: 32     Fields:    Translation:AnimalsCells
    79. Tarcha EJ, Basrur V, Hung CY, Gardner MJ, Cole GT. A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice. Infect Immun. 2006 Jan; 74(1):516-27. PMID: 16369008.
      Citations: 33     Fields:    Translation:AnimalsCells
    80. Mirbod-Donovan F, Schaller R, Hung CY, Xue J, Reichard U, Cole GT. Urease produced by Coccidioides posadasii contributes to the virulence of this respiratory pathogen. Infect Immun. 2006 Jan; 74(1):504-15. PMID: 16369007.
      Citations: 50     Fields:    Translation:AnimalsCells
    81. Perera IY, Hung CY, Brady S, Muday GK, Boss WF. A universal role for inositol 1,4,5-trisphosphate-mediated signaling in plant gravitropism. Plant Physiol. 2006 Feb; 140(2):746-60. PMID: 16384898.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    82. Yu JJ, Kirkland TN, Hall LK, Wopschall J, Smith RC, Hung CY, Chen X, Tarcha E, Thomas PW, Cole GT. Characterization of a serodiagnostic complement fixation antigen of Coccidioides posadasii expressed in the nonpathogenic Fungus Uncinocarpus reesii. J Clin Microbiol. 2005 Nov; 43(11):5462-9. PMID: 16272471.
      Citations: 6     Fields:    Translation:Animals
    83. Hung CY, Seshan KR, Yu JJ, Schaller R, Xue J, Basrur V, Gardner MJ, Cole GT. A metalloproteinase of Coccidioides posadasii contributes to evasion of host detection. Infect Immun. 2005 Oct; 73(10):6689-703. PMID: 16177346.
      Citations: 51     Fields:    Translation:AnimalsCells
    84. Johannesson H, Townsend JP, Hung CY, Cole GT, Taylor JW. Concerted evolution in the repeats of an immunomodulating cell surface protein, SOWgp, of the human pathogenic fungi Coccidioides immitis and C. posadasii. Genetics. 2005 Sep; 171(1):109-17. PMID: 15965255.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    85. Xue J, Hung CY, Yu JJ, Cole GT. Immune response of vaccinated and non-vaccinated mice to Coccidioides posadasii infection. Vaccine. 2005 May 20; 23(27):3535-44. PMID: 15855012.
      Citations: 17     Fields:    Translation:Animals
    86. Cole GT, Xue JM, Okeke CN, Tarcha EJ, Basrur V, Schaller RA, Herr RA, Yu JJ, Hung CY. A vaccine against coccidioidomycosis is justified and attainable. Med Mycol. 2004 Jun; 42(3):189-216. PMID: 15283234.
      Citations: 41     Fields:    Translation:HumansAnimalsPHPublic Health
    87. Delgado N, Hung CY, Tarcha E, Gardner MJ, Cole GT. Profiling gene expression in Coccidioides posadasii. Med Mycol. 2004 Feb; 42(1):59-71. PMID: 14982115.
      Citations: 9     Fields:    Translation:AnimalsCells
    88. Delgado N, Xue J, Yu JJ, Hung CY, Cole GT. A recombinant beta-1,3-glucanosyltransferase homolog of Coccidioides posadasii protects mice against coccidioidomycosis. Infect Immun. 2003 Jun; 71(6):3010-9. PMID: 12761077.
      Citations: 30     Fields:    Translation:AnimalsCellsPHPublic Health
    89. Hung CY, Yu JJ, Seshan KR, Reichard U, Cole GT. A parasitic phase-specific adhesin of Coccidioides immitis contributes to the virulence of this respiratory Fungal pathogen. Infect Immun. 2002 Jul; 70(7):3443-56. PMID: 12065484.
      Citations: 63     Fields:    Translation:AnimalsCells
    90. Li K, Yu JJ, Hung CY, Lehmann PF, Cole GT. Recombinant urease and urease DNA of Coccidioides immitis elicit an immunoprotective response against coccidioidomycosis in mice. Infect Immun. 2001 May; 69(5):2878-87. PMID: 11292702.
      Citations: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    91. Hung CY, Yu JJ, Lehmann PF, Cole GT. Cloning and expression of the gene which encodes a tube precipitin antigen and wall-associated beta-glucosidase of Coccidioides immitis. Infect Immun. 2001 Apr; 69(4):2211-22. PMID: 11254576.
      Citations: 17     Fields:    Translation:AnimalsCells
    92. Cole GT, Hung CY. The parasitic cell wall of Coccidioides immitis. Med Mycol. 2001; 39 Suppl 1:31-40. PMID: 11800267.
      Citations: 14     Fields:    Translation:AnimalsCells
    93. Reichard U, Hung CY, Thomas PW, Cole GT. Disruption of the gene which encodes a serodiagnostic antigen and chitinase of the human fungal pathogen Coccidioides immitis. Infect Immun. 2000 Oct; 68(10):5830-8. PMID: 10992492.
      Citations: 15     Fields:    Translation:HumansAnimals
    94. Hung CY, Ampel NM, Christian L, Seshan KR, Cole GT. A major cell surface antigen of Coccidioides immitis which elicits both humoral and cellular immune responses. Infect Immun. 2000 Feb; 68(2):584-93. PMID: 10639421.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    95. Guevara-Olvera L, Hung CY, Yu JJ, Cole GT. Sequence, expression and functional analysis of the Coccidioides immitis ODC (ornithine decarboxylase) gene. Gene. 2000 Jan 25; 242(1-2):437-48. PMID: 10721738.
      Citations: 12     Fields:    Translation:AnimalsCells
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