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Luis Haro

InstitutionUniversity of Texas at San Antonio
Address1 UTSA Cir
San Antonio TX 78249
Phone(210) 458-5484
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    Dr. Haro’s research program has centered on the identification, isolation and characterization of new human pituitary and placental hormones (growth hormones/cytokines/chemokines) and delineation of their biological roles in normal physiology (metabolism, growth, differentiation, aging, immunology, brain function) and abnormal physiology (cancer, diabetes, HIV infection). The hormones studied include synthetic mutants (site-directed mutants, deletion mutants), naturally occurring hormones, and post-translational or alternatively spliced hormones. After isolation of these hormones, their structures are determined and their biopotencies were tested in a variety of in vitro (cell culture and organ explant culture) and in vivo bioassays that measure the immunologic, lactogenic, metabolic, physiologic, and anatomic affects associated with these hormones. These types of studies help us understand the structure-function relationships of these hormones. In order to carry out physiological investigations of these hormones, the lab has developed novel protein separation methodologies, radioimmunoassays, radioreceptorassays, and immunological techniques used for their isolation, detection, and quantification in tissues and in biological fluids. The study of these hormones and their receptors help us understand how they regulate cell and organ function in normal and abnormal physiology.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blackmore DG, Reynolds BA, Golmohammadi MG, Large B, Aguilar RM, Haro L, Waters MJ, Rietze RL. Growth hormone responsive neural precursor cells reside within the adult mammalian brain. Sci Rep. 2012; 2:250. PMID: 22355762.
      Citations: 8     Fields:    Translation:AnimalsCells
    2. Bustamante JJ, Grigorian AL, Muñoz J, Aguilar RM, Treviño LR, Martinez AO, Haro LS. Human growth hormone: 45-kDa isoform with extraordinarily stable interchain disulfide links has attenuated receptor-binding and cell-proliferative activities. Growth Horm IGF Res. 2010 Aug; 20(4):298-304. PMID: 20472479.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    3. Bustamante JJ, Gonzalez L, Carroll CA, Weintraub ST, Aguilar RM, Muñoz J, Martinez AO, Haro LS. O-Glycosylated 24 kDa human growth hormone has a mucin-like biantennary disialylated tetrasaccharide attached at Thr-60. Proteomics. 2009 Jul; 9(13):3474-88. PMID: 19579232.
      Citations: 5     Fields:    Translation:HumansCells
    4. Aguilar RM, Talamantes FJ, Bustamante JJ, Muñoz J, Treviño LR, Martinez AO, Haro LS. MAP dendrimer elicits antibodies for detecting rat and mouse GH-binding proteins. J Pept Sci. 2009 Feb; 15(2):78-88. PMID: 19089805.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Grigorian AL, Bustamante JJ, Muñoz J, Aguilar RM, Martinez AO, Haro LS. Preparative alkaline urea gradient PAGE: application to purification of extraordinarily-stable disulfide-linked homodimer of human growth hormone. Electrophoresis. 2007 Nov; 28(21):3829-36. PMID: 17922505.
      Citations: 2     Fields:    Translation:HumansCells
    6. Gonzalez L, Bustamante JJ, Barea-Rodriguez EJ, Martinez AO, Haro LS. 2-D native-PAGE/SDS-PAGE visualization of an oligomer's subunits: application to the analysis of IgG. Electrophoresis. 2006 May; 27(10):2016-23. PMID: 16703630.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Bustamante JJ, Garcia M, Gonzalez L, Garcia J, Flores R, Aguilar RM, Trevino A, Benavides L, Martinez AO, Haro LS. Separation of proteins with a molecular mass difference of 2 kDa utilizing preparative double-inverted gradient polyacrylamide gel electrophoresis under nonreducing conditions: application to the isolation of 24 kDa human growth hormone. Electrophoresis. 2005 Dec; 26(23):4389-95. PMID: 16273588.
      Citations: 1     Fields:    Translation:Humans
    8. Grigorian AL, Bustamante JJ, Hernandez P, Martinez AO, Haro LS. Extraordinarily stable disulfide-linked homodimer of human growth hormone. Protein Sci. 2005 Apr; 14(4):902-13. PMID: 15741328.
      Citations: 9     Fields:    Translation:HumansCells
    9. Pizarro JM, Haro LS, Barea-Rodriguez EJ. Learning associated increase in heat shock cognate 70 mRNA and protein expression. Neurobiol Learn Mem. 2003 Mar; 79(2):142-51. PMID: 12591223.
      Citations: 7     Fields:    Translation:Animals
    10. Sanchez DJ, Armstrong L, Aguilar R, Adrian GS, Haro L, Martinez AO. Haptoglobin gene expression in human glioblastoma cell lines. Neurosci Lett. 2001 May 11; 303(3):181-4. PMID: 11323115.
      Citations: 1     Fields:    Translation:HumansCells
    11. Mummidi S, Bamshad M, Ahuja SS, Gonzalez E, Feuillet PM, Begum K, Galvis MC, Kostecki V, Valente AJ, Murthy KK, Haro L, Dolan MJ, Allan JS, Ahuja SK. Evolution of human and non-human primate CC chemokine receptor 5 gene and mRNA. Potential roles for haplotype and mRNA diversity, differential haplotype-specific transcriptional activity, and altered transcription factor binding to polymorphic nucleotides in the pathogenesis of HIV-1 and simian immunodeficiency virus. J Biol Chem. 2000 Jun 23; 275(25):18946-61. PMID: 10747879.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    12. Haro LS, Bustamante J, Hernandez P, Flores R, Aguilar R, Lopez-Guajardo C, Martinez AO. Biochemistry and pharmacology of rabbit cardiac growth hormone (GH) receptors. Mol Cell Endocrinol. 1999 Jun 25; 152(1-2):179-87. PMID: 10432235.
      Citations:    Fields:    Translation:AnimalsCells
    13. Aguilar RM, Bustamante JJ, Hernandez PG, Martinez AO, Haro LS. Precipitation of dilute chromatographic samples (ng/ml) containing interfering substances for SDS-PAGE. Anal Biochem. 1999 Feb 15; 267(2):344-50. PMID: 10036140.
      Citations: 10     Fields:    Translation:Cells
    14. Westfall DA, Flores RR, Negrete GR, Martinez AO, Haro LS. High-resolution polyacrylamide gel electrophoresis of carbohydrates derivatized with a visible dye. Anal Biochem. 1998 Dec 15; 265(2):232-7. PMID: 9882397.
      Citations:    Fields:    
    15. Haro LS, Cubriel A, Bustamante J, Flores R, Martinez AO. Divalent metal cation chelators enhance chromatographic separation of structurally similar macromolecules: separation of human growth hormone isoforms. J Chromatogr B Biomed Sci Appl. 1998 Dec 11; 720(1-2):39-47. PMID: 9892065.
      Citations: 1     Fields:    Translation:Humans
    16. López-Guajardo CC, Armstrong LS, Jordan L, Staten NR, Krivi GG, Martinez AO, Haro LS. Generation, characterization and utilization of anti-human growth hormone 1-43, (hGH1-43), monoclonal antibodies in an ELISA. J Immunol Methods. 1998 Jun 01; 215(1-2):179-85. PMID: 9744760.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    17. Haro LS, Lewis UJ, Garcia M, Bustamante J, Martinez AO, Ling NC. Glycosylated human growth hormone (hGH): a novel 24 kDa hGH-N variant. Biochem Biophys Res Commun. 1996 Nov 12; 228(2):549-56. PMID: 8920950.
      Citations: 8     Fields:    Translation:HumansCells
    18. Haro LS, Singh RN, Lewis UJ, Martinez AO, Galosy SS, Staten NR, Krivi GG. Human growth hormone deletion mutant (hGH44-191) binds with high affinity to lactogenic receptors but not to somatogenic receptors. Biochem Biophys Res Commun. 1996 May 15; 222(2):421-6. PMID: 8670221.
      Citations:    Fields:    Translation:HumansAnimalsCells
    19. Lewis UJ, Sinha YN, Haro LS. Variant forms and fragments of human growth hormone in serum. Acta Paediatr Suppl. 1994 Apr; 399:29-31; discussion 32. PMID: 7949613.
      Citations: 10     Fields:    Translation:Humans
    20. Diaz MJ, Dominguez F, Haro LS, Ling N, Devesa J. A 12-kilodalton N-glycosylated growth hormone-related peptide is present in human pituitary extracts. J Clin Endocrinol Metab. 1993 Jul; 77(1):134-8. PMID: 8325936.
      Citations: 8     Fields:    Translation:HumansCells
    21. Sinha YN, DePaolo LV, Haro LS, Singh RN, Jacobsen BP, Scott KE, Lewis UJ. Isolation and biochemical properties of four forms of glycosylated porcine prolactin. Mol Cell Endocrinol. 1991 Sep; 80(1-3):203-13. PMID: 1955078.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Haro LS, Lee DW, Singh RN, Bee G, Markoff E, Lewis UJ. Glycosylated human prolactin: alterations in glycosylation pattern modify affinity for lactogen receptor and values in prolactin radioimmunoassay. J Clin Endocrinol Metab. 1990 Aug; 71(2):379-83. PMID: 2380335.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    23. Salem MA, Lewis UJ, Haro LS, Kishi K, McAllister DL, Seavey BK, Bee G, Wolff GL. Effects of hypophysectomy and the insulin-like and anti-insulin pituitary peptides on carbohydrate metabolism in yellow Avy/A (BALB/c x VY)F1 hybrid mice. Proc Soc Exp Biol Med. 1989 Sep; 191(4):408-19. PMID: 2672006.
      Citations: 1     Fields:    Translation:AnimalsCells
    24. Haro LS, Talamantes FJ. Studies on dissociation of mouse prolactin from mouse hepatic receptors. Mol Cell Endocrinol. 1986 Feb; 44(2):159-64. PMID: 3005086.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Haro LS, Talamantes FJ. Thermodynamics and kinetics of mouse prolactin-hepatic receptor interaction. Mol Cell Endocrinol. 1985 Dec; 43(2-3):199-204. PMID: 3000853.
      Citations: 2     Fields:    Translation:Animals
    26. Haro LS, Talamantes FJ. Interaction of mouse prolactin with mouse hepatic receptors. Mol Cell Endocrinol. 1985 Jun; 41(1):93-104. PMID: 2989041.
      Citations: 4     Fields:    Translation:Animals
    27. Haro LS, Talamantes FJ. Secreted mouse prolactin (PRL) and stored ovine PRL. I. Biochemical characterization, isolation, and purification of their electrophoretic isoforms. Endocrinology. 1985 Jan; 116(1):346-52. PMID: 3964749.
      Citations: 1     Fields:    Translation:Animals
    28. Haro LS, Talamantes FJ. Secreted mouse prolactin (PRL) and stored ovine PRL. II. Role of amides in receptor binding and immunoreactivity. Endocrinology. 1985 Jan; 116(1):353-8. PMID: 2981070.
      Citations: 5     Fields:    Translation:AnimalsCells
    29. Haro LS, Talamantes FJ. Protein hormones: detection and extraction of functional forms from alkaline polyacrylamide gels. J Biochem Biophys Methods. 1984 Dec; 10(3-4):173-9. PMID: 6085087.
      Citations: 2     Fields:    Translation:HumansAnimals
    30. Haro LS, Collier RJ, Talamantes FJ. Homologous somatotropin radioreceptor assay utilizing recombinant bovine growth hormone. Mol Cell Endocrinol. 1984 Dec; 38(2-3):109-16. PMID: 6096183.
      Citations: 5     Fields:    Translation:AnimalsCells
    31. Colosi P, Marr G, Lopez J, Haro L, Ogren L, Talamantes F. Isolation, purification, and characterization of mouse placental lactogen. Proc Natl Acad Sci U S A. 1982 Feb; 79(3):771-5. PMID: 6950428.
      Citations: 11     Fields:    Translation:AnimalsCells
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