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Mikhail Inyushin

InstitutionUniversidad Central Del Caribe
AddressPO Box 60327
Bayamon PR 00960-6032
Phone(787)798-3001 ext 2063
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    Collapse Biography 
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    1991 - 1992Fellowship, British Royal Society

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    Our work focuses on low-affinity, high-capacity monoamine transporters found on brain cells named astrocytes. The literature, and our preliminary data, suggests a special role for these transporters during chronic use of addictive drugs or during other situations leading to monoamine disbalance. Studying of these transporters give a new target for the pharmacotherapy to challenge monoamine disbalance and may eventually lead to a new treatments for some of these diseases.
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    SC2GM111149     (INYUSHIN, MIKHAIL)May 1, 2016 - Apr 30, 2021
    Glial uptake of dopamine after L-DOPA medication
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zayas-Santiago A, Díaz-García A, Nuñez-Rodríguez R, Inyushin M. Accumulation of amyloid beta in human glioblastomas. Clin Exp Immunol. 2020 Jul 12. PMID: 32654112.
    2. Zueva L, Golubeva T, Korneeva E, Resto O, Inyushin M, Khmelinskii I, Makarov V. Electron microscopy study of the central retinal fovea in Pied flycatcher: evidence of a mechanism of light energy transmission through the retina. Heliyon. 2020 Jun; 6(6):e04146. PMID: 32566783.
    3. Martins AH, Zayas-Santiago A, Ferrer-Acosta Y, Martinez-Jimenez SM, Zueva L, Diaz-Garcia A, Inyushin M. Accumulation of Amyloid Beta (Aß) Peptide on Blood Vessel Walls in the Damaged Brain after Transient Middle Cerebral Artery Occlusion. Biomolecules. 2019 08 08; 9(8). PMID: 31398804.
      Citations:    Fields:    Translation:Animals
    4. Zueva L, Golubeva T, Korneeva E, Resto O, Inyushin M, Khmelinskii I, Makarov V. Quantum mechanism of light energy propagation through an avian retina. J Photochem Photobiol B. 2019 Aug; 197:111543. PMID: 31279896.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Inyushin M, Meshalkina D, Zueva L, Zayas-Santiago A. Tissue Transparency In Vivo. Molecules. 2019 Jun 28; 24(13). PMID: 31261621.
      Citations:    Fields:    Translation:HumansAnimals
    6. Kucheryavykh LY, Ortiz-Rivera J, Kucheryavykh YV, Zayas-Santiago A, Diaz-Garcia A, Inyushin MY. Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors. Int J Mol Sci. 2019 May 20; 20(10). PMID: 31137462.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Kucheryavykh YV, Davila J, Ortiz-Rivera J, Inyushin M, Almodovar L, Mayol M, Morales-Cruz M, Cruz-Montañez A, Barcelo-Bovea V, Griebenow K, Kucheryavykh LY. Targeted Delivery of Nanoparticulate Cytochrome C into Glioma Cells Through the Proton-Coupled Folate Transporter. Biomolecules. 2019 04 18; 9(4). PMID: 31003476.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    8. Inyushin M, Zayas-Santiago A, Rojas L, Kucheryavykh Y, Kucheryavykh L. Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma. Histol Histopathol. 2019 Aug; 34(8):843-856. PMID: 30945258.
      Citations: 2     Fields:    Translation:HumansCells
    9. Zayas-Santiago A, Ríos DS, Zueva LV, Inyushin MY. Localization of aA-Crystallin in Rat Retinal Müller Glial Cells and Photoreceptors. Microsc Microanal. 2018 10; 24(5):545-552. PMID: 30253817.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Valentín-Guillama G, López S, Kucheryavykh YV, Chorna NE, Pérez J, Ortiz-Rivera J, Inyushin M, Makarov V, Valentín-Acevedo A, Quinones-Hinojosa A, Boukli N, Kucheryavykh LY. HIV-1 Envelope Protein gp120 Promotes Proliferation and the Activation of Glycolysis in Glioma Cell. Cancers (Basel). 2018 Sep 01; 10(9). PMID: 30200472.
    11. Kucheryavykh LY, Kucheryavykh YV, Washington AV, Inyushin MY. Amyloid Beta Peptide Is Released during Thrombosis in the Skin. Int J Mol Sci. 2018 06 08; 19(6). PMID: 29890636.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Inyushin MY, Sanabria P, Rojas L, Kucheryavykh Y, Kucheryavykh L. Aß Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development. Biomed Res Int. 2017; 2017:3948360. PMID: 29018812.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Khmelinskii I, Golubeva T, Korneeva E, Inyushin M, Zueva L, Makarov V. Spectral selectivity model for light transmission by the intermediate filaments in Müller cells. J Photochem Photobiol B. 2017 Aug; 173:282-290. PMID: 28623820.
      Citations: 2     Fields:    Translation:Cells
    14. Kucheryavykh LY, Dávila-Rodríguez J, Rivera-Aponte DE, Zueva LV, Washington AV, Sanabria P, Inyushin MY. Platelets are responsible for the accumulation of ß-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis. Brain Res Bull. 2017 01; 128:98-105. PMID: 27908798.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Makarov V, Zueva L, Golubeva T, Korneeva E, Khmelinskii I, Inyushin M. Errata: Quantum mechanism of light transmission by the intermediate filaments in some specialized optically transparent cells. Neurophotonics. 2017 Jan; 4(1):019801. PMID: 27660802.
    16. Makarov V, Zueva L, Golubeva T, Korneeva E, Khmelinskii I, Inyushin M. Quantum mechanism of light transmission by the intermediate filaments in some specialized optically transparent cells. Neurophotonics. 2017 Jan; 4(1):011005. PMID: 27570792.
    17. Morales-Cruz M, Cruz-Montañez A, Figueroa CM, González-Robles T, Davila J, Inyushin M, Loza-Rosas SA, Molina AM, Muñoz-Perez L, Kucheryavykh LY, Tinoco AD, Griebenow K. Combining Stimulus-Triggered Release and Active Targeting Strategies Improves Cytotoxicity of Cytochrome c Nanoparticles in Tumor Cells. Mol Pharm. 2016 08 01; 13(8):2844-54. PMID: 27283751.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    18. Inyushin M, Kucheryavih Y, Kucheryavih L, Rojas L, Khmelinskii I, Makarov V. Superparamagnetic Properties of Hemozoin. Sci Rep. 2016 05 18; 6:26212. PMID: 27188748.
      Citations: 1     Fields:    
    19. Zueva L, Golubeva T, Korneeva E, Makarov V, Khmelinskii I, Inyushin M. Foveolar Müller Cells of the Pied Flycatcher: Morphology and Distribution of Intermediate Filaments Regarding Cell Transparency. Microsc Microanal. 2016 Apr; 22(2):379-86. PMID: 26926795.
      Citations: 4     Fields:    Translation:AnimalsCells
    20. Makarov V, Zueva L, Sanabria P, Wessinger WD, Golubeva T, Khmelinskii I, Inyushin M. On the Role of the Blood Vessel Endothelial Microvilli in the Blood Flow in Small Capillaries. J Biophys. 2015; 2015:529746. PMID: 26604921.
    21. Khmelinskii I, Zueva L, Inyushin M, Makarov V. Model of Polarization Selectivity of the Intermediate Filament Optical Channels. Photonics Nanostruct. 2015 Aug; 16:24-33. PMID: 26435707.
    22. Rolón-Reyes K, Kucheryavykh YV, Cubano LA, Inyushin M, Skatchkov SN, Eaton MJ, Harrison JK, Kucheryavykh LY. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PLoS One. 2015; 10(6):e0131059. PMID: 26098895.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    23. Skatchkov SN, Bukauskas FF, Benedikt J, Inyushin M, Kucheryavykh YV. Intracellular spermine prevents acid-induced uncoupling of Cx43 gap junction channels. Neuroreport. 2015 Jun 17; 26(9):528-32. PMID: 26011388.
      Citations: 4     Fields:    Translation:HumansCells
    24. Zueva L, Rivera Y, Kucheryavykh L, Skatchkov SN, Eaton MJ, Sanabria P, Inyushin M. Electron microscopy in rat brain slices reveals rapid accumulation of Cisplatin on ribosomes and other cellular components only in glia. Chemother Res Pract. 2014; 2014:174039. PMID: 25610648.
    25. Huertas A, Wessinger WD, Kucheryavykh YV, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Maldonado-Martínez G, Inyushin MY. Quinine enhances the behavioral stimulant effect of cocaine in mice. Pharmacol Biochem Behav. 2015 Feb; 129:26-33. PMID: 25482328.
      Citations: 1     Fields:    Translation:Animals
    26. Zueva L, Makarov V, Zayas-Santiago A, Golubeva T, Korneeva E, Savvinov A, Eaton M, Skatchkov S, Inyushin M. Müller cell alignment in bird fovea: possible role in vision. J Neurosci Neuroeng. 2014 12 01; 3(2):85-91. PMID: 25866702.
    27. Zayas-Santiago A, Agte S, Rivera Y, Benedikt J, Ulbricht E, Karl A, Dávila J, Savvinov A, Kucheryavykh Y, Inyushin M, Cubano LA, Pannicke T, Veh RW, Francke M, Verkhratsky A, Eaton MJ, Reichenbach A, Skatchkov SN. Unidirectional photoreceptor-to-Müller glia coupling and unique K+ channel expression in Caiman retina. PLoS One. 2014; 9(5):e97155. PMID: 24831221.
      Citations: 8     Fields:    Translation:AnimalsCells
    28. Kucheryavykh LY, Rolón-Reyes K, Kucheryavykh YV, Skatchkov S, Eaton MJ, Sanabria P, Wessinger WD, Inyushin M. Glioblastoma development in mouse brain: general reduction of OCTs and mislocalization of OCT3 transporter and subsequent uptake of ASP+ substrate to the nuclei. J Neurosci Neuroeng. 2014 Feb; 3(1):3-9. PMID: 25165637.
    29. Makarov V, Kucheryavykh L, Kucheryavykh Y, Rivera A, Eaton MJ, Skatchkov SN, Inyushin M. Transport Reversal during Heteroexchange: A Kinetic Study. J Biophys. 2013; 2013:683256. PMID: 24307897.
    30. Iniouchine MY, Sibarov DA, Vol'nova AB. Comparative analysis of changes in membrane currents in neurons and astrocytes in rat hippocampal slices after stimulation of glutamatergic transmission. Dokl Biol Sci. 2013 Mar; 449:65-7. PMID: 23652428.
      Citations:    Fields:    Translation:AnimalsCells
    31. Mikhail U. Inyushin, Francisco Arencibia-Albite, Angel de la Cruz, Rafael Vázquez-Torres, Katiria Colon, Priscila Sanabria, and Carlos A. Jiménez-Rivera. New Method to Visualize Neurons with DAT in Slices of Rat VTA Using Fluorescent Substrate for DAT, ASP+. J. Neurosci. Neuroeng. 2013; 2:98-103. View Publication.
    32. Inyushin MU, Arencibia-Albite F, de la Cruz A, Vázquez-Torres R, Colon K, Sanabria P, Jiménez-Rivera CA. New method to visualize neurons with DAT in slices of rat VTA using fluorescent substrate for DAT, ASP+ J Neurosci Neuroeng. 2013 Apr; 2(2):98-103. PMID: 24052926.
    33. Sala-Rabanal M, Li DC, Dake GR, Kurata HT, Inyushin M, Skatchkov SN, Nichols CG. Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Mol Pharm. 2013 Apr 01; 10(4):1450-8. PMID: 23458604.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    34. Benedikt J, Inyushin M, Kucheryavykh YV, Rivera Y, Kucheryavykh LY, Nichols CG, Eaton MJ, Skatchkov SN. Intracellular polyamines enhance astrocytic coupling. Neuroreport. 2012 Dec 05; 23(17):1021-5. PMID: 23076119.
      Citations: 17     Fields:    Translation:AnimalsCells
    35. Kucheryavykh LY, Kucheryavykh YV, Rolón-Reyes K, Skatchkov SN, Eaton MJ, Cubano LA, Inyushin M. Visualization of implanted GL261 glioma cells in living mouse brain slices using fluorescent 4-(4-(dimethylamino)-styryl)-N-methylpyridinium iodide (ASP+). Biotechniques. 2012 Nov; 53(5):305-9. PMID: 23570046.
      Citations: 8     Fields:    Translation:HumansAnimals
    36. Inyushin MY, Huertas A, Kucheryavykh YV, Kucheryavykh LY, Tsydzik V, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Wessinger WD. L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain. Parkinsons Dis. 2012; 2012:321406. PMID: 22888467.
    37. Inyushin M, Kucheryavykh LY, Kucheryavykh YV, Nichols CG, Buono RJ, Ferraro TN, Skatchkov SN, Eaton MJ. Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. Epilepsia. 2010 Sep; 51(9):1707-13. PMID: 20831751.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    38. Inyushin M, Kucheryaykh Y, Kucheryavykh L, Sanabria P, Jiménez-Rivera C, Struganova I, Eaton M, Skatchkov S. Membrane potential and pH-dependent accumulation of decynium-22 (1,1'-diethyl-2,2'-cyanine iodide) flourencence through OCT transporters in astrocytes. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):5-12. PMID: 23875515.
      Citations: 4     Fields:    Translation:AnimalsCells
    39. Inyushin MU, Arencibia-Albite F, Vázquez-Torres R, Vélez-Hernández ME, Jiménez-Rivera CA. Alpha-2 noradrenergic receptor activation inhibits the hyperpolarization-activated cation current (Ih) in neurons of the ventral tegmental area. Neuroscience. 2010 May 05; 167(2):287-97. PMID: 20122999.
      Citations: 20     Fields:    Translation:AnimalsCells
    40. Kucheryavykh LY, Kucheryavykh YV, Inyushin M, Shuba YM, Sanabria P, Cubano LA, Skatchkov SN, Eaton MJ. Ischemia Increases TREK-2 Channel Expression in Astrocytes: Relevance to Glutamate Clearance. Open Neurosci J. 2009 Jan 01; 3:40-47. PMID: 19890471.
    41. Kucheryavykh YV, Shuba YM, Antonov SM, Inyushin MY, Cubano L, Pearson WL, Kurata H, Reichenbach A, Veh RW, Nichols CG, Eaton MJ, Skatchkov SN. Complex rectification of Müller cell Kir currents. Glia. 2008 May; 56(7):775-90. PMID: 18293411.
      Citations: 15     Fields:    Translation:AnimalsCells
    42. Iniouchine MY, Sibarov DA, Volnova AB, Jimenez-Rivera CA, Nozdrachev AD. Blockers of monoamine transporters influence high dopamine concentration uptake in rat brain slices. Dokl Biol Sci. 2008 Mar-Apr; 419:80-2. PMID: 18536267.
      Citations: 4     Fields:    Translation:Animals
    43. Inyushin MY, Volnova AB, Lenkov DN. Use of a simplified method of optical recording to identify foci of maximal neuron activity in the somatosensory cortex of white rats. Neurosci Behav Physiol. 2001 Mar-Apr; 31(2):201-5. PMID: 11388374.
      Citations: 8     Fields:    Translation:AnimalsCells
    44. Iniushin MIu, Vol'nova AB, Lenkov DN. [Application of the simplified method of optic recording for mapping focuses of the neuronal activity in the somatosensory cortex of the white rats]. Ross Fiziol Zh Im I M Sechenova. 1999 Nov; 85(11):1385-90. PMID: 10687170.
      Citations:    Fields:    Translation:AnimalsCells
    45. Lenkov DN. Use of artificial ion channels for quasi-intracellular recording of cerebral cortex neuron activity. Neurosci Behav Physiol. 1997 Nov-Dec; 27(6):702-7. PMID: 9406225.
      Citations: 3     Fields:    Translation:AnimalsCells
    46. Iniushin MIu, Tsytsarev VIu, Ignashchenkova AIu, Lenkov DN. [The use of artificial ion channels for the quasi-intracellular recording of the activity of cerebral cortex neurons]. Fiziol Zh Im I M Sechenova. 1996 Jan; 82(1):18-24. PMID: 8829673.
      Citations:    Fields:    Translation:AnimalsCells
    47. Lobanova EA, Iniushin MIu, Andreev NIu, Kiselev OI. [The membranotropic and neurotropic properties of remantadine and deitiforin in experimental models]. Vopr Virusol. 1991 Mar-Apr; 36(2):142-4. PMID: 1882521.
      Citations:    Fields:    Translation:AnimalsCells
    48. Zhuravlev VL, Iniushin MIu, Safonova TA. [The central neurons that inhibit the work of the heart in the edible snail]. Nauchnye Doki Vyss Shkoly Biol Nauki. 1990; (4):58-65. PMID: 2383603.
      Citations: 1     Fields:    Translation:AnimalsCells
    49. Zhuravlev VL, Iniushin MIu, Safonova TA. [Postsynaptic potentials in the myocardium of snails in the genus Helix]. Zh Evol Biokhim Fiziol. 1989 Sep-Oct; 25(5):589-97. PMID: 2556873.
      Citations: 1     Fields:    Translation:AnimalsCells
    50. Zhuravlev VL, Safonova TA, Iniushin MIu, Mestnikov VA. [Identified neuronal networks in the edible snail]. Nerv Sist. 1988; 27:34-41. PMID: 3254450.
      Citations:    Fields:    Translation:AnimalsCells
    51. Iniushin MIu, Zhuravlev VL, Safonova TA. [Command neurons of the pneumostome initiate synaptic potentials in the heart and lung of the snail]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 May-Jun; 37(3):581-3. PMID: 2820165.
      Citations: 2     Fields:    Translation:AnimalsCells
    52. Iniushin MIu, Zhuravlev VL. [Stabilization of the flow rate of perfusion solutions by the means of a floating chamber]. Fiziol Zh SSSR Im I M Sechenova. 1983 Mar; 69(3):414-5. PMID: 6852298.
      Citations:    Fields:    Translation:AnimalsCells
    53. Zhuravlev VL, Iniushin MIu. [Does hypoxia affect electrophysiologic characteristics of Helix pomatia neurons?]. Neirofiziologiia. 1983; 15(1):96-8. PMID: 6835432.
      Citations:    Fields:    Translation:Animals
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