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Renato J. Aguilera

TitleDirector BBRC Research Infrastructure Core
Faculty RankProfessor
InstitutionUniversity of Texas at El Paso
DepartmentBiological Sciences
AddressBiological Sciences, 500 W University Drive
El Paso TX 79968-0519
Phone9157476852
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    Other Positions
    TitleProgram Director of the Border Biomedical Research Center
    InstitutionThe University of Texas at El Paso
    DepartmentBiological Sciences


    Collapse Affiliation 

    Collapse Biography 
    Collapse awards and honors
    1982 - 1985NSF-Predoctoral Fellowship, University of California at Berkeley
    1986 - 1987Ford Foundation Dissertation Fellow, University of California at Berkeley
    1987 - 1989University of California President’s Postdoctoral Fellowship, University of California at Berkeley
    1995Departmental Distinguished Teaching Award, UCLA
    2007College of Science Distinguished Teaching Award, The University of Texas at El Paso
    2010American Society for Microbiology, William A. Hinton Research Training Award, ASM
    2013Distinguished Research Mentor Award, Socieity for the Advancement of Chicanos and Native Americans in Science

    Collapse Overview 
    Collapse overview
    As an Immunologist, the PI has extensive experience in cell culture, rodent husbandry and drug screening. With the use of recently acquired drug screening equipment within the Cytometry, Screening and Imaging Core, his group has recently developed assays for screening of chemical libraries on a variety of human cancer cells. The ultimate goal of these assays is to discover compounds that can kill specific cancer cells but not others. In recent months, the simultaneous screening of compounds of various human cancer cell lines has resulted in the detection of novel lead compounds with potent anti-lymphoma and anti-breast cancer activities. This research involves the participation and training of several undergraduates and graduate students; the majority of whom are from underrepresented minority groups.

    Short Biography:
    Dr. Renato Aguilera obtained his Ph.D. from U.C. Berkeley in 1987 and was a tenured professor at UCLA for 14 years. Dr. Aguilera's research has been continuously funded by federal grants since 1989 and he currently works on anticancer drug discovery. Dr. Aguilera obtained his BS and MS degrees in Microbiology from The University of Texas at El Paso (UTEP) and joined this university in 2002 as a Full Professor and Director of the Biology Graduate Program. He is the director of the Cytometry, Screening and Imaging Core facility and RCMI Program Director of the Border Biomedical Research Center at UTEP. Dr. Aguilera has been the director of the Research Initiative for Scientific Enhancement (RISE) Scholars training program since 2003 and will continue to direct this program till 2022. The recently renewed RISE program will train 25 undergraduates and 15 graduate students from underrepresented minority groups. For his long-standing commitment to student training and mentorship, he received the prestigious American Society for Microbiology William A. Hinton Research Training Award in 2010 and the SACNAS Distinguished Research Mentor Award in 2013 . Dr. Aguilera was the chair of the Minority Affairs Committee of the American Society for Cell Biology from 2010-16). In addition, he has served on the Board of Scientific Councilor’s of the NIEHS, on the Committee of Visitors of NSF, and on several NIH grant review panels.

    Collapse Research 
    Collapse research resources
    This researcher has shared information about their research resources
    in the eagle-i Network. To update or add resource records, contact
    support@rtrn.net.
    Cytometry, Screening and Imaging Core Facility

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Borrego EA, Guerena CD, Schiaffino Bustamante AY, Gutierrez DA, Valenzuela CA, Betancourt AP, Varela-Ramirez A, Aguilera RJ. A Novel Pyrazole Exhibits Potent Anticancer Cytotoxicity via Apoptosis, Cell Cycle Arrest, and the Inhibition of Tubulin Polymerization in Triple-Negative Breast Cancer Cells. Cells. 2024 Jul 20; 13(14). PMID: 39056806.
      Citations:    Fields:    Translation:HumansCells
    2. ElMorsy SM, Gutierrez DA, Valdez S, Kumar J, Aguilera RJ, Noufal M, Sarma H, Chinnam S, Narayan M. Graphene acid quantum dots: A highly active multifunctional carbon nano material that intervene in the trajectory towards neurodegeneration. J Colloid Interface Sci. 2024 Sep 15; 670:357-363. PMID: 38763031.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Swain RM, Sanchez A, Gutierrez DA, Varela-Ramirez A, Aguilera RJ. Thiophene derivative inflicts cytotoxicity via an intrinsic apoptotic pathway on human acute lymphoblastic leukemia cells. PLoS One. 2023; 18(12):e0295441. PMID: 38127921.
      Citations:    Fields:    Translation:HumansCells
    4. Bhatt HN, Diwan R, Borrego EA, P?rez CAM, Varela-Ramirez A, Kumar R, Aguilera RJ, Nurunnabi M. A photothermal driven chemotherapy for the treatment of metastatic melanoma. J Control Release. 2023 09; 361:314-333. PMID: 37562554.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Jain PM, Gutierrez DA, Kumar S, Aguilera RJ, Karki SS. Synthesis of Novel Pyrazole-Oxindole Conjugates with Cytotoxicity in Human Cancer Cells via Apoptosis. Chem Biodivers. 2023 Sep; 20(9):e202300843. PMID: 37501576.
      Citations:    Fields:    Translation:HumansCells
    6. Huda MN, Borrego EA, Guerena CD, Varela-Ramirez A, Aguilera RJ, Hamadani CM, Tanner EEL, Badruddoza AZM, Agarwal SK, Nurunnabi M. Topical Administration of an Apoptosis Inducer Mitigates Bleomycin-Induced Skin Fibrosis. ACS Pharmacol Transl Sci. 2023 May 12; 6(5):829-841. PMID: 37200808.
      Citations:    
    7. Tchounwou PB, Malouhi M, Ofili EO, Fern?ndez-Repollet E, Sarpong DF, Yanagihara R, Aguilera RJ, Ay?n C, Chen X, Dasmahapatra A, Gao S, Hinton CV, Holt R, Kolesnichenko V, Powell MD, Merchant F, Redda KK, Roche-Lima A, Shikuma CM, Stevens JJ, Torres JA, Trotter RT, Wachira J, Wang P, Wells KJ, White J, Wu Y. Research Infrastructure Core Facilities at Research Centers in Minority Institutions: Part I-Research Resources Management, Operation, and Best Practices. Int J Environ Res Public Health. 2022 12 17; 19(24). PMID: 36554864.
      Citations: 1     Fields:    Translation:Humans
    8. Aguilera RJ. A virus changed my life. Mol Biol Cell. 2022 12 01; 33(14):ae2. PMID: 36441842.
      Citations:    Fields:    Translation:HumansAnimals
    9. Ma Y, Qiu C, Wang B, Zhang X, Wang X, Aguilera RJ, Zhang JY. Autoantibody against Tumor-Associated Antigens as Diagnostic Biomarkers in Hispanic Patients with Hepatocellular Carcinoma. Cells. 2022 10 14; 11(20). PMID: 36291095.
      Citations: 2     Fields:    Translation:Humans
    10. Chhikara A, Roayapalley PK, Sakagami H, Amano S, Satoh K, Uesawa Y, Das U, Das S, Borrego EA, Guerena CD, Hernandez CR, Aguilera RJ, Dimmock JR. Novel Unsymmetric 3,5-Bis(benzylidene)-4-piperidones That Display Tumor-Selective Toxicity. Molecules. 2022 Oct 09; 27(19). PMID: 36235258.
      Citations:    Fields:    Translation:HumansCells
    11. Huda MN, Deaguero IG, Borrego EA, Kumar R, Islam T, Afrin H, Varela-Ramirez A, Aguilera RJ, Tanner EEL, Nurunnabi M. Ionic liquid-mediated delivery of a BCL-2 inhibitor for topical treatment of skin melanoma. J Control Release. 2022 09; 349:783-795. PMID: 35908622.
      Citations: 6     Fields:    Translation:HumansAnimals
    12. Swain RM, Contreras L, Varela-Ramirez A, Hossain M, Das U, Valenzuela CA, Penichet ML, Dimmock JR, Aguilera RJ. Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines. Invest New Drugs. 2022 Oct; 40(5):905-921. PMID: 35793039.
      Citations: 1     Fields:    Translation:HumansCells
    13. Hess JD, Macias LH, Gutierrez DA, Moran-Santibanez K, Contreras L, Medina S, Villanueva PJ, Kirken RA, Varela-Ramirez A, Penichet ML, Aguilera RJ. Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro. Biology (Basel). 2022 Jun 18; 11(6). PMID: 35741451.
      Citations:    
    14. Gutierrez DA, Contreras L, Villanueva PJ, Borrego EA, Mor?n-Santiba?ez K, Hess JD, DeJesus R, Larragoity M, Betancourt AP, Mohl JE, Robles-Escajeda E, Begum K, Roy S, Kirken RA, Varela-Ramirez A, Aguilera RJ. Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways. Cells. 2022 01 12; 11(2). PMID: 35053370.
      Citations: 7     Fields:    Translation:HumansCells
    15. Roayapalley PK, Sakagami H, Satoh K, Amano S, Bandow K, Aguilera RJ, Hernandez KGC, Schiaffino Bustamante AY, Dimmock SG, Sharma RK, Das U, Dimmock JR. Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring. Medicines (Basel). 2021 Dec 16; 8(12). PMID: 34940290.
      Citations:    
    16. Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U. Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts. Molecules. 2021 Nov 25; 26(23). PMID: 34885719.
      Citations: 4     Fields:    Translation:HumansCells
    17. Contreras L, Medina S, Schiaffino Bustamante AY, Borrego EA, Valenzuela CA, Das U, Karki SS, Dimmock JR, Aguilera RJ. Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms. Pharmacol Rep. 2022 Feb; 74(1):159-174. PMID: 34448104.
      Citations: 4     Fields:    Translation:HumansCells
    18. Boyce M, Aguilera RJ. Preparing for tenure at a research-intensive university. BMC Proc. 2021 Jun 22; 15(Suppl 2):14. PMID: 34158043.
      Citations:    
    19. Lakhani K, Borrego EA, Cano KG, Dimmock JR, Aguilera RJ, Das S, Roayapalley PK, Sharma RK, Das U. Design, Syntheses, and Bioevaluations of Some Novel N2-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents. Medicines (Basel). 2021 Jun 03; 8(6). PMID: 34205029.
      Citations:    
    20. Tilekar K, Hess JD, Upadhyay N, Bianco AL, Schweipert M, Laghezza A, Loiodice F, Meyer-Almes FJ, Aguilera RJ, Lavecchia A, C S R. Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects. J Med Chem. 2021 05 27; 64(10):6949-6971. PMID: 34006099.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    21. Villanueva PJ, Gutierrez DA, Contreras L, Parra K, Segura-Cabrera A, Varela-Ramirez A, Aguilera RJ. The Antimalarial Drug Pyronaridine Inhibits Topoisomerase II in Breast Cancer Cells and Hinders Tumor Progression In Vivo. Clin Cancer Drugs. 2021 Mar; 8(1):50-56. PMID: 35178342.
      Citations:    
    22. Choodamani B, Cano Hernandez KG, Kumar S, Tony AM, Schiaffino Bustamante AY, Aguilera RJ, Schols D, Gopi Mohan C, Karki SS. Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4-Methoxybenzyl Derivatives Bearing Imidazo[2,1-b][1,3,4]thiadiazole. Chem Biodivers. 2021 Feb; 18(2):e2000800. PMID: 33274824.
      Citations:    Fields:    Translation:HumansAnimalsCells
    23. Nakamura-Bencomo S, Gutierrez DA, Robles-Escajeda E, Iglesias-Figueroa B, Siqueiros-Cend?n TS, Espinoza-S?nchez EA, Ar?valo-Gallegos S, Aguilera RJ, Rasc?n-Cruz Q, Varela-Ramirez A. Recombinant human lactoferrin carrying humanized glycosylation exhibits antileukemia selective cytotoxicity, microfilament disruption, cell cycle arrest, and apoptosis activities. Invest New Drugs. 2021 04; 39(2):400-415. PMID: 33063290.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    24. Philipovskiy A, Dwivedi AK, Gamez R, McCallum R, Mukherjee D, Nahleh Z, Aguilera RJ, Gaur S. Association between tumor mutation profile and clinical outcomes among Hispanic Latina women with triple-negative breast cancer. PLoS One. 2020; 15(9):e0238262. PMID: 32886682.
      Citations: 10     Fields:    Translation:Humans
    25. Tilekar K, Upadhyay N, Schweipert M, Hess JD, Macias LH, Mrowka P, Meyer-Almes FJ, Aguilera RJ, Iancu CV, Choe JY, Ramaa CS. Permuted 2,4-thiazolidinedione (TZD) analogs as GLUT inhibitors and their in-vitro evaluation in leukemic cells. Eur J Pharm Sci. 2020 Nov 01; 154:105512. PMID: 32801003.
      Citations: 10     Fields:    Translation:Cells
    26. Tilekar K, Upadhyay N, Hess JD, Macias LH, Mrowka P, Aguilera RJ, Meyer-Almes FJ, Iancu CV, Choe JY, Ramaa CS. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Sep 15; 202:112603. PMID: 32634629.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    27. Donoso-Bustamante V, Borrego EA, Schiaffino-Bustamante Y, Guti?rrez DA, Millas-Vargas JP, Fuentes-Retamal S, Correa P, Carrillo I, Aguilera RJ, Miranda D, Ch?vez-B?ez I, Pulgar R, Urra FA, Varela-Ram?rez A, Araya-Maturana R. An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells. Bioorg Chem. 2020 07; 100:103935. PMID: 32454391.
      Citations: 8     Fields:    Translation:HumansCells
    28. Upadhyay N, Tilekar K, J?nsch N, Schweipert M, Hess JD, Henze Macias L, Mrowka P, Aguilera RJ, Choe JY, Meyer-Almes FJ, Ramaa CS. Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. Bioorg Chem. 2020 07; 100:103934. PMID: 32446120.
      Citations: 9     Fields:    Translation:HumansCells
    29. Segarra VA, Blatch S, Boyce M, Carrero-Martinez F, Aguilera RJ, Leibowitz MJ, Zavala M, Hammonds-Odie L, Edwards A. Scientific Societies Advancing STEM Workforce Diversity: Lessons and Outcomes from the Minorities Affairs Committee of the American Society for Cell Biology. J Microbiol Biol Educ. 2020; 21(1). PMID: 32313596.
      Citations:    
    30. Fratev F, Gutierrez DA, Aguilera RJ, Tyagi A, Damodaran C, Sirimulla S. Discovery of new AKT1 inhibitors by combination of in silico structure based virtual screening approaches and biological evaluations. J Biomol Struct Dyn. 2021 01; 39(1):368-377. PMID: 31933423.
      Citations: 3     Fields:    Translation:Cells
    31. Philipovskiy A, Campbell A, Heydarian R, Castillo B, Dwivedi AK, McCallum R, Aguilera R, Gaur S, Nahleh Z. Adherence to Adjuvant Aromatase Inhibitor Therapy Among Postmenopausal Hispanic/Latino Women With Breast Cancer. Anticancer Res. 2020 02; 40(2):857-864. PMID: 32014929.
      Citations: 8     Fields:    Translation:Humans
    32. Khandaker TA, Hess JD, Aguilera R, Andrei G, Snoeck R, Schols D, Pradhan P, Lakshman MK. Synthesis and Evaluations of "1,4-Triazolyl Combretacoumarins" and Desmethoxy Analogues. European J Org Chem. 2019 Sep 08; 2019(33):5610-5623. PMID: 31579393.
      Citations:    
    33. Iglesias-Figueroa BF, Siqueiros-Cend?n TS, Gutierrez DA, Aguilera RJ, Espinoza-S?nchez EA, Ar?valo-Gallegos S, Varela-Ramirez A, Rasc?n-Cruz Q. Recombinant human lactoferrin induces apoptosis, disruption of F-actin structure and cell cycle arrest with selective cytotoxicity on human triple negative breast cancer cells. Apoptosis. 2019 08; 24(7-8):562-577. PMID: 30941553.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    34. Montoya A, Varela-Ramirez A, Dickerson E, Pasquier E, Torabi A, Aguilera R, Nahleh Z, Bryan B. The beta adrenergic receptor antagonist propranolol alters mitogenic and apoptotic signaling in late stage breast cancer. Biomed J. 2019 06; 42(3):155-165. PMID: 31466709.
      Citations: 37     Fields:    Translation:HumansCells
    35. Solis LH, Ayala Y, Portillo S, Varela-Ramirez A, Aguilera R, Boland T. Thermal inkjet bioprinting triggers the activation of the VEGF pathway in human microvascular endothelial cells in vitro. Biofabrication. 2019 07 09; 11(4):045005. PMID: 31151129.
      Citations: 32     Fields:    Translation:HumansCells
    36. Sharma S, Aguilera R, Rao J, Gimzewski JK. Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions. Sci Rep. 2019 06 26; 9(1):9282. PMID: 31243301.
      Citations: 2     Fields:    Translation:HumansAnimals
    37. Ruiz-Medina BE, Lerma D, Hwang M, Ross JA, Skouta R, Aguilera RJ, Kirken RA, Varela-Ramirez A, Robles-Escajeda E. Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways. Sci Rep. 2019 04 12; 9(1):6005. PMID: 30979953.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    38. Gutierrez DA, DeJesus RE, Contreras L, Rodriguez-Palomares IA, Villanueva PJ, Balderrama KS, Monterroza L, Larragoity M, Varela-Ramirez A, Aguilera RJ. A new pyridazinone exhibits potent cytotoxicity on human cancer cells via apoptosis and poly-ubiquitinated protein accumulation. Cell Biol Toxicol. 2019 12; 35(6):503-519. PMID: 30825052.
      Citations: 20     Fields:    Translation:HumansCells
    39. Castro E, Cer?n MR, Garcia AH, Kim Q, Etcheverry-Berr?os A, Morel MJ, D?az-Torres R, Qian W, Martinez Z, Mendez L, Perez F, Santoyo CA, Gimeno-Mu?oz R, Esper R, Gutierrez DA, Varela-Ramirez A, Aguilera RJ, Llano M, Soler M, Aliaga-Alcalde N, Echegoyen L. Correction: A new family of fullerene derivatives: fullerene-curcumin conjugates for biological and photovoltaic applications. RSC Adv. 2019 Jan 18; 9(5):2379. PMID: 35520488.
      Citations:    
    40. Castro E, Cer?n MR, Garcia AH, Kim Q, Etcheverry-Berr?os A, Morel M, D?az-Torres R, Qian W, Martinez Z, Mendez L, Perez F, Santoyo CA, Gimeno-Mu?oz R, Esper R, Gutierrez DA, Varela-Ramirez A, Aguilera RJ, Llano M, Soler M, Aliaga-Alcalde N, Echegoyen L. A new family of fullerene derivatives: Fullerene-curcumin conjugates for biological and photovoltaic applications. RSC Adv. 2018; 8(73):41692-41698. PMID: 31543960.
      Citations:    
    41. Villanueva PJ, Martinez A, Baca ST, DeJesus RE, Larragoity M, Contreras L, Gutierrez DA, Varela-Ramirez A, Aguilera RJ. Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis. PLoS One. 2018; 13(11):e0206467. PMID: 30395606.
      Citations: 19     Fields:    Translation:HumansCells
    42. Contreras L, Calderon RI, Varela-Ramirez A, Zhang HY, Quan Y, Das U, Dimmock JR, Skouta R, Aguilera RJ. Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones. Cell Oncol (Dordr). 2018 Dec; 41(6):623-636. PMID: 30088262.
      Citations: 17     Fields:    Translation:HumansCells
    43. Varela-Ramirez A, Abendroth J, Mejia AA, Phan IQ, Lorimer DD, Edwards TE, Aguilera RJ. Structure of acid deoxyribonuclease. Nucleic Acids Res. 2017 Jun 02; 45(10):6217-6227. PMID: 28369538.
      Citations: 9     Fields:    Translation:Cells
    44. Montoya A, Amaya CN, Belmont A, Diab N, Trevino R, Villanueva G, Rains S, Sanchez LA, Badri N, Otoukesh S, Khammanivong A, Liss D, Baca ST, Aguilera RJ, Dickerson EB, Torabi A, Dwivedi AK, Abbas A, Chambers K, Bryan BA, Nahleh Z. Use of non-selective ?-blockers is associated with decreased tumor proliferative indices in early stage breast cancer. Oncotarget. 2017 Jan 24; 8(4):6446-6460. PMID: 28031536.
      Citations: 71     Fields:    Translation:HumansCells
    45. Nunes LM, Hossain M, Varela-Ramirez A, DAS U, Ayala-Marin YM, Dimmock JR, Aguilera RJ. A novel class of piperidones exhibit potent, selective and pro-apoptotic anti-leukemia properties. Oncol Lett. 2016 Jun; 11(6):3842-3848. PMID: 27313705.
      Citations:    
    46. Robles-Escajeda E, Das U, Ortega NM, Parra K, Francia G, Dimmock JR, Varela-Ramirez A, Aguilera RJ. A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells. Cell Oncol (Dordr). 2016 Jun; 39(3):265-77. PMID: 26920032.
      Citations: 44     Fields:    Translation:HumansCells
    47. Santiago-V?zquez Y, Das U, Varela-Ramirez A, Baca ST, Ayala-Marin Y, Lema C, Das S, Baryyan A, Dimmock JR, Aguilera RJ. Tumor-selective cytotoxicity of a novel pentadiene analogue on human leukemia/ lymphoma cells. Clin Cancer Drugs. 2016; 3(2):138-146. PMID: 27857884.
      Citations:    
    48. Liu M, Varela-Ramirez A, Li J, Dai L, Aguilera RJ, Zhang JY. Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma. Oncol Rep. 2015 May; 33(5):2245-52. PMID: 25779011.
      Citations: 5     Fields:    Translation:Humans
    49. Oldham ED, Nunes LM, Varela-Ramirez A, Rankin SE, Knutson BL, Aguilera RJ, Lehmler HJ. Cytotoxic activity of triazole-containing alkyl ?-D-glucopyranosides on a human T-cell leukemia cell line. Chem Cent J. 2015; 9:3. PMID: 25705252.
      Citations:    
    50. Gonzalez H, Lema C, Kirken RA, Maldonado RA, Varela-Ramirez A, Aguilera RJ. Arsenic-exposed Keratinocytes Exhibit Differential microRNAs Expression Profile; Potential Implication of miR-21, miR-200a and miR-141 in Melanoma Pathway. Clin Cancer Drugs. 2015; 2(2):138-147. PMID: 27054085.
      Citations:    
    51. Seong CS, Varela-Ramirez A, Tang X, Anchondo B, Magallanes D, Aguilera RJ. Cloning and characterization of a novel Drosophila stress induced DNase. PLoS One. 2014; 9(8):e103564. PMID: 25083901.
      Citations: 8     Fields:    Translation:AnimalsCells
    52. Nunes LM, Robles-Escajeda E, Santiago-Vazquez Y, Ortega NM, Lema C, Muro A, Almodovar G, Das U, Das S, Dimmock JR, Aguilera RJ, Varela-Ramirez A. The gender of cell lines matters when screening for novel anti-cancer drugs. AAPS J. 2014 Jul; 16(4):872-4. PMID: 24875051.
      Citations: 17     Fields:    Translation:HumansCells
    53. Santiago-Vazquez Y, Das S, Das U, Robles-Escajeda E, Ortega NM, Lema C, Varela-Ram?rez A, Aguilera RJ, Balzarini J, De Clercq E, Dimmock SG, Gorecki DK, Dimmock JR. Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity. Eur J Med Chem. 2014 Apr 22; 77:315-22. PMID: 24657568.
      Citations: 13     Fields:    Translation:HumansCells
    54. Pedroza DA, De Leon F, Varela-Ramirez A, Lema C, Aguilera RJ, Mito S. The cytotoxic effect of 2-acylated-1,4-naphthohydroquinones on leukemia/lymphoma cells. Bioorg Med Chem. 2014 Jan 15; 22(2):842-7. PMID: 24368029.
      Citations: 5     Fields:    Translation:HumansCells
    55. Robles-Escajeda E, Mart?nez A, Varela-Ramirez A, S?nchez-Delgado RA, Aguilera RJ. Analysis of the cytotoxic effects of ruthenium-ketoconazole and ruthenium-clotrimazole complexes on cancer cells. Cell Biol Toxicol. 2013 Dec; 29(6):431-43. PMID: 24272524.
      Citations: 18     Fields:    Translation:HumansCells
    56. Robles-Escajeda E, Lerma D, Nyakeriga AM, Ross JA, Kirken RA, Aguilera RJ, Varela-Ramirez A. Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells. PLoS One. 2013; 8(9):e73508. PMID: 24039967.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    57. Oldham ED, Seelam S, Lema C, Aguilera RJ, Fiegel J, Rankin SE, Knutson BL, Lehmler HJ. Synthesis, surface properties, and biocompatibility of 1,2,3-triazole-containing alkyl ?-D-xylopyranoside surfactants. Carbohydr Res. 2013 Sep 20; 379:68-77. PMID: 23872788.
      Citations: 2     Fields:    Translation:HumansCells
    58. Aguilera RJ. Issues on diversity, training, and mentorship of young scientists: an interview. Mol Biol Cell. 2012 Jun; 23(12):2237-9. PMID: 22695482.
      Citations: 3     Fields:    Translation:Humans
    59. Zhao L, Peralta-Videa JR, Varela-Ramirez A, Castillo-Michel H, Li C, Zhang J, Aguilera RJ, Keller AA, Gardea-Torresdey JL. Effect of surface coating and organic matter on the uptake of CeO2 NPs by corn plants grown in soil: Insight into the uptake mechanism. J Hazard Mater. 2012 Jul 30; 225-226:131-8. PMID: 22633924.
      Citations: 15     Fields:    Translation:Animals
    60. Zhao, L., Peralta-Videa J.R., Ren, M., Varela-Ramirez, A., Li, C., Hernandez-Viezcas, J.A., Aguilera, R.J., Gardea-Torresdey, J.L. . Transport of Zn in a sandy loam soil treated with ZnO NPs and uptake by corn plants: Electron microprobe and confocal microscopy studies. Chem. Eng . J. 2012; 184:1– 8.
    61. Zhao, L., Peralta-Videa J.R., Varela-Ramirez, A., Castillo-Michel, H., Li, C., Zhang, J., Aguilera, R.J., Keller, A.A., Gardea-Torresdey, J.L. . (2012). Effect of surface coating and organic matter on the uptake of CeO2 NPs by corn plants grown in soil: Insight into the uptake mechanism. J. Hazard. Mater. 2012; 225-226:131-138..
    62. Aguilera, R.J. . Issues on Diversity, Training and Mentorship of Young Scientists: An interview. Molecular Biology of the Cell. 2012; 23:2237-39..
    63. Xu W, Osei-Prempeh G, Lema C, Davis Oldham E, Aguilera RJ, Parkin S, Rankin SE, Knutson BL, Lehmler HJ. Synthesis, thermal properties, and cytotoxicity evaluation of hydrocarbon and fluorocarbon alkyl ?-D-xylopyranoside surfactants. Carbohydr Res. 2012 Feb 15; 349:12-23. PMID: 22207000.
      Citations: 4     Fields:    Translation:HumansCells
    64. Gonz?lez-Pantoja JF, Stern M, Jarzecki AA, Royo E, Robles-Escajeda E, Varela-Ram?rez A, Aguilera RJ, Contel M. Titanocene-phosphine derivatives as precursors to cytotoxic heterometallic TiAu2 and TiM (M = Pd, Pt) compounds. Studies of their interactions with DNA. Inorg Chem. 2011 Nov 07; 50(21):11099-110. PMID: 21958150.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    65. Lema C, Varela-Ramirez A, Aguilera RJ. Differential nuclear staining assay for high-throughput screening to identify cytotoxic compounds. Curr Cell Biochem. 2011; 1(1):1-14. PMID: 27042697.
      Citations:    
    66. Liu F, Anis R, Hwang E, Ovalle R, Varela-Ram?rez A, Aguilera RJ, Contel M. Group 11 Metal Compounds with Tripodal Bis(imidazole) Thioether Ligands. Applications as Catalysts in the Oxidation of Alkenes and as Antimicrobial Agents. Molecules. 2011 Aug 08; 16(8):6701-20. PMID: 25134773.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    67. Das S, Das U, Varela-Ram?rez A, Lema C, Aguilera RJ, Balzarini J, De Clercq E, Dimmock SG, Gorecki DK, Dimmock JR. Bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides: a novel class of potent cytotoxins. ChemMedChem. 2011 Oct 04; 6(10):1892-9. PMID: 21826795.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    68. Lema, C., Varela-Ramirez, A., and Aguilera, R.J. (2011). Differential nuclear staining assay for high-throughput screening to identify cytotoxic compounds. J.Curr.Cell.Biochem. 2011; 1:1-14..
    69. Liu, F., Anis, R., Hwang, E., Ovalle, R., Varela-Ramirez, A., Aguilera, R.J., Contel, M. (2011) . Group 11 metal compounds with tripodal bis(imidazole) thioether ligands. Applications as catalysts in the oxidation of alkenes and as antimicrobial agents. Molecules. 2011; 16(8):6701-6720 .
    70. Varela-Ramirez A, Costanzo M, Carrasco YP, Pannell KH, Aguilera RJ. Cytotoxic effects of two organotin compounds and their mode of inflicting cell death on four mammalian cancer cells. Cell Biol Toxicol. 2011 Jun; 27(3):159-68. PMID: 21069563.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    71. Nohara LL, Lema C, Bader JO, Aguilera RJ, Almeida IC. High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi. Parasitol Int. 2010 Dec; 59(4):565-70. PMID: 20688189.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    72. Mart?nez A, Rajapakse CS, S?nchez-Delgado RA, Varela-Ramirez A, Lema C, Aguilera RJ. Arene-Ru(II)-chloroquine complexes interact with DNA, induce apoptosis on human lymphoid cell lines and display low toxicity to normal mammalian cells. J Inorg Biochem. 2010 Sep; 104(9):967-77. PMID: 20605217.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    73. Elie BT, Levine C, Ubarretxena-Belandia I, Varela-Ram?rez A, Aguilera RJ, Ovalle R, Contel M. Water Soluble Phosphane-Gold(I) Complexes. Applications as Recyclable Catalysts in a Three-component Coupling Reaction and as Antimicrobial and Anticancer Agents. Eur J Inorg Chem. 2009 Aug 01; 2009(23):3421-3430. PMID: 23524957.
      Citations:    
    74. Shaik N, Mart?nez A, Augustin I, Giovinazzo H, Varela-Ram?rez A, Sana? M, Aguilera RJ, Contel M. Synthesis of apoptosis-inducing iminophosphorane organogold(III) complexes and study of their interactions with biomolecular targets. Inorg Chem. 2009 Feb 16; 48(4):1577-87. PMID: 19146434.
      Citations: 23     Fields:    Translation:HumansCells
    75. Shpak M, Kugelman JR, Varela-Ramirez A, Aguilera RJ. The phylogeny and evolution of deoxyribonuclease II: an enzyme essential for lysosomal DNA degradation. Mol Phylogenet Evol. 2008 May; 47(2):841-54. PMID: 18226927.
      Citations: 5     Fields:    Translation:AnimalsCells
    76. Cruz-Campa I, Arzola A, Santiago L, Parsons JG, Varela-Ramirez A, Aguilera RJ, Noveron JC. A novel class of metal-directed supramolecular DNA-delivery systems. Chem Commun (Camb). 2007 Jul 28; (28):2944-6. PMID: 17622439.
      Citations: 4     Fields:    Translation:HumansCells
    77. Seong CS, Varela-Ramirez A, Aguilera RJ. DNase II deficiency impairs innate immune function in Drosophila. Cell Immunol. 2006 Mar; 240(1):5-13. PMID: 16854402.
      Citations: 14     Fields:    Translation:AnimalsCells
    78. Montoya J, Varela-Ramirez A, Shanmugasundram M, Martinez LE, Primm TP, Aguilera RJ. Tandem screening of toxic compounds on GFP-labeled bacteria and cancer cells in microtiter plates. Biochem Biophys Res Commun. 2005 Sep 23; 335(2):367-72. PMID: 16081045.
      Citations: 4     Fields:    Translation:HumansCells
    79. Varela-Ramirez A, Mejia A, Garcia D, Bader J, Aguilera RJ. HIV infection and risk behavior of Hispanic farm workers at the west Texas-Mexico border. Ethn Dis. 2005; 15(4 Suppl 5):S5-92-6. PMID: 16312943.
      Citations: 7     Fields:    Translation:Humans
    80. Rajabi L, Courreges C, Montoya J, Aguilera RJ, Primm TP. Acetophenones with selective antimycobacterial activity. Lett Appl Microbiol. 2005; 40(3):212-7. PMID: 15715647.
      Citations: 7     Fields:    Translation:HumansCells
    81. Montoya J, Varela-Ramirez A, Estrada A, Martinez LE, Garza K, Aguilera RJ. A fluorescence-based rapid screening assay for cytotoxic compounds. Biochem Biophys Res Commun. 2004 Dec 24; 325(4):1517-23. PMID: 15555600.
      Citations: 6     Fields:    Translation:HumansCells
    82. Evans CJ, Aguilera RJ. DNase II: genes, enzymes and function. Gene. 2003 Dec 11; 322:1-15. PMID: 14644493.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    83. Solorzano-Vargas RS, Wang J, Jiang L, Tsai HV, Ontiveros LO, Vazir MA, Aguilera RJ, Mart?n MG. Multiple transcription factors in 5'-flanking region of human polymeric Ig receptor control its basal expression. Am J Physiol Gastrointest Liver Physiol. 2002 Aug; 283(2):G415-25. PMID: 12121890.
      Citations:    Fields:    Translation:HumansAnimalsCells
    84. Evans CJ, Merriam JR, Aguilera RJ. Drosophila acid DNase is a homolog of mammalian DNase II. Gene. 2002 Jul 24; 295(1):61-70. PMID: 12242012.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    85. Miranda GA, Villalvazo M, Galic Z, Alva J, Abrines R, Yates Y, Evans CJ, Aguilera RJ. Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors. Mol Immunol. 2002 Jun; 38(15):1151-9. PMID: 12044781.
      Citations: 3     Fields:    Translation:AnimalsCells
    86. Lyon CJ, Evans CJ, Bill BR, Otsuka AJ, Aguilera RJ. The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II. Gene. 2000 Jul 11; 252(1-2):147-54. PMID: 10903446.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    87. Galic Z, Alva JA, Lin A, Lyon CJ, Aguilera RJ. Characterization of a novel DNA binding domain within the amino-terminal region of the RAG-1 protein. Biochem Mol Biol Int. 1998 Jul; 45(3):535-44. PMID: 9679654.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    88. Brown ST, Miranda GA, Galic Z, Hartman IZ, Lyon CJ, Aguilera RJ. Regulation of the RAG-1 promoter by the NF-Y transcription factor. J Immunol. 1997 Jun 01; 158(11):5071-4. PMID: 9164918.
      Citations: 9     Fields:    Translation:AnimalsCells
    89. de la Pompa JL, Wakeham A, Correia KM, Samper E, Brown S, Aguilera RJ, Nakano T, Honjo T, Mak TW, Rossant J, Conlon RA. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development. 1997 Mar; 124(6):1139-48. PMID: 9102301.
      Citations: 191     Fields:    Translation:AnimalsCells
    90. Lyon CJ, Aguilera RJ. Purification and characterization of the immunoglobulin switch sequence-specific endonuclease (Endo-SR) from bovine spleen. Mol Immunol. 1997 Feb; 34(3):209-19. PMID: 9224963.
      Citations: 4     Fields:    Translation:AnimalsCells
    91. Lyon CJ, Miranda GA, Piao JS, Aguilera RJ. Characterization of an endonuclease activity which preferentially cleaves the G-rich immunoglobulin switch repeat sequences. Mol Immunol. 1996 Feb; 33(2):157-69. PMID: 8649437.
      Citations: 4     Fields:    Translation:AnimalsCells
    92. Miranda GA, Chokler I, Aguilera RJ. The murine nucleolin protein is an inducible DNA and ATP binding protein which is readily detected in nuclear extracts of lipopolysaccharide-treated splenocytes. Exp Cell Res. 1995 Apr; 217(2):294-308. PMID: 7698229.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    93. Casillas AM, Thompson AD, Cheshier S, Hernandez S, Aguilera RJ. RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines. Mol Immunol. 1995 Feb; 32(3):167-75. PMID: 7898493.
      Citations:    Fields:    Translation:AnimalsCells
    94. Aguilera RJ, Akira S, Okazaki K, Sakano H. A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences. Cell. 1987 Dec 24; 51(6):909-17. PMID: 3500792.
      Citations: 18     Fields:    Translation:AnimalsCells
    95. Hope TJ, Aguilera RJ, Minie ME, Sakano H. Endonucleolytic activity that cleaves immunoglobulin recombination sequences. Science. 1986 Mar 07; 231(4742):1141-5. PMID: 3003919.
      Citations: 12     Fields:    Translation:AnimalsCells
    96. Aguilera RJ, Hope TJ, Sakano H. Characterization of immunoglobulin enhancer deletions in murine plasmacytomas. EMBO J. 1985 Dec 30; 4(13B):3689-93. PMID: 4092693.
      Citations: 18     Fields:    Translation:AnimalsCells
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