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Jianying Zhang

Faculty RankProfessor
InstitutionUniversity of Texas at El Paso
DepartmentBiological Sciences
AddressUniversity of Texas at El Paso
500 West University Avenue
El Paso TX 79968
Phone915747 6995
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    Collapse Overview 
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    I am currently a tenured full professor in the Department of Biological Sciences, and a principal investigator of NIH-Sponsored Border Biomedical Research Center (BBRC) at The University of Texas at EL Paso (UTEP). My research career goal is to become a world-leading scientist in the field of cancer biomarker and cancer immunodiagnosis. I have focused my research career on the identification, characterization, and evaluation of tumor-associated antigens as biomarkers in cancer detection, and I have expertise in all the molecular, histo-pathological, immunological, and proteomic approaches proposed in this application for the cancer biomarker research. I joined Eng Tan’s lab at the Scripps Research Institute (La Jolla, CA) at the end of 1995 for postdoctoral training on cancer autoimmunity research, and I left to take a faculty position in the Department of Biological Sciences at UTEP (University of Texas at El Paso) in December 2001. During this time, I have developed and completed several research projects. With serum antibodies from patients with hepatocellular carcinoma (HCC), I was able to immunoscreen a cDNA expression library and isolate a cDNA encoding a 62 kDa protein (p62), which was further identified as a tumor-associated antigen [J. Exp. Med. 1999]. p62 is an IGF-2 mRNA binding protein and belongs to a new class of TAAs. This was an exciting finding because IGF-2 is a growth factor and overexpression had been shown before to be involved in promoting malignancy. p62 is thought to play a role in protecting IGF-2 mRNA from degradation, therefore more of the growth factor was being produced in cancer cells. Autoantibodies to p62 are present in 15-20% of patients with HCC and in a slightly lower but also significant frequency in many other human tumors. This finding has opened a new field of studies for understanding cancer biology and for cancer diagnosis. In a subsequent study, I identified another cDNA encoding an important TAA p90 [Oncogenes, 2002]. In the past 15 years, I have published over 80 papers on TAA-related research in peer-reviewed biomedical journals. In this field, I was well recognized by peers as one of the leaders. I was invited by several peer-reviewed Immunology journals to write reviews or comments in this TAA-related field (Autoimmunity Reviews 2002, 2007, 2011, 2014; Immunological Reviews 2008; Expert Rev. Mol. Diagn. 2010, 2015). I was also invited by Journal of Immunology Research as Lead Guest Editor to edit two special issues (2014, 2016) of the journal on "Cancer Immunodiagnosis and Cancer Immunotherapy". Based on the Google Scholar, some of my previous publications have been cited over 3600 times; h-index was 36, and i10-index was 68. see http://www.researcherid.com/rid/F-3798-2010).

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sanchez TW, Zhang G, Li J, Dai L, Mirshahidi S, Wall NR, Yates C, Wilson C, Montgomery S, Zhang JY, Casiano CA. Immunoseroproteomic Profiling in African American Men with Prostate Cancer: Evidence for an Autoantibody Response to Glycolysis and Plasminogen-Associated Proteins. Mol Cell Proteomics. 2016 Dec; 15(12):3564-3580. PMID: 27742740.
      Citations: 9     Fields:    Translation:HumansCells
    2. Dai L, Tsay JC, Li J, Yie TA, Munger JS, Pass H, Rom WN, Zhang Y, Tan EM, Zhang JY. Autoantibodies against tumor-associated antigens in the early detection of lung cancer. Lung Cancer. 2016 09; 99:172-9. PMID: 27565936.
      Citations: 21     Fields:    Translation:Humans
    3. Dai L, Li J, Xing M, Sanchez TW, Casiano CA, Zhang JY. Using Serological Proteome Analysis to Identify Serum Anti-Nucleophosmin 1 Autoantibody as a Potential Biomarker in European-American and African-American Patients With Prostate Cancer. Prostate. 2016 11; 76(15):1375-86. PMID: 27418398.
      Citations: 10     Fields:    Translation:HumansCells
    4. Li J, Dai L, Lei N, Xing M, Li P, Luo C, Casiano CA, Zhang JY. Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer. Oncotarget. 2016 Jul 12; 7(28):43546-43556. PMID: 27286458.
      Citations: 4     Fields:    Translation:Humans
    5. Li P, Shi JX, Dai LP, Chai YR, Zhang HF, Kankonde M, Kankonde P, Yu BF, Zhang JY. Serum anti-MDM2 and anti-c-Myc autoantibodies as biomarkers in the early detection of lung cancer. Oncoimmunology. 2016 May; 5(5):e1138200. PMID: 27467958.
    6. Dai L, Peng XX, Tan EM, Zhang JY. Tumor-associated antigen CAPERa and microvessel density in hepatocellular carcinoma. Oncotarget. 2016 Mar 29; 7(13):16985-95. PMID: 26934653.
      Citations: 5     Fields:    Translation:Humans
    7. Li Y, Francia G, Zhang JY. p62/IMP2 stimulates cell migration and reduces cell adhesion in breast cancer. Oncotarget. 2015 Oct 20; 6(32):32656-68. PMID: 26416451.
      Citations: 14     Fields:    Translation:HumansCells
    8. Guo C, Peng B, Song M, Wu CW, Yang MJ, Zhang JY, Li H. Live Edwardsiella tarda vaccine enhances innate immunity by metabolic modulation in zebrafish. Fish Shellfish Immunol. 2015 Dec; 47(2):664-73. PMID: 26394266.
      Citations: 2     Fields:    Translation:AnimalsCells
    9. Zhou JW, Li Y, Yue LX, Luo CL, Chen Y, Zhang JY. Autoantibody response to Sui1 and its tissue-specific expression in hepatocellular carcinoma. Tumour Biol. 2016 Feb; 37(2):2547-53. PMID: 26386724.
      Citations: 2     Fields:    Translation:Humans
    10. Peng B, Ma YM, Zhang JY, Li H. Metabolome strategy against Edwardsiella tarda infection through glucose-enhanced metabolic modulation in tilapias. Fish Shellfish Immunol. 2015 Aug; 45(2):869-76. PMID: 26057462.
      Citations: 6     Fields:    Translation:AnimalsCells
    11. Zhu Q, Han SX, Zhou CY, Cai MJ, Dai LP, Zhang JY. Autoimmune response to PARP and BRCA1/BRCA2 in cancer. Oncotarget. 2015 May 10; 6(13):11575-84. PMID: 25865228.
      Citations: 8     Fields:    Translation:Humans
    12. Liu M, Varela-Ramirez A, Li J, Dai L, Aguilera RJ, Zhang JY. Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma. Oncol Rep. 2015 May; 33(5):2245-52. PMID: 25779011.
      Citations: 4     Fields:    Translation:Humans
    13. Peng B, Lei N, Chai Y, Chan EK, Zhang JY. CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer. Mol Biosyst. 2015 Jan; 11(1):105-14. PMID: 25325377.
      Citations: 7     Fields:    Translation:HumansCells
    14. Liu X, Peng B, Li Y, Lei N, Li W, Zhang JY. p90/CIP2A mediates breast cancer cell proliferation and apoptosis. Mol Biol Rep. 2014 Nov; 41(11):7471-8. PMID: 25086622.
      Citations: 4     Fields:    Translation:HumansCells
    15. Li Y, Zhang Q, Peng B, Shao Q, Qian W, Zhang JY. Identification of glutathione S-transferase omega 1 (GSTO1) protein as a novel tumor-associated antigen and its autoantibody in human esophageal squamous cell carcinoma. Tumour Biol. 2014 Nov; 35(11):10871-7. PMID: 25085586.
      Citations: 5     Fields:    Translation:Humans
    16. Lei N, Peng B, Zhang JY. CIP2A regulates cell proliferation via the AKT signaling pathway in human lung cancer. Oncol Rep. 2014 Oct; 32(4):1689-94. PMID: 25109354.
      Citations: 16     Fields:    Translation:HumansCells
    17. Liu M, Zheng SJ, Chen Y, Li N, Ren PF, Dai LP, Duan ZP, Zhang JY. Autoantibody response to murine double minute 2 protein in immunodiagnosis of hepatocellular carcinoma. J Immunol Res. 2014; 2014:906532. PMID: 24955377.
      Citations: 6     Fields:    Translation:Humans
    18. Liu X, Ye H, Li L, Li W, Zhang Y, Zhang JY. Humoral autoimmune responses to insulin-like growth factor II mRNA-binding proteins IMP1 and p62/IMP2 in ovarian cancer. J Immunol Res. 2014; 2014:326593. PMID: 24872956.
      Citations: 7     Fields:    Translation:HumansCells
    19. Dai L, Li J, Ortega R, Qian W, Casiano CA, Zhang JY. Preferential autoimmune response in prostate cancer to cyclin B1 in a panel of tumor-associated antigens. J Immunol Res. 2014; 2014:827827. PMID: 24860838.
      Citations: 16     Fields:    Translation:Humans
    20. Dai L, Ren P, Liu M, Imai H, Tan EM, Zhang JY. Using immunomic approach to enhance tumor-associated autoantibody detection in diagnosis of hepatocellular carcinoma. Clin Immunol. 2014 May-Jun; 152(1-2):127-39. PMID: 24667685.
      Citations: 20     Fields:    Translation:Humans
    21. Chai Y, Liu X, Dai L, Li Y, Liu M, Zhang JY. Overexpression of HCC1/CAPERa may play a role in lung cancer carcinogenesis. Tumour Biol. 2014 Jul; 35(7):6311-7. PMID: 24643682.
      Citations: 6     Fields:    Translation:Humans
    22. Zhu Q, Liu M, Dai L, Ying X, Ye H, Zhou Y, Han S, Zhang JY. Using immunoproteomics to identify tumor-associated antigens (TAAs) as biomarkers in cancer immunodiagnosis. Autoimmun Rev. 2013 Oct; 12(12):1123-8. PMID: 23806562.
      Citations: 18     Fields:    Translation:Humans
    23. Dai L, Lei N, Liu M, Zhang JY. Autoantibodies to tumor-associated antigens as biomarkers in human hepatocellular carcinoma (HCC). Exp Hematol Oncol. 2013 May 20; 2(1):15. PMID: 23687996.
    24. Rico CM, Hong J, Morales MI, Zhao L, Barrios AC, Zhang JY, Peralta-Videa JR, Gardea-Torresdey JL. Effect of cerium oxide nanoparticles on rice: a study involving the antioxidant defense system and in vivo fluorescence imaging. Environ Sci Technol. 2013 Jun 04; 47(11):5635-42. PMID: 23662857.
      Citations: 18     Fields:    Translation:AnimalsCells
    25. Peng B, Huang X, Nakayasu ES, Petersen JR, Qiu S, Almeida IC, Zhang JY. Using immunoproteomics to identify alpha-enolase as an autoantigen in liver fibrosis. J Proteome Res. 2013 Apr 05; 12(4):1789-96. PMID: 23458688.
      Citations: 13     Fields:    Translation:Humans
    26. Zhao L, Peng B, Hernandez-Viezcas JA, Rico C, Sun Y, Peralta-Videa JR, Tang X, Niu G, Jin L, Varela-Ramirez A, Zhang JY, Gardea-Torresdey JL. Stress response and tolerance of Zea mays to CeO2 nanoparticles: cross talk among H2O2, heat shock protein, and lipid peroxidation. ACS Nano. 2012 Nov 27; 6(11):9615-22. PMID: 23050848.
      Citations: 21     Fields:    Translation:AnimalsCells
    27. Zhang JY, Tan EM. Autoantibodies to tumor-associated antigens as diagnostic biomarkers in hepatocellular carcinoma and other solid tumors. Expert Rev Mol Diagn. 2010 Apr; 10(3):321-8. PMID: 20370589.
      Citations: 37     Fields:    Translation:HumansAnimals
    28. Chen Y, Zhou Y, Qiu S, Wang K, Liu S, Peng XX, Li J, Tan EM, Zhang JY. Autoantibodies to tumor-associated antigens combined with abnormal alpha-fetoprotein enhance immunodiagnosis of hepatocellular carcinoma. Cancer Lett. 2010 Mar 01; 289(1):32-9. PMID: 19683863.
      Citations: 30     Fields:    Translation:HumansCells
    29. Zhang JY, Looi KS, Tan EM. Identification of tumor-associated antigens as diagnostic and predictive biomarkers in cancer. Methods Mol Biol. 2009; 520:1-10. PMID: 19381943.
      Citations: 7     Fields:    Translation:HumansCells
    30. Looi KS, Nakayasu ES, Diaz RA, Tan EM, Almeida IC, Zhang JY. Using proteomic approach to identify tumor-associated antigens as markers in hepatocellular carcinoma. J Proteome Res. 2008 Sep; 7(9):4004-12. PMID: 18672925.
      Citations: 29     Fields:    Translation:HumansCells
    31. Chen Y, Lin P, Qiu S, Peng XX, Looi K, Farquhar MG, Zhang JY. Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. Int J Oncol. 2007 May; 30(5):1137-44. PMID: 17390015.
      Citations: 14     Fields:    Translation:HumansCells
    32. Looi K, Megliorino R, Shi FD, Peng XX, Chen Y, Zhang JY. Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies. Oncol Rep. 2006 Nov; 16(5):1105-10. PMID: 17016600.
      Citations: 35     Fields:    Translation:Humans
    33. Zhang JY. Mini-array of multiple tumor-associated antigens to enhance autoantibody detection for immunodiagnosis of hepatocellular carcinoma. Autoimmun Rev. 2007 Jan; 6(3):143-8. PMID: 17289549.
      Citations: 13     Fields:    Translation:Humans
    34. Zhang JY, Megliorino R, Peng XX, Tan EM, Chen Y, Chan EK. Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma. J Hepatol. 2007 Jan; 46(1):107-14. PMID: 17067715.
      Citations: 47     Fields:    Translation:Humans
    35. Megliorino R, Shi FD, Peng XX, Wang X, Chan EK, Tan EM, Zhang JY. Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection. Cancer Detect Prev. 2005; 29(3):241-8. PMID: 15896923.
      Citations: 13     Fields:    Translation:Humans
    36. Zhang JY. Tumor-associated antigen arrays to enhance antibody detection for cancer diagnosis. Cancer Detect Prev. 2004; 28(2):114-8. PMID: 15068835.
      Citations: 12     Fields:    Translation:Humans
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