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Siddhartha Das

Faculty RankProfessor
InstitutionUniversity of Texas at El Paso
DepartmentBiological Sciences
AddressUniversity of Texas at El Paso
500 West University Avenue
El Paso TX 79902
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    InstitutionUniversity of Texas at El Paso
    DepartmentBiological Sciences

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    Dr. Siddhartha Das maintains a strong research program in Biological Sciences at UTEP. His laboratory investigates the lipid metabolism and lipid signaling in parasitic protozoan, Giardia lamblia. Giardiasis caused by Giardia lamblia, is transmitted via infective cysts through contaminated water and prevalent in the US-Mexico Border Regions. He is also interested in identifying the role of arachidonic acid (present in high fat diet) in inducing inflammatory reactions in breast cancer. His laboratory has recently observed that leukotriene B4 (LTB4) is synthesized under the influence of excess arachidonic acid that plays a significant role in triggering inflammatory reactions and determining the metastatic migration and invasion of breast cancer cells. Dr. Das has published over 50 papers in peer-reviewed journals. He is on the editorial board and a permanent reviewer for various prestigious journals devoted to biochemistry, microbiology, molecular biology and parasitology. The work in Dr. Das’ laboratory is supported by the grants from the National Institutes of Health (NIH). Over the years, he has mentored many students, post-doctoral fellows, and new faculty members. Currently, he is the director of Immunology and Infectious Disease Program of the Border Biomedical Research Center (BBRC) supported by a grant from the NIH. At UTEP he teaches microbiology, biochemistry and molecular biology both at the undergraduate and graduate levels.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Das S, Somisetty VS, Ulven SM, Matthews J. Resveratrol and 3,3'-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells. Int J Mol Sci. 2023 Sep 26; 24(19). PMID: 37834026.
      Citations:    Fields:    Translation:HumansCells
    2. Grajeda BI, De Chatterjee A, Villalobos CM, Pence BC, Ellis CC, Enriquez V, Roy S, Roychowdhury S, Neumann AK, Almeida IC, Patterson SE, Das S. Giardial lipid rafts share virulence factors with secreted vesicles and participate in parasitic infection in mice. Front Cell Infect Microbiol. 2022; 12:974200. PMID: 36081774.
      Citations: 4     Fields:    Translation:AnimalsCells
    3. Kong W, Chen C, Chen G, Wang C, Liu D, Das S, Chen G, Li T, Li J, Liu Y, Li Z, Clifford BC, Hu L. Wood Ionic Cable. Small. 2021 10; 17(40):e2008200. PMID: 34496143.
      Citations:    Fields:    
    4. Sierra-Fonseca JA, Miranda M, Das S, Roychowdhury S. The ?? subunit of heterotrimeric G proteins interacts with actin filaments during neuronal differentiation. Biochem Biophys Res Commun. 2021 04 16; 549:98-104. PMID: 33667715.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Pogula PK, De Chatterjee A, Chi M, VanKoten HW, Das S, Patterson SE. Triazoxins: Novel nucleosides with anti-Giardia activity. Bioorg Med Chem Lett. 2020 06 15; 30(12):127175. PMID: 32327222.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Duarte TT, Ellis CC, Grajeda BI, De Chatterjee A, Almeida IC, Das S. A Targeted Mass Spectrometric Analysis Reveals the Presence of a Reduced but Dynamic Sphingolipid Metabolic Pathway in an Ancient Protozoan, Giardia lamblia. Front Cell Infect Microbiol. 2019; 9:245. PMID: 31396488.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Sierra-Fonseca JA, Bracamontes C, Saldecke J, Das S, Roychowdhury S. Activation of ?- and a2-adrenergic receptors stimulate tubulin polymerization and promote the association of G?? with microtubules in cultured NIH3T3 cells. Biochem Biophys Res Commun. 2018 09 03; 503(1):102-108. PMID: 29852176.
      Citations:    Fields:    Translation:AnimalsCells
    8. Chatterjee A, Roy D, Guevara P, Pal R, Naryan M, Roychowdhury S, Das S. Arachidonic Acid Induces the Migration of MDA-MB-231 Cells by Activating Raft-associated Leukotriene B4 Receptors. Clin Cancer Drugs. 2018; 5(1):28-41. PMID: 30443489.
    9. Zhu M, Li Y, Chen G, Jiang F, Yang Z, Luo X, Wang Y, Lacey SD, Dai J, Wang C, Jia C, Wan J, Yao Y, Gong A, Yang B, Yu Z, Das S, Hu L. Tree-Inspired Design for High-Efficiency Water Extraction. Adv Mater. 2017 Nov; 29(44). PMID: 29024077.
      Citations: 29     Fields:    
    10. Robles-Martinez L, Mendez TL, Apodaca J, Das S. Glucosylceramide transferase in Giardia preferentially catalyzes the synthesis of galactosylceramide during encystation. Mol Biochem Parasitol. 2017 01; 211:75-83. PMID: 27840079.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Mendez TL, De Chatterjee A, Duarte T, De Leon J, Robles-Martinez L, Das S. Sphingolipids, Lipid Rafts, and Giardial Encystation: The Show Must Go On. Curr Trop Med Rep. 2015 Sep 01; 2(3):136-143. PMID: 26587369.
    12. De Chatterjee A, Mendez TL, Roychowdhury S, Das S. The assembly of GM1 glycolipid- and cholesterol-enriched raft-like membrane microdomains is important for giardial encystation. Infect Immun. 2015 May; 83(5):2030-42. PMID: 25733521.
      Citations: 11     Fields:    Translation:AnimalsCells
    13. Das S, Martinez LR, Ray S. Phospholipid remodeling and eicosanoid signaling in colon cancer cells. Indian J Biochem Biophys. 2014 Dec; 51(6):512-9. PMID: 25823224.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Varela JG, De Chatterjee A, Guevara P, Ramirez V, Metta-Maga?a AJ, Villagr?n D, Varela-Ramirez A, Das S, Nu?ez JE. Synthesis, characterization, and evaluation of cis-diphenyl pyridineamine platinum(II) complexes as potential anti-breast cancer agents. J Biol Inorg Chem. 2014 Aug; 19(6):967-979. PMID: 24737042.
      Citations: 3     Fields:    Translation:HumansCells
    15. Mendez TL, De Chatterjee A, Duarte TT, Gazos-Lopes F, Robles-Martinez L, Roy D, Sun J, Maldonado RA, Roychowdhury S, Almeida IC, Das S. Glucosylceramide transferase activity is critical for encystation and viable cyst production by an intestinal protozoan, Giardia lamblia. J Biol Chem. 2013 Jun 07; 288(23):16747-16760. PMID: 23589290.
      Citations: 5     Fields:    Translation:HumansAnimals
    16. Mahdi AA, Fatima G, Das SK, Verma NS. Abnormality of circadian rhythm of serum melatonin and other biochemical parameters in fibromyalgia syndrome. Indian J Biochem Biophys. 2011 Apr; 48(2):82-7. PMID: 21682138.
      Citations: 15     Fields:    Translation:Humans
    17. Staake M, Chauhan J, Zhou D, Shanker A, De Chatterjee A, Das S, Patterson SE. Phosphonoxins III: synthesis of a-aminophosphonate analogs of antifungal polyoxins with anti-Giardia activity. Org Lett. 2010 Oct 15; 12(20):4596-9. PMID: 20857975.
      Citations:    Fields:    Translation:AnimalsCells
    18. Yichoy M, Duarte TT, De Chatterjee A, Mendez TL, Aguilera KY, Roy D, Roychowdhury S, Aley SB, Das S. Lipid metabolism in Giardia: a post-genomic perspective. Parasitology. 2011 Mar; 138(3):267-78. PMID: 20880419.
      Citations: 31     Fields:    Translation:HumansAnimals
    19. Yichoy M, Nakayasu ES, Shpak M, Aguilar C, Aley SB, Almeida IC, Das S. Lipidomic analysis reveals that phosphatidylglycerol and phosphatidylethanolamine are newly generated phospholipids in an early-divergent protozoan, Giardia lamblia. Mol Biochem Parasitol. 2009 May; 165(1):67-78. PMID: 19393163.
      Citations: 12     Fields:    Translation:Animals
    20. Hernandez Y, Shpak M, Duarte TT, Mendez TL, Maldonado RA, Roychowdhury S, Rodrigues ML, Das S. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul; 76(7):2939-49. PMID: 18426892.
      Citations: 11     Fields:    Translation:AnimalsCells
    21. Montoya V, Gutierrez C, Najera O, Leony D, Varela-Ramirez A, Popova J, Rasenick MM, Das S, Roychowdhury S. G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells. Cell Motil Cytoskeleton. 2007 Dec; 64(12):936-50. PMID: 17705289.
      Citations: 8     Fields:    Translation:AnimalsCells
    22. Hernandez Y, Zamora G, Ray S, Chapoy J, Chavez E, Valvarde R, Williams E, Aley SB, Das S. Transcriptional analysis of three major putative phosphatidylinositol kinase genes in a parasitic protozoan, Giardia lamblia. J Eukaryot Microbiol. 2007 Jan-Feb; 54(1):29-32. PMID: 17300515.
      Citations: 7     Fields:    Translation:AnimalsCells
    23. Hernandez Y, Castillo C, Roychowdhury S, Hehl A, Aley SB, Das S. Clathrin-dependent pathways and the cytoskeleton network are involved in ceramide endocytosis by a parasitic protozoan, Giardia lamblia. Int J Parasitol. 2007 Jan; 37(1):21-32. PMID: 17087963.
      Citations: 19     Fields:    Translation:AnimalsCells
    24. Das S, Incarvito CD, Crabtree RH, Brudvig GW. Molecular recognition in the selective oxygenation of saturated C-H bonds by a dimanganese catalyst. Science. 2006 Jun 30; 312(5782):1941-3. PMID: 16809537.
      Citations: 72     Fields:    Translation:Cells
    25. Roychowdhury S, Martinez L, Salgado L, Das S, Rasenick MM. G protein activation is prerequisite for functional coupling between Galpha/Gbetagamma and tubulin/microtubules. Biochem Biophys Res Commun. 2006 Feb 10; 340(2):441-8. PMID: 16380086.
      Citations: 11     Fields:    Translation:AnimalsCells
    26. Chen H, Tagore R, Das S, Incarvito C, Faller JW, Crabtree RH, Brudvig GW. General synthesis of di-mu-oxo dimanganese complexes as functional models for the oxygen evolving complex of photosystem II. Inorg Chem. 2005 Oct 17; 44(21):7661-70. PMID: 16212393.
      Citations: 13     Fields:    
    27. Pope-Delatorre H, Das S, Irwin LN. Uptake of [3H]-gangliosides by an intestinal protozoan, Giardia lamblia. Parasitol Res. 2005 May; 96(2):102-6. PMID: 15812669.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    28. Jones R, Adel-Alvarez LA, Alvarez OR, Broaddus R, Das S. Arachidonic acid and colorectal carcinogenesis. Mol Cell Biochem. 2003 Nov; 253(1-2):141-9. PMID: 14619964.
      Citations: 29     Fields:    Translation:Humans
    29. Das S, Stevens T, Castillo C, Villasen?r A, Arredondo H, Reddy K. Lipid metabolism in mucous-dwelling amitochondriate protozoa. Int J Parasitol. 2002 Jun; 32(6):655-75. PMID: 12062485.
      Citations: 30     Fields:    Translation:HumansAnimals
    30. Das S, Castillo C, Stevens T. Phospholipid remodeling/generation in Giardia: the role of the Lands cycle. Trends Parasitol. 2001 Jul; 17(7):316-9. PMID: 11423372.
      Citations: 20     Fields:    Translation:AnimalsCells
    31. Subramanian AB, Navarro S, Carrasco RA, Marti M, Das S. Role of exogenous inositol and phosphatidylinositol in glycosylphosphatidylinositol anchor synthesis of GP49 by Giardia lamblia. Biochim Biophys Acta. 2000 Jan 03; 1483(1):69-80. PMID: 10601696.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    32. Gibson GR, Ramirez D, Maier J, Castillo C, Das S. Giardia lamblia: incorporation of free and conjugated fatty acids into glycerol-based phospholipids. Exp Parasitol. 1999 May; 92(1):1-11. PMID: 10329359.
      Citations: 14     Fields:    Translation:AnimalsCells
    33. Das S, Schteingart CD, Hofmann AF, Reiner DS, Aley SB, Gillin FD. Giardia lamblia: evidence for carrier-mediated uptake and release of conjugated bile acids. Exp Parasitol. 1997 Oct; 87(2):133-41. PMID: 9326888.
      Citations: 10     Fields:    Translation:HumansAnimals
    34. Stevens TL, Gibson GR, Adam R, Maier J, Allison-Ennis M, Das S. Uptake and cellular localization of exogenous lipids by Giardia lamblia, a primitive eukaryote. Exp Parasitol. 1997 Jun; 86(2):133-43. PMID: 9207743.
      Citations: 17     Fields:    Translation:AnimalsCells
    35. Das S, Gillin FD. Giardia lamblia: increased UDP-N-acetyl-D-glucosamine and N-acetyl-D-galactosamine transferase activities during encystation. Exp Parasitol. 1996 Jun; 83(1):19-29. PMID: 8654548.
      Citations: 8     Fields:    Translation:AnimalsCells
    36. Das S, Traynor-Kaplan A, Kachintorn U, Aley SB, Gillin FD. GP49, an invariant GPI-anchored antigen of Giardia lamblia. Braz J Med Biol Res. 1994 Feb; 27(2):463-9. PMID: 8081266.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    37. Reiner DS, Hetsko ML, Das S, Ward HD, McCaffery M, Gillin FD. Giardia lamblia: absence of cyst antigens and reduced secretory vesicle formation and bile salt uptake in an encystation-deficient subline. Exp Parasitol. 1993 Dec; 77(4):461-72. PMID: 7504633.
      Citations: 5     Fields:    Translation:Animals
    38. Das S, Gillin FD. Chitin synthase in encysting Entamoeba invadens. Biochem J. 1991 Dec 15; 280 ( Pt 3):641-7. PMID: 1764027.
      Citations: 16     Fields:    Translation:AnimalsCells
    39. Das S, Traynor-Kaplan A, Reiner DS, Meng TC, Gillin FD. A surface antigen of Giardia lamblia with a glycosylphosphatidylinositol anchor. J Biol Chem. 1991 Nov 05; 266(31):21318-25. PMID: 1657957.
      Citations: 11     Fields:    Translation:AnimalsCells
    40. Gillin FD, Cooper RW, Reiner DS, Das S. Secretory defenses against Giardia lamblia. Adv Exp Med Biol. 1991; 310:227-33. PMID: 1809002.
      Citations: 1     Fields:    Translation:HumansAnimals
    41. Glew RH, Saha AK, Das S, Remaley AT. Biochemistry of the Leishmania species. Microbiol Rev. 1988 Dec; 52(4):412-32. PMID: 3070318.
      Citations: 27     Fields:    Translation:HumansAnimals
    42. Das S, Reiner DS, Zenian J, Hogan DL, Koss MA, Wang CS, Gillin FD. Killing of Giardia lamblia trophozoites by human intestinal fluid in vitro. J Infect Dis. 1988 Jun; 157(6):1257-60. PMID: 3373026.
      Citations: 10     Fields:    Translation:HumansAnimals
    43. Gillin FD, Reiner DS, Gault MJ, Douglas H, Das S, Wunderlich A, Sauch JF. Encystation and expression of cyst antigens by Giardia lamblia in vitro. Science. 1987 Feb 27; 235(4792):1040-3. PMID: 3547646.
      Citations: 38     Fields:    Translation:Animals
    44. Das S, Saha AK, Nerad TA, Martinez AJ, Lamarco KL, Basu A, Legler G, Glew RH. Partial purification and characterization of Naegleria fowleri beta-glucosidase. J Protozool. 1987 Feb; 34(1):68-74. PMID: 3106621.
      Citations: 3     Fields:    Translation:Animals
    45. Das S, Saha AK, Mukhopadhyay NK, Glew RH. A cyclic nucleotide-independent protein kinase in Leishmania donovani. Biochem J. 1986 Dec 15; 240(3):641-9. PMID: 3030283.
      Citations: 9     Fields:    Translation:AnimalsCells
    46. Olomu N, Martinez AJ, Lamarco KL, Nerad TA, Saha AK, Das S, Glew RH. Demonstration of various acid hydrolases and preliminary characterization of acid phosphatase in Naegleria fowleri. J Protozool. 1986 Aug; 33(3):317-21. PMID: 3018238.
      Citations: 3     Fields:    Translation:AnimalsCells
    47. Das S, Saha AK, Remaley AT, Glew RH, Dowling JN, Kajiyoshi M, Gottlieb M. Hydrolysis of phosphoproteins and inositol phosphates by cell surface phosphatase of Leishmania donovani. Mol Biochem Parasitol. 1986 Aug; 20(2):143-53. PMID: 3018559.
      Citations: 10     Fields:    Translation:AnimalsCells
    48. Saha AK, Das S, Glew RH, Gottlieb M. Resistance of leishmanial phosphatases to inactivation by oxygen metabolites. J Clin Microbiol. 1985 Sep; 22(3):329-32. PMID: 2995435.
      Citations: 11     Fields:    Translation:AnimalsCells
    49. Remaley AT, Das S, Campbell PI, LaRocca GM, Pope MT, Glew RH. Characterization of Leishmania donovani acid phosphatases. J Biol Chem. 1985 Jan 25; 260(2):880-6. PMID: 3968070.
      Citations: 29     Fields:    Translation:Animals
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