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Balasubramanyam Karanam

TitleDr
InstitutionTuskegee University
DepartmentBiology and Cancer Research
AddressRm 44, Carver Research Building
1200. W. Montgomery Rd
Tuskegee AL 36088
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    My primary research interest lies at the interface between chemistry, biology, and medicine. We employ biological functional assays to identify modulators/inhibitors of various cellular processes and pathways that have been implicated in cancer. Once biologically active inhibitors are identified, they will serve both as chemical probes of the biological processes of interest and as leads for the development of new drugs for treating cancer. I completed my Ph.D in chemistry from India, completed a fellowship in Pharmacology and molecular sciences at Johns Hopkins University in 2006.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ghebremedhin A, Salam AB, Adu-Addai B, Noonan S, Stratton R, Ahmed MSU, Khantwal C, Martin GR, Lin H, Andrews C, Karanam B, Rudloff U, Lopez H, Jaynes J, Yates C. A Novel CD206 Targeting Peptide Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice. bioRxiv. 2020 Jul 29. PMID: 32766584.
      Citations:    
    2. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3226-3228. PMID: 32214199.
      Citations:    Fields:    
    3. Jaynes JM, Sable R, Ronzetti M, Bautista W, Knotts Z, Abisoye-Ogunniyan A, Li D, Calvo R, Dashnyam M, Singh A, Guerin T, White J, Ravichandran S, Kumar P, Talsania K, Chen V, Ghebremedhin A, Karanam B, Bin Salam A, Amin R, Odzorig T, Aiken T, Nguyen V, Bian Y, Zarif JC, de Groot AE, Mehta M, Fan L, Hu X, Simeonov A, Pate N, Abu-Asab M, Ferrer M, Southall N, Ock CY, Zhao Y, Lopez H, Kozlov S, de Val N, Yates CC, Baljinnyam B, Marugan J, Rudloff U. Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses. Sci Transl Med. 2020 Feb 12; 12(530). PMID: 32051227.
      Citations: 1     Fields:    
    4. Vantaku V, Putluri V, Bader DA, Maity S, Ma J, Arnold JM, Rajapakshe K, Donepudi SR, von Rundstedt FC, Devarakonda V, Dubrulle J, Karanam B, McGuire SE, Stossi F, Jain AK, Coarfa C, Cao Q, Sikora AG, Villanueva H, Kavuri SM, Lotan Y, Sreekumar A, Putluri N. Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. Oncogene. 2019 Aug 05. PMID: 31383940.
      Citations:    Fields:    
    5. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3089-3101. PMID: 31308490.
      Citations:    Fields:    
    6. Gohlke JH, Lloyd SM, Basu S, Putluri V, Vareed SK, Rasaily U, Piyarathna DWB, Fuentes H, Rajendiran TM, Dorsey TH, Ambati CR, Sonavane R, Karanam B, Bhowmik SK, Kittles R, Ambs S, Mims MP, Ittmann M, Jones JA, Palapattu G, Putluri N, Michailidis G, Sreekumar A. Methionine-Homocysteine Pathway in African-American Prostate Cancer. JNCI Cancer Spectr. 2019 Jun; 3(2):pkz019. PMID: 31360899.
      Citations:    
    7. Piyarathna DWB, Balasubramanian A, Arnold JM, Lloyd SM, Karanam B, Castro P, Ittmann MM, Putluri N, Navone N, Jones JA, Yu W, Sandulache VC, Sikora AG, Michailidis G, Sreekumar A. ERR1 and PGC1a associated mitochondrial alterations correlate with pan-cancer disparity in African Americans. J Clin Invest. 2019 03 28; 129(6):2351-2356. PMID: 30920960.
      Citations: 1     Fields:    Translation:HumansCells
    8. Vantaku V, Dong J, Ambati CR, Perera D, Donepudi SR, Amara CS, Putluri V, Ravi SS, Robertson MJ, Piyarathna DWB, Villanueva M, von Rundstedt FC, Karanam B, Ballester LY, Terris MK, Bollag RJ, Lerner SP, Apolo AB, Villanueva H, Lee M, Sikora AG, Lotan Y, Sreekumar A, Coarfa C, Putluri N. Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer. Clin Cancer Res. 2019 06 15; 25(12):3689-3701. PMID: 30846479.
      Citations: 3     Fields:    
    9. Jones KM, Karanam B, Jones-Triche J, Sandey M, Henderson HJ, Samant RS, Temesgen S, Yates C, Bedi D. Phage Ligands for Identification of Mesenchymal-Like Breast Cancer Cells and Cancer-Associated Fibroblasts. Front Oncol. 2018; 8:625. PMID: 30619759.
      Citations:    
    10. Davis M, Tripathi S, Hughley R, He Q, Bae S, Karanam B, Martini R, Newman L, Colomb W, Grizzle W, Yates C. AR negative triple negative or "quadruple negative" breast cancers in African American women have an enriched basal and immune signature. PLoS One. 2018; 13(6):e0196909. PMID: 29912871.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    11. Abisoye-Ogunniyan A, Lin H, Ghebremedhin A, Salam AB, Karanam B, Theodore S, Jones-Trich J, Davis M, Grizzle W, Wang H, Yates C. Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c. Cancer Lett. 2018 09 01; 431:1-10. PMID: 29751044.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Henderson HJ, Karanam B, Samant R, Vig K, Singh SR, Yates C, Bedi D. Neuroligin 4X overexpression in human breast cancer is associated with poor relapse-free survival. PLoS One. 2017; 12(12):e0189662. PMID: 29244827.
      Citations: 1     Fields:    Translation:HumansCells
    13. Narayanan A, Khanchandani P, Borkar RM, Ambati CR, Roy A, Han X, Bhoskar RN, Ragampeta S, Gannon F, Mysorekar V, Karanam B, V SM, Sivaramakrishnan V. Avascular Necrosis of Femoral Head: A Metabolomic, Biophysical, Biochemical, Electron Microscopic and Histopathological Characterization. Sci Rep. 2017 09 06; 7(1):10721. PMID: 28878383.
      Citations: 2     Fields:    Translation:Humans
    14. Jin F, Thaiparambil J, Donepudi SR, Vantaku V, Piyarathna DWB, Maity S, Krishnapuram R, Putluri V, Gu F, Purwaha P, Bhowmik SK, Ambati CR, von Rundstedt FC, Roghmann F, Berg S, Noldus J, Rajapakshe K, Gödde D, Roth S, Störkel S, Degener S, Michailidis G, Kaipparettu BA, Karanam B, Terris MK, Kavuri SM, Lerner SP, Kheradmand F, Coarfa C, Sreekumar A, Lotan Y, El-Zein R, Putluri N. Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer. Cancer Prev Res (Phila). 2017 Oct; 10(10):588-597. PMID: 28851690.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    15. Jones J, Mukherjee A, Karanam B, Davis M, Jaynes J, Reams RR, Dean-Colomb W, Yates C. African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression. Cancer Lett. 2016 10 01; 380(2):513-22. PMID: 27424525.
      Citations: 4     Fields:    Translation:Humans
    16. Arora R, Schmitt D, Karanam B, Tan M, Yates C, Dean-Colomb W. Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers. Oncotarget. 2015 Jan 20; 6(2):662-78. PMID: 25575825.
      Citations: 13     Fields:    Translation:HumansCells
    17. Peng S, Wang JW, Karanam B, Wang C, Huh WK, Alvarez RD, Pai SI, Hung CF, Wu TC, Roden RB. Sequential cisplatin therapy and vaccination with HPV16 E6E7L2 fusion protein in saponin adjuvant GPI-0100 for the treatment of a model HPV16+ cancer. PLoS One. 2015; 10(1):e116389. PMID: 25560237.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. Karthigeyan D, Siddhanta S, Kishore AH, Perumal SS, Ågren H, Sudevan S, Bhat AV, Balasubramanyam K, Subbegowda RK, Kundu TK, Narayana C. SERS and MD simulation studies of a kinase inhibitor demonstrate the emergence of a potential drug discovery tool. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10416-21. PMID: 24972791.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Jones J, Wang H, Karanam B, Theodore S, Dean-Colomb W, Welch DR, Grizzle W, Yates C. Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas. Clin Exp Metastasis. 2014 Jun; 31(5):497-510. PMID: 24570268.
      Citations: 14     Fields:    Translation:HumansCells
    20. Anchoori RK, Karanam B, Peng S, Wang JW, Jiang R, Tanno T, Orlowski RZ, Matsui W, Zhao M, Rudek MA, Hung CF, Chen X, Walters KJ, Roden RB. A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell. 2013 Dec 09; 24(6):791-805. PMID: 24332045.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    21. Jagu S, Kwak K, Karanam B, Huh WK, Damotharan V, Chivukula SV, Roden RB. Optimization of multimeric human papillomavirus L2 vaccines. PLoS One. 2013; 8(1):e55538. PMID: 23383218.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    22. Kamiyama H, Rauenzahn S, Shim JS, Karikari CA, Feldmann G, Hua L, Kamiyama M, Schuler FW, Lin MT, Beaty RM, Karanam B, Liang H, Mullendore ME, Mo G, Hidalgo M, Jaffee E, Hruban RH, Jinnah HA, Roden RB, Jimeno A, Liu JO, Maitra A, Eshleman JR. Personalized chemotherapy profiling using cancer cell lines from selectable mice. Clin Cancer Res. 2013 Mar 01; 19(5):1139-46. PMID: 23340293.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Nieto K, Weghofer M, Sehr P, Ritter M, Sedlmeier S, Karanam B, Seitz H, Müller M, Kellner M, Hörer M, Michaelis U, Roden RB, Gissmann L, Kleinschmidt JA. Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate. PLoS One. 2012; 7(6):e39741. PMID: 22761884.
      Citations: 33     Fields:    Translation:AnimalsCells
    24. Mamoor S, Onder Z, Karanam B, Kwak K, Bordeaux J, Crosby L, Roden RB, Moroianu J. The high risk HPV16 L2 minor capsid protein has multiple transport signals that mediate its nucleocytoplasmic traffic. Virology. 2012 Jan 20; 422(2):413-24. PMID: 22154072.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    25. Wu WH, Gersch E, Kwak K, Jagu S, Karanam B, Huh WK, Garcea RL, Roden RB. Capsomer vaccines protect mice from vaginal challenge with human papillomavirus. PLoS One. 2011; 6(11):e27141. PMID: 22069498.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    26. Bazzaro M, Anchoori RK, Mudiam MK, Issaenko O, Kumar S, Karanam B, Lin Z, Isaksson Vogel R, Gavioli R, Destro F, Ferretti V, Roden RB, Khan SR. a,ß-Unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells. J Med Chem. 2011 Jan 27; 54(2):449-56. PMID: 21186794.
      Citations: 13     Fields:    Translation:HumansCells
    27. Karanam B, Peng S, Li T, Buck C, Day PM, Roden RB. Papillomavirus infection requires gamma secretase. J Virol. 2010 Oct; 84(20):10661-70. PMID: 20702627.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    28. Selvi BR, Batta K, Kishore AH, Mantelingu K, Varier RA, Balasubramanyam K, Pradhan SK, Dasgupta D, Sriram S, Agrawal S, Kundu TK. Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17. J Biol Chem. 2010 Mar 05; 285(10):7143-52. PMID: 20022955.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    29. Gambhira R, Jagu S, Karanam B, Day PM, Roden R. Role of L2 cysteines in papillomavirus infection and neutralization. Virol J. 2009 Oct 27; 6:176. PMID: 19860897.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    30. Jagu S, Karanam B, Gambhira R, Chivukula SV, Chaganti RJ, Lowy DR, Schiller JT, Roden RB. Concatenated multitype L2 fusion proteins as candidate prophylactic pan-human papillomavirus vaccines. J Natl Cancer Inst. 2009 Jun 03; 101(11):782-92. PMID: 19470949.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    31. Karanam B, Jagu S, Huh WK, Roden RB. Developing vaccines against minor capsid antigen L2 to prevent papillomavirus infection. Immunol Cell Biol. 2009 May-Jun; 87(4):287-99. PMID: 19421199.
      Citations: 23     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    32. Karanam B, Gambhira R, Peng S, Jagu S, Kim DJ, Ketner GW, Stern PL, Adams RJ, Roden RB. Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity. Vaccine. 2009 Feb 11; 27(7):1040-9. PMID: 19095032.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    33. Alphs HH, Gambhira R, Karanam B, Roberts JN, Jagu S, Schiller JT, Zeng W, Jackson DC, Roden RB. Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5850-5. PMID: 18413606.
      Citations: 60     Fields:    Translation:HumansAnimals
    34. Kim D, Gambhira R, Karanam B, Monie A, Hung CF, Roden R, Wu TC. Generation and characterization of a preventive and therapeutic HPV DNA vaccine. Vaccine. 2008 Jan 17; 26(3):351-60. PMID: 18096279.
      Citations: 25     Fields:    Translation:AnimalsCells
    35. Gambhira R, Karanam B, Jagu S, Roberts JN, Buck CB, Bossis I, Alphs H, Culp T, Christensen ND, Roden RB. A protective and broadly cross-neutralizing epitope of human papillomavirus L2. J Virol. 2007 Dec; 81(24):13927-31. PMID: 17928339.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    36. Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. De novo discovery of serotonin N-acetyltransferase inhibitors. J Med Chem. 2007 Nov 01; 50(22):5330-8. PMID: 17924613.
      Citations: 5     Fields:    Translation:AnimalsCells
    37. Gambhira R, Jagu S, Karanam B, Gravitt PE, Culp TD, Christensen ND, Roden RB. Protection of rabbits against challenge with rabbit papillomaviruses by immunization with the N terminus of human papillomavirus type 16 minor capsid antigen L2. J Virol. 2007 Nov; 81(21):11585-92. PMID: 17715230.
      Citations: 64     Fields:    Translation:AnimalsCells
    38. Karanam B, Wang L, Wang D, Liu X, Marmorstein R, Cotter R, Cole PA. Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry. 2007 Jul 17; 46(28):8207-16. PMID: 17590016.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    39. Karanam B, Jiang L, Wang L, Kelleher NL, Cole PA. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem. 2006 Dec 29; 281(52):40292-301. PMID: 17065153.
      Citations: 33     Fields:    Translation:Cells
    40. Zheng Y, Balasubramanyam K, Cebrat M, Buck D, Guidez F, Zelent A, Alani RM, Cole PA. Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor. J Am Chem Soc. 2005 Dec 14; 127(49):17182-3. PMID: 16332055.
      Citations: 24     Fields:    
    41. Davidson SM, Townsend PA, Carroll C, Yurek-George A, Balasubramanyam K, Kundu TK, Stephanou A, Packham G, Ganesan A, Latchman DS. The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin. Chembiochem. 2005 Jan; 6(1):162-70. PMID: 15593114.
      Citations: 11     Fields:    Translation:AnimalsCells
    42. Balasubramanyam K, Varier RA, Altaf M, Swaminathan V, Siddappa NB, Ranga U, Kundu TK. Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. J Biol Chem. 2004 Dec 03; 279(49):51163-71. PMID: 15383533.
      Citations: 194     Fields:    Translation:HumansCells
    43. Varier RA, Swaminathan V, Balasubramanyam K, Kundu TK. Implications of small molecule activators and inhibitors of histone acetyltransferases in chromatin therapy. Biochem Pharmacol. 2004 Sep 15; 68(6):1215-20. PMID: 15313419.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    44. Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP, Kundu TK. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J Biol Chem. 2004 Aug 06; 279(32):33716-26. PMID: 15155757.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    45. Balasubramanyam K, Swaminathan V, Ranganathan A, Kundu TK. Small molecule modulators of histone acetyltransferase p300. J Biol Chem. 2003 May 23; 278(21):19134-40. PMID: 12624111.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
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