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Michelle M. Martinez-Montemayor

TitleAssistant Professor
InstitutionUniversidad Central Del Caribe
DepartmentDepartment of Biochemistry
AddressP.O. Box 60327
Bayamon PR 00960-6032
Phone787-798-3001 ext 2153
Fax787-740-4390
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    Collapse Biography 
    Collapse awards and honors
    - 2007American Association for Cancer Research Minority Scholar in Cancer Research Award , Universidad Central del Caribe
    - 2009American Association for Cancer Research Minority-Serving Institution Faculty Scholar Award , Universidad Central del Caribe
    - 2010American Association for Cancer Research Minority-Serving Institution Faculty Scholar Award, Universidad Central del Caribe
    - 2004Distinguished Jacob Hoefer Fellowship, Michigan State University
    - 2011Scientific Research Development Unit Fellowship recipient, Universidad Central del Caribe
    2000 - 2004Competitive Doctoral Enrichment Fellowship, Michigan State University
    2010 - 2011Member of the American Association for Cancer Research Minority Scholar in Training Award Committee , Universidad Central del Caribe

    Collapse Overview 
    Collapse overview
    Our lab focuses on molecular, cellular and cancer biology investigating natural therapeutics, breast cancer and diabetes. Currently, we investigate inflammatory breast cancer (IBC) biology and potential natural therapeutics for this intractable disease. My long-term goal is to lead independent research programs to identify molecular targets and develop effective strategies for the prevention and treatment of breast cancer. Currently, I stimulate the participation of minority students in cancer research both at the undergraduate and graduate level. I have three Ph.D. level students, one M.S. student, and three undergraduates in my laboratory. The Ph.D. students are in diverse stages within their training, where one of them is a NIH-F31 recipient. Our lab has two funded projects, which focus on training students in cutting edge techniques in cancer research, and investigating Reishi mushroom mechanistic effects against IBC in vitro and in vivo.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ling T, Lang WH, Martinez-Montemayor MM, Rivas F. Development of ergosterol peroxide probes for cellular localisation studies. Org Biomol Chem. 2019 05 29; 17(21):5223-5229. PMID: 31025693.
      Citations: 1     Fields:    Translation:HumansCells
    2. Martínez-Montemayor MM, Ling T, Suárez-Arroyo IJ, Ortiz-Soto G, Santiago-Negrón CL, Lacourt-Ventura MY, Valentín-Acevedo A, Lang WH, Rivas F. Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro. Front Pharmacol. 2019; 10:115. PMID: 30837881.
      Citations:    
    3. Rios-Fuller TJ, Ortiz-Soto G, Lacourt-Ventura M, Maldonado-Martinez G, Cubano LA, Schneider RJ, Martinez-Montemayor MM. Ganoderma lucidum extract (GLE) impairs breast cancer stem cells by targeting the STAT3 pathway. Oncotarget. 2018 Nov 13; 9(89):35907-35921. PMID: 30542507.
      Citations: 1     Fields:    
    4. Suárez-Arroyo IJ, Loperena-Alvarez Y, Rosario-Acevedo R, Martínez-Montemayor MM. Ganoderma spp.: A Promising Adjuvant Treatment for Breast Cancer. Medicines (Basel). 2017 Mar; 4(1). PMID: 28758107.
      Citations:    
    5. Suárez-Arroyo IJ, Feliz-Mosquea YR, Pérez-Laspiur J, Arju R, Giashuddin S, Maldonado-Martínez G, Cubano LA, Schneider RJ, Martínez-Montemayor MM. The proteome signature of the inflammatory breast cancer plasma membrane identifies novel molecular markers of disease. Am J Cancer Res. 2016; 6(8):1720-40. PMID: 27648361.
      Citations:    
    6. Suárez-Arroyo IJ, Rios-Fuller TJ, Feliz-Mosquea YR, Lacourt-Ventura M, Leal-Alviarez DJ, Maldonado-Martinez G, Cubano LA, Martínez-Montemayor MM. Ganoderma lucidum Combined with the EGFR Tyrosine Kinase Inhibitor, Erlotinib Synergize to Reduce Inflammatory Breast Cancer Progression. J Cancer. 2016; 7(5):500-11. PMID: 26958085.
      Citations:    
    7. Satishkumar S, Vuram PK, Relangi SS, Gurram V, Zhou H, Kreitman RJ, Martínez Montemayor MM, Yang L, Kaliyaperumal M, Sharma S, Pottabathini N, Lakshman MK. Cladribine Analogues via O6-(Benzotriazolyl) Derivatives of Guanine Nucleosides. Molecules. 2015 Oct 09; 20(10):18437-63. PMID: 26473811.
      Citations:    Fields:    Translation:HumansCells
    8. Gavillán-Suárez J, Aguilar-Perez A, Rivera-Ortiz N, Rodríguez-Tirado K, Figueroa-Cuilan W, Morales-Santiago L, Maldonado-Martínez G, Cubano LA, Martínez-Montemayor MM. Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico. BMC Complement Altern Med. 2015 Jul 22; 15:244. PMID: 26198986.
      Citations: 4     Fields:    Translation:Animals
    9. Suarez-Arroyo IJ, Rosario-Acevedo R, Aguilar-Perez A, Clemente PL, Cubano LA, Serrano J, Schneider RJ, Martínez-Montemayor MM. Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. PLoS One. 2013; 8(2):e57431. PMID: 23468988.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    10. de la Parra C, Otero-Franqui E, Martinez-Montemayor M, Dharmawardhane S. The soy isoflavone equol may increase cancer malignancy via up-regulation of eukaryotic protein synthesis initiation factor eIF4G. J Biol Chem. 2012 Dec 07; 287(50):41640-50. PMID: 23095751.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Martínez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA, Dharmawardhane SF. Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer. Nutr Cancer. 2011; 63(7):1085-94. PMID: 21888505.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    12. Martínez-Montemayor MM, Otero-Franqui E, Martinez J, De La Mota-Peynado A, Cubano LA, Dharmawardhane S. Individual and combined soy isoflavones exert differential effects on metastatic cancer progression. Clin Exp Metastasis. 2010 Oct; 27(7):465-80. PMID: 20517637.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    13. Castillo-Pichardo L, Martínez-Montemayor MM, Martínez JE, Wall KM, Cubano LA, Dharmawardhane S. Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin Exp Metastasis. 2009; 26(6):505-16. PMID: 19294520.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    14. Martínez-Montemayor MM, Hill GM, Raney NE, Rilington VD, Tempelman RJ, Link JE, Wilkinson CP, Ramos AM, Ernst CW. Gene expression profiling in hepatic tissue of newly weaned pigs fed pharmacological zinc and phytase supplemented diets. BMC Genomics. 2008 Sep 17; 9:421. PMID: 18799003.
      Citations: 6     Fields:    Translation:Animals
    15. Colón-Cesario WI, Martínez-Montemayor MM, Morales S, Félix J, Cruz J, Adorno M, Pereira L, Colón N, Maldonado-Vlaar CS, Peña de Ortiz S. Knockdown of Nurr1 in the rat hippocampus: implications to spatial discrimination learning and memory. Learn Mem. 2006 Nov-Dec; 13(6):734-44. PMID: 17142303.
      Citations: 30     Fields:    Translation:Animals
    16. Martínez MM, Link JE, Hill GM. Dietary pharmacological or excess zinc and phytase effects on tissue mineral concentrations, metallothionein, and apparent mineral retention in the newly weaned pig. Biol Trace Elem Res. 2005; 105(1-3):97-115. PMID: 16034157.
      Citations: 2     Fields:    Translation:Animals
    17. Martínez MM, Hill GM, Link JE, Raney NE, Tempelman RJ, Ernst CW. Pharmacological zinc and phytase supplementation enhance metallothionein mRNA abundance and protein concentration in newly weaned pigs. J Nutr. 2004 Mar; 134(3):538-44. PMID: 14988443.
      Citations: 6     Fields:    Translation:AnimalsCells
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