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Temesgen Samuel

TitleDr
InstitutionTuskegee University
DepartmentPathobiology
AddressTuskegee University
1200 West Montgomery Road
College of Veterinary Medicine
Tuskegee AL 36088
Phone334-724-4547/ -4671
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    Other Positions
    TitleAssociate Prof.
    InstitutionTuskegee University
    DepartmentPathobiology


    Collapse Biography 
    Collapse awards and honors
    - 2005AACR Aflac Scholar-in-Training Travel Award , AACR
    - 2010AACR Minority Serving Institution Faculty travel award , AACR, AACR
    - 2004Breast Cancer Research Program fellowship, Burnham Institute , DoD
    - 1997The DAAD prize for outstanding students, Hannover, Germany, DAAD, Germany
    - 2009Tuskegee University Faculty Senate Research Award, , Tuskegee University
    - 2014Zoetis award for excellence in research , Zoetis , Zoetis
    2008 - 2009Health Disparity Research Training Scholar, TU/Morehouse/UAB cancer center partnership

    Collapse Overview 
    Collapse overview
    Samuel Lab Research Interest Areas
    1. Enhancing the efficacy of anti-cancer therapy. The efficacy of cancer therapy is severely compromised due to serious side effects and resistance. Our laboratory is interested in improving the outcomes of cancer therapy through:
    a. Understanding of the molecular responses in cells exposed to clinically used targeted or broad-acting therapeutic agents. We characterize the activation of critical signaling mechanisms when neoplastic epithelial or stromal cells are exposed to therapeutic drugs.
    b. Designing rational combination strategies that will improve the therapeutic index of clinically used drugs. We test natural compounds and novel agents for their enhancing activities when combined with known anti-neoplastic agents. The overarching goal of our research interest in this area is to rationalize the use of combination therapy in cancer management. We employ molecular and cell biology techniques as well as in vitro cell line and in vivo preclinical models to address these questions.
    c. Strategies using nanomaterial- or biomimetic vehicles for drug delivery. In collaboration with Material Sciences Engineering department faculty, we formulate and test bio-derived nanomaterials for delivery of drugs that would otherwise be unstable for example in the upper digestive tract or would not reach distal organs such as the large bowel.

    2. Collaborative: Development of molecular tools and novel methods for the detection of pathogens. Projects in this area are focused on developing rapid and sensitive strategies to detect pathogens that cause major foodborne diseases. Specifically, we work on establishing molecular and nanotechnology-based tools to reduce the time length for pathogen identification after an outbreak or overt disease.


    Collapse Research 
    Collapse research activities and funding
    SC2CA138178     (SAMUEL, TEMESGEN)Aug 1, 2008 - Jul 31, 2011
    NIH/NCI
    Molecular Determinants for the Bioactivity of the Flavonoid Quercetin
    Role: Principal Investigator

    SC3GM109314     (SAMUEL, TEMESGEN)May 1, 2014 - Jan 31, 2017
    NIH/NIGMS
    Quercetin as an enhancer of the efficacy of 5-FU in mouse models of colon cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Appleton KM, Barrie E, Samuel TJ. Modelling positive consequences: Increased vegetable intakes following modelled enjoyment versus modelled intake. Appetite. 2019 09 01; 140:76-81. PMID: 31055009.
      Citations:    Fields:    
    2. Apalangya VA, Rangari VK, Tiimob BJ, Jeelani S, Samuel T. Eggshell Based Nano-Engineered Hydroxyapatite and Poly(lactic) Acid Electrospun Fibers as Potential Tissue Scaffold. Int J Biomater. 2019; 2019:6762575. PMID: 31186650.
      Citations:    
    3. Bedi D, Henderson HJ, Manne U, Samuel T. Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells. Medicines (Basel). 2019 Apr 24; 6(2). PMID: 31022845.
      Citations:    
    4. Mansour M, van Ginkel S, Dennis JC, Mason B, Elhussin I, Abbott K, Pondugula SR, Samuel T, Morrison E. The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells. J Cancer. 2018; 9(23):4536-4546. PMID: 30519360.
      Citations:    
    5. Haykowsky MJ, Samuel TJ, Nelson MD, La Gerche A. Athlete's Heart: Is the Morganroth Hypothesis Obsolete? Heart Lung Circ. 2018 Sep; 27(9):1037-1041. PMID: 29773412.
      Citations: 1     Fields:    Translation:Humans
    6. Samuel TJ, Rosenberry RP, Lee S, Pan Z. Correcting Calcium Dysregulation in Chronic Heart Failure Using SERCA2a Gene Therapy. Int J Mol Sci. 2018 Apr 05; 19(4). PMID: 29621141.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    7. Chowdhury R, Gales D, Valenzuela P, Miller S, Yehualaeshet T, Manne U, Francia G, Samuel T. Bromoethylindole (BEI-9) redirects NF-?B signaling induced by camptothecin and TNFa to promote cell death in colon cancer cells. Apoptosis. 2017 Dec; 22(12):1553-1563. PMID: 29116428.
      Citations:    Fields:    Translation:HumansCells
    8. Miller SA, White JA, Chowdhury R, Gales DN, Tameru B, Tiwari AK, Samuel T. Effects of consumption of whole grape powder on basal NF-?B signaling and inflammatory cytokine secretion in a mouse model of inflammation. J Nutr Intermed Metab. 2018 Mar; 11:1-8. PMID: 29568797.
      Citations:    
    9. Afroj S, Aldahami K, Reddy G, Guard J, Adesiyun A, Samuel T, Abdela W. Simultaneous Detection of Multiple Salmonella Serovars from Milk and Chicken Meat by Real-Time PCR Using Unique Genomic Target Regions. J Food Prot. 2017 Oct 23; 1944-1957. PMID: 29058479.
      Citations:    Fields:    
    10. Amawi H, Ashby CR, Samuel T, Peraman R, Tiwari AK. Polyphenolic Nutrients in Cancer Chemoprevention and Metastasis: Role of the Epithelial-to-Mesenchymal (EMT) Pathway. Nutrients. 2017 Aug 21; 9(8). PMID: 28825675.
      Citations: 6     Fields:    Translation:Humans
    11. Amawi H, Hussein NA, Karthikeyan C, Manivannan E, Wisner A, Williams FE, Samuel T, Trivedi P, Ashby CR, Tiwari AK. HM015k, a Novel Silybin Derivative, Multi-Targets Metastatic Ovarian Cancer Cells and Is Safe in Zebrafish Toxicity Studies. Front Pharmacol. 2017; 8:498. PMID: 28824426.
      Citations:    
    12. Jia X, Shanmugam C, Paluri RK, Jhala NC, Behring MP, Katkoori VR, Sugandha SP, Bae S, Samuel T, Manne U. Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer. Oncotarget. 2017 Mar 21; 8(12):20198-20212. PMID: 28423626.
      Citations:    Fields:    Translation:HumansCells
    13. Tiimob BJ, Mwinyelle G, Abdela W, Samuel T, Jeelani S, Rangari VK. Nanoengineered Eggshell-Silver Tailored Copolyester Polymer Blend Film with Antimicrobial Properties. J Agric Food Chem. 2017 Mar 08; 65(9):1967-1976. PMID: 28206760.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Tiimob BJ, Mwinyelle G, Abdela W, Samuel T, Jeelani S, Rangari VK. J Agric Food Chem. 2017 Mar 8;65(9):1967-1976. . J Agric Food Chem. Nanoengineered Eggshell-Silver Tailored Copolyester Polymer Blend Film with Antimicrobial Properties. 2017; 65:1967-1976.
    15. Manne U, Jadhav T, Putcha BK, Samuel T, Soni S, Shanmugam C, Suswam EA. Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective. Curr Colorectal Cancer Rep. 2016 Dec; 12(6):332-344. PMID: 28626361.
      Citations:    
    16. Render D, Samuel T, King H, Vig M, Jeelani S, Babu RJ, Rangari V. Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery. J Nanomater. 2016; 2016. PMID: 30740129.
      Citations:    
    17. Render, D., Samuel, T., King, H., Vig, M., Jeelani, S., Jayachandra, R. B. and Rangari, V. Journal of Nanomaterials (Open Access). Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery. 2016; 2016 :Article ID 3170248. View Publication.
    18. Abdelrahman Mohamed, Gopal P. Reddy, Temesgen Samuel, Mahmoud Mansour, Abdela Woubit. . SOJ Veterinary Sciences. Clostridium difficile (Cd) in Shelter Dogs: Rationale for Screening of Pets Slated for Adoption. 2016; 2(1):1-6.
    19. Fadlalla K, Elgendy R, Gilbreath E, Pondugula SR, Yehualaeshet T, Mansour M, Serbessa T, Manne U, Samuel T. 3-(2-Bromoethyl)-indole inhibits the growth of cancer cells and NF-?B activation. Oncol Rep. 2015 Jul; 34(1):495-503. PMID: 26063116.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    20. Tiimob, B., Apalangya, V., Samuel, T., Jeelani, S., Vijaya, R. British Journal of Applied Science & Technology. Synthesis, Characterization and In vitro Cytotoxicity Assessment of Eggshell-derived ß-CaSiO3 Nano Biomaterial. 2015; 8(2):180 -192.
    21. Pondugula SR, Flannery PC, Abbott KL, Coleman ES, Mani S, Samuel T, Xie W. Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR. Toxicol Lett. 2015 Feb 03; 232(3):580-9. PMID: 25542144.
      Citations: 8     Fields:    Translation:HumansCells
    22. Samuel T, Fadlalla K, Gales DN, Putcha BD, Manne U. Variable NF-?B pathway responses in colon cancer cells treated with chemotherapeutic drugs. BMC Cancer. 2014 Aug 18; 14:599. PMID: 25134433.
      Citations: 8     Fields:    Translation:HumansCells
    23. Delesa EK, Yohannes A, Alemayehu M, Samuel T, Yehualaeshet T. Calves' sex ratio in naturally and artificially bred cattle in central Ethiopia. Theriogenology. 2014 Aug; 82(3):433-9. PMID: 24908336.
      Citations:    Fields:    Translation:Animals
    24. Render, D.; Fadlalla, K.; Rangari, V.; Samuel, T.; and Jeelani, S. . Int. J. of Biomedical Nanoscience and Nanotechnology. Bio-based calcium carbonate (CaCO3) nanoparticles for drug delivery applications. 2014; 3(3):221 - 235.
    25. Woubit A, Yehualaeshet T, Roberts S, Graham M, Kim M, Samuel T. Customizable PCR-microplate array for differential identification of multiple pathogens. J Food Prot. 2013 Nov; 76(11):1948-57. PMID: 24215700.
      Citations:    Fields:    Translation:CellsPHPublic Health
    26. Gales D, Clark C, Manne U, Samuel T. The Chemokine CXCL8 in Carcinogenesis and Drug Response. ISRN Oncol. 2013 Oct 09; 2013:859154. PMID: 24224100.
      Citations:    
    27. Khazal KF, Samuel T, Hill DL, Grubbs CJ. Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas. Anticancer Res. 2013 Apr; 33(4):1519-23. PMID: 23564793.
      Citations: 8     Fields:    Translation:Animals
    28. Woubit A, Yehualaeshet T, Habtemariam T, Samuel T. Novel genomic tools for specific and real-time detection of biothreat and frequently encountered foodborne pathogens. J Food Prot. 2012 Apr; 75(4):660-70. PMID: 22488053.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    29. Rodriguez S, Fadlalla K, Graham T, Tameru B, Fermin CD, Samuel T. Immunohistochemical evaluation of AKT protein activation in canine mast cell tumours. J Comp Pathol. 2012 Aug-Oct; 147(2-3):171-6. PMID: 22289273.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Katkoori VR, Shanmugam C, Jia X, Vitta SP, Sthanam M, Callens T, Messiaen L, Chen D, Zhang B, Bumpers HL, Samuel T, Manne U. Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas. PLoS One. 2012; 7(1):e30020. PMID: 22276141.
      Citations: 10     Fields:    Translation:HumansCells
    31. Samuel T, Fadlalla K, Mosley L, Katkoori V, Turner T, Manne U. Dual-mode interaction between quercetin and DNA-damaging drugs in cancer cells. Anticancer Res. 2012 Jan; 32(1):61-71. PMID: 22213289.
      Citations: 10     Fields:    Translation:HumansCells
    32. Fadlalla K, Watson A, Yehualaeshet T, Turner T, Samuel T. Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res. 2011 Jan; 31(1):233-41. PMID: 21273604.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    33. Samuel T, Fadlalla K, Turner T, Yehualaeshet TE. The flavonoid quercetin transiently inhibits the activity of taxol and nocodazole through interference with the cell cycle. Nutr Cancer. 2010; 62(8):1025-35. PMID: 21058190.
      Citations: 4     Fields:    Translation:HumansCells
    34. Santoro MM, Samuel T, Mitchell T, Reed JC, Stainier DY. Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis. Nat Genet. 2007 Nov; 39(11):1397-402. PMID: 17934460.
      Citations: 54     Fields:    Translation:AnimalsCells
    35. Hyer ML, Samuel T, Reed JC. The FLIP-side of Fas signaling. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 1):5929-31. PMID: 17028246.
      Citations: 12     Fields:    Translation:HumansCells
    36. Samuel T, Welsh K, Lober T, Togo SH, Zapata JM, Reed JC. Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J Biol Chem. 2006 Jan 13; 281(2):1080-90. PMID: 16282325.
      Citations: 58     Fields:    Translation:HumansCells
    37. Samuel T, Okada K, Hyer M, Welsh K, Zapata JM, Reed JC. cIAP1 Localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 2005 Jan 01; 65(1):210-8. PMID: 15665297.
      Citations: 46     Fields:    Translation:HumansCells
    38. Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC. Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. J Biol Chem. 2004 Nov 12; 279(46):48168-76. PMID: 15337764.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    39. Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC. An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004 Aug 13; 279(33):34087-90. PMID: 15218035.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    40. Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC. Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. Blood. 2004 Aug 15; 104(4):932. PMID: 14739219.
      Citations:    Fields:    
    41. Weber HO, Samuel T, Rauch P, Funk JO. Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. Oncogene. 2002 May 09; 21(20):3207-12. PMID: 12082636.
      Citations: 10     Fields:    Translation:HumansCells
    42. Samuel T, Weber HO, Funk JO. Linking DNA damage to cell cycle checkpoints. Cell Cycle. 2002 May-Jun; 1(3):162-8. PMID: 12429926.
      Citations: 18     Fields:    Translation:HumansCells
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