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Seth Y. Ablordeppey

Faculty RankProfessor
InstitutionFlorida A&M University
DepartmentCoPPS, IPH Pharmaceutical Sciences
Address1415 S Martin Luther King Jr Blvd
LL2-230 East Wing
Tallahassee FL 32307
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bricker BA, Voshavar C, Onyameh EK, Gonela UM, Lin X, Swanson TL, Kozell LB, Schmachtenberg JL, Bloom SH, Janowsky AJ, Ablordeppey SY. Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT1A and 5-HT7A Receptors. ACS Omega. 2023 Jun 20; 8(24):21736-21744. PMID: 37360419.
    2. Asong GM, Voshavar C, Amissah F, Bricker B, Lamango NS, Ablordeppey SY. An Evaluation of the Anticancer Properties of SYA014, a Homopiperazine-Oxime Analog of Haloperidol in Triple Negative Breast Cancer Cells. Cancers (Basel). 2022 Dec 08; 14(24). PMID: 36551533.
    3. Onyameh EK, Ofori E, Bricker BA, Gonela UM, Eyunni SVK, Kang HJ, Voshavar C, Ablordeppey SY. Design and discovery of a high affinity, selective and ?-arrestin biased 5-HT7 Receptor Agonist. Med Chem Res. 2022 Feb; 31(2):274-283. PMID: 35340752.
    4. Ofori E, Onyameh EK, Gonela UM, Voshavar C, Bricker B, Swanson TL, Eshleman AJ, Schmachtenberg JL, Bloom SH, Janowsky AJ, Ablordeppey SY. New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263. Eur J Med Chem. 2021 Mar 15; 214:113243. PMID: 33582388.
      Citations: 2     Fields:    Translation:HumansCells
    5. Asong GM, Amissah F, Voshavar C, Nkembo AT, Ntantie E, Lamango NS, Ablordeppey SY. A Mechanistic Investigation on the Anticancer Properties of SYA013, a Homopiperazine Analogue of Haloperidol with Activity against Triple Negative Breast Cancer Cells. ACS Omega. 2020 Dec 29; 5(51):32907-32918. PMID: 33403252.
    6. Onyameh EK, Bricker BA, Eyunni SVK, Voshavar C, Gonela UM, Ofori E, Jenkins A, Ablordeppey SY. A study of the structure-affinity relationship in SYA16263; is a D2 receptor interaction essential for inhibition of apormorphine-induced climbing behavior in mice? Bioorg Med Chem. 2021 01 15; 30:115943. PMID: 33338898.
      Citations: 1     Fields:    Translation:AnimalsCells
    7. Onyameh EK, Bricker BA, Ofori E, Ablordeppey SY. Enantioseparation of 5-chloro-2-{2-[3,4-dihydroisoquinoline-2(1H)-yl]ethyl}-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 40247), a high-affinity 5-HT7 receptor ligand, by HPLC-PDA using amylose tris-(3, 5- dimethylphenylcarbamate) as a chiral stationary phase. Biomed Chromatogr. 2019 Sep; 33(9):e4565. PMID: 31032988.
      Citations: 3     Fields:    
    8. Asong G, Zhu XY, Bricker B, Andey T, Amissah F, Lamango N, Ablordeppey SY. New analogs of SYA013 as sigma-2 ligands with anticancer activity. Bioorg Med Chem. 2019 06 15; 27(12):2629-2636. PMID: 30987780.
      Citations: 6     Fields:    Translation:HumansCells
    9. Bricker BA, Peprah K, Kang HJ, Ablordeppey SY. Evaluation of SYA16263 as a new potential antipsychotic agent without catalepsy. Pharmacol Biochem Behav. 2019 04; 179:55-62. PMID: 30768942.
      Citations: 2     Fields:    Translation:Animals
    10. Al-Ghanim L, Zhu XY, Asong G, Ablordeppey SY. SYA 013 analogs as moderately selective sigma-2 (s2) ligands: Structure-affinity relationship studies. Bioorg Med Chem. 2019 06 15; 27(12):2421-2426. PMID: 30737135.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Gonela UM, Ablordeppey SY. Copper-Catalyzed, Ceric Ammonium Nitrate Mediated N-Arylation of Amines. New J Chem. 2019 Feb 21; 43(7):2861-2864. PMID: 30886516.
    12. Mazzio E, Badisa R, Eyunni S, Ablordeppey S, George B, Soliman KFA. Bioactivity-Guided Isolation of Neuritogenic Factor from the Seeds of the Gac Plant (Momordica cochinchinensis). Evid Based Complement Alternat Med. 2018; 2018:8953958. PMID: 29955238.
    13. Ofori E, Zhu XY, Etukala JR, Bricker BA, Ablordeppey SY. Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors. Bioorg Med Chem. 2016 11 15; 24(22):5730-5740. PMID: 27717652.
      Citations: 5     Fields:    Translation:HumansCells
    14. Etukala JR, Zhu XY, Eyunni SV, Onyameh EK, Ofori E, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores. Bioorg Med Chem. 2016 08 15; 24(16):3671-9. PMID: 27364609.
      Citations: 1     Fields:    Translation:HumansAnimals
    15. Ofori E, Zhu XY, Etukala JR, Peprah K, Jordan KR, Adkins AA, Bricker BA, Kang HJ, Huang XP, Roth BL, Ablordeppey SY. Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands. Bioorg Med Chem. 2016 08 15; 24(16):3464-71. PMID: 27312422.
      Citations: 7     Fields:    
    16. Mazu TK, Bricker BA, Flores-Rozas H, Ablordeppey SY. The Mechanistic Targets of Antifungal Agents: An Overview. Mini Rev Med Chem. 2016; 16(7):555-78. PMID: 26776224.
      Citations: 57     Fields:    Translation:HumansAnimals
    17. Sampson D, Bricker B, Zhu XY, Peprah K, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Further evaluation of the tropane analogs of haloperidol. Bioorg Med Chem Lett. 2014 Sep 01; 24(17):4294-7. PMID: 25070422.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Aguilar BJ, Nkembo AT, Duverna R, Poku RA, Amissah F, Ablordeppey SY, Lamango NS. Polyisoprenylated methylated protein methyl esterase: a putative biomarker and therapeutic target for pancreatic cancer. Eur J Med Chem. 2014 Jun 23; 81:323-33. PMID: 24852279.
      Citations: 9     Fields:    Translation:HumansCells
    19. Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Identification of a new selective dopamine D4 receptor ligand. Bioorg Med Chem. 2014 Jun 15; 22(12):3105-14. PMID: 24800940.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    20. Bricker B, Sampson D, Ablordeppey SY. Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: assessment of a new, commercially available, semi-automated instrument. Pharmacol Biochem Behav. 2014 May; 120:109-16. PMID: 24565832.
      Citations: 5     Fields:    Translation:Animals
    21. Bolden S, Zhu XY, Etukala JR, Boateng C, Mazu T, Flores-Rozas H, Jacob MR, Khan SI, Walker LA, Ablordeppey SY. Structure-activity relationship (SAR) and preliminary mode of action studies of 3-substituted benzylthioquinolinium iodide as anti-opportunistic infection agents. Eur J Med Chem. 2013; 70:130-42. PMID: 24141203.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Bolden S, Boateng CA, Zhu XY, Etukala JR, Eyunni SK, Jacob MR, Khan SI, Ablordeppey SY. CoMFA studies and in vitro evaluation of some 3-substituted benzylthio quinolinium salts as anticryptococcal agents. Bioorg Med Chem. 2013 Nov 15; 21(22):7194-201. PMID: 24080102.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Sikazwe D, Grillo A, Ramsinghani S, Davis J, McQuiston K, Ablordeppey SY. Small diverse antioxidant functionalities for oxidative stress disease drug discovery. Mini Rev Med Chem. 2012 Jul; 12(8):768-74. PMID: 22512567.
      Citations: 1     Fields:    Translation:HumansAnimals
    24. Bricker B, Jackson T, Boateng B, Zhu XY, Ablordeppey SY. Evaluation of the behavioral and pharmacokinetic profile of SYA013, a homopiperazine analog of haloperidol in rats. Pharmacol Biochem Behav. 2012 Aug; 102(2):294-301. PMID: 22588199.
      Citations: 3     Fields:    Translation:Animals
    25. Zhu XY, Etukala JR, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. Eur J Med Chem. 2012 Jul; 53:124-32. PMID: 22520153.
      Citations: 7     Fields:    
    26. Peprah K, Zhu XY, Eyunni SV, Etukala JR, Setola V, Roth BL, Ablordeppey SY. Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol. Bioorg Med Chem. 2012 Mar 01; 20(5):1671-8. PMID: 22336245.
      Citations: 15     Fields:    
    27. Peprah K, Zhu XY, Eyunni SV, Setola V, Roth BL, Ablordeppey SY. Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents. Bioorg Med Chem. 2012 Feb 01; 20(3):1291-7. PMID: 22245230.
      Citations: 20     Fields:    Translation:Humans
    28. Mazu TK, Etukala JR, Jacob MR, Khan SI, Walker LA, Ablordeppey SY. d-Carbolines and their ring-opened analogs: synthesis and evaluation against fungal and bacterial opportunistic pathogens. Eur J Med Chem. 2011 Jun; 46(6):2378-85. PMID: 21459492.
      Citations: 10     Fields:    Translation:AnimalsCells
    29. Boateng CA, Zhu XY, Jacob MR, Khan SI, Walker LA, Ablordeppey SY. Optimization of 3-(phenylthio)quinolinium compounds against opportunistic fungal pathogens. Eur J Med Chem. 2011 May; 46(5):1789-97. PMID: 21402432.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Boateng CA, Eyunni SV, Zhu XY, Etukala JR, Bricker BA, Ashfaq MK, Jacob MR, Khan SI, Walker LA, Ablordeppey SY. Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium compounds: Synthesis and evaluation against opportunistic fungal pathogens. Bioorg Med Chem. 2011 Jan 01; 19(1):458-70. PMID: 21134759.
      Citations: 8     Fields:    Translation:Animals
    31. Mazu TK, Etukala JR, Zhu XY, Jacob MR, Khan SI, Walker LA, Ablordeppey SY. Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens. Bioorg Med Chem. 2011 Jan 01; 19(1):524-33. PMID: 21130660.
      Citations: 4     Fields:    Translation:AnimalsCells
    32. Duverna R, Ablordeppey SY, Lamango NS. Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase. Curr Cancer Drug Targets. 2010 Sep; 10(6):634-48. PMID: 20491620.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    33. Billups J, Jones C, Jackson TL, Ablordeppey SY, Spencer SD. Simultaneous RP-HPLC-DAD quantification of bromocriptine, haloperidol and its diazepane structural analog in rat plasma with droperidol as internal standard for application to drug-interaction pharmacokinetics. Biomed Chromatogr. 2010 Jul; 24(7):699-705. PMID: 19908205.
      Citations: 4     Fields:    Translation:AnimalsCells
    34. Lamango NS, Duverna R, Zhang W, Ablordeppey SY. Porcine Liver Carboxylesterase Requires Polyisoprenylation for High Affinity Binding to Cysteinyl Substrates. Open Enzym Inhib J. 2009 Jan 01; 2:12-27. PMID: 20664805.
    35. Sikazwe DM, Nkansah NT, Altundas R, Zhu XY, Roth BL, Setola V, Ablordeppey SY. Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups. Bioorg Med Chem. 2009 Feb 15; 17(4):1716-23. PMID: 19155177.
      Citations: 6     Fields:    Translation:HumansCells
    36. Ablordeppey SY, Altundas R, Bricker B, Zhu XY, Kumar EV, Jackson T, Khan A, Roth BL. Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. Bioorg Med Chem. 2008 Aug 01; 16(15):7291-301. PMID: 18595716.
      Citations: 18     Fields:    Translation:AnimalsCells
    37. Kumar EV, Etukala JR, Ablordeppey SY. Indolo[3,2-b]quinolines: synthesis, biological evaluation and structure activity-relationships. Mini Rev Med Chem. 2008 Jun; 8(6):538-54. PMID: 18537709.
      Citations: 13     Fields:    Translation:HumansAnimals
    38. Zhu XY, Mardenborough LG, Li S, Khan A, Zhang W, Fan P, Jacob M, Khan S, Walker L, Ablordeppey SY. Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents. Bioorg Med Chem. 2007 Jan 15; 15(2):686-95. PMID: 17134906.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    39. Ablordeppey SY, Lyles-Eggleston M, Bricker B, Zhang W, Zhu X, Goodman C, Roth BL. Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3219-23. PMID: 16621538.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    40. Mardenborough LG, Zhu XY, Fan P, Jacob MR, Khan SI, Walker LA, Ablordeppey SY. Identification of bis-quindolines as new antiinfective agents. Bioorg Med Chem. 2005 Jun 02; 13(12):3955-63. PMID: 15911310.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Sikazwe DM, Li S, Mardenborough L, Cody V, Roth BL, Ablordeppey SY. Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors. Bioorg Med Chem Lett. 2004 Dec 06; 14(23):5739-42. PMID: 15501032.
      Citations: 10     Fields:    Translation:Cells
    42. Glennon RA, Ismaiel AM, Ablordeppey S, El-Ashmawy M, Fisher JB. Thioxanthene-derived analogs as sigma(1) receptor ligands. Bioorg Med Chem Lett. 2004 May 03; 14(9):2217-20. PMID: 15081012.
      Citations: 1     Fields:    
    43. Lyles-Eggleston M, Altundas R, Xia J, Sikazwe DM, Fan P, Yang Q, Li S, Zhang W, Zhu X, Schmidt AW, Vanase-Frawley M, Shrihkande A, Villalobos A, Borne RF, Ablordeppey SY. Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species. J Med Chem. 2004 Jan 29; 47(3):497-508. PMID: 14736232.
      Citations: 14     Fields:    Translation:HumansAnimals
    44. Sikazwe DM, Li S, Lyles-Eggleston M, Ablordeppey SY. The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+. Bioorg Med Chem Lett. 2003 Nov 03; 13(21):3779-82. PMID: 14552778.
      Citations: 7     Fields:    Translation:HumansAnimals
    45. Ablordeppey SY, Fischer JB, Law H, Glennon RA. Probing the proposed phenyl-A region of the sigma-1 receptor. Bioorg Med Chem. 2002 Aug; 10(8):2759-65. PMID: 12057665.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    46. Ablordeppey SY, Fan P, Li S, Clark AM, Hufford CD. Substituted indoloquinolines as new antifungal agents. Bioorg Med Chem. 2002 May; 10(5):1337-46. PMID: 11886797.
      Citations: 12     Fields:    Translation:Animals
    47. Ablordeppey SY, Fischer JB, Glennon RA. Is a nitrogen atom an important pharmacophoric element in sigma ligand binding? Bioorg Med Chem. 2000 Aug; 8(8):2105-11. PMID: 11003156.
      Citations: 21     Fields:    Translation:AnimalsCells
    48. Ablordeppey SY, Fan P, Ablordeppey JH, Mardenborough L. Systemic antifungal agents against AIDS-related opportunistic infections: current status and emerging drugs in development. Curr Med Chem. 1999 Dec; 6(12):1151-95. PMID: 10519919.
      Citations: 10     Fields:    Translation:HumansAnimals
    49. Ablordeppey SY, Fan P, Clark AM, Nimrod A. Probing the N-5 region of the indoloquinoline alkaloid, cryptolepine for anticryptococcal activity. Bioorg Med Chem. 1999 Feb; 7(2):343-9. PMID: 10218827.
      Citations: 12     Fields:    Translation:AnimalsCells
    50. Glennon RA, Ablordeppey SY, Ismaiel AM, el-Ashmawy MB, Fischer JB, Howie KB. Structural features important for sigma 1 receptor binding. J Med Chem. 1994 Apr 15; 37(8):1214-9. PMID: 8164264.
      Citations: 24     Fields:    Translation:AnimalsCells
    51. Ablordeppey SY, Borne RF. Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats. Pharmacol Biochem Behav. 1993 Nov; 46(3):739-44. PMID: 8278454.
      Citations: 3     Fields:    Translation:Animals
    52. Oyekan AO, Ablordeppey SY. Effects of cryptolepine on collagen-induced aggregation and on the mobilization and metabolism of arachidonic acid by rabbit platelets. Gen Pharmacol. 1993 Sep; 24(5):1285-90. PMID: 8270188.
      Citations: 3     Fields:    Translation:AnimalsCells
    53. Oyekan AO, Ablordeppey SY. The mechanism(s) of the antiaggregatory effects of cryptolepine: the role of cyclic adenosine monophosphate and cellular Ca2+. Gen Pharmacol. 1993 Mar; 24(2):461-9. PMID: 7683302.
      Citations: 3     Fields:    Translation:Animals
    54. Ablordeppey SY, Hufford CD, Borne RF, Dwuma-Badu D. 1H-NMR and 13C-NMR Assignments of Cryptolepine, A 3:4-Benz-delta-carboline Derivative Isolated from Cryptolepis sanguinolenta. Planta Med. 1990 Aug; 56(4):416-7. PMID: 17221441.
      Citations: 11     Fields:    
    55. Salako Q, Ablordeppey SY, Dwuma-Badu D, Thornback JR. Radioiodination and preliminary in vivo investigation of the alkaloid cryptolepine. Int J Appl Radiat Isot. 1985 Dec; 36(12):1003-4. PMID: 2867977.
      Citations: 2     Fields:    Translation:Animals
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