Hedgehog Proteins

"Hedgehog Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intercellular signaling proteins that play an important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.

Descriptor ID	D053823
MeSH Number(s)	D12.644.276.671 D12.776.467.671 D23.529.671
Concept/Terms	Hedgehog Proteins Hedgehog Proteins Sonic Hedgehog Protein Sonic Hedgehog Protein Hedgehog Protein, Sonic Hedgehog Protein, Vertebrate Hedgehog Protein, Vertebrate Vertebrate Hedgehog Protein Indian Hedgehog Protein Indian Hedgehog Protein Hedgehog Protein, Indian Banded Hedgehog Protein Banded Hedgehog Protein Hedgehog Protein, Banded Desert Hedgehog Protein Desert Hedgehog Protein Hedgehog Protein, Desert

Below are MeSH descriptors whose meaning is more general than "Hedgehog Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Hedgehog Proteins [D12.644.276.671]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Hedgehog Proteins [D12.776.467.671]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Hedgehog Proteins [D23.529.671]

Below are MeSH descriptors whose meaning is more specific than "Hedgehog Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hedgehog Proteins" by people in this website by year, and whether "Hedgehog Proteins" was a major or minor topic of these publications.

Bar chart showing 39 publications over 17 distinct years, with a maximum of 5 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	1	1
2003	0	1	1
2004	0	2	2
2006	1	0	1
2008	1	0	1
2009	2	0	2
2011	2	1	3
2012	1	3	4
2014	2	3	5
2015	1	3	4
2017	2	2	4
2018	1	1	2
2019	2	0	2
2020	3	0	3
2021	2	0	2
2022	0	1	1

Below are the most recent publications written about "Hedgehog Proteins" by people in Profiles.

Burton DF, Boa-Amponsem OM, Dixon MS, Hopkins MJ, Herbin TA, Toney S, Tarpley M, Rodriguez BV, Fish EW, Parnell SE, Cole GJ, Williams KP. Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol-induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder. J Neurosci Res. 2022 08; 100(8):1585-1601.

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Malave L, Zuelke DR, Uribe-Cano S, Starikov L, Rebholz H, Friedman E, Qin C, Li Q, Bezard E, Kottmann AH. Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia. Commun Biol. 2021 09 22; 4(1):1071.

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Peng Y, Zhang X, Lin H, Deng S, Qin Y, He J, Hu F, Zhu X, Feng X, Wang J, Wei Y, Fan X, Lin H, Ashktorab H, Smoot D, Lv Y, Li S, Meltzer SJ, Jin Z. Dual activation of Hedgehog and Wnt/?-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer. Aging (Albany NY). 2021 04 12; 13(7):10749-10769.

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Singh SK, Gordetsky JB, Bae S, Acosta EP, Lillard JW, Singh R. Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer. Cells. 2020 08 27; 9(9).

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Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. Elife. 2020 08 06; 9.

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Boa-Amponsem O, Zhang C, Burton D, Williams KP, Cole GJ. Ethanol and Cannabinoids Regulate Zebrafish GABAergic Neuron Development and Behavior in a Sonic Hedgehog and Fibroblast Growth Factor-Dependent Mechanism. Alcohol Clin Exp Res. 2020 07; 44(7):1366-1377.

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Gonzalez-Reyes LE, Chiang CC, Zhang M, Johnson J, Arrillaga-Tamez M, Couturier NH, Reddy N, Starikov L, Capadona JR, Kottmann AH, Durand DM. Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus. Sci Rep. 2019 11 22; 9(1):17402.

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Fish EW, Murdaugh LB, Zhang C, Boschen KE, Boa-Amponsem O, Mendoza-Romero HN, Tarpley M, Chdid L, Mukhopadhyay S, Cole GJ, Williams KP, Parnell SE. Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction. Sci Rep. 2019 11 05; 9(1):16057.

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Noubissi FK, Yedjou CG, Spiegelman VS, Tchounwou PB. Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma. Int J Environ Res Public Health. 2018 07 09; 15(7).

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Chamcheu JC, Rady I, Chamcheu RN, Siddique AB, Bloch MB, Banang Mbeumi S, Babatunde AS, Uddin MB, Noubissi FK, Jurutka PW, Liu YY, Spiegelman VS, Whitfield GK, El Sayed KA. Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling. Int J Mol Sci. 2018 Jun 16; 19(6).

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