Hedgehog Proteins

"Hedgehog Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of intercellular signaling proteins that play an important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.

Descriptor ID	D053823
MeSH Number(s)	D12.644.276.671 D12.776.467.671 D23.529.671
Concept/Terms	Hedgehog Proteins Hedgehog Proteins Sonic Hedgehog Protein Sonic Hedgehog Protein Hedgehog Protein, Sonic Hedgehog Protein, Vertebrate Hedgehog Protein, Vertebrate Vertebrate Hedgehog Protein Indian Hedgehog Protein Indian Hedgehog Protein Hedgehog Protein, Indian Banded Hedgehog Protein Banded Hedgehog Protein Hedgehog Protein, Banded Desert Hedgehog Protein Desert Hedgehog Protein Hedgehog Protein, Desert

Below are MeSH descriptors whose meaning is more general than "Hedgehog Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Hedgehog Proteins [D12.644.276.671]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Hedgehog Proteins [D12.776.467.671]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Hedgehog Proteins [D23.529.671]

Below are MeSH descriptors whose meaning is more specific than "Hedgehog Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hedgehog Proteins" by people in this website by year, and whether "Hedgehog Proteins" was a major or minor topic of these publications.

Bar chart showing 44 publications over 22 distinct years, with a maximum of 5 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2002	0	1	1
2003	0	1	1
2004	0	2	2
2006	1	0	1
2008	1	0	1
2009	2	0	2
2011	2	1	3
2012	1	2	3
2014	2	2	4
2015	1	1	2
2016	0	1	1
2017	3	2	5
2018	1	1	2
2019	2	0	2
2020	3	0	3
2021	2	0	2
2022	0	1	1
2023	0	1	1
2024	3	1	4
2025	1	0	1
2026	1	0	1

Below are the most recent publications written about "Hedgehog Proteins" by people in Profiles.

Ji X, Salim E, Tarpley M, Duncan C, Rabe DA, Cole GJ, Williams KP. The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects. Adv Exp Med Biol. 2026; 1500:49-82.

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Nara A, Shimada S, Akiyama Y, Hatano M, Chino Y, Miyazawa S, Tamura H, Asano D, Ishikawa Y, Ueda H, Watanabe S, Katsuta E, Akahoshi K, Ohashi K, Tanabe M, Ban D, Tanaka S. Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis. Cancer Sci. 2026 Mar; 117(3):670-682.

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Lamson DR, Tarpley M, Addo K, Ji X, Abu Rabe D, Ehe B, Hughes M, Smith GR, Daye LR, Musso DL, Zheng W, Williams KP. Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays. Biochim Biophys Acta Gen Subj. 2024 11; 1868(11):130692.

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Yoshida S, Kawamura A, Aoki K, Wiriyasermkul P, Sugimoto S, Tomiyoshi J, Tajima A, Ishida Y, Katoh Y, Tsukada T, Tsuneoka Y, Yamada K, Nagamori S, Nakayama K, Yoshida K. Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2320070121.

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Yoshida S, Tsuneoka Y, Tsukada T, Nakakura T, Kawamura A, Kai W, Yoshida K. Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 01; 165(8).

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Abu Rabe D, Chdid L, Lamson DR, Laudeman CP, Tarpley M, Elsayed N, Smith GR, Zheng W, Dixon MS, Williams KP. Identification of Novel GANT61 Analogs with Activity in Hedgehog Functional Assays and GLI1-Dependent Cancer Cells. Molecules. 2024 Jun 28; 29(13).

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Zhang C, Ezem N, Mackinnon S, Cole GJ. Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction. Cells. 2023 05 06; 12(9).

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Burton DF, Boa-Amponsem OM, Dixon MS, Hopkins MJ, Herbin TA, Toney S, Tarpley M, Rodriguez BV, Fish EW, Parnell SE, Cole GJ, Williams KP. Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol-induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder. J Neurosci Res. 2022 08; 100(8):1585-1601.

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Malave L, Zuelke DR, Uribe-Cano S, Starikov L, Rebholz H, Friedman E, Qin C, Li Q, Bezard E, Kottmann AH. Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia. Commun Biol. 2021 09 22; 4(1):1071.

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Peng Y, Zhang X, Lin H, Deng S, Qin Y, He J, Hu F, Zhu X, Feng X, Wang J, Wei Y, Fan X, Lin H, Ashktorab H, Smoot D, Lv Y, Li S, Meltzer SJ, Jin Z. Dual activation of Hedgehog and Wnt/?-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer. Aging (Albany NY). 2021 04 12; 13(7):10749-10769.

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