"Integrin alpha6beta4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
| Descriptor ID |
D039161
|
| MeSH Number(s) |
D12.776.543.750.705.408.460.170 D12.776.543.750.705.876.750
|
| Concept/Terms |
Integrin alpha6beta4- Integrin alpha6beta4
- alpha6beta4, Integrin
- alpha(6)beta(4) Integrin
- alpha6 beta4 Integrin
- Integrin, alpha6 beta4
- beta4 Integrin, alpha6
- Integrin alpha(6),beta(4)
- A9 Antigen
- Antigen, A9
- TSP-180
- Tumor Specific Protein-180 Complex
- Tumor Specific Protein 180 Complex
- alpha(6)beta(4) Epithelial Integrin
- Laminin-5 Receptor (alpha6beta4 Integrin)
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha6beta4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6beta4".
This graph shows the total number of publications written about "Integrin alpha6beta4" by people in this website by year, and whether "Integrin alpha6beta4" was a major or minor topic of these publications.
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Below are the most recent publications written about "Integrin alpha6beta4" by people in Profiles.
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Cruz-Monserrate Z, O'Connor KL. Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation. Neoplasia. 2008 May; 10(5):408-17.
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Chen M, O'Connor KL. Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene. 2005 Jul 28; 24(32):5125-30.