Nuclear Localization Signals
"Nuclear Localization Signals" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.
| Descriptor ID |
D019913
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| MeSH Number(s) |
D12.644.770.610 G02.111.570.060.670.610
|
| Concept/Terms |
Nuclear Localization Signals- Nuclear Localization Signals
- Nuclear Localization Signal Peptide
- Nuclear Localization Signal
- Signal, Nuclear Localization
- Signals, Nuclear Localization
- NLS Peptide
- NLS Peptides
- Peptide, NLS
- Peptides, NLS
|
Below are MeSH descriptors whose meaning is more general than "Nuclear Localization Signals".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Localization Signals".
This graph shows the total number of publications written about "Nuclear Localization Signals" by people in this website by year, and whether "Nuclear Localization Signals" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 2 | 3 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 2 | 3 |
| 2008 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
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Below are the most recent publications written about "Nuclear Localization Signals" by people in Profiles.
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Ehe BK, Lamson DR, Tarpley M, Onyenwoke RU, Graves LM, Williams KP. Identification of a DYRK1A-mediated phosphorylation site within the nuclear localization sequence of the hedgehog transcription factor GLI1. Biochem Biophys Res Commun. 2017 09 23; 491(3):767-772.
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Burton LJ, Henderson V, Liburd L, Odero-Marah VA. Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1. Biochem Biophys Res Commun. 2017 09 09; 491(1):59-64.
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Adams-Cioaba MA, Guo Y, Bian C, Amaya MF, Lam R, Wasney GA, Vedadi M, Xu C, Min J. Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. PLoS One. 2010 Nov 02; 5(11):e13559.
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Theodore M, Kawai Y, Yang J, Kleshchenko Y, Reddy SP, Villalta F, Arinze IJ. Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2. J Biol Chem. 2008 Apr 04; 283(14):8984-94.
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Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol. 2006 Jul 07; 360(2):421-34.
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Llano M, Vanegas M, Hutchins N, Thompson D, Delgado S, Poeschla EM. Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75. J Mol Biol. 2006 Jul 21; 360(4):760-73.
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de Jesus LA, Hoffmann PR, Michaud T, Forry EP, Small-Howard A, Stillwell RJ, Morozova N, Harney JW, Berry MJ. Nuclear assembly of UGA decoding complexes on selenoprotein mRNAs: a mechanism for eluding nonsense-mediated decay? Mol Cell Biol. 2006 Mar; 26(5):1795-805.
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Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E. Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. J Cell Sci. 2005 Apr 15; 118(Pt 8):1733-43.
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Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J Cell Biol. 2004 Nov 08; 167(3):469-78.
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Llano M, Vanegas M, Fregoso O, Saenz D, Chung S, Peretz M, Poeschla EM. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol. 2004 Sep; 78(17):9524-37.