Chemokine CCL2

"Chemokine CCL2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

Descriptor ID	D018932
MeSH Number(s)	D12.644.276.374.200.110.990.600 D12.776.467.374.200.110.990.600 D23.125.300.110.990.600 D23.469.200.110.990.600 D23.529.374.200.110.990.500
Concept/Terms	Chemokine CCL2 Chemokine CCL2 CCL2, Chemokine Monocyte Chemotactic and Activating Factor Monocyte Chemoattractant Protein-1 Chemoattractant Protein-1, Monocyte Monocyte Chemoattractant Protein 1 Chemokines CCL2 CCL2, Chemokines CCL2 Chemokine Chemokine, CCL2 Chemokine (C-C Motif) Ligand 2 Monocyte Chemotactic Protein-1 Chemotactic Protein-1, Monocyte Monocyte Chemotactic Protein 1

Below are MeSH descriptors whose meaning is more general than "Chemokine CCL2".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Chemokines [D12.644.276.374.200]
Chemokines, CC [D12.644.276.374.200.110]
Monocyte Chemoattractant Proteins [D12.644.276.374.200.110.990]
Chemokine CCL2 [D12.644.276.374.200.110.990.600]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Chemokines [D12.776.467.374.200]
Chemokines, CC [D12.776.467.374.200.110]
Monocyte Chemoattractant Proteins [D12.776.467.374.200.110.990]
Chemokine CCL2 [D12.776.467.374.200.110.990.600]
Biological Factors [D23]
Chemotactic Factors [D23.125]
Chemokines [D23.125.300]
Chemokines, CC [D23.125.300.110]
Monocyte Chemoattractant Proteins [D23.125.300.110.990]
Chemokine CCL2 [D23.125.300.110.990.600]
Inflammation Mediators [D23.469]
Chemokines [D23.469.200]
Chemokines, CC [D23.469.200.110]
Monocyte Chemoattractant Proteins [D23.469.200.110.990]
Chemokine CCL2 [D23.469.200.110.990.600]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Chemokines [D23.529.374.200]
Chemokines, CC [D23.529.374.200.110]
Monocyte Chemoattractant Proteins [D23.529.374.200.110.990]
Chemokine CCL2 [D23.529.374.200.110.990.500]

Below are MeSH descriptors whose meaning is related to "Chemokine CCL2".

Below are MeSH descriptors whose meaning is more specific than "Chemokine CCL2".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chemokine CCL2" by people in this website by year, and whether "Chemokine CCL2" was a major or minor topic of these publications.

Bar chart showing 60 publications over 24 distinct years, with a maximum of 8 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	1	1
2002	1	2	3
2003	0	2	2
2004	2	1	3
2005	2	2	4
2006	1	2	3
2007	1	0	1
2008	1	4	5
2010	0	3	3
2011	2	0	2
2012	2	6	8
2013	1	0	1
2014	2	0	2
2015	3	1	4
2016	1	0	1
2017	1	0	1
2018	3	0	3
2019	2	0	2
2020	2	2	4
2021	1	1	2
2022	0	1	1
2024	1	0	1
2025	1	1	2

Below are the most recent publications written about "Chemokine CCL2" by people in Profiles.

Milicic A, Wilson S, Javandel S, Allen IE, Tsoy E, Ndhlovu LC, Kibuuka H, Semwogerere M, Langat R, Daud I, Bahemana E, David G, Rehema W, Ouma I, Ogari C, Anyebe V, Parker Z, Streeck H, Polyak CS, Shah N, Ake JA, Valcour V. Plasma Inflammatory Biomarkers Link to Worse Cognition Among Africans With HIV. J Acquir Immune Defic Syndr. 2025 Aug 01; 99(4):405-416.

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Soni UK, Tripathi R, Sankhwar P, Kumari S, Soni M, Manoj A, Ubba V, Gupta S, Verma RK, Pratap JV, Jha RK. MCP-1 promotes ILK phosphorylation at Ser246 during endometriosis development and affects the pregnancy outcome. Mol Hum Reprod. 2025 Apr 03; 31(2).

View in: PubMed
Soni UK, Tripathi R, Jha RK. MCP-1 exerts the inflammatory response via ILK activation during endometriosis pathogenesis. Life Sci. 2024 Sep 15; 353:122902.

View in: PubMed
Messeha SS, Zarmouh NO, Antonie L, Soliman KFA. Sanguinarine Inhibition of TNF-a-Induced CCL2, IKBKE/NF-?B/ERK1/2 Signaling Pathway, and Cell Migration in Human Triple-Negative Breast Cancer Cells. Int J Mol Sci. 2022 Jul 28; 23(15).

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Kanga KJW, Mendonca P, Soliman KFA, Ferguson DT, Darling-Reed SF. Effect of Diallyl Trisulfide on TNF-a-induced CCL2/MCP-1 Release in Genetically Different Triple-negative Breast Cancer Cells. Anticancer Res. 2021 Dec; 41(12):5919-5933.

View in: PubMed
Wang Y, Tiruthani K, Li S, Hu M, Zhong G, Tang Y, Roy S, Zhang L, Tan J, Liao C, Liu R. mRNA Delivery of a Bispecific Single-Domain Antibody to Polarize Tumor-Associated Macrophages and Synergize Immunotherapy against Liver Malignancies. Adv Mater. 2021 Jun; 33(23):e2007603.

View in: PubMed
Thomas MU, Messex JK, Dang T, Abdulkadir SA, Jorcyk CL, Liou GY. Macrophages expedite cell proliferation of prostate intraepithelial neoplasia through their downstream target ERK. FEBS J. 2021 03; 288(6):1871-1886.

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Han SJ, Williams RM, Kim M, Heller DA, D'Agati V, Schmidt-Supprian M, Lee HT. Renal proximal tubular NEMO plays a critical role in ischemic acute kidney injury. JCI Insight. 2020 09 17; 5(19).

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Messeha SS, Zarmouh NO, Mendonca P, Cotton C, Soliman KFA. Molecular mechanism of gossypol mediating CCL2 and IL-8 attenuation in triple-negative breast cancer cells. Mol Med Rep. 2020 08; 22(2):1213-1226.

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Hao Q, Vadgama JV, Wang P. CCL2/CCR2 signaling in cancer pathogenesis. Cell Commun Signal. 2020 05 29; 18(1):82.

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