"PrPC Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Normal cellular isoform of PRION PROTEINS encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity.
| Descriptor ID |
D018621
|
| MeSH Number(s) |
D12.776.785.340.500
|
| Concept/Terms |
PrPC Proteins- PrPC Proteins
- PrP-sen
- PrP sen
- Cp 33-35
- Scrapie Amyloid Precursor Protein
- Cp33-35, Scrapie
|
Below are MeSH descriptors whose meaning is more general than "PrPC Proteins".
Below are MeSH descriptors whose meaning is more specific than "PrPC Proteins".
This graph shows the total number of publications written about "PrPC Proteins" by people in this website by year, and whether "PrPC Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "PrPC Proteins" by people in Profiles.
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Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG. Cellular prion protein is essential for oligomeric amyloid-?-induced neuronal cell death. Hum Mol Genet. 2012 Mar 01; 21(5):1138-44.
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Yuan J, Kinter M, McGeehan J, Perry G, Kneale G, Gambetti P, Zou WQ. Concealment of epitope by reduction and alkylation in prion protein. Biochem Biophys Res Commun. 2005 Jan 21; 326(3):652-9.
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Kang SC, Brown DR, Whiteman M, Li R, Pan T, Perry G, Wisniewski T, Sy MS, Wong BS. Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice. J Pathol. 2004 May; 203(1):603-8.
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Wong BS, Liu T, Li R, Pan T, Petersen RB, Smith MA, Gambetti P, Perry G, Manson JC, Brown DR, Sy MS. Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. J Neurochem. 2001 Jan; 76(2):565-72.
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Capellari S, Zaidi SI, Urig CB, Perry G, Smith MA, Petersen RB. Prion protein glycosylation is sensitive to redox change. J Biol Chem. 1999 Dec 03; 274(49):34846-50.