Lymphocyte Function-Associated Antigen-1
"Lymphocyte Function-Associated Antigen-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
| Descriptor ID |
D016169
|
| MeSH Number(s) |
D12.776.395.550.200.074.937 D12.776.395.550.200.625.550 D12.776.543.550.200.093.937 D12.776.543.550.200.625.550 D12.776.543.750.705.408.600.400 D12.776.543.750.705.877.550 D23.050.301.350.074.400 D23.050.301.350.625.550
|
| Concept/Terms |
Lymphocyte Function-Associated Antigen-1- Lymphocyte Function-Associated Antigen-1
- Antigen-1, Lymphocyte Function-Associated
- Lymphocyte Function Associated Antigen 1
- Integrin alphaLbeta2
- alphaLbeta2, Integrin
- Leukocyte Function Associated Antigen-1
- LFA-1
|
Below are MeSH descriptors whose meaning is more general than "Lymphocyte Function-Associated Antigen-1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Glycoproteins [D12.776.395]
- Membrane Glycoproteins [D12.776.395.550]
- Cell Adhesion Molecules [D12.776.395.550.200]
- CD11 Antigens [D12.776.395.550.200.074]
- Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.074.937]
- Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.625.550]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Cell Adhesion Molecules [D12.776.543.550.200]
- CD11 Antigens [D12.776.543.550.200.093]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.093.937]
- Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.625.550]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Immunologic [D12.776.543.750.705]
- Integrins [D12.776.543.750.705.408]
- Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.408.600.400]
- Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
- Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.877.550]
- Biological Factors [D23]
- Antigens [D23.050]
- Antigens, Surface [D23.050.301]
- Cell Adhesion Molecules [D23.050.301.350]
- CD11 Antigens [D23.050.301.350.074]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.074.400]
- Receptors, Lymphocyte Homing [D23.050.301.350.625]
- Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.625.550]
Below are MeSH descriptors whose meaning is more specific than "Lymphocyte Function-Associated Antigen-1".
This graph shows the total number of publications written about "Lymphocyte Function-Associated Antigen-1" by people in this website by year, and whether "Lymphocyte Function-Associated Antigen-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Lymphocyte Function-Associated Antigen-1" by people in Profiles.
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Ascierto ML, Idowu MO, Zhao Y, Khalak H, Payne KK, Wang XY, Dumur CI, Bedognetti D, Tomei S, Ascierto PA, Shanker A, Bear HD, Wang E, Marincola FM, De Maria A, Manjili MH. Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients. J Transl Med. 2013 Jun 12; 11:145.
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Mor A, Campi G, Du G, Zheng Y, Foster DA, Dustin ML, Philips MR. The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol. 2007 Jun; 9(6):713-9.
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Wadehra M, Su H, Gordon LK, Goodglick L, Braun J. The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. Clin Immunol. 2003 May; 107(2):129-36.
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Wormley FL, Chaiban J, Fidel PL. Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis. Infect Immun. 2001 Aug; 69(8):5072-9.
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Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, Field JA, Steere AC, Huber BT. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science. 1998 Jul 31; 281(5377):703-6.