Rats, Inbred SHR

"Rats, Inbred SHR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.

Descriptor ID	D011918
MeSH Number(s)	B01.050.050.199.520.760.300 B01.050.150.900.649.313.992.635.505.700.400.300
Concept/Terms	Rats, Inbred SHR Rats, Inbred SHR Inbred SHR Rat Inbred SHR Rats Rat, Inbred SHR SHR Rat, Inbred SHR Rats, Inbred Rats, SHR Rat, SHR SHR Rat SHR Rats Rats, Spontaneously Hypertensive Rat, Spontaneously Hypertensive Spontaneously Hypertensive Rat Spontaneously Hypertensive Rats

Below are MeSH descriptors whose meaning is more general than "Rats, Inbred SHR".

Organisms [B]
Eukaryota [B01]
Animals [B01.050]
Animal Population Groups [B01.050.050]
Animals, Laboratory [B01.050.050.199]
Animals, Inbred Strains [B01.050.050.199.520]
Rats, Inbred Strains [B01.050.050.199.520.760]
Rats, Inbred SHR [B01.050.050.199.520.760.300]
Chordata [B01.050.150]
Vertebrates [B01.050.150.900]
Mammals [B01.050.150.900.649]
Eutheria [B01.050.150.900.649.313]
Rodentia [B01.050.150.900.649.313.992]
Muridae [B01.050.150.900.649.313.992.635]
Murinae [B01.050.150.900.649.313.992.635.505]
Rats [B01.050.150.900.649.313.992.635.505.700]
Rats, Inbred Strains [B01.050.150.900.649.313.992.635.505.700.400]
Rats, Inbred SHR [B01.050.150.900.649.313.992.635.505.700.400.300]

Below are MeSH descriptors whose meaning is related to "Rats, Inbred SHR".

Below are MeSH descriptors whose meaning is more specific than "Rats, Inbred SHR".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Rats, Inbred SHR" by people in this website by year, and whether "Rats, Inbred SHR" was a major or minor topic of these publications.

Bar chart showing 25 publications over 17 distinct years, with a maximum of 3 publications in 2007

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
2001	2	2
2002	1	1
2003	1	1
2005	1	1
2007	3	3
2009	1	1
2011	2	2
2013	1	1
2014	2	2
2015	2	2
2016	2	2
2017	2	2
2018	1	1
2019	1	1
2020	1	1
2021	1	1
2023	1	1

Below are the most recent publications written about "Rats, Inbred SHR" by people in Profiles.

Ramsey AM, Stowie A, Hill A, Ellis I, Rhodes MK, Pollock DM, Davidson AJ. Long-term circadian disruption shortens life span and dampens blood pressure diurnal rhythms in stroke-prone spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2023 07 01; 325(1):H106-H112.

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Jiang J, Ding FX, Zhou X, Bateman TJ, Dong S, Gu X, Keh deJesus R, Pio B, Tang H, Chobanian HR, Levorse D, Hu M, Thomas-Fowlkes B, Margulis M, Koehler M, Weinglass A, Gibson J, Houle K, Yudkovitz J, Hampton C, Pai LY, Samuel K, Cutarelli T, Sullivan K, Parmee ER, Davies I, Pasternak A. Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic. J Med Chem. 2021 06 10; 64(11):7691-7701.

View in: PubMed
Hill AM, Crislip GR, Stowie A, Ellis I, Ramsey A, Castanon-Cervantes O, Gumz ML, Davidson AJ. Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats. Am J Physiol Renal Physiol. 2021 02 01; 320(2):F224-F233.

View in: PubMed
Johnson M, McElhenney WH, Egnin M. Influence of Green Leafy Vegetables in Diets with an Elevated ?-6:?-3 Fatty Acid Ratio on Rat Blood Pressure, Plasma Lipids, Antioxidant Status and Markers of Inflammation. Nutrients. 2019 Jan 31; 11(2).

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Johnson M, Pace RD, McElhenney WH. Green leafy vegetables in diets with a 25:1 omega-6/omega-3 fatty acid ratio modify the erythrocyte fatty acid profile of spontaneously hypertensive rats. Lipids Health Dis. 2018 Jun 15; 17(1):140.

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Toussaint J, Raval CB, Nguyen T, Fadaifard H, Joshi S, Wolberg G, Quarfordt S, Jan KM, Rumschitzki DS. Chronic hypertension increases aortic endothelial hydraulic conductivity by upregulating endothelial aquaporin-1 expression. Am J Physiol Heart Circ Physiol. 2017 Nov 01; 313(5):H1063-H1073.

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Dong S, VanGelder K, Shi ZC, Yu Y, Wu Z, Ferguson R, Guo ZZ, Tang H, Frie J, Fu Q, Gu X, Priest BT, Thomas-Fowlkes B, Weinglass A, Margulis M, Liu J, Pai LY, Hampton C, Haimbach RE, Owens K, Tong V, Xu S, Hu M, Zingaro GJ, Morissette P, Ehrhart J, Roy S, Sullivan K, Pasternak A. Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett. 2017 06 01; 27(11):2559-2566.

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Chobanian HR, Guo Y, Pio B, Tang H, Teumelsan N, Clements M, Frie J, Ferguson R, Guo Z, Thomas-Fowlkes BS, Felix JP, Liu J, Kohler M, Priest B, Hampton C, Pai LY, Corona A, Metzger J, Tong V, Joshi EM, Xu L, Owens K, Maloney K, Sullivan K, Pasternak A. The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics. Bioorg Med Chem Lett. 2017 02 15; 27(4):1109-1114.

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Girgih AT, Nwachukwu ID, Onuh JO, Malomo SA, Aluko RE. Antihypertensive Properties of a Pea Protein Hydrolysate during Short- and Long-Term Oral Administration to Spontaneously Hypertensive Rats. J Food Sci. 2016 May; 81(5):H1281-7.

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Malomo SA, Onuh JO, Girgih AT, Aluko RE. Structural and Antihypertensive Properties of Enzymatic Hemp Seed Protein Hydrolysates. Nutrients. 2015 Sep 10; 7(9):7616-32.

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