Pyrimidines

"Pyrimidines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.

Descriptor ID	D011743
MeSH Number(s)	D03.383.742
Concept/Terms	Pyrimidines Pyrimidines

Below are MeSH descriptors whose meaning is more general than "Pyrimidines".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]

Below are MeSH descriptors whose meaning is related to "Pyrimidines".

Below are MeSH descriptors whose meaning is more specific than "Pyrimidines".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pyrimidines" by people in this website by year, and whether "Pyrimidines" was a major or minor topic of these publications.

Bar chart showing 97 publications over 26 distinct years, with a maximum of 9 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
2001	0	1	1
2002	1	1	2
2003	0	1	1
2004	1	2	3
2005	0	2	2
2006	3	1	4
2007	3	0	3
2008	1	4	5
2009	3	1	4
2010	4	1	5
2011	3	4	7
2012	2	2	4
2013	3	3	6
2014	3	4	7
2015	2	1	3
2016	1	3	4
2017	5	4	9
2018	1	1	2
2019	1	0	1
2020	2	2	4
2021	1	4	5
2022	0	1	1
2023	1	0	1
2024	3	4	7
2025	1	3	4

Below are the most recent publications written about "Pyrimidines" by people in Profiles.

Dela Cruz MC, Yao X, Roberts N, Iheukwumere P, Carmouche A, Medina PM, Biliran H. TLE1 drives EGFR-TKI resistance in EGFR-mutant lung adenocarcinoma through epithelial to mesenchymal transition. Biochem Biophys Res Commun. 2025 Aug 15; 775:152146.

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Aishwarya S, Torres GC, Lopez-Saenz JA, Gutierrez DA, Kumar S, Madarakhandi A, Metikurki B, Teraiya N, Aguilera RJ, Karki SS. Synthesis of novel pyridazine and pyrimidine linked pyrazole derivatives as DNA ligase 1 and IV inhibitors that induce apoptosis. Chem Biol Interact. 2025 Jun 01; 414:111509.

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Nathani A, Sun L, Li Y, Lazarte J, Aare M, Singh M. Targeting EGFR-TKI resistance in lung cancer: Role of miR-5193/miR-149-5p loaded NK-EVs and Carboplatin combination. Int J Pharm. 2025 Apr 30; 675:125573.

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Ramos-Benitez MJ, Miao R, Rivera-Torres AP, Lacourt-Ventura M, Malavez-Cajigas SJ, Tian X, Teague HL, De Jesus-Rojas W, Reger R, Suffredini AF, King C, Nathan SD, Childs RW, Strich JR. Surfactant Protein D and Club Cell Secretory Protein as Biomarkers of Disease Severity and Fostamatinib Efficacy in Severe COVID-19. Crit Care Explor. 2025 Apr 01; 7(4):e1252.

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Kashyap VK, Sharma BP, Pandey D, Singh AK, Peasah-Darkwah G, Singh B, Roy KK, Yallapu MM, Chauhan SC. Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis. Cells. 2024 12 12; 13(24).

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Nathani A, Khan I, Tanimoto MH, Mej?a JAA, DE Miranda AM, Rishi A, Dev S, Bastos JK, Singh M. Antitumor Potential of Guttiferone E Combined With Carboplatin Against Osimertinib-resistant H1975 Lung Cancer Through Apoptosis. Anticancer Res. 2024 Oct; 44(10):4175-4188.

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Brennan E, Noell S, Davis EW, Giovannoni SJ, Suffridge CP. Whole cell affinity for 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in the marine bacterium Candidatus Pelagibacter st. HTCC7211 explains marine dissolved HMP concentrations. Environ Microbiol Rep. 2024 Oct; 16(5):e70023.

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Warner S, Teague HL, Ramos-Benitez MJ, Panicker S, Allen K, Gairhe S, Moyer T, Parachalil Gopalan B, Douagi I, Shet A, Kanthi Y, Suffredini AF, Chertow DS, Strich JR. R406 reduces lipopolysaccharide-induced neutrophil activation. Cell Immunol. 2024 Sep-Oct; 403-404:104860.

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Abu Rabe D, Chdid L, Lamson DR, Laudeman CP, Tarpley M, Elsayed N, Smith GR, Zheng W, Dixon MS, Williams KP. Identification of Novel GANT61 Analogs with Activity in Hedgehog Functional Assays and GLI1-Dependent Cancer Cells. Molecules. 2024 Jun 28; 29(13).

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Yaeger R, Uboha NV, Pelster MS, Bekaii-Saab TS, Barve M, Saltzman J, Sabari JK, Peguero JA, Paulson AS, J?nne PA, Cruz-Correa M, Anderes K, Velastegui K, Yan X, Der-Torossian H, Klempner SJ, Kopetz SE. Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer. Cancer Discov. 2024 Jun 03; 14(6):982-993.

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