Pyrimidines

"Pyrimidines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.

Descriptor ID	D011743
MeSH Number(s)	D03.383.742
Concept/Terms	Pyrimidines Pyrimidines

Below are MeSH descriptors whose meaning is more general than "Pyrimidines".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]

Below are MeSH descriptors whose meaning is related to "Pyrimidines".

Below are MeSH descriptors whose meaning is more specific than "Pyrimidines".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pyrimidines" by people in this website by year, and whether "Pyrimidines" was a major or minor topic of these publications.

Bar chart showing 97 publications over 26 distinct years, with a maximum of 9 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
2001	0	1	1
2002	1	1	2
2003	0	1	1
2004	1	2	3
2005	0	2	2
2006	3	1	4
2007	3	0	3
2008	1	4	5
2009	3	1	4
2010	4	1	5
2011	3	4	7
2012	2	2	4
2013	3	3	6
2014	3	4	7
2015	2	1	3
2016	1	3	4
2017	5	4	9
2018	1	1	2
2019	1	0	1
2020	2	2	4
2021	1	4	5
2022	0	1	1
2023	1	0	1
2024	3	4	7
2025	1	3	4

Below are the most recent publications written about "Pyrimidines" by people in Profiles.

Parapini S, D'Alessandro S, Travaglione S, Paone S, Madera Cuevas IM, Dipol T, Zongo DWR, Figueroa V?zquez AM, Morsilli O, Fabbri A, Vlaar CP, Olivieri A. Design, synthesis and biological evaluation of Rac1-targeting carbazole-pyrimidines as host-directed antimalarials. Eur J Med Chem. 2026 Apr 15; 308:118690.

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Barajas J, Yang Z, Agyare E, Zhu X, Yoon SJ, Han B. Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids. PLoS One. 2025; 20(12):e0326550.

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Patra S, Namballa HK, Gudipally AR, Xie L, Xie L, Harding WW. Discovery of a selective a2C-AR scaffold from a molecular hybridization approach. Bioorg Med Chem. 2025 Dec 15; 131:118424.

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Dela Cruz MC, Yao X, Roberts N, Iheukwumere P, Carmouche A, Medina PM, Biliran H. TLE1 drives EGFR-TKI resistance in EGFR-mutant lung adenocarcinoma through epithelial to mesenchymal transition. Biochem Biophys Res Commun. 2025 08 15; 775:152146.

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Aishwarya S, Torres GC, Lopez-Saenz JA, Gutierrez DA, Kumar S, Madarakhandi A, Metikurki B, Teraiya N, Aguilera RJ, Karki SS. Synthesis of novel pyridazine and pyrimidine linked pyrazole derivatives as DNA ligase 1 and IV inhibitors that induce apoptosis. Chem Biol Interact. 2025 Jun 01; 414:111509.

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Nathani A, Sun L, Li Y, Lazarte J, Aare M, Singh M. Targeting EGFR-TKI resistance in lung cancer: Role of miR-5193/miR-149-5p loaded NK-EVs and Carboplatin combination. Int J Pharm. 2025 Apr 30; 675:125573.

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Ramos-Benitez MJ, Miao R, Rivera-Torres AP, Lacourt-Ventura M, Malavez-Cajigas SJ, Tian X, Teague HL, De Jesus-Rojas W, Reger R, Suffredini AF, King C, Nathan SD, Childs RW, Strich JR. Surfactant Protein D and Club Cell Secretory Protein as Biomarkers of Disease Severity and Fostamatinib Efficacy in Severe COVID-19. Crit Care Explor. 2025 Apr 01; 7(4):e1252.

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Kashyap VK, Sharma BP, Pandey D, Singh AK, Peasah-Darkwah G, Singh B, Roy KK, Yallapu MM, Chauhan SC. Small Molecule with Big Impact: Metarrestin Targets the Perinucleolar Compartment in Cancer Metastasis. Cells. 2024 12 12; 13(24).

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Nathani A, Khan I, Tanimoto MH, Mej?a JAA, DE Miranda AM, Rishi A, Dev S, Bastos JK, Singh M. Antitumor Potential of Guttiferone E Combined With Carboplatin Against Osimertinib-resistant H1975 Lung Cancer Through Apoptosis. Anticancer Res. 2024 Oct; 44(10):4175-4188.

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Brennan E, Noell S, Davis EW, Giovannoni SJ, Suffridge CP. Whole cell affinity for 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) in the marine bacterium Candidatus Pelagibacter st. HTCC7211 explains marine dissolved HMP concentrations. Environ Microbiol Rep. 2024 Oct; 16(5):e70023.

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