Pregnenolone Carbonitrile
"Pregnenolone Carbonitrile" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.
| Descriptor ID |
D011285
|
| MeSH Number(s) |
D02.626.745 D04.210.500.745.745.725.703
|
| Concept/Terms |
Pregnenolone Carbonitrile- Pregnenolone Carbonitrile
- Carbonitrile, Pregnenolone
- Pregnenolone 16 alpha-Carbonitrile
- 16 alpha-Carbonitrile, Pregnenolone
- Pregnenolone 16 alpha Carbonitrile
- PCN
|
Below are MeSH descriptors whose meaning is more general than "Pregnenolone Carbonitrile".
Below are MeSH descriptors whose meaning is more specific than "Pregnenolone Carbonitrile".
This graph shows the total number of publications written about "Pregnenolone Carbonitrile" by people in this website by year, and whether "Pregnenolone Carbonitrile" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
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Below are the most recent publications written about "Pregnenolone Carbonitrile" by people in Profiles.
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Jim?nez BD, Maldonado L, Dahl RH, Quattrochi LC, Guzelian PS. Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16 alpha-carbonitrile and dexamethasone. Life Sci. 2002 Jun 07; 71(3):311-23.
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Jim?nez BD, Quattrochi LC, Yockey CB, Guzelian PS. Identification by differential display of the IF1 inhibitor peptide of ATP synthase/ATPase as a gene inducible in rat liver by pregnenolone 16alpha-carbonitrile. Life Sci. 2000 Sep 01; 67(15):1825-32.