L-Lactate Dehydrogenase

"L-Lactate Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.

Descriptor ID	D007770
MeSH Number(s)	D08.811.682.047.551.400 D08.811.682.047.820.493
Concept/Terms	L-Lactate Dehydrogenase L-Lactate Dehydrogenase Dehydrogenase, L-Lactate L Lactate Dehydrogenase Lactate Dehydrogenase Dehydrogenase, Lactate

Below are MeSH descriptors whose meaning is more general than "L-Lactate Dehydrogenase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Oxidoreductases [D08.811.682]
Alcohol Oxidoreductases [D08.811.682.047]
Lactate Dehydrogenases [D08.811.682.047.551]
L-Lactate Dehydrogenase [D08.811.682.047.551.400]
NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases [D08.811.682.047.820]
L-Lactate Dehydrogenase [D08.811.682.047.820.493]

Below are MeSH descriptors whose meaning is related to "L-Lactate Dehydrogenase".

Below are MeSH descriptors whose meaning is more specific than "L-Lactate Dehydrogenase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "L-Lactate Dehydrogenase" by people in this website by year, and whether "L-Lactate Dehydrogenase" was a major or minor topic of these publications.

Bar chart showing 37 publications over 22 distinct years, with a maximum of 3 publications in 2003 and 2007 and 2009 and 2011 and 2014 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2001	0	1	1
2002	0	1	1
2003	0	3	3
2004	1	1	2
2005	0	1	1
2006	0	1	1
2007	0	3	3
2008	1	1	2
2009	1	2	3
2010	0	1	1
2011	0	3	3
2012	0	1	1
2013	0	2	2
2014	2	1	3
2015	0	1	1
2017	1	0	1
2018	0	3	3
2019	1	0	1
2020	1	0	1
2021	1	0	1
2025	0	1	1

Below are the most recent publications written about "L-Lactate Dehydrogenase" by people in Profiles.

Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S. ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T?cells in hepatocellular carcinoma. Cell Rep Med. 2025 Apr 15; 6(4):102038.

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Mack N, Mazzio E, Badisa R, Soliman KFA. Metabolic Response to the Mitochondrial Toxin 1-Methyl-4-phenylpyridinium (MPP+) in LDH-A/B Double-knockout LS174T Colon Cancer Cells. Cancer Genomics Proteomics. 2021 May-Jun; 18(3 Suppl):385-405.

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Mazzio E, Badisa R, Mack N, Cassim S, Zdralevic M, Pouyssegur J, Soliman KFA. Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. Cancer Genomics Proteomics. 2020 Sep-Oct; 17(5):469-497.

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Turner TL, Lane S, Jayakody LN, Zhang GC, Kim H, Cho W, Jin YS. Deletion of JEN1 and ADY2 reduces lactic acid yield from an engineered Saccharomyces cerevisiae, in xylose medium, expressing a heterologous lactate dehydrogenase. FEMS Yeast Res. 2019 09 01; 19(6).

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Kumar S, Farah IO, Tchounwou PB. Trisenox induces cytotoxicity through phosphorylation of mitogen-activated protein kinase molecules in acute leukemia cells. J Biochem Mol Toxicol. 2018 Oct; 32(10):e22207.

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Keogh D, Lam LN, Doyle LE, Matysik A, Pavagadhi S, Umashankar S, Low PM, Dale JL, Song Y, Ng SP, Boothroyd CB, Dunny GM, Swarup S, Williams RBH, Marsili E, Kline KA. Extracellular Electron Transfer Powers Enterococcus faecalis Biofilm Metabolism. mBio. 2018 04 10; 9(2).

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Om?b?w?l? TO, Oyagbemi AA, Folasire AM, Ajibade TO, Asenuga ER, Adejumobi OA, Ola-Davies OE, Oyetola O, James G, Adedapo AA, Yakubu MA. Ameliorative effect of gallic acid on doxorubicin-induced cardiac dysfunction in rats. J Basic Clin Physiol Pharmacol. 2018 Jan 26; 29(1):19-27.

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Mack N, Mazzio EA, Bauer D, Flores-Rozas H, Soliman KF. Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival. Anticancer Res. 2017 03; 37(3):1205-1212.

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Kaya H, Duysak M, Akbulut M, Yilmaz S, G?rkan M, Arslan Z, Demir V, Ates M. Effects of subchronic exposure to zinc nanoparticles on tissue accumulation, serum biochemistry, and histopathological changes in tilapia (Oreochromis niloticus). Environ Toxicol. 2017 Apr; 32(4):1213-1225.

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Arora R, Schmitt D, Karanam B, Tan M, Yates C, Dean-Colomb W. Inhibition of the Warburg effect with a natural compound reveals a novel measurement for determining the metastatic potential of breast cancers. Oncotarget. 2015 Jan 20; 6(2):662-78.

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