Fanconi Anemia

"Fanconi Anemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)

Descriptor ID	D005199
MeSH Number(s)	C15.378.071.085.080.280 C15.378.190.196.080.280 C16.320.077.280 C18.452.284.280
Concept/Terms	Fanconi Anemia Fanconi Anemia Anemias, Fanconi Fanconi Anemias Fanconi's Anemia Anemia, Fanconi's Fanconi Pancytopenia Fanconi Panmyelopathy Anemia, Fanconi Fanconi Hypoplastic Anemia

Below are MeSH descriptors whose meaning is more general than "Fanconi Anemia".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Anemia [C15.378.071]
Anemia, Aplastic [C15.378.071.085]
Anemia, Hypoplastic, Congenital [C15.378.071.085.080]
Fanconi Anemia [C15.378.071.085.080.280]
Bone Marrow Diseases [C15.378.190]
Anemia, Aplastic [C15.378.190.196]
Anemia, Hypoplastic, Congenital [C15.378.190.196.080]
Fanconi Anemia [C15.378.190.196.080.280]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Anemia, Hypoplastic, Congenital [C16.320.077]
Fanconi Anemia [C16.320.077.280]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
DNA Repair-Deficiency Disorders [C18.452.284]
Fanconi Anemia [C18.452.284.280]

Below are MeSH descriptors whose meaning is related to "Fanconi Anemia".

Below are MeSH descriptors whose meaning is more specific than "Fanconi Anemia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fanconi Anemia" by people in this website by year, and whether "Fanconi Anemia" was a major or minor topic of these publications.

Bar chart showing 11 publications over 7 distinct years, with a maximum of 3 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	1	2
2011	3	0	3
2012	0	1	1
2015	1	0	1
2017	2	0	2
2018	0	1	1
2021	1	0	1

Below are the most recent publications written about "Fanconi Anemia" by people in Profiles.

Zhan S, Siu J, Wang Z, Yu H, Bezabeh T, Deng Y, Du W, Fei P. Focal Point of Fanconi Anemia Signaling. Int J Mol Sci. 2021 Nov 30; 22(23).

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Slavin TP, Neuhausen SL, Nehoray B, Niell-Swiller M, Solomon I, Rybak C, Blazer K, Adamson A, Yang K, Sand S, Guerrero-Llamas N, Castillo D, Herzog J, Wu X, Tao S, Raja S, Chung V, Singh G, Nadesan S, Brown S, Cruz-Correa M, Petersen GM, Weitzel J. The spectrum of genetic variants in hereditary pancreatic cancer includes Fanconi anemia genes. Fam Cancer. 2018 04; 17(2):235-245.

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Nepal M, Che R, Zhang J, Ma C, Fei P. Fanconi Anemia Signaling and Cancer. Trends Cancer. 2017 12; 3(12):840-856.

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Nepal M, Che R, Ma C, Zhang J, Fei P. FANCD2 and DNA Damage. Int J Mol Sci. 2017 Aug 19; 18(8).

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Shen Y, Lee YH, Panneerselvam J, Zhang J, Loo LW, Fei P. Mutated Fanconi anemia pathway in non-Fanconi anemia cancers. Oncotarget. 2015 Aug 21; 6(24):20396-403.

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Tao Y, Jin C, Li X, Qi S, Chu L, Niu L, Yao X, Teng M. The structure of the FANCM-MHF complex reveals physical features for functional assembly. Nat Commun. 2012 Apr 17; 3:782.

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Kao WH, Riker AI, Kushwaha DS, Ng K, Enkemann SA, Jove R, Buettner R, Zinn PO, S?nchez NP, Villa JL, D'Andrea AD, S?nchez JL, Kennedy RD, Chen CC, Matta JL. Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol. 2011 Oct; 131(10):2139-42.

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Lee DW, Yang JH, Won CH, Chang SE, Lee MW, Choi JH, Moon KC. A case of congenital pigmented dermatofibrosarcoma protuberans (Bednar tumor) in a patient with Fanconi anemia. Pediatr Dermatol. 2011 Sep-Oct; 28(5):583-5.

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Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM. Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J. 2011 Feb 16; 30(4):692-705.

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Gupta R, Sharma S, Sommers JA, Kenny MK, Cantor SB, Brosh RM. FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein. Blood. 2007 Oct 01; 110(7):2390-8.

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