Etoposide

"Etoposide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Descriptor ID	D005047
MeSH Number(s)	D02.455.426.559.847.638.960.675.250 D04.615.638.960.675.250 D09.408.348.275
Concept/Terms	Etoposide Etoposide Demethyl Epipodophyllotoxin Ethylidine Glucoside Eposide Etopos Etopos Etoposide, (5a alpha,9 alpha)-Isomer Etoposide, (5a alpha,9 alpha)-Isomer Etoposide, (5S)-Isomer Etoposide, (5S)-Isomer Etoposide, alpha-D-Glucopyranosyl Isomer Etoposide, alpha-D-Glucopyranosyl Isomer Etoposide, alpha D Glucopyranosyl Isomer alpha-D-Glucopyranosyl Isomer Etoposide Etoposido Ferrer Farma Etoposido Ferrer Farma Exitop Exitop Lastet Lastet NSC-141540 NSC-141540 NSC 141540 NSC141540 Onkoposid Onkoposid Riboposid Riboposid Toposar Toposar Etoposide Teva Teva, Etoposide Vepesid Vepesid VP 16-213 VP 16-213 VP 16 213 VP 16213 VP-16 VP-16 VP 16 VP16 Vépéside-Sandoz Vépéside-Sandoz Vépéside Sandoz Celltop Celltop Eposin Eposin Etomedac Eto-GRY Eto-GRY Eto GRY Etoposide Pierre Fabre Etoposide Pierre Fabre Etoposide, (5a alpha)-Isomer Etoposide, (5a alpha)-Isomer

Below are MeSH descriptors whose meaning is more general than "Etoposide".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Hydrocarbons [D02.455]
Hydrocarbons, Cyclic [D02.455.426]
Hydrocarbons, Aromatic [D02.455.426.559]
Polycyclic Aromatic Hydrocarbons [D02.455.426.559.847]
Naphthalenes [D02.455.426.559.847.638]
Tetrahydronaphthalenes [D02.455.426.559.847.638.960]
Podophyllotoxin [D02.455.426.559.847.638.960.675]
Etoposide [D02.455.426.559.847.638.960.675.250]
Polycyclic Compounds [D04]
Polycyclic Aromatic Hydrocarbons [D04.615]
Naphthalenes [D04.615.638]
Tetrahydronaphthalenes [D04.615.638.960]
Podophyllotoxin [D04.615.638.960.675]
Etoposide [D04.615.638.960.675.250]
Carbohydrates [D09]
Glycosides [D09.408]
Glucosides [D09.408.348]
Etoposide [D09.408.348.275]

Below are MeSH descriptors whose meaning is related to "Etoposide".

Below are MeSH descriptors whose meaning is more specific than "Etoposide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Etoposide" by people in this website by year, and whether "Etoposide" was a major or minor topic of these publications.

Bar chart showing 20 publications over 16 distinct years, with a maximum of 2 publications in 2005 and 2010 and 2012 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1998	0	1	1
2002	1	0	1
2004	0	1	1
2005	0	2	2
2008	0	1	1
2009	0	1	1
2010	1	1	2
2012	0	2	2
2014	0	1	1
2015	0	2	2
2016	0	1	1
2019	1	0	1
2020	0	1	1
2021	0	1	1
2024	0	1	1

Below are the most recent publications written about "Etoposide" by people in Profiles.

Grajal-Puche A, Driver EM, Propper CR. Review: Abandoned mines as a resource or liability for wildlife. Sci Total Environ. 2024 Apr 15; 921:171017.

View in: PubMed
Noubissi FK, McBride AA, Leppert HG, Millet LJ, Wang X, Davern SM. Detection and quantification of ?-H2AX using a dissociation enhanced lanthanide fluorescence immunoassay. Sci Rep. 2021 04 26; 11(1):8945.

View in: PubMed
Abe K, Dowsett L, Wada R, Hutchins K. A pediatric case of acute myeloid leukemia with KMT2A gene rearrangement t(10;11) and 16p11.2 microdeletion syndrome. Pediatr Blood Cancer. 2021 02; 68(2):e28764.

View in: PubMed
Chan Wah Hak C, Coyle C, Kocache A, Short D, Sarwar N, Seckl MJ, Gonzalez MA. Emergency Etoposide-Cisplatin (Em-EP) for patients with germ cell tumours (GCT) and trophoblastic neoplasia (TN). BMC Cancer. 2019 Aug 05; 19(1):770.

View in: PubMed
Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers. Mol Pharm. 2017 01 03; 14(1):252-263.

View in: PubMed
Saulnier Sholler GL, Gerner EW, Bergendahl G, MacArthur RB, VanderWerff A, Ashikaga T, Bond JP, Ferguson W, Roberts W, Wada RK, Eslin D, Kraveka JM, Kaplan J, Mitchell D, Parikh NS, Neville K, Sender L, Higgins T, Kawakita M, Hiramatsu K, Moriya SS, Bachmann AS. A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma. PLoS One. 2015; 10(5):e0127246.

View in: PubMed
Elhag R, Mazzio EA, Soliman KF. The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines. Anticancer Res. 2015 Mar; 35(3):1263-9.

View in: PubMed
Goldman S, Smith L, Galardy P, Perkins SL, Frazer JK, Sanger W, Anderson JR, Gross TG, Weinstein H, Harrison L, Shiramizu B, Barth M, Cairo MS. Rituximab with chemotherapy in children and adolescents with central nervous system and/or bone marrow-positive Burkitt lymphoma/leukaemia: a Children's Oncology Group Report. Br J Haematol. 2014 Nov; 167(3):394-401.

View in: PubMed
Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Smulson ME, Brim H, Boulares AH. Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem. 2013 Feb 01; 288(5):3460-8.

View in: PubMed
Velma V, Carrero ZI, Allen CB, Hebert MD. Coilin levels modulate cell cycle progression and ?H2AX levels in etoposide treated U2OS cells. FEBS Lett. 2012 Sep 21; 586(19):3404-9.

View in: PubMed

People

Explore

Similar Concepts

Top Journals