"Anesthetics, Local" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
| Descriptor ID |
D000779
|
| MeSH Number(s) |
D27.505.696.277.100.200 D27.505.696.663.850.025 D27.505.954.427.210.100.200
|
| Concept/Terms |
Anesthetics, Local- Anesthetics, Local
- Local Anesthetics
- Conduction-Blocking Anesthetics
- Conduction Blocking Anesthetics
- Anesthetics, Conduction-Blocking
- Anesthetics, Conduction Blocking
|
Below are MeSH descriptors whose meaning is more general than "Anesthetics, Local".
Below are MeSH descriptors whose meaning is more specific than "Anesthetics, Local".
This graph shows the total number of publications written about "Anesthetics, Local" by people in this website by year, and whether "Anesthetics, Local" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 2 | 1 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 1 | 3 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Anesthetics, Local" by people in Profiles.
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Maher DP, Serna-Gallegos D, Mardirosian R, Thomas OJ, Zhang X, McKenna R, Yumul R, Zhang V. The Combination of IV and Perineural Dexamethasone Prolongs the Analgesic Duration of Intercostal Nerve Blocks Compared with IV Dexamethasone Alone. Pain Med. 2017 06 01; 18(6):1152-1160.
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Cao X, Elvir-Lazo OL, White PF, Yumul R, Tang J. An update on pain management for elderly patients undergoing ambulatory surgery. Curr Opin Anaesthesiol. 2016 Dec; 29(6):674-682.
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Ochoa N, Gogola GR, Gorniak SL. Contribution of tactile dysfunction to manual motor dysfunction in type II diabetes. Muscle Nerve. 2016 11; 54(5):895-902.
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Leng TD, Lin J, Sun HW, Zeng Z, O'Bryant Z, Inoue K, Xiong ZG. Local anesthetic lidocaine inhibits TRPM7 current and TRPM7-mediated zinc toxicity. CNS Neurosci Ther. 2015 Jan; 21(1):32-9.
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von Arx T, Lozanoff S, Zinkernagel M. Ophthalmologic complications after intraoral local anesthesia. Swiss Dent J. 2014; 124(7-8):784-806.
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Turabekova MA, Rasulev BF, Dzhakhangirov FN, Toropov AA, Leszczynska D, Leszczynski J. Aconitum and delphinium diterpenoid alkaloids of local anesthetic activity: comparative QSAR analysis based on GA-MLRA/PLS and optimal descriptors approach. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014; 32(3):213-38.
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Leng T, Lin J, Cottrell JE, Xiong ZG. Subunit and frequency-dependent inhibition of acid sensing ion channels by local anesthetic tetracaine. Mol Pain. 2013 Jun 10; 9:27.
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Kaneshiro B, Grimes DA, Lopez LM. Pain management for tubal sterilization by hysteroscopy. Cochrane Database Syst Rev. 2012 Aug 15; (8):CD009251.
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Gou M, Wu L, Yin Q, Guo Q, Guo G, Liu J, Zhao X, Wei Y, Qian Z. Transdermal anaesthesia with lidocaine nano-formulation pretreated with low-frequency ultrasound in rats model. J Nanosci Nanotechnol. 2009 Nov; 9(11):6360-5.
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Gong C, Shi S, Wu L, Gou M, Yin Q, Guo Q, Dong P, Zhang F, Luo F, Zhao X, Wei Y, Qian Z. Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: sol-gel-sol transition and drug delivery behavior. Acta Biomater. 2009 Nov; 5(9):3358-70.