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Benjamin Fogelgren, PhD

Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentCell & Molecular Biology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI
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    Collapse Research 
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    K01DK087852     (FOGELGREN, BENJAMIN C.)Jul 1, 2010 - Aug 31, 2011
    The exocyst in kidney development and cyst formation
    Role: Principal Investigator

    R03DK100738     (FOGELGREN, BENJAMIN C.)Feb 1, 2014 - Jan 31, 2016
    A novel genetic model for congenital obstructive nephropathy
    Role: Principal Investigator

    R01DK117308     (FOGELGREN, BENJAMIN C.)Sep 15, 2018 - Jul 31, 2021
    The exocyst in ureter development and congenital obstructions
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zuo X, Kwon SH, Janech MG, Dang Y, Lauzon SD, Fogelgren B, Polgar N, Lipschutz JH. Primary cilia and the exocyst are linked to urinary extracellular vesicle production and content. J Biol Chem. 2019 12 13; 294(50):19099-19110. PMID: 31694916.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Fujimoto BA, Young M, Carter L, Pang APS, Corley MJ, Fogelgren B, Polgar N. The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells. Am J Physiol Endocrinol Metab. 2019 12 01; 317(6):E957-E972. PMID: 31593505.
      Citations:    Fields:    Translation:AnimalsCells
    3. Fulmer D, Toomer K, Guo L, Moore K, Glover J, Moore R, Stairley R, Lobo G, Zuo X, Dang Y, Su Y, Fogelgren B, Gerard P, Chung D, Heydarpour M, Mukherjee R, Body SC, Norris RA, Lipschutz JH. Defects in the Exocyst-Cilia Machinery Cause Bicuspid Aortic Valve Disease and Aortic Stenosis. Circulation. 2019 10 15; 140(16):1331-1341. PMID: 31387361.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    4. Nihalani D, Solanki AK, Arif E, Srivastava P, Rahman B, Zuo X, Dang Y, Fogelgren B, Fermin D, Gillies CE, Sampson MG, Lipschutz JH. Disruption of the exocyst induces podocyte loss and dysfunction. J Biol Chem. 2019 06 28; 294(26):10104-10119. PMID: 31073028.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Lee B, Baek JI, Min H, Bae SH, Moon K, Kim MA, Kim YR, Fogelgren B, Lipschutz JH, Lee KY, Bok J, Kim UK. Correction to: Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Mol Neurobiol. 2019 Mar; 56(3):2300. PMID: 30637586.
      Citations:    Fields:    
    6. Polgar N, Fogelgren B. Regulation of Cell Polarity by Exocyst-Mediated Trafficking. Cold Spring Harb Perspect Biol. 2018 03 01; 10(3). PMID: 28264817.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    7. O'Brien LL, Guo Q, Bahrami-Samani E, Park JS, Hasso SM, Lee YJ, Fang A, Kim AD, Guo J, Hong TM, Peterson KA, Lozanoff S, Raviram R, Ren B, Fogelgren B, Smith AD, Valouev A, McMahon AP. Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet. 2018 01; 14(1):e1007181. PMID: 29377931.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Lee B, Baek JI, Min H, Bae SH, Moon K, Kim MA, Kim YR, Fogelgren B, Lipschutz JH, Lee KY, Bok J, Kim UK. Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing. Mol Neurobiol. 2018 Aug; 55(8):6518-6532. PMID: 29327200.
      Citations: 2     Fields:    Translation:AnimalsCells
    9. Lobo GP, Fulmer D, Guo L, Zuo X, Dang Y, Kim SH, Su Y, George K, Obert E, Fogelgren B, Nihalani D, Norris RA, Rohrer B, Lipschutz JH. The exocyst is required for photoreceptor ciliogenesis and retinal development. J Biol Chem. 2017 09 08; 292(36):14814-14826. PMID: 28729419.
      Citations: 16     Fields:    Translation:AnimalsCells
    10. Lee AJ, Polgar N, Napoli JA, Lui VH, Tamashiro KK, Fujimoto BA, Thompson KS, Fogelgren B. Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Sci Rep. 2016 08 11; 6:31137. PMID: 27511831.
      Citations:    Fields:    Translation:Animals
    11. Ching T, Peplowska K, Huang S, Zhu X, Shen Y, Molnar J, Yu H, Tiirikainen M, Fogelgren B, Fan R, Garmire LX. Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis. EBioMedicine. 2016 May; 7:62-72. PMID: 27322459.
      Citations: 13     Fields:    Translation:HumansCells
    12. Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 05 01; 9(5):585-96. PMID: 26989192.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Seixas C, Choi SY, Polgar N, Umberger NL, East MP, Zuo X, Moreiras H, Ghossoub R, Benmerah A, Kahn RA, Fogelgren B, Caspary T, Lipschutz JH, Barral DC. Arl13b and the exocyst interact synergistically in ciliogenesis. Mol Biol Cell. 2016 Jan 15; 27(2):308-20. PMID: 26582389.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    14. Fogelgren B, Polgar N, Lui VH, Lee AJ, Tamashiro KK, Napoli JA, Walton CB, Zuo X, Lipschutz JH. Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions. PLoS One. 2015; 10(6):e0129346. PMID: 26046524.
      Citations: 17     Fields:    Translation:HumansAnimals
    15. Polgar N, Lee AJ, Lui VH, Napoli JA, Fogelgren B. The exocyst gene Sec10 regulates renal epithelial monolayer homeostasis and apoptotic sensitivity. . 2015 Aug 01; 309(3):C190-201. PMID: 26040895.
    16. Fogelgren B, Zuo X, Buonato JM, Vasilyev A, Baek JI, Choi SY, Chacon-Heszele MF, Palmyre A, Polgar N, Drummond I, Park KM, Lazzara MJ, Lipschutz JH. Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1334-41. PMID: 25298525.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Choi SY, Fogelgren B, Zuo X, Huang L, McKenna S, Lingappa VR, Lipschutz JH. Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum. Nephron Exp Nephrol. 2012; 120(4):e134-40. PMID: 23037926.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    18. Chung DC, Fogelgren B, Park KM, Heidenberg J, Zuo X, Huang L, Bennett J, Lipschutz JH. Adeno-Associated Virus-Mediated Gene Transfer to Renal Tubule Cells via a Retrograde Ureteral Approach. Nephron Extra. 2011 Jan; 1(1):217-23. PMID: 22470395.
    19. Somponpun SJ, Wong B, Hynd TE, Fogelgren B, Lozanoff S. Osmoregulatory defect in adult mice associated with deficient prenatal expression of six2. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R682-9. PMID: 21653879.
      Citations: 1     Fields:    Translation:Animals
    20. Zuo X, Fogelgren B, Lipschutz JH. The small GTPase Cdc42 is necessary for primary ciliogenesis in renal tubular epithelial cells. J Biol Chem. 2011 Jun 24; 286(25):22469-77. PMID: 21543338.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    21. Fogelgren B, Lin SY, Zuo X, Jaffe KM, Park KM, Reichert RJ, Bell PD, Burdine RD, Lipschutz JH. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. PLoS Genet. 2011 Apr; 7(4):e1001361. PMID: 21490950.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    22. Park KM, Fogelgren B, Zuo X, Kim J, Chung DC, Lipschutz JH. Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F818-26. PMID: 20053792.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Fogelgren B, Yang S, Sharp IC, Huckstep OJ, Ma W, Somponpun SJ, Carlson EC, Uyehara CF, Lozanoff S. Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice. Am J Physiol Renal Physiol. 2009 May; 296(5):F1166-78. PMID: 19193724.
      Citations: 16     Fields:    Translation:AnimalsCells
    24. Fogelgren B, Kuroyama MC, McBratney-Owen B, Spence AA, Malahn LE, Anawati MK, Cabatbat C, Alarcon VB, Marikawa Y, Lozanoff S. Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice. Dev Dyn. 2008 Jul; 237(7):1767-79. PMID: 18570229.
      Citations: 20     Fields:    Translation:AnimalsCells
    25. Cao T, Racz P, Szauter KM, Groma G, Nakamatsu GY, Fogelgren B, Pankotai E, He QP, Csiszar K. Mutation in Mpzl3, a novel [corrected] gene encoding a predicted [corrected] adhesion protein, in the rough coat (rc) mice with severe skin and hair abnormalities. J Invest Dermatol. 2007 Jun; 127(6):1375-86. PMID: 17273165.
      Citations: 8     Fields:    Translation:AnimalsCells
    26. Polgar N, Fogelgren B, Shipley JM, Csiszar K. Lysyl oxidase interacts with hormone placental lactogen and synergistically promotes breast epithelial cell proliferation and migration. J Biol Chem. 2007 Feb 02; 282(5):3262-72. PMID: 17130123.
      Citations: 9     Fields:    Translation:HumansCells
    27. Payne SL, Fogelgren B, Hess AR, Seftor EA, Wiley EL, Fong SF, Csiszar K, Hendrix MJ, Kirschmann DA. Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Cancer Res. 2005 Dec 15; 65(24):11429-36. PMID: 16357151.
      Citations: 93     Fields:    Translation:HumansCells
    28. Fogelgren B, Polgár N, Szauter KM, Ujfaludi Z, Laczkó R, Fong KS, Csiszar K. Cellular fibronectin binds to lysyl oxidase with high affinity and is critical for its proteolytic activation. J Biol Chem. 2005 Jul 01; 280(26):24690-7. PMID: 15843371.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    29. Molnar J, Ujfaludi Z, Fong SF, Bollinger JA, Waro G, Fogelgren B, Dooley DM, Mink M, Csiszar K. Drosophila lysyl oxidases Dmloxl-1 and Dmloxl-2 are differentially expressed and the active DmLOXL-1 influences gene expression and development. J Biol Chem. 2005 Jun 17; 280(24):22977-85. PMID: 15811848.
      Citations: 6     Fields:    Translation:AnimalsCells
    30. Hayashi K, Cao T, Passmore H, Jourdan-Le Saux C, Fogelgren B, Khan S, Hornstra I, Kim Y, Hayashi M, Csiszar K. Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. J Invest Dermatol. 2004 Nov; 123(5):864-71. PMID: 15482472.
      Citations: 5     Fields:    Translation:Animals
    31. Molnar J, Fong KS, He QP, Hayashi K, Kim Y, Fong SF, Fogelgren B, Szauter KM, Mink M, Csiszar K. Structural and functional diversity of lysyl oxidase and the LOX-like proteins. Biochim Biophys Acta. 2003 Apr 11; 1647(1-2):220-4. PMID: 12686136.
      Citations: 70     Fields:    Translation:Animals
    32. Asuncion L, Fogelgren B, Fong KS, Fong SF, Kim Y, Csiszar K. A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. Matrix Biol. 2001 Nov; 20(7):487-91. PMID: 11691588.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    33. Mink M, Fogelgren B, Olszewski K, Maroy P, Csiszar K. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans. Genomics. 2001 Jun 01; 74(2):234-44. PMID: 11386760.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    34. Biegel JA, Fogelgren B, Zhou JY, James CD, Janss AJ, Allen JC, Zagzag D, Raffel C, Rorke LB. Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system. Clin Cancer Res. 2000 Jul; 6(7):2759-63. PMID: 10914721.
      Citations: 31     Fields:    Translation:HumansCells
    35. Biegel JA, Fogelgren B, Wainwright LM, Zhou JY, Bevan H, Rorke LB. Germline INI1 mutation in a patient with a central nervous system atypical teratoid tumor and renal rhabdoid tumor. Genes Chromosomes Cancer. 2000 May; 28(1):31-7. PMID: 10738300.
      Citations: 26     Fields:    Translation:Humans
    36. Zhou J, Fogelgren B, Wang Z, Roe BA, Biegel JA. Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. Gene. 2000 Jan 04; 241(1):133-41. PMID: 10607907.
      Citations: 2     Fields:    Translation:HumansCells
    37. Biegel JA, Zhou JY, Rorke LB, Stenstrom C, Wainwright LM, Fogelgren B. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res. 1999 Jan 01; 59(1):74-9. PMID: 9892189.
      Citations: 230     Fields:    Translation:Humans
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