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Roy Sourav

Faculty RankAssistant Professor
InstitutionUniversity of Texas at El Paso
DepartmentBiological Sciences
2.172 Bioscience Research Building
El Paso TX 79968
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    Collapse Biography 
    Collapse education and training
    University of California Riverside, CaliforniaPhD09/2011Genetics, Genomics, Bioinformatics
    Indiana University Bloomington, IndianaMS05/2006Bioinformatics

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    Dr. Roy is a computational biologist with a research background in genetics, genomics, bioinformatics, and molecular biology. His research has involved the utilization of diverse in-silico, in-vitro, and in-vivo methodologies to understand the regulation of gene expression. Dr. Roy received his doctoral degree in Genetics, Genomics, and Bioinformatics from the University of California, Riverside (UCR). He joined the Department of Entomology at UCR after his Ph.D. and worked as a Post-doctoral scholar and Assistant Professional Researcher for seven years. His current research projects include regulatory genomic studies of vector mosquitoes; evolutionary and comparative genomic studies of molecular pathways in insect vectors; the role of miRNAs in various organisms; and investigation of oxidative stress-induced cellular survival pathways in colorectal cancer health disparities, all of which involve analysis and validation of high throughput and next-generation sequencing data using bioinformatics tools and molecular techniques. Dr. Roy has multiple active collaborations with researchers in the USA and abroad on projects related to vector biology, insect physiology, virology, cancer, and diabetes. He has co-authored research and review articles in journals like Nature, PNAS, Annual Reviews of Entomology, PLoS Pathogens, PLoS Genetics, BMC Genomics, etc. His research contributions have resulted in two RO1 grants from NIH and a $5.8 M CPRIT-TREC award.
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    R01AI036959     (RAIKHEL, ALEXANDER SIMEON ;ROY, SOURAV)Jul 1, 1995 - Apr 30, 2024
    Molecular Basis of Ecdysteroid Action in the Mosquito
    Role: Principal Investigator

    RP210153     (Marc Cox)Aug 31, 2021 - Aug 31, 2026
    UTEP/UTMDACC Partnership for Hispanic Cancer Disparities Research
    Role: Co-PI

    63-312-0218952-67470L     (Michael Schatz; Sourav Roy; Rajiv McCoy)Sep 20, 2023 - Sep 19, 2025
    AnVIL/SB-CGC interoperability project to study the genetic and transcriptomic contributions towards Hispanic colorectal cancer health disparities
    Role: Co-PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kulkarni A, Delgadillo FM, Gayathrinathan S, Grajeda BI, Roy S. Current Status of Omics Studies Elucidating the Features of Reproductive Biology in Blood-Feeding Insects. Insects. 2023 10 06; 14(10). PMID: 37887814.
    2. Soto OB, Ramirez CS, Koyani R, Rodriguez-Palomares IA, Dirmeyer JR, Grajeda B, Roy S, Cox MB. Structure and function of the TPR-domain immunophilins FKBP51 and FKBP52 in normal physiology and disease. J Cell Biochem. 2023 Apr 23. PMID: 37087733.
      Citations:    Fields:    
    3. Silva Grij? Farani P, Iandra da Silva Ferreira B, Begum K, Vilar-Pereira G, Pereira IR, Fern?ndez-Figueroa EA, Cardenas-Ovando RA, Almeida IC, Roy S, Lannes-Vieira J, Moreira OC. Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy. PLoS Negl Trop Dis. 2023 03; 17(3):e0011223. PMID: 36972298.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Acu?a ML, Garc?a-Morin A, Orozco-Sep?lveda R, Ontiveros C, Flores A, Diaz AV, Guti?rrez-Zubiate I, Patil AR, Alvarado LA, Roy S, Russell WK, Rosas-Acosta G. Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms. Sci Rep. 2023 02 09; 13(1):2309. PMID: 36759644.
      Citations: 1     Fields:    Translation:HumansCells
    5. Grajeda BI, De Chatterjee A, Villalobos CM, Pence BC, Ellis CC, Enriquez V, Roy S, Roychowdhury S, Neumann AK, Almeida IC, Patterson SE, Das S. Giardial lipid rafts share virulence factors with secreted vesicles and participate in parasitic infection in mice. Front Cell Infect Microbiol. 2022; 12:974200. PMID: 36081774.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Kulkarni A, Gayathrinathan S, Nair S, Basu A, Al-Hilal TA, Roy S. Regulatory Roles of Noncoding RNAs in the Progression of Gastrointestinal Cancers and Health Disparities. Cells. 2022 08 07; 11(15). PMID: 35954293.
      Citations:    Fields:    Translation:Humans
    7. Diversifying the genomic data science research community. Genome Res. 2022 Jul 20; 32(7):1231-41. PMID: 35858750.
    8. Roy S, Saha TT, Ha J, Banerjee R, Aksoy E, Kulkarni A, Raikhel AS. Direct and indirect gene repression by the ecdysone cascade during mosquito reproductive cycle. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2116787119. PMID: 35254892.
      Citations: 3     Fields:    Translation:CellsPHPublic Health
    9. Zhang X, Karim M, Hasan MM, Hooper J, Wahab R, Roy S, Al-Hilal TA. Cancer-on-a-Chip: Models for Studying Metastasis. Cancers (Basel). 2022 Jan 27; 14(3). PMID: 35158914.
    10. Gutierrez DA, Contreras L, Villanueva PJ, Borrego EA, Mor?n-Santiba?ez K, Hess JD, DeJesus R, Larragoity M, Betancourt AP, Mohl JE, Robles-Escajeda E, Begum K, Roy S, Kirken RA, Varela-Ramirez A, Aguilera RJ. Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways. Cells. 2022 01 12; 11(2). PMID: 35053370.
      Citations: 5     Fields:    Translation:HumansCells
    11. Meza CA, Amador M, McAinch AJ, Begum K, Roy S, Bajpeyi S. Eight weeks of combined exercise training do not alter circulating microRNAs-29a, -133a, -133b, and -155 in young, healthy men. Eur J Appl Physiol. 2022 Apr; 122(4):921-933. PMID: 35015112.
      Citations:    Fields:    Translation:Humans
    12. Ortiz-Hernandez GL, Sanchez-Hernandez ES, Ochoa PT, Elix CC, Alkashgari HR, McMullen JRW, Soto U, Martinez SR, Diaz Osterman CJ, Mahler M, Roy S, Casiano CA. The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells. Cells. 2021 10 12; 10(10). PMID: 34685704.
      Citations: 7     Fields:    Translation:HumansCells
    13. Rood K, Begum K, Wang H, Wangworawat YC, Davis R, Yamauchi CR, Perez MC, Simental AA, Laxa RT, Wang C, Roy S, Khan S. Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups. Curr Oncol. 2021 09 19; 28(5):3610-3628. PMID: 34590612.
      Citations: 2     Fields:    Translation:Humans
    14. Farani PSG, Begum K, Vilar-Pereira G, Pereira IR, Almeida IC, Roy S, Lannes-Vieira J, Moreira OC. Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy. Front Cell Infect Microbiol. 2021; 11:692655. PMID: 34381739.
      Citations: 6     Fields:    Translation:Animals
    15. Patil AR, Leung MY, Roy S. Identification of Hub Genes in Different Stages of Colorectal Cancer through an Integrated Bioinformatics Approach. Int J Environ Res Public Health. 2021 05 23; 18(11). PMID: 34070979.
      Citations: 2     Fields:    Translation:Humans
    16. Basnet U, Patil AR, Kulkarni A, Roy S. Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective. Int J Environ Res Public Health. 2021 05 21; 18(11). PMID: 34063993.
      Citations:    Fields:    Translation:HumansCells
    17. Saha TT, Roy S, Pei G, Dou W, Zou Z, Raikhel AS. Synergistic action of the transcription factors Krüppel homolog 1 and Hairy in juvenile hormone/Methoprene-tolerant-mediated gene-repression in the mosquito Aedes aegypti. PLoS Genet. 2019 Oct; 15(10):e1008443. PMID: 31661489.
    18. Matthews BJ, Dudchenko O, Kingan SB, Koren S, Antoshechkin I, Crawford JE, Glassford WJ, Herre M, Redmond SN, Rose NH, Weedall GD, Wu Y, Batra SS, Brito-Sierra CA, Buckingham SD, Campbell CL, Chan S, Cox E, Evans BR, Fansiri T, Filipovic I, Fontaine A, Gloria-Soria A, Hall R, Joardar VS, Jones AK, Kay RGG, Kodali VK, Lee J, Lycett GJ, Mitchell SN, Muehling J, Murphy MR, Omer AD, Partridge FA, Peluso P, Aiden AP, Ramasamy V, Rašic G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith ML, Turner J, Weakley AM, Zhao Z, Akbari OS, Black WC, Cao H, Darby AC, Hill CA, Johnston JS, Murphy TD, Raikhel AS, Sattelle DB, Sharakhov IV, White BJ, Zhao L, Aiden EL, Mann RS, Lambrechts L, Powell JR, Sharakhova MV, Tu Z, Robertson HM, McBride CS, Hastie AR, Korlach J, Neafsey DE, Phillippy AM, Vosshall LB. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 2018 Nov; 563(7732):501-507. PMID: 30429615.
    19. Woods-Burnham L, Cajigas-Du Ross CK, Love A, Basu A, Sanchez-Hernandez ES, Martinez SR, Ortiz-Hern?ndez GL, Stiel L, Dur?n AM, Wilson C, Montgomery S, Roy S, Casiano CA. Glucocorticoids Induce Stress Oncoproteins Associated with Therapy-Resistance in African American and European American Prostate Cancer Cells. Sci Rep. 2018 10 10; 8(1):15063. PMID: 30305646.
      Citations: 11     Fields:    Translation:HumansCells
    20. Cajigas-Du Ross CK, Martinez SR, Woods-Burnham L, Dur?n AM, Roy S, Basu A, Ramirez JA, Ortiz-Hern?ndez GL, R?os-Col?n L, Chirshev E, Sanchez-Hernandez ES, Soto U, Greco C, Boucheix C, Chen X, Unternaehrer J, Wang C, Casiano CA. RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance. Oncotarget. 2018 Jul 13; 9(54):30363-30384. PMID: 30100995.
      Citations: 12     Fields:    
    21. Roy S, Saha TT, Zou Z, Raikhel AS. Regulatory Pathways Controlling Female Insect Reproduction. Annu Rev Entomol. 2018 Jan 07; 63:489-511. PMID: 29058980.
    22. Woods-Burnham L, Basu A, Cajigas-Du Ross CK, Love A, Yates C, De Leon M, Roy S, Casiano CA. The 22Rv1 prostate cancer cell line carries mixed genetic ancestry: Implications for prostate cancer health disparities research using pre-clinical models. Prostate. 2017 Dec; 77(16):1601-1608. PMID: 29030865.
      Citations: 11     Fields:    Translation:HumansCells
    23. Zhao B, Lucas KJ, Saha TT, Ha J, Ling L, Kokoza VA, Roy S, Raikhel AS. MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut. PLoS Genet. 2017 Aug; 13(8):e1006943. PMID: 28787446.
    24. Zhang Y, Zhao B, Roy S, Saha TT, Kokoza VA, Li M, Raikhel AS. microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2016 Aug 16; 113(33):E4828-36. PMID: 27489347.
    25. Saha TT, Shin SW, Dou W, Roy S, Zhao B, Hou Y, Wang XL, Zou Z, Girke T, Raikhel AS. Hairy and Groucho mediate the action of juvenile hormone receptor Methoprene-tolerant in gene repression. Proc Natl Acad Sci U S A. 2016 Feb 09; 113(6):E735-43. PMID: 26744312.
    26. Saha SK, Roy S, Khuda-Bukhsh AR. Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro. J Integr Med. 2015 Nov; 13(6):400-11. PMID: 26559365.
    27. Roy S, Saha TT, Johnson L, Zhao B, Ha J, White KP, Girke T, Zou Z, Raikhel AS. Regulation of Gene Expression Patterns in Mosquito Reproduction. PLoS Genet. 2015 Aug; 11(8):e1005450. PMID: 26274815.
    28. Hou Y, Wang XL, Saha TT, Roy S, Zhao B, Raikhel AS, Zou Z. Temporal Coordination of Carbohydrate Metabolism during Mosquito Reproduction. PLoS Genet. 2015 Jul; 11(7):e1005309. PMID: 26158648.
    29. Lucas KJ, Roy S, Ha J, Gervaise AL, Kokoza VA, Raikhel AS. MicroRNA-8 targets the Wingless signaling pathway in the female mosquito fat body to regulate reproductive processes. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1440-5. PMID: 25605933.
    30. Lucas KJ, Zhao B, Roy S, Gervaise AL, Raikhel AS. Mosquito-specific microRNA-1890 targets the juvenile hormone-regulated serine protease JHA15 in the female mosquito gut. RNA Biol. 2015; 12(12):1383-90. PMID: 26488481.
    31. Liu S, Lucas KJ, Roy S, Ha J, Raikhel AS. Mosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14460-5. PMID: 25246546.
    32. Zhao B, Kokoza VA, Saha TT, Wang S, Roy S, Raikhel AS. Regulation of the gut-specific carboxypeptidase: a study using the binary Gal4/UAS system in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 2014 Nov; 54:1-10. PMID: 25152428.
    33. Zou Z, Saha TT, Roy S, Shin SW, Backman TW, Girke T, White KP, Raikhel AS. Juvenile hormone and its receptor, methoprene-tolerant, control the dynamics of mosquito gene expression. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2173-81. PMID: 23633570.
    34. Roy S, Kagda M, Judelson HS. Genome-wide prediction and functional validation of promoter motifs regulating gene expression in spore and infection stages of Phytophthora infestans. PLoS Pathog. 2013 Mar; 9(3):e1003182. PMID: 23516354.
      Citations: 17     Fields:    Translation:AnimalsCells
    35. Roy S, Poidevin L, Jiang T, Judelson HS. Novel core promoter elements in the oomycete pathogen Phytophthora infestans and their influence on expression detected by genome-wide analysis. BMC Genomics. 2013 Feb 16; 14:106. PMID: 23414203.
    36. Basu A, Banerjee H, Rojas H, Martinez SR, Roy S, Jia Z, Lilly MB, De Le?n M, Casiano CA. Differential expression of peroxiredoxins in prostate cancer: consistent upregulation of PRDX3 and PRDX4. Prostate. 2011 May 15; 71(7):755-65. PMID: 21031435.
      Citations: 47     Fields:    Translation:HumansCells
    37. Haas BJ, Kamoun S, Zody MC, Jiang RH, Handsaker RE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T, Bozkurt TO, Ah-Fong AM, Alvarado L, Anderson VL, Armstrong MR, Avrova A, Baxter L, Beynon J, Boevink PC, Bollmann SR, Bos JI, Bulone V, Cai G, Cakir C, Carrington JC, Chawner M, Conti L, Costanzo S, Ewan R, Fahlgren N, Fischbach MA, Fugelstad J, Gilroy EM, Gnerre S, Green PJ, Grenville-Briggs LJ, Griffith J, Grünwald NJ, Horn K, Horner NR, Hu CH, Huitema E, Jeong DH, Jones AM, Jones JD, Jones RW, Karlsson EK, Kunjeti SG, Lamour K, Liu Z, Ma L, Maclean D, Chibucos MC, McDonald H, McWalters J, Meijer HJ, Morgan W, Morris PF, Munro CA, O'Neill K, Ospina-Giraldo M, Pinzón A, Pritchard L, Ramsahoye B, Ren Q, Restrepo S, Roy S, Sadanandom A, Savidor A, Schornack S, Schwartz DC, Schumann UD, Schwessinger B, Seyer L, Sharpe T, Silvar C, Song J, Studholme DJ, Sykes S, Thines M, van de Vondervoort PJ, Phuntumart V, Wawra S, Weide R, Win J, Young C, Zhou S, Fry W, Meyers BC, van West P, Ristaino J, Govers F, Birch PR, Whisson SC, Judelson HS, Nusbaum C. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature. 2009 Sep 17; 461(7262):393-8. PMID: 19741609.
    38. Xiang Q, Kim KS, Roy S, Judelson HS. A motif within a complex promoter from the oomycete Phytophthora infestans determines transcription during an intermediate stage of sporulation. Fungal Genet Biol. 2009 May; 46(5):400-9. PMID: 19250972.
    39. Schnell S, Fortunato S, Roy S. Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks? Proteomics. 2007 Mar; 7(6):961-4. PMID: 17285562.
    40. Roy S, Schnell S, Radivojac P. Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map. Comput Biol Chem. 2006 Aug; 30(4):241-8. PMID: 16798096.
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