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James Taylor

Faculty RankProfessor
InstitutionHoward University
DepartmentInternal Medicine
AddressHoward University College of Medicine
Washington DC 20059
ORCID ORCID Icon0000-0002-4421-1809 Additional info
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    Collapse Biography 
    Collapse education and training
    Creighton University, Omaha, NEBS05/1991 biology
    Medical College of Wisconsin, Milwaukee, WIMD05/1995 medicine
    Washington University, St. Louis, MDN/A06/1998general pediatrics residency
    NCI/Johns Hopkins Program, Bethesda/Baltimore, MDN/A06/2001pediatric hematology/oncology fellowship
    National Cancer Institute, NIH, Bethesda, MDN/A06/2004post-doc in genetics
    NHLBI, NIH, Bethesda, MDN/A10/2004post-doc in vascular medicine
    Collapse awards and honors
    1991Achiever Award, Nebraska Trio Programs
    1991Magna Cum Laude, Creighton University
    1995Research Award, Medical College of Wisconsin
    1995Honors in Research, Medical College of Wisconsin
    1998 - 2005Loan Repayment Program (LRP), National Institutes of Health
    2014Scientific Research and Service Award, Queens Sickle Cell Advocacy Network
    2014Citation of Achievement, City Council, City of New York, NY
    2014Citation, Office of the President, Borough of Brooklyn, NY
    2019Humanitarian Award, Sickle Cell Disease Association of America; Queens, NY chapter
    2019Citation, New York State Assembly, Albany, NY

    Collapse Overview 

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kumari N, Nouraie M, Ahmad A, Lassiter H, Khan J, Diaz S, Afangbedji N, Wang S, Houston PE, Ammosova T, de Mulder Rougvie M, Rana S, Nixon DF, Anastos K, Lazar J, French AL, Gange S, Adimora AA, Weitzmann MN, Fischl M, Kempf MC, Kassaye S, Taylor JG, Nekhai S. Restriction of HIV-1 infection in sickle cell trait. Blood Adv. 2021 Dec 14; 5(23):4922-4934. PMID: 34496009.
      Citations: 1     Fields:    Translation:HumansCells
    2. Nekhai S, Lin X, Soni S, Taye A, Smith N, Afangbedji N, Saraf SL, Gordeuk VR, Taylor JG, Jerebtsova M. Urinary Kringle Domain-Containing Protein HGFL: A Validated Biomarker of Early Sickle Cell Anemia-Associated Kidney Disease. Am J Nephrol. 2021; 52(7):582-587. PMID: 34375971.
      Citations:    Fields:    Translation:HumansCells
    3. Niu X, Parry CS, Mason A, Harrison B, Nouraie SM, Ammosova T, Salomon-Andonie J, Oneal PA, Gordeuk VR, Taylor JG, Nekhai S. Prevalence of Sickle Cell Trait and Rare Hemoglobin Variants in the Metropolitan Washington DC Area. J Hematol. 2020 Sep; 9(3):93-95. PMID: 32855759.
    4. Zhang X, Kershaw KN, Minniti CP, Campbell A, Rana SR, Darbari DS, Luchtman-Jones L, Sable C, Dham N, Ensing G, Arteta M, Taylor JG, Hsu LL, Nekhai S, Gordeuk VR. Influence of single parenthood on cardiopulmonary function in pediatric patients with sickle cell anemia. Blood Adv. 2020 07 28; 4(14):3311-3314. PMID: 32706890.
      Citations:    Fields:    Translation:Humans
    5. Jerebtsova M, Taye A, Smith N, Afangbedji N, Stokes D, Niu X, Diaz S, Taylor JG, Nekhai S. Association between plasma and urinary orosomucoid and chronic kidney disease in adults with sickle cell disease. Br J Haematol. 2020 07; 190(1):e45-e48. PMID: 32372411.
      Citations: 3     Fields:    Translation:Humans
    6. Nouraie M, Darbari DS, Rana S, Minniti CP, Castro OL, Luchtman-Jones L, Sable C, Dham N, Kato GJ, Gladwin MT, Ensing G, Arteta M, Campbell A, Taylor JG, Nekhai S, Gordeuk VR. Tricuspid regurgitation velocity and other biomarkers of mortality in children, adolescents and young adults with sickle cell disease in the United States: The PUSH study. Am J Hematol. 2020 07; 95(7):766-774. PMID: 32243618.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    7. Dokekias AE, Ngolet L, Salomon-Andonie J, Nekhai S, Taylor JG. Establishing a national sickle cell disease program in the Republic of Congo. Blood Adv. 2018 11 30; 2(Suppl 1):17-18. PMID: 30504190.
      Citations: 1     Fields:    Translation:Humans
    8. Darbari DS, Vaughan KJ, Roskom K, Seamon C, Diaw L, Quinn M, Conrey A, Schechter AN, Haythornthwaite JA, Waclawiw MA, Wallen GR, Belfer I, Taylor JG. Central sensitization associated with low fetal hemoglobin levels in adults with sickle cell anemia. Scand J Pain. 2017 10; 17:279-286. PMID: 28969994.
      Citations: 3     Fields:    Translation:Humans
    9. Weir NA, Saiyed R, Alam S, Conrey A, Desai HD, George MP, Keeley JH, Klings ES, Mehari A, Taylor JG, Minniti CP, Kato GJ. Prostacyclin-analog therapy in sickle cell pulmonary hypertension. Haematologica. 2017 05; 102(5):e163-e165. PMID: 28126964.
      Citations: 9     Fields:    Translation:Humans
    10. Hosokawa K, Muranski P, Feng X, Townsley DM, Liu B, Knickelbein J, Keyvanfar K, Dumitriu B, Ito S, Kajigaya S, Taylor JG, Kaplan MJ, Nussenblatt RB, Barrett AJ, O'Shea J, Young NS. Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia. J Immunol. 2016 Feb 15; 196(4):1568-78. PMID: 26764034.
      Citations: 29     Fields:    Translation:HumansCells
    11. Fitzhugh CD, Hsieh MM, Allen D, Coles WA, Seamon C, Ring M, Zhao X, Minniti CP, Rodgers GP, Schechter AN, Tisdale JF, Taylor JG. Hydroxyurea-Increased Fetal Hemoglobin Is Associated with Less Organ Damage and Longer Survival in Adults with Sickle Cell Anemia. PLoS One. 2015; 10(11):e0141706. PMID: 26576059.
      Citations: 20     Fields:    Translation:Humans
    12. Hosokawa K, Muranski P, Feng X, Keyvanfar K, Townsley DM, Dumitriu B, Chen J, Kajigaya S, Taylor JG, Hourigan CS, Barrett AJ, Young NS. Identification of novel microRNA signatures linked to acquired aplastic anemia. Haematologica. 2015 Dec; 100(12):1534-45. PMID: 26354756.
      Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
    13. Darbari DS, Hampson JP, Ichesco E, Kadom N, Vezina G, Evangelou I, Clauw DJ, Taylor Vi JG, Harris RE. Frequency of Hospitalizations for Pain and Association With Altered Brain Network Connectivity in Sickle Cell Disease. J Pain. 2015 Nov; 16(11):1077-86. PMID: 26291276.
      Citations: 29     Fields:    Translation:Humans
    14. Baird JH, Minniti CP, Lee JM, Tian X, Wu C, Jackson M, Alam S, Taylor JG, Kato GJ. Oscillatory haematopoiesis in adults with sickle cell disease treated with hydroxycarbamide. Br J Haematol. 2015 Mar; 168(5):737-46. PMID: 25377027.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    15. van Beers EJ, Yang Y, Raghavachari N, Tian X, Allen DT, Nichols JS, Mendelsohn L, Nekhai S, Gordeuk VR, Taylor JG, Kato GJ. Iron, inflammation, and early death in adults with sickle cell disease. Circ Res. 2015 Jan 16; 116(2):298-306. PMID: 25378535.
      Citations: 29     Fields:    Translation:HumansCellsCTClinical Trials
    16. Wallen GR, Minniti CP, Krumlauf M, Eckes E, Allen D, Oguhebe A, Seamon C, Darbari DS, Hildesheim M, Yang L, Schulden JD, Kato GJ, Taylor JG. Sleep disturbance, depression and pain in adults with sickle cell disease. BMC Psychiatry. 2014 Jul 21; 14:207. PMID: 25047658.
      Citations: 33     Fields:    Translation:HumansCTClinical Trials
    17. Gladwin MT, Barst RJ, Gibbs JS, Hildesheim M, Sachdev V, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Berman Rosenzweig E, Badesch DB, Lanzkron S, Castro OL, Taylor JG, Goldsmith JC, Kato GJ, Gordeuk VR, Machado RF. Risk factors for death in 632 patients with sickle cell disease in the United States and United Kingdom. PLoS One. 2014; 9(7):e99489. PMID: 24988120.
      Citations: 49     Fields:    Translation:HumansCTClinical Trials
    18. Wang X, Mendelsohn L, Rogers H, Leitman S, Raghavachari N, Yang Y, Yau YY, Tallack M, Perkins A, Taylor JG, Noguchi CT, Kato GJ. Heme-bound iron activates placenta growth factor in erythroid cells via erythroid Krüppel-like factor. Blood. 2014 Aug 07; 124(6):946-54. PMID: 24916507.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    19. Milton JN, Gordeuk VR, Taylor JG, Gladwin MT, Steinberg MH, Sebastiani P. Prediction of fetal hemoglobin in sickle cell anemia using an ensemble of genetic risk prediction models. Circ Cardiovasc Genet. 2014 Apr; 7(2):110-5. PMID: 24585758.
      Citations: 19     Fields:    Translation:Humans
    20. Belfer I, Youngblood V, Darbari DS, Wang Z, Diaw L, Freeman L, Desai K, Dizon M, Allen D, Cunnington C, Channon KM, Milton J, Hartley SW, Nolan V, Kato GJ, Steinberg MH, Goldman D, Taylor JG. A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia. Am J Hematol. 2014 Feb; 89(2):187-93. PMID: 24136375.
      Citations: 19     Fields:    Translation:HumansCells
    21. Darbari DS, Nouraie M, Taylor JG, Brugnara C, Castro O, Ballas SK. Alpha-thalassaemia and response to hydroxyurea in sickle cell anaemia. Eur J Haematol. 2014 Apr; 92(4):341-5. PMID: 24330217.
      Citations: 6     Fields:    Translation:Humans
    22. Darbari DS, Wang Z, Kwak M, Hildesheim M, Nichols J, Allen D, Seamon C, Peters-Lawrence M, Conrey A, Hall MK, Kato GJ, Taylor JG. Severe painful vaso-occlusive crises and mortality in a contemporary adult sickle cell anemia cohort study. PLoS One. 2013; 8(11):e79923. PMID: 24224021.
      Citations: 47     Fields:    Translation:Humans
    23. Mehari A, Alam S, Tian X, Cuttica MJ, Barnett CF, Miles G, Xu D, Seamon C, Adams-Graves P, Castro OL, Minniti CP, Sachdev V, Taylor JG, Kato GJ, Machado RF. Hemodynamic predictors of mortality in adults with sickle cell disease. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):840-7. PMID: 23348978.
      Citations: 53     Fields:    Translation:Humans
    24. Youngblood V, Taylor JG. Sequencing PCR-amplified DNA in lipoprotein and cardiovascular disease research. Methods Mol Biol. 2013; 1027:139-55. PMID: 23912985.
      Citations:    Fields:    Translation:HumansCells
    25. Diaw L, Youngblood V, Taylor JG. Introduction to next-generation nucleic acid sequencing in cardiovascular disease research. Methods Mol Biol. 2013; 1027:157-79. PMID: 23912986.
      Citations:    Fields:    Translation:HumansCells
    26. Nekhai S, Xu M, Foster A, Kasvosve I, Diaz S, Machado RF, Castro OL, Kato GJ, Taylor JG, Gordeuk VR. Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin. Haematologica. 2013 Mar; 98(3):455-63. PMID: 23065513.
      Citations: 6     Fields:    Translation:HumansCells
    27. Liu WM, Maivelett J, Kato GJ, Taylor JG, Yang WC, Liu YC, Yang YG, Gorbach AM. Reconstruction of Thermographic Signals to Map Perforator Vessels in Humans. Quant Infrared Thermogr J. 2012 Jan 01; 9(2):123-133. PMID: 23667389.
    28. Taylor JG, Darbari DS, Darari DS, Maric I, McIver Z, Arthur DC. Therapy-related acute myelogenous leukemia in a hydroxyurea-treated patient with sickle cell anemia. Ann Intern Med. 2011 Nov 15; 155(10):722-4. PMID: 22084346.
      Citations: 6     Fields:    Translation:Humans
    29. Sachdev V, Kato GJ, Gibbs JS, Barst RJ, Machado RF, Nouraie M, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli EM, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Taylor JG, Hannoush H, Goldsmith JC, Gladwin MT, Gordeuk VR. Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation. 2011 Sep 27; 124(13):1452-60. PMID: 21900080.
      Citations: 67     Fields:    Translation:HumansCTClinical Trials
    30. Darbari DS, Onyekwere O, Nouraie M, Minniti CP, Luchtman-Jones L, Rana S, Sable C, Ensing G, Dham N, Campbell A, Arteta M, Gladwin MT, Castro O, Taylor JG, Kato GJ, Gordeuk V. Markers of severe vaso-occlusive painful episode frequency in children and adolescents with sickle cell anemia. J Pediatr. 2012 Feb; 160(2):286-90. PMID: 21890147.
      Citations: 33     Fields:    Translation:Humans
    31. Liu P, Barb J, Woodhouse K, Taylor JG, Munson PJ, Raghavachari N. Transcriptome profiling and sequencing of differentiated human hematopoietic stem cells reveal lineage-specific expression and alternative splicing of genes. Physiol Genomics. 2011 Oct 20; 43(20):1117-34. PMID: 21828245.
      Citations: 7     Fields:    Translation:HumansCells
    32. Minniti CP, Taylor JG, Hildesheim M, O'Neal P, Wilson J, Castro O, Gordeuk VR, Kato GJ. Laboratory and echocardiography markers in sickle cell patients with leg ulcers. Am J Hematol. 2011 Aug; 86(8):705-8. PMID: 21630312.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    33. Solovieff N, Hartley SW, Baldwin CT, Klings ES, Gladwin MT, Taylor JG, Kato GJ, Farrer LA, Steinberg MH, Sebastiani P. Ancestry of African Americans with sickle cell disease. Blood Cells Mol Dis. 2011 Jun 15; 47(1):41-5. PMID: 21546286.
      Citations: 14     Fields:    Translation:Humans
    34. Zorca S, Freeman L, Hildesheim M, Allen D, Remaley AT, Taylor JG, Kato GJ. Lipid levels in sickle-cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension. Br J Haematol. 2010 May; 149(3):436-45. PMID: 20230401.
      Citations: 40     Fields:    Translation:Humans
    35. Kato GJ, Taylor JG. Pleiotropic effects of intravascular haemolysis on vascular homeostasis. Br J Haematol. 2010 Mar; 148(5):690-701. PMID: 19958359.
      Citations: 28     Fields:    Translation:Humans
    36. Taylor JG, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock SJ, Khan J. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest. 2009 Nov; 119(11):3395-407. PMID: 19809159.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    37. Darbari DS, Fasano RS, Minniti CP, Castro OO, Gordeuk VR, Taylor JG, Rehm JY. Severe Vaso-Occlusive Episodes Associated with Use of Systemic Corticosteroids in Patients with Sickle Cell Disease. J Natl Med Assoc. 2008 Aug; 100(8):948-951. PMID: 28643632.
      Citations: 23     Fields:    
    38. Taylor JG, Nolan VG, Mendelsohn L, Kato GJ, Gladwin MT, Steinberg MH. Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain. PLoS One. 2008 May 07; 3(5):e2095. PMID: 18461136.
      Citations: 63     Fields:    Translation:Humans
    39. Kato GJ, Wang Z, Machado RF, Blackwelder WC, Taylor JG, Hazen SL. Endogenous nitric oxide synthase inhibitors in sickle cell disease: abnormal levels and correlations with pulmonary hypertension, desaturation, haemolysis, organ dysfunction and death. Br J Haematol. 2009 May; 145(4):506-13. PMID: 19344390.
      Citations: 42     Fields:    Translation:Humans
    40. Kumkhaek C, Taylor JG, Zhu J, Hoppe C, Kato GJ, Rodgers GP. Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia. Br J Haematol. 2008 Apr; 141(2):254-9. PMID: 18318767.
      Citations: 20     Fields:    Translation:HumansCells
    41. Gordeuk VR, Sachdev V, Taylor JG, Gladwin MT, Kato G, Castro OL. Relative systemic hypertension in patients with sickle cell disease is associated with risk of pulmonary hypertension and renal insufficiency. Am J Hematol. 2008 Jan; 83(1):15-8. PMID: 17696198.
      Citations: 53     Fields:    Translation:Humans
    42. Taylor JG, Woods GM, Machado R, Kato GJ, Gladwin MT. Severe pulmonary hypertension in an adolescent with sickle cell disease. Am J Hematol. 2008 Jan; 83(1):71-2. PMID: 17726682.
      Citations: 2     Fields:    Translation:Humans
    43. Taylor JG, Ackah D, Cobb C, Orr N, Percy MJ, Sachdev V, Machado R, Castro O, Kato GJ, Chanock SJ, Gladwin MT. Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease. Am J Hematol. 2008 Jan; 83(1):6-14. PMID: 17724704.
      Citations: 20     Fields:    Translation:HumansCells
    44. Eck P, Erichsen HC, Taylor JG, Corpe C, Chanock SJ, Levine M. Genomic and functional analysis of the sodium-dependent vitamin C transporter SLC23A1-SVCT1. Genes Nutr. 2007 Oct; 2(1):143-5. PMID: 18850166.
    45. Idelman G, Taylor JG, Tongbai R, Chen RA, Haggerty CM, Bilke S, Chanock SJ, Gardner K. Functional profiling of uncommon VCAM1 promoter polymorphisms prevalent in African American populations. Hum Mutat. 2007 Aug; 28(8):824-9. PMID: 17431880.
      Citations: 6     Fields:    Translation:HumansCells
    46. Sebastiani P, Nolan VG, Baldwin CT, Abad-Grau MM, Wang L, Adewoye AH, McMahon LC, Farrer LA, Taylor JG, Kato GJ, Gladwin MT, Steinberg MH. A network model to predict the risk of death in sickle cell disease. Blood. 2007 Oct 01; 110(7):2727-35. PMID: 17600133.
      Citations: 64     Fields:    Translation:HumansCells
    47. Little JA, McGowan VR, Kato GJ, Partovi KS, Feld JJ, Maric I, Martyr S, Taylor JG, Machado RF, Heller T, Castro O, Gladwin MT. Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review. Haematologica. 2006 Aug; 91(8):1076-83. PMID: 16885048.
      Citations: 17     Fields:    Translation:Humans
    48. Choi EH, Taylor JG, Foster CB, Walsh TJ, Anttila VJ, Ruutu T, Palotie A, Chanock SJ. Common polymorphisms in critical genes of innate immunity do not contribute to the risk for chronic disseminated candidiasis in adult leukemia patients. Med Mycol. 2005 Jun; 43(4):349-53. PMID: 16110781.
      Citations: 6     Fields:    Translation:Humans
    49. Eck P, Erichsen HC, Taylor JG, Yeager M, Hughes AL, Levine M, Chanock S. Comparison of the genomic structure and variation in the two human sodium-dependent vitamin C transporters, SLC23A1 and SLC23A2. Hum Genet. 2004 Sep; 115(4):285-94. PMID: 15316768.
      Citations: 25     Fields:    Translation:Humans
    50. Choi EH, Foster CB, Taylor JG, Erichsen HC, Chen RA, Walsh TJ, Anttila VJ, Ruutu T, Palotie A, Chanock SJ. Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes. J Infect Dis. 2003 Apr 01; 187(7):1153-6. PMID: 12660931.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    51. Taylor JG, Tang DC, Savage SA, Leitman SF, Heller SI, Serjeant GR, Rodgers GP, Chanock SJ. Variants in the VCAM1 gene and risk for symptomatic stroke in sickle cell disease. Blood. 2002 Dec 15; 100(13):4303-9. PMID: 12393616.
      Citations: 22     Fields:    Translation:HumansCells
    52. Chanock S, Taylor JG. Using genetic variation to study immunomodulation. Curr Opin Pharmacol. 2002 Aug; 2(4):463-9. PMID: 12127882.
      Citations: 3     Fields:    Translation:HumansAnimals
    53. Taylor JG, Tang D, Foster CB, Serjeant GR, Rodgers GP, Chanock SJ. Patterns of low-affinity immunoglobulin receptor polymorphisms in stroke and homozygous sickle cell disease. Am J Hematol. 2002 Feb; 69(2):109-14. PMID: 11835346.
      Citations: 1     Fields:    Translation:Humans
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