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Geou-Yarh Liou

TitleDr.
Faculty RankAssistant Professor
InstitutionClark Atlanta University
DepartmentCCRTD
Address223 James P. Brawley S.W.
Thomas W. Cole, Jr. Science Research Center RCST 4005B
Atlanta GA 30314
Phone4048806981
ORCID ORCID Icon0000-0003-2728-3752 Additional info
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    Collapse Biography 
    Collapse education and training
    National Central University, TaiwanB.S. 06/1997Chemical Engineering
    National Tsing-Hua University, TaiwanM.S.06/1999Molecular Medicine
    Michigan State University, East Lansing, MI, USPh.D.12/2007Biochemistry and Molecular Biology
    Michigan State University, East Lansing, MI, USPostdoc training10/2008Physiology
    Mayo Clinic, Jacksonville, FL, USpostdoc training06/2016Cancer Biology

    Collapse Research 
    Collapse research activities and funding
    U54MD007590     (KHAN, SHAFIQ A)Jun 1, 1997 - Feb 29, 2024
    NIH
    Enhancement of Cancer Research at Clark Atlanta University
    Role: PI for the pilot project in the Investigator Development Core (3/1/2020-2/28/2022)
         (Geou-Yarh Liou)Jul 1, 2014 - Jun 30, 2016
    the Center for Regenerative Medicine at Mayo Clinic
    Reprogramming of pancreatic acini to a pluripotent stem cell that transdifferentiates to an insulin-producing cell.
    Role: Principal Investigator
    17-80-44-LIOU     (Geou-Yarh Liou)Dec 1, 2017 - Nov 30, 2018
    AACR
    Targeting inflammatory cytokine signaling during initiation and development of pancreatic cancer
    Role Description: The goal of this study is to examine cytokine CCL9 in modulating ADM formation and PanIN development.
    Role: Principal Investigator
    SC1GM140907     (LIOU, GEOU-YARH)Mar 17, 2021 - Feb 28, 2025
    NIH
    Dissecting mechanisms of tumor initiation via immunomodulation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liou GY, C'lay-Pettis R, Kavuri S. Involvement of Reactive Oxygen Species in Prostate Cancer and Its Disparity in African Descendants. Int J Mol Sci. 2024 Jun 17; 25(12). PMID: 38928370.
      Citations:    Fields:    Translation:Humans
    2. Liou GY, Byrd CJ, Storz P, Messex JK. Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases. Int J Mol Sci. 2024 Apr 26; 25(9). PMID: 38731942.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Liou GY, Fleming Martinez AK, D?ppler HR, Bastea LI, Storz P. Inflammatory and alternatively activated macrophages independently induce metaplasia but cooperatively drive pancreatic precancerous lesion growth. iScience. 2023 Jun 16; 26(6):106820. PMID: 37250781.
      Citations:    
    4. Liou GY, Byrd CJ. Diagnostic Bioliquid Markers for Pancreatic Cancer: What We Have vs. What We Need. Cancers (Basel). 2023 Apr 25; 15(9). PMID: 37173913.
      Citations:    
    5. Messex JK, Liou GY. Impact of Immune Cells in the Tumor Microenvironment of Prostate Cancer Metastasis. Life (Basel). 2023 Jan 26; 13(2). PMID: 36836690.
      Citations:    
    6. Fleming Martinez AK, D?ppler HR, Bastea LI, Edenfield BH, Liou GY, Storz P. Ym1+ macrophages orchestrate fibrosis, lesion growth, and progression during development of murine pancreatic cancer. iScience. 2022 May 20; 25(5):104327. PMID: 35602933.
      Citations:    
    7. Messex JK, Adams KLA, Hawkins WG, DeNardo D, Bardeesy N, Billadeau DD, Liou GY. Oncogenic Kras-Mediated Cytokine CCL15 Regulates Pancreatic Cancer Cell Migration and Invasion through ROS. Cancers (Basel). 2022 Apr 26; 14(9). PMID: 35565279.
      Citations:    
    8. Messex JK, Byrd CJ, Thomas MU, Liou GY. Macrophages Cytokine Spp1 Increases Growth of Prostate Intraepithelial Neoplasia to Promote Prostate Tumor Progression. Int J Mol Sci. 2022 Apr 12; 23(8). PMID: 35457063.
      Citations: 6     Fields:    Translation:HumansCells
    9. D?ppler HR, Liou GY, Storz P. Generation of Hydrogen Peroxide and Downstream Protein Kinase D1 Signaling Is a Common Feature of Inducers of Pancreatic Acinar-to-Ductal Metaplasia. Antioxidants (Basel). 2022 Jan 08; 11(1). PMID: 35052641.
      Citations:    
    10. Messex JK, Liou GY. Targeting BTK Signaling in the Microenvironment of Solid Tumors as a Feasible Cancer Therapy Option. Cancers (Basel). 2021 May 03; 13(9). PMID: 34063667.
      Citations:    
    11. Fleming Martinez AK, D?ppler HR, Bastea LI, Edenfield B, Patel T, Leitges M, Liou GY, Storz P. Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells. iScience. 2021 Jan 22; 24(1):102019. PMID: 33521594.
      Citations:    
    12. Thomas MU, Messex JK, Dang T, Abdulkadir SA, Jorcyk CL, Liou GY. Macrophages expedite cell proliferation of prostate intraepithelial neoplasia through their downstream target ERK. FEBS J. 2021 03; 288(6):1871-1886. PMID: 32865335.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    13. Messex JK, Byrd CJ, Liou GY. Signaling of Macrophages that Contours the Tumor Microenvironment for Promoting Cancer Development. Cells. 2020 04 09; 9(4). PMID: 32283687.
      Citations: 10     Fields:    Translation:HumansCells
    14. Bastea LI, Liou GY, Pandey V, Fleming AK, von Roemeling CA, Doeppler H, Li Z, Qiu Y, Edenfield B, Copland JA, Tun HW, Storz P. Pomalidomide Alters Pancreatic Macrophage Populations to Generate an Immune-Responsive Environment at Precancerous and Cancerous Lesions. Cancer Res. 2019 04 01; 79(7):1535-1548. PMID: 30696657.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    15. Liou GY. CD133 as a regulator of cancer metastasis through the cancer stem cells. Int J Biochem Cell Biol. 2019 01; 106:1-7. PMID: 30399449.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    16. Dang T, Liou GY. Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. Sci Rep. 2018 05 16; 8(1):7718. PMID: 29769604.
      Citations: 31     Fields:    Translation:HumansCells
    17. Liou GY. Inflammatory Cytokine Signaling during Development of Pancreatic and Prostate Cancers. J Immunol Res. 2017; 2017:7979637. PMID: 29379802.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    18. Akanuma N, Liu J, Liou GY, Yin X, Bejar KR, Liu C, Sun LZ, Storz P, Wang P. Paracrine Secretion of Transforming Growth Factor ? by Ductal Cells Promotes Acinar-to-Ductal Metaplasia in Cultured Human Exocrine Pancreas Tissues. Pancreas. 2017 10; 46(9):1202-1207. PMID: 28902792.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    19. Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD. Glycogen synthase kinase-3? ablation limits pancreatitis-induced acinar-to-ductal metaplasia. J Pathol. 2017 09; 243(1):65-77. PMID: 28639695.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Liou GY, Bastea L, Fleming A, D?ppler H, Edenfield BH, Dawson DW, Zhang L, Bardeesy N, Storz P. The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis. Cell Rep. 2017 05 16; 19(7):1322-1333. PMID: 28514653.
      Citations: 58     Fields:    Translation:AnimalsCells
    21. Liou GY, D?ppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P. Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Cell Rep. 2016 Mar 15; 14(10):2325-36. PMID: 26947075.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    22. Liou GY, Storz P, Leitges M. A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer. Mol Cell Oncol. 2016 Jan; 3(1):e1035477. PMID: 27308552.
      Citations:    
    23. Hessmann E, Zhang JS, Chen NM, Hasselluhn M, Liou GY, Storz P, Ellenrieder V, Billadeau DD, Koenig A. NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation. Stem Cells Int. 2016; 2016:5272498. PMID: 26697077.
      Citations:    
    24. Liou GY, Storz P. Protein kinase D enzymes: novel kinase targets in pancreatic cancer. Expert Rev Gastroenterol Hepatol. 2015; 9(9):1143-6. PMID: 26174103.
      Citations: 2     Fields:    Translation:HumansCells
    25. Liou GY, Storz P. Inflammatory macrophages in pancreatic acinar cell metaplasia and initiation of pancreatic cancer. Oncoscience. 2015; 2(3):247-51. PMID: 25897428.
      Citations:    
    26. Liou GY, D?ppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun. 2015 Feb 20; 6:6200. PMID: 25698580.
      Citations: 50     Fields:    Translation:AnimalsCells
    27. Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, K?hnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E. NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas. Gastroenterology. 2015 May; 148(5):1024-1034.e9. PMID: 25623042.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    28. Liou GY, Leitges M, Storz P. Pancreatic oncogenic signaling cascades converge at Protein Kinase D1. Cell Cycle. 2015; 14(10):1489-90. PMID: 25928263.
      Citations: 1     Fields:    Translation:AnimalsCells
    29. Liou GY, Storz P. Detecting reactive oxygen species by immunohistochemistry. Methods Mol Biol. 2015; 1292:97-104. PMID: 25804750.
      Citations: 26     Fields:    Translation:Animals
    30. Liou GY, D?ppler H, Necela B, Edenfield B, Zhang L, Dawson DW, Storz P. Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions. Cancer Discov. 2015 Jan; 5(1):52-63. PMID: 25361845.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    31. Liou GY, D?ppler H, Necela B, Krishna M, Crawford HC, Raimondo M, Storz P. Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-?B and MMPs. J Cell Biol. 2013 Aug 05; 202(3):563-77. PMID: 23918941.
      Citations: 136     Fields:    Translation:AnimalsCells
    32. D?ppler H, Liou GY, Storz P. Downregulation of TRAF2 mediates NIK-induced pancreatic cancer cell proliferation and tumorigenicity. PLoS One. 2013; 8(1):e53676. PMID: 23301098.
      Citations: 25     Fields:    Translation:HumansCells
    33. Ardito CM, Gr?ner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell. 2012 Sep 11; 22(3):304-17. PMID: 22975374.
      Citations: 291     Fields:    Translation:HumansAnimalsCells
    34. Liou GY, Storz P. Reactive oxygen species in cancer. Free Radic Res. 2010 May; 44(5):479-96. PMID: 20370557.
      Citations: 1124     Fields:    Translation:HumansAnimalsCells
    35. Liou GY, Zhang H, Miller EM, Seibold SA, Chen W, Gallo KA. Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling. Biochem J. 2010 Apr 14; 427(3):435-43. PMID: 20158498.
      Citations: 4     Fields:    Translation:HumansCells
    36. Liou GY, Gallo KA. New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2. Biochem J. 2009 Oct 23; 424(1):e1-3. PMID: 19839940.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    37. Shih JY, Tsai MF, Chang TH, Chang YL, Yuan A, Yu CJ, Lin SB, Liou GY, Lee ML, Chen JJ, Hong TM, Yang SC, Su JL, Lee YC, Yang PC. Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin Cancer Res. 2005 Nov 15; 11(22):8070-8. PMID: 16299238.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
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