Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2.

Celada SI, Li G, Celada LJ, Kanagasabai T, Lu W, Brown LK, Mark ZA, Izban MG, Ballard BR, Zhou X, Adunyah SE, Matusik RJ, Wang X, Chen Z. Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2. Sci Signal. 2024 Dec 17; 17(867):eadk4122.

View in: PubMed

subject areas

Androgens
Animals
Apoptosis
Autophagy
Cell Line, Tumor
Cell Proliferation
Humans
Male
Mice
Receptors, Androgen
S-Phase Kinase-Associated Proteins
Xenograft Model Antitumor Assays

authors with profiles

Guoliang Li, PhD
Thanigaivelan
Samuel Adunyah

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