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Zhigang Xiong
Title Dr.
Faculty Rank Professor
Degree MD, PhD
Institution Morehouse School of Medicine
Department Neurobiology
Clusters Neurological Disorders and Mental Health
720 Westview Drive SW
City Atlanta
State GA
Postal Code 30310
Telephone 4047528683
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1. Vann KT, Xiong ZG. Acid-sensing ion channel 1 contributes to normal olfactory function. Behav Brain Res. 2018 Jan 30; 337:246-251.
2. Leng T, Lin S, Xiong Z, Lin J. Lidocaine suppresses glioma cell proliferation by inhibiting TRPM7 channels. Int J Physiol Pathophysiol Pharmacol. 2017; 9(2):8-15.
3. Inoue K, Sakuma E, Morimoto H, Asai H, Koide Y, Leng T, Wada I, Xiong ZG, Ueki T. Serum- and glucocorticoid-inducible kinases in microglia. Biochem Biophys Res Commun. 2016 09 09; 478(1):53-59.
4. O'Bryant Z, Leng T, Liu M, Inoue K, Vann KT, Xiong ZG. Acid Sensing Ion Channels (ASICs) in NS20Y cells - potential role in neuronal differentiation. Mol Brain. 2016 06 24; 9(1):68.
5. Inoue K, Leng T, Yang T, Zeng Z, Ueki T, Xiong ZG. Role of serum- and glucocorticoid-inducible kinases in stroke. J Neurochem. 2016 07; 138(2):354-61.
6. Vann KT, Xiong ZG. Optogenetics for neurodegenerative diseases. Int J Physiol Pathophysiol Pharmacol. 2016; 8(1):1-8.
7. Leng TD, Si HF, Li J, Yang T, Zhu M, Wang B, Simon RP, Xiong ZG. Amiloride Analogs as ASIC1a Inhibitors. CNS Neurosci Ther. 2016 06; 22(6):468-76.
8. Leng T, Liu A, Wang Y, Chen X, Zhou S, Li Q, Zhu W, Zhou Y, Su X, Huang Y, Yin W, Qiu P, Hu H, Xiong ZG, Zhang J, Yan G. Naturally occurring marine steroid 24-methylenecholestane-3ß,5a,6ß,19-tetraol functions as a novel neuroprotectant. Steroids. 2016 Jan; 105:96-105.
9. Omosun Y, McKeithen D, Ryans K, Kibakaya C, Blas-Machado U, Li D, Singh R, Inoue K, Xiong ZG, Eko F, Black C, Igietseme J, He Q. Interleukin-10 modulates antigen presentation by dendritic cells through regulation of NLRP3 inflammasome assembly during Chlamydia infection. Infect Immun. 2015 Dec; 83(12):4662-72.
10. Huang Y, Jiang N, Li J, Ji YH, Xiong ZG, Zha XM. Two aspects of ASIC function: Synaptic plasticity and neuronal injury. Neuropharmacology. 2015 Jul; 94:42-8.
11. Inoue K, O'Bryant Z, Xiong ZG. Zinc-permeable ion channels: effects on intracellular zinc dynamics and potential physiological/pathophysiological significance. Curr Med Chem. 2015; 22(10):1248-57.
12. Zeng Z, Inoue K, Sun H, Leng T, Feng X, Zhu L, Xiong ZG. TRPM7 regulates vascular endothelial cell adhesion and tube formation. Am J Physiol Cell Physiol. 2015 Feb 15; 308(4):C308-18.
13. Leng TD, Li MH, Shen JF, Liu ML, Li XB, Sun HW, Branigan D, Zeng Z, Si HF, Li J, Chen J, Xiong ZG. Suppression of TRPM7 inhibits proliferation, migration, and invasion of malignant human glioma cells. CNS Neurosci Ther. 2015 Mar; 21(3):252-61.
14. Liu M, Inoue K, Leng T, Guo S, Xiong ZG. TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways. Cell Signal. 2014 Dec; 26(12):2773-81.
15. Leng TD, Lin J, Sun HW, Zeng Z, O'Bryant Z, Inoue K, Xiong ZG. Local anesthetic lidocaine inhibits TRPM7 current and TRPM7-mediated zinc toxicity. CNS Neurosci Ther. 2015 Jan; 21(1):32-9.
16. Zhou W, Guo S, Xiong Z, Liu M. Oncogenic role and therapeutic target of transient receptor potential melastatin 7 channel in malignancy. Expert Opin Ther Targets. 2014 Oct; 18(10):1177-96.
17. Leng T, Shi Y, Xiong ZG, Sun D. Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke? Prog Neurobiol. 2014 Apr; 115:189-209.
18. O'Bryant Z, Vann KT, Xiong ZG. Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a. Transl Stroke Res. 2014 Feb; 5(1):59-68.
19. Sun H, Leng T, Zeng Z, Gao X, Inoue K, Xiong ZG. Role of TRPM7 channels in hyperglycemia-mediated injury of vascular endothelial cells. PLoS One. 2013; 8(11):e79540.
20. Lu X, Ke J, Luo X, Zhu Y, Zou L, Li H, Zhu B, Xiong Z, Chen W, Deng L, Lou J, Wang X, Zhang Y, Wang Z, Miao X, Cheng L. The SNP rs402710 in 5p15.33 is associated with lung cancer risk: a replication study in Chinese population and a meta-analysis. PLoS One. 2013; 8(10):e76252.
21. Xiong ZG, Xu TL. The role of ASICS in cerebral ischemia. Wiley Interdiscip Rev Membr Transp Signal. 2012; 1(5):655-662.
22. Leng TD, Xiong ZG. The pharmacology and therapeutic potential of small molecule inhibitors of acid-sensing ion channels in stroke intervention. Acta Pharmacol Sin. 2013 Jan; 34(1):33-8.
23. Lin J, Chu X, Maysami S, Li M, Si H, Cottrell JE, Simon RP, Xiong Z. Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg. 2011 Apr; 112(4):977-81.
24. Zhan S, Zhao H, J White A, Minami M, Pignataro G, Yang T, Zhu X, Lan J, Xiong Z, Steiner DF, Simon RP, Zhou A. Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains. J Cereb Blood Flow Metab. 2009 Apr; 29(4):698-706.
25. Guo Q, Xiong Z, Akbarali H, Wang D. Announcement of International Journal of Physiology, Pathophysiology and Pharmacology. Int J Physiol Pathophysiol Pharmacol. 2009 Jan 01; 1(1):i.
26. Pignataro G, Meller R, Inoue K, Ordonez AN, Ashley MD, Xiong Z, Gala R, Simon RP. In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: ischemic postconditioning. J Cereb Blood Flow Metab. 2008 Feb; 28(2):232-41.
27. Murphy B, Dunleavy M, Shinoda S, Schindler C, Meller R, Bellver-Estelles C, Hatazaki S, Dicker P, Yamamoto A, Koegel I, Chu X, Wang W, Xiong Z, Prehn J, Simon R, Henshall D. Bcl-w protects hippocampus during experimental status epilepticus. Am J Pathol. 2007 Oct; 171(4):1258-68.
28. Xiong Z, Wei Q, Chen H, Chen S, Xu W, Qiu G, Liang S, Hu X. Microbial transformation of androst-4-ene-3,17-dione by Beauveria bassiana. Steroids. 2006 Nov; 71(11-12):979-83.
29. Xiong Z, Xu Y, Zhu L, Zhao J. Enhanced photodegradation of 2,4,6-trichlorophenol over palladium phthalocyaninesulfonate modified organobentonite. Langmuir. 2005 Nov 08; 21(23):10602-7.
30. Xiong Z, Xu Y, Zhu L, Zhao J. Photosensitized oxidation of substituted phenols on aluminum phthalocyanine-intercalated organoclay. Environ Sci Technol. 2005 Jan 15; 39(2):651-7.
31. Stenzel-Poore MP, Stevens SL, Xiong Z, Lessov NS, Harrington CA, Mori M, Meller R, Rosenzweig HL, Tobar E, Shaw TE, Chu X, Simon RP. Effect of ischaemic preconditioning on genomic response to cerebral ischaemia: similarity to neuroprotective strategies in hibernation and hypoxia-tolerant states. Lancet. 2003 Sep 27; 362(9389):1028-37.
32. Chen D, Jin K, Kawaguchi K, Nakayama M, Zhou X, Xiong Z, Zhou A, Mao XO, Greenberg DA, Graham SH, Simon RP. Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism. J Neurochem. 2003 May; 85(3):670-9.

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