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John Piletz
Title Professor
Faculty Rank
Degree PhD
Institution Jackson State University
Department Chemistry and Biochemistry
Clusters Neurological Disorders and Mental Health
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14 Peach Tree Lane
City Madison
State MS
Postal Code 39110
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2007AGMATINASE INHIBITORS FOR HYPOXIC-ISCHEMIC NEW BORN BRAIN DAMAGE5R21NS054862-02
2.
2006AGMATINASE INHIBITORS FOR HYPOXIC-ISCHEMIC NEW BORN BRAIN DAMAGE1R21NS054862-01
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2006AGMATINASE INHIBITORS FOR HYPOXIC-ISCHEMIC NEW BORN BRAIN DAMAGE3R21NS054862-01S1
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2001IMIDAZOLINE RECEPTORS IN DEPRESSION--BASIC STUDIES5R01MH049248-08
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2000IMIDAZOLINE RECEPTORS IN DEPRESSION--BASIC STUDIES5R01MH049248-07
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1999IMIDAZOLINE RECEPTORS IN DEPRESSION--BASIC STUDIES5R01MH049248-06
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1998IMIDAZOLINE RECEPTORS IN DEPRESSION--BASIC STUDIES2R01MH049248-05A2
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1997REGULATION OF LIMDAZOLINE SITES3R01MH049248-04S1
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1994REGULATION OF LIMDAZOLINE SITES5R01MH049248-04
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1993REGULATION OF IMIDAZOLINE BINDING SITES IN DEPRESSION5R01MH049248-02
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1993TRANSFER OF GRANT - REGULATION OF LIMDAZOLINE SITES7R01MH049248-03
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1992REGULATION OF IMIDAZOLINE BINDING SITES IN DEPRESSION1R01MH049248-01
13.
1990PLATELET A2 ADRENOCEPTORS IN DEPRESSION5R29MH043020-03
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1989PLATELET A2 ADRENOCEPTORS IN DEPRESSION5R29MH043020-02
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1988PLATELET A2 ADRENOCEPTORS IN DEPRESSION1R29MH043020-01A1
16.
1987PLATELET ADRENORECEPTOR DESENSITIZATION IN DEPRESSION1R03MH041997-01A1

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1. Piletz JE, Aricioglu F, Cheng JT, Fairbanks CA, Gilad VH, Haenisch B, Halaris A, Hong S, Lee JE, Li J, Liu P, Molderings GJ, Rodrigues AL, Satriano J, Seong GJ, Wilcox G, Wu N, Gilad GM. Agmatine: clinical applications after 100 years in translation. Drug Discov Today. 2013 Sep; 18(17-18):880-93.
2. Piletz JE, Klenotich S, Lee KS, Zhu QL, Valente E, Collins MA, Jones V, Lee SN, Yangzheng F. Putative agmatinase inhibitor for hypoxic-ischemic new born brain damage. Neurotox Res. 2013 Aug; 24(2):176-90.
3. Piletz JE, Zhang X, Ranade R, Liu C. Database of genetic studies of bipolar disorder. Psychiatr Genet. 2011 Apr; 21(2):57-68.
4. Piletz JE, Halaris A, Iqbal O, Hoppensteadt D, Fareed J, Zhu H, Sinacore J, Devane CL. Pro-inflammatory biomakers in depression: treatment with venlafaxine. World J Biol Psychiatry. 2009; 10(4):313-23.
5. Piletz J, Baker R, Halaris A. Platelet imidazoline receptors as state marker of depressive symptomatology. J Psychiatr Res. 2008 Jan; 42(1):41-9.
6. Alford GS, Szebeni K, Klimek V, Piletz JE, Orr S, Ordway GA. Effect of smokeless tobacco extract on catecholamine metabolic enzymes in rat brain: "dippers" are getting only half of the bang. Addict Behav. 2006 Aug; 31(8):1503-9.
7. Wu N, Su RB, Xu B, Lu XQ, Liu Y, Zheng JQ, Piletz JE, Li J, Qin BY. IRAS, a candidate for I1-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence. Biochem Pharmacol. 2005 Oct 01; 70(7):1079-87.
8. Chan CK, Burke SL, Zhu H, Piletz JE, Head GA. Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine. Neuroscience. 2005; 132(4):991-1007.
9. Zhu MY, Iyo A, Piletz JE, Regunathan S. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. Biochim Biophys Acta. 2004 Jan 22; 1670(2):156-64.
10. Halaris A, Piletz JE. Relevance of imidazoline receptors and agmatine to psychiatry: a decade of progress. Ann N Y Acad Sci. 2003 Dec; 1009:1-20.
11. Regunathan S, Piletz JE. Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes. Ann N Y Acad Sci. 2003 Dec; 1009:20-9.
12. Huang MJ, Regunathan S, Botta M, Lee K, McClendon E, Yi GB, Pedersen ML, Berkowitz DB, Wang G, Travagli M, Piletz JE. Structure-activity analysis of guanidine group in agmatine for brain agmatinase. Ann N Y Acad Sci. 2003 Dec; 1009:52-63.
13. Piletz JE, May PJ, Wang G, Zhu H. Agmatine crosses the blood-brain barrier. Ann N Y Acad Sci. 2003 Dec; 1009:64-74.
14. Aricioglu F, Regunathan S, Piletz JE. Is agmatine an endogenous factor against stress? Ann N Y Acad Sci. 2003 Dec; 1009:127-32.
15. Zhu H, Halaris A, Piletz JE. Atypical [(3)H]clonidine binding sites in human caudate and platelets on cryostat-cut sections. Ann N Y Acad Sci. 2003 Dec; 1009:296-301.
16. Ma JK, Zhu HE, Piletz JE. Effect of postmortem delay on imidazoline receptor-binding proteins in human and mouse brain. Ann N Y Acad Sci. 2003 Dec; 1009:341-6.
17. Zhu H, Piletz JE. Association between I(2) binding sites and monoamine oxidase-B activity in platelets. Ann N Y Acad Sci. 2003 Dec; 1009:347-52.
18. Piletz JE, Wang G, Zhu H. Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue. Ann N Y Acad Sci. 2003 Dec; 1009:392-9.
19. Dontenwill M, Piletz JE, Chen M, Baldwin J, Pascal G, Ronde P, Dupuy L, Greney H, Takeda K, Bousquetd P. IRAS is an anti-apoptotic protein. Ann N Y Acad Sci. 2003 Dec; 1009:400-12.
20. Musgrave IF, Dehle FC, Piletz J. Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I(1)-receptor action. Ann N Y Acad Sci. 2003 Dec; 1009:413-8.
21. Piletz JE, Deleersnijder W, Roth BL, Ernsberger P, Zhu H, Ziegler D. IRAS splice variants. Ann N Y Acad Sci. 2003 Dec; 1009:419-26.
22. Chen MJ, Zhu HE, Piletz JE. Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor. Ann N Y Acad Sci. 2003 Dec; 1009:427-38.
23. Zhu H, Hayes J, Chen M, Baldwin J, Piletz JE. Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS. Ann N Y Acad Sci. 2003 Dec; 1009:439-46.
24. Zhu MY, Piletz JE, Halaris A, Regunathan S. Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells. Cell Mol Neurobiol. 2003 Oct; 23(4-5):865-72.
25. Piletz JE, Ordway GA, Rajkowska G, Zhu H, Klimek V, Swilley S, Duncan BJ, May W, Halaris AE. Differential expression of alpha2-adrenoceptor vs. imidazoline binding sites in postmortem orbitofrontal cortex and amygdala of depressed subjects. J Psychiatr Res. 2003 Sep-Oct; 37(5):399-409.
26. Dontenwill M, Pascal G, Piletz JE, Chen M, Baldwin J, Rondé P, Dupuy L, Urosevic D, Greney H, Takeda K, Bousquet P. IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells. Cell Death Differ. 2003 Aug; 10(8):933-5.
27. Zhu H, Paul IA, Stec DE, Peeler DF, Piletz JE. Non-adrenergic exploratory behavior induced by moxonidine at mildly hypotensive doses. Brain Res. 2003 Feb 21; 964(1):9-20.
28. Feng Y, Piletz JE, Leblanc MH. Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res. 2002 Oct; 52(4):606-11.
29. Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE. Insulin receptor substrate 4 associates with the protein IRAS. J Biol Chem. 2002 May 31; 277(22):19439-47.
30. Halaris A, Zhu H, Ali J, Nasrallah A, Lindsay De Vane C, Piletz JE. Down-regulation of platelet imidazoline-1-binding sites after bupropion treatment. Int J Neuropsychopharmacol. 2002 Mar; 5(1):37-46.
31. Halaris A, Piletz JE. Imidazoline receptors: possible involvement in the pathophysiology and treatment of depression. Hum Psychopharmacol. 2001 Jan; 16(1):65-69.
32. Piletz JE, Ordway GA, Zhu H, Duncan BJ, Halaris A. Autoradiographic comparison of [3H]-clonidine binding to non-adrenergic sites and alpha(2)-adrenergic receptors in human brain. Neuropsychopharmacology. 2000 Dec; 23(6):697-708.
33. Piletz JE, Zhu H, Ordway G, Stockmeier C, Dilly G, Reis D, Halaris A. Imidazoline receptor proteins are decreased in the hippocampus of individuals with major depression. Biol Psychiatry. 2000 Nov 01; 48(9):910-9.
34. Piletz JE, Halbreich U. Imidazoline and alpha(2a)-adrenoceptor binding sites in postmenopausal women before and after estrogen replacement therapy. Biol Psychiatry. 2000 Nov 01; 48(9):932-9.
35. Piletz JE, Zhu H, Madakasira S, Pazzaglia P, Lindsay DeVane C, Goldman N, Halaris A. Elevated P-selectin on platelets in depression: response to bupropion. J Psychiatr Res. 2000 Nov-Dec; 34(6):397-404.
36. Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ. Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization. DNA Cell Biol. 2000 Jun; 19(6):319-29.
37. Zhu H, Halaris A, Madakasira S, Pazzaglia P, Goldman N, DeVane CL, Andrew M, Reis D, Piletz JE. Effect of bupropion on immunodensity of putative imidazoline receptors on platelets of depressed patients. J Psychiatr Res. 1999 Jul-Aug; 33(4):323-33.
38. Piletz JE, Jones JC, Zhu H, Bishara O, Ernsberger P. Imidazoline receptor antisera-selected cDNA clone and mRNA distribution. Ann N Y Acad Sci. 1999 Jun 21; 881:1-7.
39. Head GA, Chan CK, Zhu H, Piletz JE. Dissociation of the effects of intramedullary monoamine neurotoxins on the hypotensive action of moxonidine and on immunodetected imidazoline and alpha 2-receptor proteins. Ann N Y Acad Sci. 1999 Jun 21; 881:300.
40. Halaris A, Zhu H, Feng Y, Piletz JE. Plasma agmatine and platelet imidazoline receptors in depression. Ann N Y Acad Sci. 1999 Jun 21; 881:445-51.
41. Suzuki T, Hori T, Baba A, Abe S, Shiraishi H, Moroji T, Piletz JE. Effectiveness of anticholinergics and neuroleptic dose reduction on neuroleptic-induced pleurothotonus (the Pisa syndrome) J Clin Psychopharmacol. 1999 Jun; 19(3):277-80.
42. Ivanov TR, Jones JC, Dontenwill M, Bousquet P, Piletz JE. Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera. J Auton Nerv Syst. 1998 Oct 15; 72(2-3):98-110.
43. Ivanov TR, Zhu H, Regunathan S, Reis DJ, Dontenwill M, Vonthron C, Bousquet P, Piletz JE. Co-detection by two imidazoline receptor protein antisera of a novel 85 kilodalton protein. Biochem Pharmacol. 1998 Mar 01; 55(5):649-55.
44. Piletz JE, Andrew M, Zhu H, Feng YZ, Rains J, Halaris A. Alpha 2-adrenoceptors and I1-imidazoline binding sites: relationship with catecholamines in women of reproductive age. J Psychiatr Res. 1998 Mar-Apr; 32(2):55-64.
45. Ivanov TR, Feng Y, Wang H, Regunathan S, Reis DJ, Chikkala DN, Gupta P, Jones JC, Piletz JE. Imidazoline receptor proteins are regulated in platelet-precursor MEG-01 cells by agonists and antagonists. J Psychiatr Res. 1998 Mar-Apr; 32(2):65-79.
46. Piletz JE, Segraves KB, Feng YZ, Maguire E, Dunger B, Halaris A. Plasma MHPG response to yohimbine treatment in women with hypoactive sexual desire. J Sex Marital Ther. 1998 Jan-Mar; 24(1):43-54.
47. Reis DJ, Piletz JE. The imidazoline receptor in control of blood pressure by clonidine and allied drugs. Am J Physiol. 1997 Nov; 273(5 Pt 2):R1569-71.
48. Feng Y, Halaris AE, Piletz JE. Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl. 1997 Apr 11; 691(2):277-86.
49. Suzuki T, Kurita H, Hori T, Sasaki M, Baba A, Shiraishi H, Piletz JE. The Pisa syndrome (pleurothotonus) during antidepressant therapy. Biol Psychiatry. 1997 Jan 15; 41(2):234-6.
50. Zhu H, Paul IA, McNamara M, Redmond A, Nowak G, Piletz JE. Chronic imipramine treatment upregulates IR2-imidazoline receptive sites in rat brain. Neurochem Int. 1997 Jan; 30(1):101-7.
51. Zhu H, Halaris A, Piletz JE. Chronic imipramine treatment downregulates IR1-imidazoline receptors in rat brainstem. Life Sci. 1997; 61(19):1973-83.
52. Piletz JE, Zhu H, Chikkala DN. Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. J Pharmacol Exp Ther. 1996 Nov; 279(2):694-702.
53. Suzuki T, Yamamoto T, Hori T, Baba A, Shiraishi H, Ito T, Piletz JE, Ho IK. Autoradiographic study on the pharmacological characteristics of [3H]3-OH-PCP binding sites in rat brain. Eur J Pharmacol. 1996 Aug 29; 310(2-3):243-55.
54. Piletz JE, Halaris A, Nelson J, Qu Y, Bari M. Platelet I1-imidazoline binding sites are elevated in depression but not generalized anxiety disorder. J Psychiatr Res. 1996 May-Jun; 30(3):147-68.
55. Piletz JE, Halaris AE, Chikkala D, Qu Y. Platelet I1-imidazoline binding sites are decreased by two dissimilar antidepressant agents in depressed patients. J Psychiatr Res. 1996 May-Jun; 30(3):169-84.
56. Ernsberger P, Piletz JE, Graff LM, Graves ME. Optimization of radioligand binding assays for I1-imidazoline sites. Ann N Y Acad Sci. 1995 Jul 12; 763:163-8.
57. Piletz JE, Halaris A. Involvement of I1-imidazoline receptors in mood disorders. Ann N Y Acad Sci. 1995 Jul 12; 763:510-9.
58. Piletz JE, Chikkala DN, Ernsberger P. Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J Pharmacol Exp Ther. 1995 Feb; 272(2):581-7.
59. Piletz JE, DeMet E, Gwirtsman HE, Halaris A. Disruption of circadian MHPG rhythmicity in major depression. Biol Psychiatry. 1994 Jun 01; 35(11):830-42.
60. Piletz JE, Halaris A, Ernsberger PR. Psychopharmacology of imidazoline and alpha 2-adrenergic receptors: implications for depression. Crit Rev Neurobiol. 1994; 9(1):29-66.
61. Piletz JE, Sletten K. Nonadrenergic imidazoline binding sites on human platelets. J Pharmacol Exp Ther. 1993 Dec; 267(3):1493-502.
62. Halbreich U, Piletz JE, Carson S, Halaris A, Rojansky N. Increased imidazoline and alpha 2 adrenergic binding in platelets of women with dysphoric premenstrual syndromes. Biol Psychiatry. 1993 Nov 15; 34(10):676-86.
63. Piletz JE, Chikkala D, Khaitan L, Jackson K, Qu Y. Delayed desensitization of alpha 2-adrenoceptor-mediated platelet aggregation in depressed patients. Neuropsychopharmacology. 1993 Aug; 9(1):55-66.
64. Halbreich U, Piletz J, Halaris A. Influence of gonadal hormones on neurotransmitters, receptor, cognition and mood. Clin Neuropharmacol. 1992; 15 Suppl 1 Pt A:590A-591A.
65. Piletz JE, Halaris A, Saran A, Marler MR. Desipramine lowers tritiated para-aminoclonidine binding in platelets of depressed patients. Arch Gen Psychiatry. 1991 Sep; 48(9):813-20.
66. Piletz JE, Sarasua M, Whitehouse P, Chotani M. Intracellular membranes are more fluid in platelets of Alzheimer's disease patients. Neurobiol Aging. 1991 Sep-Oct; 12(5):401-6.
67. Piletz JE, Andorn AC, Unnerstall JR, Halaris A. Binding of [3H]-p-aminoclonidine to alpha 2-adrenoceptor states plus a non-adrenergic site on human platelet plasma membranes. Biochem Pharmacol. 1991 Jul 15; 42(3):569-84.
68. Piletz JE, Sarasua M, Chotani M, Saran A, Halaris A. Relationship between membrane fluidity and adrenoceptor binding in depression. Psychiatry Res. 1991 Jul; 38(1):1-12.
69. Piletz JE, Halaris A, Saran A, Marler M. Elevated 3H-para-aminoclonidine binding to platelet purified plasma membranes from depressed patients. Neuropsychopharmacology. 1990 Jun; 3(3):201-10.
70. Marler M, Halaris A, Piletz JE. MHPG circadian rhythmicity in blood of healthy subjects. Chronobiologia. 1990 Apr-Jun; 17(2):117-34.
71. Piletz JE, Halaris A. Comparison of 3H-para-aminoclonidine binding to different platelet preparations. J Neural Transm Gen Sect. 1990; 82(1):11-29.
72. Piletz JE, Halaris A. Gas-liquid chromatographic method for routine detection of plasma sulfo-, gluco-, and free 3-methoxy-4-hydroxyphenylglycol. Clin Chim Acta. 1989 Nov; 185(2):165-76.
73. Gwirtsman HE, Halaris AE, Wolf AW, DeMet E, Piletz JE, Marler M. Apparent phase advance in diurnal MHPG rhythm in depression. Am J Psychiatry. 1989 Nov; 146(11):1427-33.
74. Piletz JE, Halaris A. Super high affinity 3H-para-aminoclonidine binding to platelet adrenoceptors in depression. Prog Neuropsychopharmacol Biol Psychiatry. 1988; 12(4):541-53.
75. Piletz JE, Herschman HR. Metallothionein synthesis and mRNA levels in cultured hepatocytes from lethal milk mutant mice. J Nutr. 1987 Jan; 117(1):183-8.
76. Piletz JE, Lönnerdal B, Hurley LS, Berry W, Ganschow RE, Herschman HR. Zinc and copper in milk and tissues of nursing lethal milk mutant mice. J Nutr. 1987 Jan; 117(1):83-90.
77. Piletz JE, Schubert DS, Halaris A. Evaluation of studies on platelet alpha 2 adrenoreceptors in depressive illness. Life Sci. 1986 Nov 03; 39(18):1589-616.
78. Piletz JE, Andorn AC, Halaris A. 3H-clonidine and 3H-yohimbine binding to glass fiber filters: implications for studies with platelet membranes. Psychopharmacology (Berl). 1986; 89(3):370-7.
79. Piletz JE, Halaris A. Yohimbine and clonidine recognize different states of adrenergic receptors on human platelets: reconsideration of studies on platelet alpha-2 receptors in depressive illness. Psychopharmacol Bull. 1985; 21(3):573-8.
80. Piletz JE, Herschman HR. Hepatic metallothionein synthesis in neonatal Mottled-Brindled mutant mice. Biochem Genet. 1983 Jun; 21(5-6):465-75.
81. Piletz JE, Andersen RD, Berry W, Herschman HR. Synthesis and degradation of hepatic metallothionein in mice differing in susceptibility to cadmium mortality. Biochem Genet. 1983 Jun; 21(5-6):561-78.
82. Piletz JE, Andersen RD, Birren BW, Herschman HR. Metallothionein synthesis in foetal, neonatal and maternal rat liver. Eur J Biochem. 1983 Apr 05; 131(3):489-95.
83. Andersen RD, Piletz JE, Birren BW, Herschman HR. Levels of metallothionein messenger RNA in foetal, neonatal and maternal rat liver. Eur J Biochem. 1983 Apr 05; 131(3):497-500.
84. Andersen RD, Birren BW, Ganz T, Piletz JE, Herschman HR. Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence. DNA. 1983; 2(1):15-22.
85. Piletz JE, Herschman HR. Induction of metallothionein by zinc in lethal milk mutant mice. Biochem Genet. 1982 Dec; 20(11-12):1221-33.
86. Piletz JE, Heinlen M, Ganschow RE. Biochemical characterization of a novel whey protein from murine milk. J Biol Chem. 1981 Nov 25; 256(22):11509-16.
87. Piletz JE, Ganschow RE. Genetic variation of milk proteins in mice. Biochem Genet. 1981 Oct; 19(9-10):1023-30.
88. Piletz JE, Ganschow RE. Is acrodermatitis enteropathica related to the absence of zinc binding ligand in bovine milk? Am J Clin Nutr. 1979 Feb; 32(2):275-7.
89. Piletz JE, Ganschow RE. Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation. Science. 1978 Jan 13; 199(4325):181-3.

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