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Mark W. Miller
Title Professor
Faculty Rank
Degree Ph.D.
Institution University of Puerto Rico
Department Department of Anatomy & Neurobiology
Clusters Other
Address
University of Puerto Rico
Medical Sciences Campus
P.O. Box 365067
City San Juan
State PR
Postal Code 00936
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  Dr. Mark Miller is Professor in the Department of Anatomy and Neurobiology, UPR School of Medicine and a senior investigator at the Institute of Neurobiology. Dr. Miller obtained his Bachelor’s degree from the University of Pennsylvania and his Master’s and Doctoral degrees from the University of Connecticut. His postdoctoral studies were conducted at the University of Hawaii, Hebrew University and UCLA. Before joining the UPR Medical Sciences Campus in 1992, he was a Research Associate at Columbia University.
Dr. Miller’s research focuses on motor systems, neurotransmitters, neuropeptides, and central pattern generators. His research work, which exceeds 50 publications, has been published in recognized scientific journals such as the Journal of Neuroscience, Journal of Neurophysiology, and the Journal of Comparative Neurology.
Funding for his research program has included P01, R01 grants from NINDS-NIH, the National Science Foundation (NSF), the Department of Defense, the NIGMS-NIH MBRS Program, and the NCRR-NIH RCMI Program.
Dr. Miller established a summer course in Tropical Neuroethology (NSF CAREER Award) created to bring talented undergraduate students to Puerto Rico for an intensive five-week research and educa-tional experience. He currently directs the NSF-funded Undergraduate Research Mentoring (URM) program in Neural Circuits and Behavior that provides mentored research training for undergraduates during their junior and senior years. He developed faculty workshops in neuroanatomical methods including Immunohistochemistry and In situ Hybridization and recently organized an international con-ference entitled Molluscan Neuroscience 2009: Recent Advances and New Vistas.

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1. Vaasjo LO, Quintana AM, Habib MR, Mendez de Jesus PA, Croll RP, Miller MW. GABA-like Immunoreactivity in Biomphalaria: Colocalization with Tyrosine Hydroxylase-like Immunoreactivity in the Feeding Motor Systems of Panpulmonate Snails. J Comp Neurol. 2018 Apr 06.
2. Rivera LE, Kraiselburd E, Meléndez LM. Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-ß-treated human macrophages. J Neurovirol. 2016 10; 22(5):666-673.
3. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. The a7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clin Transl Immunology. 2015 Dec; 4(12):e53.
4. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. Proteomics Clin Appl. 2016 Feb; 10(2):144-55.
5. Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM. Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. AIDS. 2015 Oct 23; 29(16):2081-92.
6. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ, Meléndez LM. HIV gp120 sequence variability associated with HAND in Hispanic Women. J Virol Antivir Res. 2015; 4(3).
7. Wolf EJ, Logue MW, Hayes JP, Sadeh N, Schichman SA, Stone A, Salat DH, Milberg W, McGlinchey R, Miller MW. Accelerated DNA methylation age: Associations with PTSD and neural integrity. Psychoneuroendocrinology. 2016 Jan; 63:155-62.
8. Miller MW, Wolf EJ, Sadeh N, Logue M, Spielberg JM, Hayes JP, Sperbeck E, Schichman SA, Stone A, Carter WC, Humphries DE, Milberg W, McGlinchey R. A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex. Psychoneuroendocrinology. 2015 Dec; 62:359-65.
9. Habib MR, Mohamed AH, Osman GY, Sharaf El-Din AT, Mossalem HS, Delgado N, Torres G, Rolón-Martínez S, Miller MW, Croll RP. Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni. PLoS One. 2015; 10(6):e0129800.
10. Sadeh N, Spielberg JM, Miller MW, Milberg WP, Salat DH, Amick MM, Fortier CB, McGlinchey RE. Neurobiological indicators of disinhibition in posttraumatic stress disorder. Hum Brain Mapp. 2015 Aug; 36(8):3076-86.
11. Logue MW, Smith AK, Baldwin C, Wolf EJ, Guffanti G, Ratanatharathorn A, Stone A, Schichman SA, Humphries D, Binder EB, Arloth J, Menke A, Uddin M, Wildman D, Galea S, Aiello AE, Koenen KC, Miller MW. An analysis of gene expression in PTSD implicates genes involved in the glucocorticoid receptor pathway and neural responses to stress. Psychoneuroendocrinology. 2015 Jul; 57:1-13.
12. Vázquez-Santiago F, García Y, Rivera-Román I, Noel RJ, Wojna V, Meléndez LM, Rivera-Amill V. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. J Virol Antivir Res. 2015; 4(1).
13. Zenón F, Segarra AC, Gonzalez M, Meléndez LM. Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. J Neuroimmune Pharmacol. 2014 Dec; 9(5):703-15.
14. Vallejo D, Habib MR, Delgado N, Vaasjo LO, Croll RP, Miller MW. Localization of tyrosine hydroxylase-like immunoreactivity in the nervous systems of Biomphalaria glabrata and Biomphalaria alexandrina, intermediate hosts for schistosomiasis. J Comp Neurol. 2014 Aug 01; 522(11):2532-52.
15. Agsalda-Garcia M, Shiramizu B, Melendez L, Plaud M, Liang CY, Wojna V. Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):8-16.
16. Cantres-Rosario Y, Plaud-Valentín M, Gerena Y, Skolasky RL, Wojna V, Meléndez LM. Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 2013 Jan 28; 27(3):347-56.
17. Delgado N, Vallejo D, Miller MW. Localization of serotonin in the nervous system of Biomphalaria glabrata, an intermediate host for schistosomiasis. J Comp Neurol. 2012 Oct 01; 520(14):3236-55.
18. Rodriguez-Franco EJ, Cantres-Rosario YM, Plaud-Valentin M, Romeu R, Rodríguez Y, Skolasky R, Meléndez V, Cadilla CL, Melendez LM. Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. PLoS One. 2012; 7(5):e36571.
19. Rivera-Rivera L, Perez-Laspiur J, Colón K, Meléndez LM. Inhibition of interferon response by cystatin B: implication in HIV replication of macrophage reservoirs. J Neurovirol. 2012 Feb; 18(1):20-9.
20. García-Crescioni K, Miller MW. Revisiting the reticulum: feedforward and feedback contributions to motor program parameters in the crab cardiac ganglion microcircuit. J Neurophysiol. 2011 Oct; 106(4):2065-77.
21. Meléndez LM, Colon K, Rivera L, Rodriguez-Franco E, Toro-Nieves D. Proteomic analysis of HIV-infected macrophages. J Neuroimmune Pharmacol. 2011 Mar; 6(1):89-106.
22. Kraft-Terry S, Gerena Y, Wojna V, Plaud-Valentin M, Rodriguez Y, Ciborowski P, Mayo R, Skolasky R, Gendelman HE, Meléndez LM. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl. 2010 Sep; 4(8-9):706-14.
23. Martínez-Rubio C, Serrano GE, Miller MW. Octopamine promotes rhythmicity but not synchrony in a bilateral pair of bursting motor neurons in the feeding circuit of Aplysia. J Exp Biol. 2010 Apr; 213(Pt 7):1182-94.
24. García-Crespo K, Cadilla C, Skolasky R, Meléndez LM. Restricted HIV-1 replication in placental macrophages is caused by inefficient viral transcription. J Leukoc Biol. 2010 Apr; 87(4):633-6.
25. Wentzell MM, Martínez-Rubio C, Miller MW, Murphy AD. Comparative neurobiology of feeding in the opisthobranch sea slug, Aplysia, and the pulmonate snail, Helisoma: evolutionary considerations. Brain Behav Evol. 2009; 74(3):219-30.
26. García-Crescioni K, Fort TJ, Stern E, Brezina V, Miller MW. Feedback from peripheral musculature to central pattern generator in the neurogenic heart of the crab Callinectes sapidus: role of mechanosensitive dendrites. J Neurophysiol. 2010 Jan; 103(1):83-96.
27. Martínez-Rubio C, Serrano GE, Miller MW. Localization of biogenic amines in the foregut of Aplysia californica: catecholaminergic and serotonergic innervation. J Comp Neurol. 2009 Jun 01; 514(4):329-42.
28. Luciano-Montalvo C, Meléndez LM. Cystatin B associates with signal transducer and activator of transcription 1 in monocyte-derived and placental macrophages. Placenta. 2009 May; 30(5):464-7.
29. Toro-Nieves DM, Rodriguez Y, Plaud M, Ciborowski P, Duan F, Pérez Laspiur J, Wojna V, Meléndez LM. Proteomic analyses of monocyte-derived macrophages infected with human immunodeficiency virus type 1 primary isolates from Hispanic women with and without cognitive impairment. J Neurovirol. 2009 Jan; 15(1):36-50.
30. Velázquez I, Plaud M, Wojna V, Skolasky R, Laspiur JP, Meléndez LM. Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment. J Neuroimmunol. 2009 Jan 03; 206(1-2):106-11.
31. García K, García V, Pérez Laspiur J, Duan F, Meléndez LM. Characterization of the placental macrophage secretome: implications for antiviral activity. Placenta. 2009 Feb; 30(2):149-55.
32. Luciano-Montalvo C, Ciborowski P, Duan F, Gendelman HE, Meléndez LM. Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages. Placenta. 2008 Dec; 29(12):1016-23.
33. Wojna V, Robles L, Skolasky RL, Mayo R, Selnes O, de la Torre T, Maldonado E, Nath A, Meléndez LM, Lasalde-Dominicci J. Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women. J Neurovirol. 2007 Dec; 13(6):561-8.
34. Laspiur JP, Anderson ER, Ciborowski P, Wojna V, Rozek W, Duan F, Mayo R, Rodríguez E, Plaud-Valentín M, Rodríguez-Orengo J, Gendelman HE, Meléndez LM. CSF proteomic fingerprints for HIV-associated cognitive impairment. J Neuroimmunol. 2007 Dec; 192(1-2):157-70.
35. Rozek W, Ricardo-Dukelow M, Holloway S, Gendelman HE, Wojna V, Melendez LM, Ciborowski P. Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. J Proteome Res. 2007 Nov; 6(11):4189-99.
36. Fort TJ, Brezina V, Miller MW. Regulation of the crab heartbeat by FMRFamide-like peptides: multiple interacting effects on center and periphery. J Neurophysiol. 2007 Nov; 98(5):2887-902.
37. Nieves DM, Plaud M, Wojna V, Skolasky R, Meléndez LM. Characterization of peripheral blood human immunodeficiency virus isolates from Hispanic women with cognitive impairment. J Neurovirol. 2007 Aug; 13(4):315-27.
38. Stern E, Fort TJ, Miller MW, Peskin CS, Brezina V. Decoding modulation of the neuromuscular transform. Neurocomputing. 2007 Jun 01; 70(10):1753-1758.
39. Serrano GE, Martínez-Rubio C, Miller MW. Endogenous motor neuron properties contribute to a program-specific phase of activity in the multifunctional feeding central pattern generator of Aplysia. J Neurophysiol. 2007 Jul; 98(1):29-42.
40. Fort TJ, García-Crescioni K, Agricola HJ, Brezina V, Miller MW. Regulation of the crab heartbeat by crustacean cardioactive peptide (CCAP): central and peripheral actions. J Neurophysiol. 2007 May; 97(5):3407-20.
41. Wojna V, Skolasky RL, Hechavarría R, Mayo R, Selnes O, McArthur JC, Meléndez LM, Maldonado E, Zorrilla CD, García H, Kraiselburd E, Nath A. Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment. J Neurovirol. 2006 Oct; 12(5):356-64.
42. Díaz-Ríos M, Miller MW. Target-specific regulation of synaptic efficacy in the feeding central pattern generator of Aplysia: potential substrates for behavioral plasticity? Biol Bull. 2006 Jun; 210(3):215-29.
43. Serrano GE, Miller MW. Conditional rhythmicity and synchrony in a bilateral pair of bursting motor neurons in Aplysia. J Neurophysiol. 2006 Oct; 96(4):2056-71.
44. Miller MW, Gronfier C. Diurnal variation of the startle reflex in relation to HPA-axis activity in humans. Psychophysiology. 2006 May; 43(3):297-301.
45. Díaz-Ríos M, Miller MW. Rapid dopaminergic signaling by interneurons that contain markers for catecholamines and GABA in the feeding circuitry of Aplysia. J Neurophysiol. 2005 Apr; 93(4):2142-56.
46. Fort TJ, Brezina V, Miller MW. Modulation of an integrated central pattern generator-effector system: dopaminergic regulation of cardiac activity in the blue crab Callinectes sapidus. J Neurophysiol. 2004 Dec; 92(6):3455-70.
47. Painter SD, Cummins SF, Nichols AE, Akalal DB, Schein CH, Braun W, Smith JS, Susswein AJ, Levy M, de Boer PA, ter Maat A, Miller MW, Scanlan C, Milberg RM, Sweedler JV, Nagle GT. Structural and functional analysis of Aplysia attractins, a family of water-borne protein pheromones with interspecific attractiveness. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):6929-33.
48. Walters ET, Bodnarova M, Billy AJ, Dulin MF, Díaz-Ríos M, Miller MW, Moroz LL. Somatotopic organization and functional properties of mechanosensory neurons expressing sensorin-A mRNA in Aplysia californica. J Comp Neurol. 2004 Mar 29; 471(2):219-40.
49. Wojna V, Carlson KA, Luo X, Mayo R, Meléndez LM, Kraiselburd E, Gendelman HE. Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study. J Neurovirol. 2004; 10 Suppl 1:74-81.
50. Luo X, Carlson KA, Wojna V, Mayo R, Biskup TM, Stoner J, Anderson J, Gendelman HE, Meléndez LM. Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment. Neurology. 2003 Jun 24; 60(12):1931-7.
51. Wu JS, Jing J, Díaz-Ríos M, Miller MW, Kupfermann I, Weiss KR. Identification of a GABA-containing cerebral-buccal interneuron-11 in Aplysia californica. Neurosci Lett. 2003 Apr 24; 341(1):5-8.
52. Robie A, Díaz-Ríos M, Miller MW. A population of pedal-buccal projection neurons associated with appetitive components of Aplysia feeding behavior. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2003 Mar; 189(3):231-44.
53. Díaz-Ríos M, Oyola E, Miller MW. Colocalization of gamma-aminobutyric acid-like immunoreactivity and catecholamines in the feeding network of Aplysia californica. J Comp Neurol. 2002 Mar 25; 445(1):29-46.
54. Delgado JY, Oyola E, Miller MW. Localization of GABA- and glutamate-like immunoreactivity in the cardiac ganglion of the lobster Panulirus argus. J Neurocytol. 2000 Aug; 29(8):605-19.
55. Díaz-Ríos M, Suess E, Miller MW. Localization of GABA-like immunoreactivity in the central nervous system of Aplysia californica. J Comp Neurol. 1999 Oct 18; 413(2):255-70.
56. Miller MW. A cellular approach to the study of complex natural behavior patterns in the ragged sea hare (Bursatella leachii), a marine invertebrate indigenous to Puerto Rico. P R Health Sci J. 1997 Mar; 16(1):23-36.
57. Giardino ND, Aloyz RS, Zollinger M, Miller MW, DesGroseillers L. L5-67 and LUQ-1 peptide precursors of Aplysia californica: distribution and localization of immunoreactivity in the central nervous system and in peripheral tissues. J Comp Neurol. 1996 Oct 14; 374(2):230-45.
58. Ramos LJ, Lopez Rocafort JL, Miller MW. Behavior patterns of the aplysiid gastropod Bursatella leachii in its natural habitat and in the laboratory. Neurobiol Learn Mem. 1995 May; 63(3):246-59.

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