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Lynn Francesconi
Title Professor of Chemistry
Faculty Rank
Degree Ph.D.
Institution Hunter College, CUNY
Department Chemistry
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Room 1307 HN, Hunter College, CUNY
695 Park Avenue
City New York
State NY
Postal Code 10065
Telephone (212) 772-5353
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Email
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1. Poty S, Francesconi LC, McDevitt MR, Morris MJ, Lewis JS. Alpha Emitters for Radiotherapy: Basic Radiochemistry to Clinical Studies _ Part 1. J Nucl Med. 2018 Mar 15.
2. Poty S, Francesconi LC, McDevitt MR, Morris MJ, Lewis JS. Alpha Emitters for Radiotherapy: Basic Radiochemistry to Clinical Studies - Part 2. J Nucl Med. 2018 Mar 01.
3. Gupta R, Huang W, Francesconi LC, Polenova T. Effect of positional isomerism and vanadium substitution on 51V magic angle spinning NMR Spectra Of Wells-Dawson polyoxotungstates. Solid State Nucl Magn Reson. 2017 Jul - Aug; 84:28-33.
4. Yazdani A, Bilton H, Vito A, Genady AR, Rathmann SM, Ahmad Z, Janzen N, Czorny S, Zeglis BM, Francesconi LC, Valliant JF. A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines. J Med Chem. 2016 Oct 27; 59(20):9381-9389.
5. Deri MA, Ponnala S, Kozlowski P, Burton-Pye BP, Cicek HT, Hu C, Lewis JS, Francesconi LC. p-SCN-Bn-HOPO: A Superior Bifunctional Chelator for (89)Zr ImmunoPET. Bioconjug Chem. 2015 Dec 16; 26(12):2579-91.
6. Wagner T, Zeglis BM, Groveman S, Hille C, Pöthig A, Francesconi LC, Herrmann WA, Kühn FE, Reiner T. Synthesis of the first radiolabeled 188Re N-heterocyclic carbene complex and initial studies on its potential use in radiopharmaceutical applications. J Labelled Comp Radiopharm. 2014 Jun 15; 57(7):441-7.
7. Deri MA, Ponnala S, Zeglis BM, Pohl G, Dannenberg JJ, Lewis JS, Francesconi LC. Alternative chelator for 8?Zr radiopharmaceuticals: radiolabeling and evaluation of 3,4,3-(LI-1,2-HOPO). J Med Chem. 2014 Jun 12; 57(11):4849-60.
8. Thompson S, Ballard B, Jiang Z, Revskaya E, Sisay N, Miller WH, Cutler CS, Dadachova E, Francesconi LC. 166Ho and 90Y labeled 6D2 monoclonal antibody for targeted radiotherapy of melanoma: comparison with 188Re radiolabel. Nucl Med Biol. 2014 Mar; 41(3):276-81.
9. Poineau F, Weck PF, Burton-Pye BP, Denden I, Kim E, Kerlin W, German KE, Fattahi M, Francesconi LC, Sattelberger AP, Czerwinski KR. Reactivity of HTcO(4) with methanol in sulfuric acid: Tc-sulfate complexes revealed by XAFS spectroscopy and first principles calculations. Dalton Trans. 2013 Apr 07; 42(13):4348-52.
10. Gordon JC, Czerwinski K, Francesconi L. Preface: forum on aspects of inorganic chemistry related to nuclear energy. Inorg Chem. 2013 Apr 01; 52(7):3405-6.
11. Deri MA, Zeglis BM, Francesconi LC, Lewis JS. PET imaging with 8?Zr: from radiochemistry to the clinic. Nucl Med Biol. 2013 Jan; 40(1):3-14.
12. McGregor D, Burton-Pye BP, Mbomekalle IM, Aparicio PA, Romo S, López X, Poblet JM, Francesconi LC. 99Tc and Re incorporated into metal oxide polyoxometalates: oxidation state stability elucidated by electrochemistry and theory. Inorg Chem. 2012 Aug 20; 51(16):9017-28.
13. Radivojevic I, Bazzan G, Burton-Pye BP, Ithisuphalap K, Saleh R, Durstock MF, Francesconi LC, Drain CM. Zirconium((IV)) and Hafnium((IV)) Porphyrin and Phthalocyanine Complexes as New Dyes for Solar Cell Devices. J Phys Chem C Nanomater Interfaces. 2012 Aug 02; 116(30):15867-15877.
14. Burton-Pye BP, Radivojevic I, McGregor D, Mbomekalle IM, Lukens WW, Francesconi LC. Photoreduction of 99Tc pertechnetate by nanometer-sized metal oxides: new strategies for formation and sequestration of low-valent technetium. J Am Chem Soc. 2011 Nov 23; 133(46):18802-15.
15. Ballard B, Jiang Z, Soll CE, Revskaya E, Cutler CS, Dadachova E, Francesconi LC. In vitro and in vivo evaluation of melanin-binding decapeptide 4B4 radiolabeled with 177Lu, 166Ho, and 153Sm radiolanthanides for the purpose of targeted radionuclide therapy of melanoma. Cancer Biother Radiopharm. 2011 Oct; 26(5):547-56.
16. Burton-Pye BP, Francesconi LC. Speciation of organic-soluble europium(III) a1-Wells-Dawson complexes. Dalton Trans. 2011 May 07; 40(17):4421-33.
17. McGregor D, Burton-Pye BP, Howell RC, Mbomekalle IM, Lukens WW, Bian F, Mausolf E, Poineau F, Czerwinski KR, Francesconi LC. Synthesis, structure elucidation, and redox properties of 99Tc complexes of lacunary Wells-Dawson polyoxometalates: insights into molecular 99Tc-metal oxide interactions. Inorg Chem. 2011 Mar 07; 50(5):1670-81.
18. Antonio MR, Jing J, Burton-Pye BP, Francesconi LC. Series behavior of lanthanoid(III) complexes with the alpha-1-Wells-Dawson heteropolyoxoanion in acetonitrile: electrochemistry and Ln coordination. Dalton Trans. 2010 Sep 14; 39(34):7980-92.
19. Jyothish K, Vemula PK, Jadhav SR, Francesconi LC, John G. Self-standing, metal nanoparticle embedded transparent films from multi-armed cardanol conjugates through in situ synthesis. Chem Commun (Camb). 2009 Sep 28; (36):5368-70.
20. Falber A, Burton-Pye BP, Radivojevic I, Todaro L, Saleh R, Francesconi L, Drain CM. Ternary Porphyrinato Hf(IV) and Zr(IV) - Polyoxometalate Complexes. Eur J Inorg Chem. 2009 Jun 01; 2009(17):2459-2466.
21. Mishra PP, Jing J, Francesconi LC, Liu T. Self-assembly of Yttrium-containing lacunary polyoxotungstate macroanions in solution with controllable supramolecular structure size by pH or solvent content. Langmuir. 2008 Sep 02; 24(17):9308-13.
22. Jing J, Burton-Pye BP, Francesconi LC, Antonio MR. Europium(III) reduction and speciation within a Wells-Dawson heteropolytungstate. Inorg Chem. 2008 Aug 04; 47(15):6889-99.
23. Bazzan G, Smith W, Francesconi LC, Drain CM. Electrostatic self-organization of robust porphyrin-polyoxometalate films. Langmuir. 2008 Apr 01; 24(7):3244-9.
24. Huang W, Schopfer M, Zhang C, Howell RC, Todaro L, Gee BA, Francesconi LC, Polenova T. 31P magic angle spinning NMR spectroscopy of paramagnetic rare-earth-substituted Keggin and Wells-Dawson solids. J Am Chem Soc. 2008 Jan 16; 130(2):481-90.
25. Huang W, Francesconi LC, Polenova T. (31)P magic angle spinning NMR spectroscopy for probing local environments in paramagnetic europium-substituted wells-dawson polyoxotungstates. Inorg Chem. 2007 Sep 17; 46(19):7861-9.
26. Cyr JE, Pearson DA, Nelson CA, Lyons BA, Zheng Y, Bartis J, He J, Cantorias MV, Howell RC, Francesconi LC. Isolation, characterization, and biological evaluation of syn and anti diastereomers of [(99m)Tc]technetium depreotide: a somatostatin receptor binding tumor imaging agent. J Med Chem. 2007 Sep 06; 50(18):4295-303.
27. Cantorias MV, Howell RC, Todaro L, Cyr JE, Berndorff D, Rogers RD, Francesconi LC. MO tripeptide diastereomers (M=99/99mTc, Re): models to identify the structure of 99mTc peptide targeted radiopharmaceuticals. Inorg Chem. 2007 Sep 03; 46(18):7326-40.
28. Huang W, Schopfer M, Zhang C, Howell RC, Gee BA, Francesconi LC, Polenova T. Probing local environments in paramagnetic europium-substituted Keggin solids by 31P magic angle spinning NMR spectroscopy. J Phys Chem B. 2006 Jun 29; 110(25):12340-50.
29. Boglio C, Lenoble G, Duhayon C, Hasenknopf B, Thouvenot R, Zhang C, Howell RC, Burton-Pye BP, Francesconi LC, Lacôte E, Thorimbert S, Malacria M, Afonso C, Tabet JC. Production and reactions of organic-soluble lanthanide complexes of the monolacunary Dawson [alpha1-P2W17O61]10- polyoxotungstate. Inorg Chem. 2006 Feb 06; 45(3):1389-98.
30. Zhang X, Zhang C, Guo H, Huang W, Polenova T, Francesconi LC, Akins DL. Optical spectra of a novel polyoxometalate occluded within modified MCM-41. J Phys Chem B. 2005 Oct 20; 109(41):19156-60.
31. Zhang C, Howell RC, Luo QH, Fieselmann HL, Todaro LJ, Francesconi LC. Influence of steric and electronic properties of the defect site, lanthanide ionic radii, and solution conditions on the composition of lanthanide(III) alpha1-P2W17O6110- polyoxometalates. Inorg Chem. 2005 May 16; 44(10):3569-78.
32. Banerjee SR, Maresca KP, Francesconi L, Valliant J, Babich JW, Zubieta J. New directions in the coordination chemistry of 99mTc: a reflection on technetium core structures and a strategy for new chelate design. Nucl Med Biol. 2005 Jan; 32(1):1-20.
33. Zhang C, Howell RC, Scotland KB, Perez FG, Todaro L, Francesconi LC. Aqueous speciation studies of europium(III) phosphotungstate. Inorg Chem. 2004 Nov 29; 43(24):7691-701.
34. Huang W, Todaro L, Yap GP, Beer R, Francesconi LC, Polenova T. 51V magic angle spinning NMR spectroscopy of Keggin anions [PVnW12-nO40](3+n)-: effect of countercation and vanadium substitution on fine structure constants. J Am Chem Soc. 2004 Sep 22; 126(37):11564-73.
35. Francesconi LC, Zheng Y, Bartis J, Blumenstein M, Costello C, De Rosch MA. Preparation and characterization of [99TcO] apcitide: a technetium labeled peptide. Inorg Chem. 2004 May 03; 43(9):2867-75.
36. Huang W, Todaro L, Francesconi LC, Polenova T. 51V magic angle spinning NMR spectroscopy of six-coordinate Lindqvist oxoanions: a sensitive probe for the electronic environment in vanadium-containing polyoxometalates. Counterions dictate the 51V fine structure constants in polyoxometalate solids. J Am Chem Soc. 2003 May 14; 125(19):5928-38.
37. Luo Q, Howell RC, Bartis J, Dankova M, Horrocks WD, Rheingold AL, Francesconi LC. Lanthanide complexes of [alpha-2-P2W17O61]10-: solid state and solution studies. Inorg Chem. 2002 Nov 18; 41(23):6112-7.
38. Efange SM, Tu Z, von Hohenberg K, Francesconi L, Howell RC, Rampersad MV, Todaro LJ, Papke RL, Kung MP. 2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization. J Med Chem. 2001 Dec 20; 44(26):4704-15.
39. Howell RC, Perez FG, Jain S, DeW Horrocks W, Rheingold AL, Francesconi LC. A New Type of Heteropolyoxometalates formed from Lacunary Polyoxotungstate Ions and Europium or Yttrium Cations We gratefully acknowledge Dr. Gerard Parkin and Dr. Brian Bridgewater for the use of the diffractometer at Columbia University and helpful discussions. Supported by NSF-CHE9502213, NIH-GM60654-01 (LCF), NIH-MARC (FGP), NSF-CHE-9705788 (W.D.H), and NSF Grant PCM8111745 for the purchase of the 400 MHz Spectrometer. Infrastructure at Hunter College is supported in part by NIH-Research Centers in Minority Institutions Grant RR03037-08S2. Angew Chem Int Ed Engl. 2001 11 05; 40(21):4031-4034.
40. Luo QH, Howell RC, Dankova M, Bartis J, Williams CW, Horrocks WD, Young VG, Rheingold AL, Francesconi LC, Antonio MR. Coordination of rare-earth elements in complexes with monovacant Wells-Dawson polyoxoanions. Inorg Chem. 2001 Apr 09; 40(8):1894-901.
41. Bartis J, Dankova M, Lessmann JJ, Luo QH, Horrocks WD, Francesconi LC. Lanthanide Complexes of the alpha-1 Isomer of the [P(2)W(17)O(61)](10-) Heteropolytungstate: Preparation, Stoichiometry, and Structural Characterization by (183)W and (31)P NMR Spectroscopy and Europium(III) Luminescence Spectroscopy. Inorg Chem. 1999 Mar 22; 38(6):1042-1053.
42. Zheng YY, Saluja S, Yap GP, Blumenstein M, Rheingold AL, Francesconi LC. Gallium and Indium Complexes of Bis(amino thiol) (N(2)S(2)) Ligands. Inorg Chem. 1996 Nov 06; 35(23):6656-6666.
43. Bartis J, Kunina Y, Blumenstein M, Francesconi LC. Preparation and Tungsten-183 NMR Characterization of [alpha-1-P(2)W(17)O(61)](10)(-), [alpha-1-Zn(H(2)O)P(2)W(17)O(61)](8)(-), and [alpha-2-Zn(H(2)O)P(2)W(17)O(61)](8)(-). Inorg Chem. 1996 Mar 13; 35(6):1497-1501.
44. Francesconi LC, Yang YY, Kung MP, Zhang XX, Billings JJ, Guo YZ, Kung HF. Technetium-99m N,N'-bis(2-mercapto-2-methylpropyl)-2-aminobenzylamine: technetium-99m complexes of a novel bis(aminoethanethiol) ligand. J Med Chem. 1994 Sep 30; 37(20):3282-8.
45. Canney DJ, Billings J, Francesconi LC, Guo YZ, Haggerty BS, Rheingold AL, Kung HF. Dicarboxylate diamide dimercaptide (N2S2) technetium-99m complexes: synthesis and biological evaluation as potential renal radiopharmaceuticals. J Med Chem. 1993 Apr 16; 36(8):1032-40.
46. Ohmomo Y, Francesconi L, Kung MP, Kung HF. New conformationally restricted 99mTc N2S2 complexes as myocardial perfusion imaging agents. J Med Chem. 1992 Jan; 35(1):157-62.
47. Kung HF, Liu BL, Mankoff D, Kung MP, Billings JJ, Francesconi L, Alavi A. A new myocardial imaging agent: synthesis, characterization, and biodistribution of gallium-68-BAT-TECH. J Nucl Med. 1990 Oct; 31(10):1635-40.
48. Pasternack RF, Huber PR, Boyd P, Engasser G, Francesconi L, Gibbs E, Fasella P, Venturo GC, Hinds Lde C. On the aggregation of meso-substituted water-soluble porphyrins. J Am Chem Soc. 1972 Jun 28; 94(13):4511-7.

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