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Elizabeth Mazzio
Title Professor
Faculty Rank
Degree PHD
Institution Florida A&M University
Department college of pharmacy
Clusters Cancer
Cardiovascular and Related Diseases
College of Pharmacy - Florida A and M University
241 SRB
City Tallahassee
State FL
Postal Code 32307
Telephone 8506945127
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Institution Florida A & M University
Department Pharmacy

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1. Badisa RB, Batton CS, Mazzio E, Grant SC, Goodman CB. Identification of biochemical and cytotoxic markers in cocaine treated PC12 cells. Sci Rep. 2018 Feb 09; 8(1):2710.
2. Mazzio EA, Lewis CA, Soliman KFA. Transcriptomic Profiling of MDA-MB-231 Cells Exposed to Boswellia Serrata and 3-O-Acetyl-B-Boswellic Acid; ER/UPR Mediated Programmed Cell Death. Cancer Genomics Proteomics. 2017 Nov-Dec; 14(6):409-425.
3. Bauer D, Redmon N, Mazzio E, Soliman KF. Apigenin inhibits TNFa/IL-1a-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cells. PLoS One. 2017; 12(4):e0175558.
4. Mack N, Mazzio EA, Bauer D, Flores-Rozas H, Soliman KF. Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival. Anticancer Res. 2017 03; 37(3):1205-1212.
5. Mazzio EA, Soliman KF. HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics. 2017 01 02; 14(1):17-33.
6. Mazzio EA, Bauer D, Mendonca P, Taka E, Soliman KF. Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFN? activated glioma cells. J Neuroimmunol. 2017 Jan 15; 302:10-19.
7. Mazzio EA, Li N, Bauer D, Mendonca P, Taka E, Darb M, Thomas L, Williams H, Soliman KF. Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis. BMC Complement Altern Med. 2016 Nov 15; 16(1):467.
8. Gangapuram M, Jean R, Mazzio E, Badisa R, Eyunni S, Goodman CB, Redda KK, Soliman KF. Substituted Tetrahydroisoquinolines as Microtubule-destabilizing Agents in Triple Negative Human Breast Cancer Cells. Anticancer Res. 2016 10; 36(10):5043-5052.
9. Ramsubhag RR, Massaro CL, Dadich CM, Janeczek AJ, Hoang TT, Mazzio EA, Eyunni S, Soliman KF, Dudley GB. Synthesis of "neoprofen", a rigidified analogue of ibuprofen, exemplifying synthetic methodology for altering the 3-D topology of pharmaceutical substances. Org Biomol Chem. 2016 Aug 16; 14(33):7855-8.
10. Zarmouh NO, Mazzio EA, Elshami FM, Messeha SS, Eyunni SV, Soliman KF. Evaluation of the Inhibitory Effects of Bavachinin and Bavachin on Human Monoamine Oxidases A and B. Evid Based Complement Alternat Med. 2015; 2015:852194.
11. Mochona B, Jackson T, McCauley D, Mazzio E, Redda KK. Synthesis and Cytotoxic Evaluation of Pyrrole Hetarylazoles Containing Benzimidazole/Pyrazolone/1,3,4-Oxadiazole Motifs. J Heterocycl Chem. 2016 11; 53(6):1871-1877.
12. Taka E, Mazzio EA, Goodman CB, Redmon N, Flores-Rozas H, Reams R, Darling-Reed S, Soliman KF. Anti-inflammatory effects of thymoquinone in activated BV-2 microglial cells. J Neuroimmunol. 2015 Sep 15; 286:5-12.
13. Bauer D, Redmon N, Mazzio E, Taka E, Reuben JS, Day A, Sadrud-Din S, Flores-Rozas H, Soliman KF, Darling-Reed S. Diallyl disulfide inhibits TNFa induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling. Cytokine. 2015 Sep; 75(1):117-26.
14. Mazzio E, Georges B, McTier O, Soliman KF. Neurotrophic Effects of Mu Bie Zi (Momordica cochinchinensis) Seed Elucidated by High-Throughput Screening of Natural Products for NGF Mimetic Effects in PC-12 Cells. Neurochem Res. 2015 Oct; 40(10):2102-12.
15. Mateeva N, Gangapuram M, Mazzio E, Eyunni S, Soliman KF, Redda KK. Biological evaluation of synthetic chalcone and flavone derivatives as anti-inflammatory agents. Med Chem Res. 2015 Apr; 24(4):1672-1680.
16. Mochona B, Mazzio E, Gangapurum M, Mateeva N, Redda KK. Synthesis of Some Benzimidazole Derivatives Bearing 1,3,4-Oxadiazole Moiety as Anticancer Agents. Chem Sci Trans. 2015 Apr; 4(2):534-540.
17. Deiab S, Mazzio E, Eyunni S, McTier O, Mateeva N, Elshami F, Soliman KF. 1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells. Evid Based Complement Alternat Med. 2015; 2015:276946.
18. Elhag R, Mazzio EA, Soliman KF. The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines. Anticancer Res. 2015 Mar; 35(3):1263-9.
19. Badisa RB, Kumar SS, Mazzio E, Haughbrook RD, Allen JR, Davidson MW, Fitch-Pye CA, Goodman CB. N-acetyl cysteine mitigates the acute effects of cocaine-induced toxicity in astroglia-like cells. PLoS One. 2015; 10(1):e0114285.
20. Mazzio KA, Luscombe CK. The future of organic photovoltaics. Chem Soc Rev. 2015 Jan 07; 44(1):78-90.
21. Bauer D, Mazzio E, Soliman KF, Taka E, Oriaku E, Womble T, Darling-Reed S. Diallyl disulfide inhibits TNFa-induced CCL2 release by MDA-MB-231 cells. Anticancer Res. 2014 Jun; 34(6):2763-70.
22. Mazzio EA, Soliman KF. Epigenetics and nutritional environmental signals. Integr Comp Biol. 2014 Jul; 54(1):21-30.
23. Gangapuram M, Mazzio E, Eyunni S, Soliman KF, Redda KK. Synthesis and biological evaluation of substituted N-[3-(1H-pyrrol-1-yl)methyl]-1,2,5,6-tetrahydropyridin-1-yl]benzamide/benzene sulfonamides as anti-inflammatory agents. Arch Pharm (Weinheim). 2014 May; 347(5):360-9.
24. Mazzio E, Badisa R, Mack N, Deiab S, Soliman KF. High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells. Phytother Res. 2014 Jun; 28(6):856-67.
25. Mazzio KA, Okamoto K, Li Z, Gutmann S, Strein E, Ginger DS, Schlaf R, Luscombe CK. A one pot organic/CdSe nanoparticle hybrid material synthesis with in situ p-conjugated ligand functionalization. Chem Commun (Camb). 2013 Feb 14; 49(13):1321-3.
26. Stephenson AP, Schneider JA, Nelson BC, Atha DH, Jain A, Soliman KF, Aschner M, Mazzio E, Renee Reams R. Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: attenuation of thymine base lesions by glutathione and N-acetylcysteine. Toxicol Lett. 2013 Apr 26; 218(3):299-307.
27. Deiab S, Mazzio E, Messeha S, Mack N, Soliman KF. High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors. European J Med Plants. 2013; 3(4):603-615.
28. Mazzio E, Deiab S, Park K, Soliman KF. High throughput screening to identify natural human monoamine oxidase B inhibitors. Phytother Res. 2013 Jun; 27(6):818-28.
29. Mazzio E, Soliman KF. Whole genome expression profile in neuroblastoma cells exposed to 1-methyl-4-phenylpyridine. Neurotoxicology. 2012 Oct; 33(5):1156-69.
30. Russell LH, Mazzio E, Badisa RB, Zhu ZP, Agharahimi M, Oriaku ET, Goodman CB. Autoxidation of gallic acid induces ROS-dependent death in human prostate cancer LNCaP cells. Anticancer Res. 2012 May; 32(5):1595-602.
31. Mazzio EA, Boukli N, Rivera N, Soliman KF. Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. Cancer Sci. 2012 Mar; 103(3):422-32.
32. Mazzio EA, Soliman KF. Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics. 2012 Feb; 7(2):119-30.
33. Taka E, Mazzio E, Soliman KF, Renee Reams R. Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells. Neurotoxicology. 2012 Mar; 33(2):162-8.
34. Russell LH, Mazzio E, Badisa RB, Zhu ZP, Agharahimi M, Millington DJ, Goodman CB. Differential cytotoxicity of triphala and its phenolic constituent gallic acid on human prostate cancer LNCap and normal cells. Anticancer Res. 2011 Nov; 31(11):3739-45.
35. Mazzio EA, Close F, Soliman KF. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. Int J Mol Sci. 2011 Jan 17; 12(1):506-69.
36. Mazzio EA, Soliman KF. In vitro screening of tumoricidal properties of international medicinal herbs: part II. Phytother Res. 2010 Dec; 24(12):1813-24.
37. Mazzio EA, Soliman YI, Soliman KF. Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell lines. Cell Biol Toxicol. 2010 Dec; 26(6):527-39.
38. Mazzio EA, Smith B, Soliman KF. Evaluation of endogenous acidic metabolic products associated with carbohydrate metabolism in tumor cells. Cell Biol Toxicol. 2010 Jun; 26(3):177-88.
39. Mazzio EA, Soliman KF. In vitro screening for the tumoricidal properties of international medicinal herbs. Phytother Res. 2009 Mar; 23(3):385-98.
40. Soliman Y, Jackson T, Mazzio E, Soliman KF. The effects of piroxicam in the attenuation of MPP+/MPTP toxicity in vitro and in vivo. Neurochem Res. 2009 Feb; 34(2):304-10.
41. Mazzio EA, Kolta MG, Reams RR, Soliman KF. Inhibitory effects of cigarette smoke on glial inducible nitric oxide synthase and lack of protective properties against oxidative neurotoxins in vitro. Neurotoxicology. 2005 Jan; 26(1):49-62.
42. Mazzio EA, Reams RR, Soliman KF. The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro. Brain Res. 2004 Apr 09; 1004(1-2):29-44.
43. Mazzio EA, Soliman KF. Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells. Biochem Pharmacol. 2004 Mar 15; 67(6):1167-84.
44. Mazzio EA, Soliman KF. Glioma cell antioxidant capacity relative to reactive oxygen species produced by dopamine. J Appl Toxicol. 2004 Mar-Apr; 24(2):99-106.
45. Mazzio E, Yoon KJ, Soliman KF. Acetyl-L-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells. Biochem Pharmacol. 2003 Jul 15; 66(2):297-306.
46. Mazzio E, Becker A, Soliman KF. Inflammation and inducible nitric oxide synthase have no effect on monoamine oxidase activity in glioma cells. Biochem Pharmacol. 2003 May 15; 65(10):1719-27.
47. Mazzio EA, Soliman KF. Cytoprotection of pyruvic acid and reduced beta-nicotinamide adenine dinucleotide against hydrogen peroxide toxicity in neuroblastoma cells. Neurochem Res. 2003 May; 28(5):733-41.
48. Mazzio E, Soliman KF. D-(+)-glucose rescue against 1-methyl-4-phenylpyridinium toxicity through anaerobic glycolysis in neuroblastoma cells. Brain Res. 2003 Feb 07; 962(1-2):48-60.
49. Mazzio E, Soliman KF. Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro. Neurosci Lett. 2003 Feb 06; 337(2):77-80.
50. Mazzio E, Soliman KF. The role of glycolysis and gluconeogenesis in the cytoprotection of neuroblastoma cells against 1-methyl 4-phenylpyridinium ion toxicity. Neurotoxicology. 2003 Jan; 24(1):137-47.
51. Soliman MK, Mazzio E, Soliman KF. Levodopa modulating effects of inducible nitric oxide synthase and reactive oxygen species in glioma cells. Life Sci. 2002 Nov 29; 72(2):185-98.
52. Mazzio E, Becker A, Soliman KF. Characterization of neurotransmitters and dopamine attenuation of inducible nitric oxide synthase in glioma cells. J Neuroimmunol. 2002 Oct; 131(1-2):70-82.
53. Mazzio E, Huber J, Darling S, Harris N, Soliman KF. Effect of antioxidants on L-glutamate and N-methyl-4-phenylpyridinium ion induced-neurotoxicity in PC12 cells. Neurotoxicology. 2001 Apr; 22(2):283-8.
54. Hill D, Ikaiddi M, Mazzio E, Soliman KF. The neurochemical basis for the behavioral effects of triadimefon. Ann N Y Acad Sci. 2000 Sep; 914:336-53.
55. Heyliger SO, Mazzio EA, Soliman KF. The anti-inflammatory effects of quinolinic acid in the rat. Life Sci. 1999; 64(14):1177-87.
56. Mazzio EA, Harris N, Soliman KF. Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Med. 1998 Oct; 64(7):603-6.
57. Soliman KF, Mazzio EA. In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. Proc Soc Exp Biol Med. 1998 Sep; 218(4):390-7.
58. Choi SJ, Mazzio E, Kolta MG, Soliman KF. Prenatal cocaine exposure affects postnatal dopaminergic systems in various regions of the rat brain. Ann N Y Acad Sci. 1998 May 30; 844:293-302.
59. Choi SJ, Mazzio E, Soliman KF. The effects of gestational cocaine exposure on pregnancy outcome, postnatal development, cognition and locomotion in rats. Ann N Y Acad Sci. 1998 May 30; 844:324-35.
60. Choi SJ, Mazzio EA, Reams RR, Soliman KF. Gestational cocaine exposure alters postnatal pituitary-adrenal axis activity and stress endurance in rats. Ann N Y Acad Sci. 1998 May 30; 844:336-45.
61. Clay LH, Mazzio EA, Kolta MG, Soliman KF. Repeated administration of cocaine alters dopamine uptake and release in the striatum nucleus accumbens. Ann N Y Acad Sci. 1998 May 30; 844:346-55.
62. Choi SJ, Mazzio E, Kolta MG, Soliman KFA. Prenatal Cocaine Exposure Affects Postnatal Dopaminergic Systems in Various Regions of the Rat Braina. Ann N Y Acad Sci. 1998 May; 844(1):293-302.
63. Choi SJ, Mazzio E, Soliman KFA. The Effects of Gestational Cocaine Exposure on Pregnancy Outcome, Postnatal Development, Cognition and Locomotion in Ratsa. Ann N Y Acad Sci. 1998 May; 844(1):324-335.
64. Choi SJ, Mazzio EA, Reams RR, Soliman KFA. Gestational Cocaine Exposure Alters Postnatal Pituitary-Adrenal Axis Activity and Stress Endurance in Ratsa. Ann N Y Acad Sci. 1998 May; 844(1):336-345.
65. Clay LH, Mazzio EA, Kolta MG, Soliman KFA. Repeated Administration of Cocaine Alters Dopamine Uptake and Release in the Striatum Nucleus Accumbensa. Ann N Y Acad Sci. 1998 May; 844(1):346-355.
66. Rasekh HR, Davis MD, Cooke LW, Mazzio EA, Reams RR, Soliman KF. The effect of selenium on the central dopaminergic system: a microdialysis study. Life Sci. 1997; 61(11):1029-35.

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