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Bao Vuong
Title Professor
Faculty Rank Assistant Professor
Degree PhD
Institution City College, CUNY
Department Biology
Clusters Cancer
Infectious and Immunological Diseases
Address
160 Convent Ave.
Marshak 526
City New York
State NY
Postal Code 10031
Telephone 212-650-8563
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  B cells of the immune system produce antibodies, which bind and neutralize infectious pathogens such as viruses and bacteria. To generate a repertoire of approximately 10^11 antibodies that can recognize the various molecules produced by different pathogenic organisms, each B cell independently reorganizes its DNA in two stages. In the first stage, which occurs during their development, the B cells will produce an antibody molecule that can bind to a target molecule but is limited in its ability to mobilize other components of the immune system. In the second stage, which occurs when the mature B cell encounters a pathogenic organism, the B cells will modify the antibody to allow it to bind more tightly to the target molecule and to activate specific arms of the immune system.

Our research studies are focused on studying the processes that promote the second stage of antibody diversification. We use molecular, biochemical, cellular, genetic, and immunological experiments to understand how the B cells modify the blueprint of the antibody they were assigned to generate during development. Although the primary function of the second stage of antibody diversification is to mount the most effective immune response, aberrant DNA reorganization during this stage can activate genes that can cause cancer, specifically B cell lymphomas. Thus, these studies are critical in understanding how we can manipulate antibody diversity to drive more effective immune responses and how specific molecular pathways are redirected towards permitting cancerous cell growth rather than immunity.

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1. Dominguez PM, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, Vuong B, Chaudhuri J, Melnick A, Vasanthakumar A, Godley LA, Papavasiliou FN, Elemento O, Shaknovich R. DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID. Cell Rep. 2015 Sep 29; 12(12):2086-98.
2. Zheng S, Vuong BQ, Vaidyanathan B, Lin JY, Huang FT, Chaudhuri J. Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNA. Cell. 2015 May 07; 161(4):762-73.
3. Dowdle JA, Mehta M, Kass EM, Vuong BQ, Inagaki A, Egli D, Jasin M, Keeney S. Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis. PLoS Genet. 2013 Nov; 9(11):e1003945.
4. Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 2013 Nov; 14(11):1183-1189.
5. Vuong BQ, Chaudhuri J. Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications. Semin Immunol. 2012 Aug; 24(4):264-72.
6. Vuong BQ, Lee M, Kabir S, Irimia C, Macchiarulo S, McKnight GS, Chaudhuri J. Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination. Nat Immunol. 2009 Apr; 10(4):420-6.
7. Cheng HL, Vuong BQ, Basu U, Franklin A, Schwer B, Astarita J, Phan RT, Datta A, Manis J, Alt FW, Chaudhuri J. Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2717-22.
8. Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol. 2007; 94:157-214.
9. Vuong BQ, Arenzana TL, Showalter BM, Losman J, Chen XP, Mostecki J, Banks AS, Limnander A, Fernandez N, Rothman PB. SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome. Mol Cell Biol. 2004 Oct; 24(20):9092-101.
10. Losman JA, Chen XP, Vuong BQ, Fay S, Rothman PB. Protein phosphatase 2A regulates the stability of Pim protein kinases. J Biol Chem. 2003 Feb 14; 278(7):4800-5.
11. Cong F, Tang J, Hwang BJ, Vuong BQ, Chu G, Goff SP. Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase. J Biol Chem. 2002 Sep 20; 277(38):34870-8.
12. Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P. Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2175-80.
13. Jiang H, Foltenyi K, Kashiwada M, Donahue L, Vuong B, Hehn B, Rothman P. Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation. J Immunol. 2001 Feb 15; 166(4):2627-34.
14. Zhou M, Pugmire MJ, Vuong BQ, Ealick SE. Cloning, expression and crystallization of pyrimidine nucleoside phosphorylase from Bacillus stearothermophilus. Acta Crystallogr D Biol Crystallogr. 1999 Jan; 55(Pt 1):287-90.
15. Kovari LC, Momany CA, Miyagi F, Lee S, Campbell S, Vuong B, Vogt VM, Rossmann MG. Crystals of Rous sarcoma virus capsid protein show a helical arrangement of protein subunits. Virology. 1997 Nov 10; 238(1):79-84.

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