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Bekir CINAR
Title Associate Professor
Faculty Rank Associate Professor
Degree Ph.D.
Institution Clark Atlanta University
Department Biological Sciences and CCRTD
Clusters Cancer
Address
Clark Atlanta University
222 James P Brawley Dr SW
Thomas W Cole RCST, Room 4029B
City Atlanta
State GA
Postal Code 30314
Telephone (404) 880-8438
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Other Positions icon

Title Associate Professor
Institution Clark Atlanta University
Department Biological Sciences and CCRTD
 
Title Assistant Professor
Institution Cedars-Sinai Medical Center
Department Medicine and Biomedical Sciences
Division Hematology oncology and Cancer Biology
 
Title Postdoctoral Fellow
Institution Harvard Medican School
Department Boston Children''s Hospital
Division Surgery
 
Title Research Assistant
Institution University of Virginia School of Medicine
Department Biochemistry and Molecular Genetics
 
Title Affiliated Member
Institution Emory University
Department Winship Cancer Institute
Division Cancer Biology Program

Narrative icon

  My research focus is on signal transduction and gene expression mechanisms relevant to cell growth, cell migration, and cell survival under changing environment or under stress. Information gained from the basic science research would help advance knowledge on how cancer and non-cancer diseases evolve. Currently, my laboratory studies the stressed activated Hippo-YAP signaling pathway to understand the molecular mechanisms of cancer cell growht, metastasis and resistance to therapy. My laboratory utilizes variety of complementary approaches including proteomics, genomics and bioinformatics as well cell cultures including 3D cultures, animal models and clinical samples to carry out the proposed research.

Programs, Membership, and Biomedical Research icon

Mentoring Mentor
BIOMEDICAL RESEARCH BIOMEDICAL - BASIC

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2019The YAP/TAZ-Nuclear Factor Kappa B Axis in Prostate Cancer2U54MD007590-32

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1. George A, Raji I, Cinar B, Kucuk O, Oyelere AK. Design, synthesis, and evaluation of the antiproliferative activity of hydantoin-derived antiandrogen-genistein conjugates. Bioorg Med Chem. 2018 May 01; 26(8):1481-1487.
2. Mohanty SK, Yagiz K, Pradhan D, Luthringer DJ, Amin MB, Alkan S, Cinar B. STAT3 and STAT5A are potential therapeutic targets in castration-resistant prostate cancer. Oncotarget. 2017 Oct 17; 8(49):85997-86010.
3. Ready D, Yagiz K, Amin P, Yildiz Y, Funari V, Bozdag S, Cinar B. Mapping the STK4/Hippo signaling network in prostate cancer cell. PLoS One. 2017; 12(9):e0184590.
4. Kuser-Abali G, Alptekin A, Lewis M, Garraway IP, Cinar B. YAP1 and AR interactions contribute to the switch from androgen-dependent to castration-resistant growth in prostate cancer. Nat Commun. 2015 Sep 01; 6:8126.
5. Cinar M, Rosenfelt F, Rokhsar S, Lopategui J, Pillai R, Cervania M, Pao A, Cinar B, Alkan S. Concurrent inhibition of MYC and BCL2 is a potentially effective treatment strategy for double hit and triple hit B-cell lymphomas. Leuk Res. 2015 Jul; 39(7):730-8.
6. Kuser-Abali G, Alptekin A, Cinar B. Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression. Epigenetics. 2014 Apr; 9(4):634-43.
7. Cinar M, Hamedani F, Mo Z, Cinar B, Amin HM, Alkan S. Bruton tyrosine kinase is commonly overexpressed in mantle cell lymphoma and its attenuation by Ibrutinib induces apoptosis. Leuk Res. 2013 Oct; 37(10):1271-7.
8. Mukhopadhyay NK, Kim J, You S, Morello M, Hager MH, Huang WC, Ramachandran A, Yang J, Cinar B, Rubin MA, Adam RM, Oesterreich S, Di Vizio D, Freeman MR. Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2. Oncogene. 2014 Jun 19; 33(25):3235-45.
9. Collak FK, Yagiz K, Luthringer DJ, Erkaya B, Cinar B. Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1. J Biol Chem. 2012 Jul 06; 287(28):23698-709.
10. Soifer HS, Souleimanian N, Wu S, Voskresenskiy AM, Collak FK, Cinar B, Stein CA. Direct regulation of androgen receptor activity by potent CYP17 inhibitors in prostate cancer cells. J Biol Chem. 2012 Feb 03; 287(6):3777-87.
11. Cinar B, Collak FK, Lopez D, Akgul S, Mukhopadhyay NK, Kilicarslan M, Gioeli DG, Freeman MR. MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling. Cancer Res. 2011 Jun 15; 71(12):4303-13.
12. Mukhopadhyay NK, Kim J, Cinar B, Ramachandran A, Hager MH, Di Vizio D, Adam RM, Rubin MA, Raychaudhuri P, De Benedetti A, Freeman MR. Heterogeneous nuclear ribonucleoprotein K is a novel regulator of androgen receptor translation. Cancer Res. 2009 Mar 15; 69(6):2210-8.
13. Cinar BM, Akpinar S, Hersekli MA, Uysal M, Cesur N, Pourbagher A, Derincek A. [The effects of two different fixation methods on femoral bone tunnel enlargement and clinical results in anterior cruciate ligament reconstruction with hamstring tendon graft]. Acta Orthop Traumatol Turc. 2009; 43(6):515-21.
14. Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J. 2007 Oct 31; 26(21):4523-34.
15. Cinar B, Mukhopadhyay NK, Meng G, Freeman MR. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem. 2007 Oct 05; 282(40):29584-93.
16. Adam RM, Mukhopadhyay NK, Kim J, Di Vizio D, Cinar B, Boucher K, Solomon KR, Freeman MR. Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res. 2007 Jul 01; 67(13):6238-46.
17. Mukhopadhyay NK, Cinar B, Mukhopadhyay L, Lutchman M, Ferdinand AS, Kim J, Chung LW, Adam RM, Ray SK, Leiter AB, Richie JP, Liu BC, Freeman MR. The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol. 2007 Sep; 21(9):2056-70.
18. Freeman MR, Cinar B, Kim J, Mukhopadhyay NK, Di Vizio D, Adam RM, Solomon KR. Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids. 2007 Feb; 72(2):210-7.
19. Mukhopadhyay NK, Ferdinand AS, Mukhopadhyay L, Cinar B, Lutchman M, Richie JP, Freeman MR, Liu BC. Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. Exp Cell Res. 2006 Nov 15; 312(19):3782-95.
20. Freeman MR, Cinar B, Lu ML. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab. 2005 Aug; 16(6):273-9.
21. Cinar B, De Benedetti A, Freeman MR. Post-transcriptional regulation of the androgen receptor by Mammalian target of rapamycin. Cancer Res. 2005 Apr 01; 65(7):2547-53.
22. Cinar B, Yeung F, Konaka H, Mayo MW, Freeman MR, Zhau HE, Chung LW. Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells. Biochem J. 2004 Apr 15; 379(Pt 2):421-31.
23. Davis R, Jia D, Cinar B, Sikka SC, Moparty K, Zhau HE, Chung LW, Agrawal KC, Abdel-Mageed AB. Functional androgen receptor confers sensitization of androgen-independent prostate cancer cells to anticancer therapy via caspase activation. Biochem Biophys Res Commun. 2003 Oct 03; 309(4):937-45.
24. Ye Q, Cinar B, Edlund M, Chung LW, Zhau HE. Inhibition of growth and cell cycle arrest of ARCaP human prostate cancer cells by ectopic expression of ER-alpha. Mol Cell Biochem. 2001 Dec; 228(1-2):105-10.
25. Cinar B, Koeneman KS, Edlund M, Prins GS, Zhau HE, Chung LW. Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line. Cancer Res. 2001 Oct 01; 61(19):7310-7.
26. Ye Q, Chung LW, Cinar B, Li S, Zhau HE. Identification and characterization of estrogen receptor variants in prostate cancer cell lines. J Steroid Biochem Mol Biol. 2000 Dec 01; 75(1):21-31.

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1. Bekir Cinar and Carlos S. Moreno. AR signaling in concert with PP2A/B regulates YAP1 expression in prostate cancer cells. 2018; 78(13):4373.
2. Munevver Cinar, Deniz Peker, Nalan Akyurek, Qin Huang, Jean Lopategui, Bekir Cinar, Serhan Alkan. Expression and functional analysis of aurora kinase A/B in double hit and triple hit B-cell lymphomas. 2015; 73(6):5251-5251.
3. Bekir Cinar, Gamze Kuser Abali, Michael Lewis, Colm Morrissey and Isla Garraway. A subset of prostate cancer cells with loss of MST1 expression confers resistance to castration through YAP1-AR interactions. 2015; 75(15):1956.
4. Munevver Cinar, Deniz Peker, Nalan Altyurek, Qin Huang, Jean Lopategui, Bekir Cinar, Serhan Alkan. Analysis of Aurora Kinase A and B in Double Hit and Triple Hit Lymphomas. 2015; 96(6):340A-340A.
5. Andrew Martowski, Munevver Cinar, Bekir Cinar, Qin Huang, Hesham Amin, Serhan Alkan. Immunohistochemical and Functional Analysis of Polycomb-Group Proteins in Mantle Cell Lymphoma. 2015; 96(6):362A-362A.
6. Munevver Cinar, Deniz Peker, Nalan Altyurek, Qin Huang, Jean Lopategui, Bekir Cinar, Serhan Alkan. Analysis of Aurora Kinase A and B in Double Hit and Triple Hit Lymphomas. 2015; 96(6):340A-340A.
7. Bekir Cinar, Almet Alptekin, Ronald B Natale. Role of mammalian Hippo Mst1/2 protein kinase signaling in lung cancer progression. 2004; 73(6):5251-5251.
8. H Konaka, B Cinar, WC Huang, CL Hsieh, M Namiki, HE Zhau, LW Chung. Novel glucocorticoid receptor mediated Psa transactivation in androgen-independent prostate cancer cells and its augmentation using chimeric Psa promoter construct. 2004; 169(4):84-84.
9. H Konaka, B Cinar, H Kubo, M Namiki, LW Chung. Androgen dprivation trigers NFkB activation in prostate cancer cells: A critical step of androgen-independent progression. 2003; 169(4):84-84.

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1. Bekir Cinar and Robert A. Sikes. Control of Steroid Hormone Receptor Action. 2000.

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