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Clement Yedjou
Title Associate Professor
Faculty Rank Faculty
Degree Ph.D.
Institution Jackson State University
Department Biology
Clusters Cancer
Address
Box 18540
1400 Lynch Street
City Jackson
State MS
Postal Code 39217
Telephone 601-979-0215
Fax 601-979-5853
Email
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Awards and Honors icon

2004 Empire Who’s Who Registry of Executives and Professionals
2004 Who’s Who Among American Students in Universities and Colleges
2006 Beta Kappa Chi National Scientific Honor Society (BKK)
2006 Phi Kappa Phi National Honor Society
2007 Alliance for Graduate Education Outstanding Leadership & Achievement Award
2008 Research Centers in Minority Institutions Health Disparities
2008 Listed in Marquis Who’s Who Publication
2010 American Association for Cancer Research Faculty Scholar Award for Cancer Research
2010 Listed in Who’s Who in American

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Clement is currently an Assistant Professor at Jackson State University. He has a strong concentration in the field of Pharmacology, Toxicology, and Therapeutics. He completed his postdoctoral training in the Cellomics and Toxicogenomics Research Laboratory and Molecular Toxicology. His current research focuses on the following aspects: (1) Preclinical assessment of physiologic doses of ascorbic acid in combination with pharmacologic dose of arsenic trioxide (Trisenox) for the management of acute promyelocytic leukemia (APL) and other malignancies. (2) Basic and translational studies of ascorbic acid and arsenic trioxide effects on tumor metastasis. (3) Role of host immune system in ascorbic acid treatment. (4) Mechanisms of action of ascorbic acid when combined with arsenic trioxide for the treatment of APL patients. (5) Preclinical assessment of vernonia amygdalina leaf extracts as anti-cancer agent in the management of human breast cancer. As Junior Investigator, Clement has secured 3 mini competitive grants and so far, he has published 30 peer-reviewed articles in prestigious journals. He is a co-author of two book chapters; an editorial board member of the Environmental Toxicology, Drug and therapy Studies, and a reviewer of many international journals including the Environmental Research and Public Health, Indian Pharmacology Journal and McGraw Hill of High Education textbooks. Many of his research publications have made international news and have been featured, reported, and highlighted on: NewsRx.com, Nigerian Tribune, MDLinx.com, and Pharmacy News & Articles.

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1. Noubissi FK, Yedjou CG, Spiegelman VS, Tchounwou PB. Cross-Talk between Wnt and Hh Signaling Pathways in the Pathology of Basal Cell Carcinoma. Int J Environ Res Public Health. 2018 Jul 09; 15(7).
2. Sims JN, Yedjou CG, Abugri D, Payton M, Turner T, Miele L, Tchounwou PB. Racial Disparities and Preventive Measures to Renal Cell Carcinoma. Int J Environ Res Public Health. 2018 May 28; 15(6).
3. Johnson W, Tchounwou PB, Yedjou CG. Therapeutic Mechanisms of Vernonia amygdalina Delile in the Treatment of Prostate Cancer. Molecules. 2017 Sep 22; 22(10).
4. Yedjou CG, Tchounwou PB, Payton M, Miele L, Fonseca DD, Lowe L, Alo RA. Assessing the Racial and Ethnic Disparities in Breast Cancer Mortality in the United States. Int J Environ Res Public Health. 2017 05 05; 14(5).
5. Tsabang N, Yedjou CG, Tchounwou PB. Phytotherapy of High Blood Pressure in Three Phytogeographic Regions of Cameroon. Pharm Anal Acta. 2017; 8(1).
6. Dugo EB, Yedjou CG, Stevens JJ, Tchounwou PB. Therapeutic Potential of Arsenic Trioxide (ATO) in Treatment of Hepatocellular Carcinoma: Role of Oxidative Stress in ATO-Induced Apoptosis. Ann Clin Pathol. 2017; 5(1).
7. Tsabang N, Tsambang L, Yedjou CG, Tchounwou PB. Socio-cultural contribution to medicinal plants assessment and sustainable development: case of antidiabetic and antihypertensive plants in Cameroon. Glob Drugs Ther. 2017 Feb; 2(1).
8. Tsabang N, Fongnzossie E, Donfack D, Yedjou CG, Tchounwou PB, Minkande JZ, Nouedou C, Van PD. Comparative Study of Epidemiological and Anthropological Aspects of Diabetes and Hypertension in Cameroon. J For Res. 2016 Mar; 5(1).
9. Skipper A, Sims JN, Yedjou CG, Tchounwou PB. Cadmium Chloride Induces DNA Damage and Apoptosis of Human Liver Carcinoma Cells via Oxidative Stress. Int J Environ Res Public Health. 2016 Jan 02; 13(1).
10. Yedjou CG, Tchounwou HM, Tchounwou PB. DNA Damage, Cell Cycle Arrest, and Apoptosis Induction Caused by Lead in Human Leukemia Cells. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010056.
11. Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 2015 Dec; 35 Suppl:S276-S304.
12. Dasari SR, Velma V, Yedjou CG, Tchounwou PB. Preclinical Assessment of Low Doses of Cisplatin in the Management of Acute Promyelocytic Leukemia. Int J Cancer Res Mol Mech. 2015 Oct; 1(3).
13. Tsabang N, Kadjob S, Mballa RN, Yedjou CG, Nnanga N, Donfagsiteli NT, Tchinda AT, Agbor GA, Ntsama C, Tchounwou PB. New Approach for the Development of Improved Traditional Medicine: Case of a Preparation of an Oral Hypoglycemic Medicine from Laportea ovalifolia (Schumach. & Thonn.) Chew. (Urticaceae). J Mol Pharm Org Process Res. 2015 Aug; 3(2).
14. Tsabang N, Yedjou CG, Tsambang L, Tchinda AT, Donfagsiteli N, Agbor GA, Tchounwou P, Nkongmeneck BA. Treatment of Diabetes and/or Hypertension Using Medicinal Plants in Cameroon. Med Aromat Plants (Los Angel). 2015; Suppl 2.
15. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondrácek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engström W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96.
16. Narayanan KB, Ali M, Barclay BJ, Cheng QS, D'Abronzo L, Dornetshuber-Fleiss R, Ghosh PM, Gonzalez Guzman MJ, Lee TJ, Leung PS, Li L, Luanpitpong S, Ratovitski E, Rojanasakul Y, Romano MF, Romano S, Sinha RK, Yedjou C, Al-Mulla F, Al-Temaimi R, Amedei A, Brown DG, Ryan EP, Colacci A, Hamid RA, Mondello C, Raju J, Salem HK, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Kim SY, Bisson WH, Lowe L, Park HH. Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis. 2015 Jun; 36 Suppl 1:S89-110.
17. Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Keith WN, Bilsland A, Halicka D, Nowsheen S, Azmi AS. Broad targeting of resistance to apoptosis in cancer. Semin Cancer Biol. 2015 Dec; 35 Suppl:S78-S103.
18. Yedjou C, Cameron J, Mbemi AT, Tchounwou P. ß-ESTRADIOL INDUCES CYTOTOXIC EFFECTS TO HUMAN T-LYMPHOMA (JURKAT) CELLS THROUGH OXIDATIVE STRESS. J Miss Acad Sci. 2015 Apr; 60(Suppl 1):279-283.
19. Kumar S, Yedjou CG, Tchounwou PB. Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. J Exp Clin Cancer Res. 2014 May 16; 33:42.
20. Rogers CS, Yedjou CG, Sutton DJ, Tchounwou PB. Vitamin D3 potentiates the antitumorigenic effects of arsenic trioxide in human leukemia (HL-60) cells. Exp Hematol Oncol. 2014 Mar 25; 3(1):9.
21. Tchounwou CK, Yedjou CG, Farah I, Tchounwou PB. D-Glucose-Induced Cytotoxic, Genotoxic, and Apoptotic Effects on Human Breast Adenocarcinoma (MCF-7) Cells. J Cancer Sci Ther. 2014; 6:156-160.
22. Yedjou CG, Izevbigie EB, Tchounwou PB. Vernonia amygdalina-Induced Growth Arrest and Apoptosis of Breast Cancer (MCF-7) Cells. Pharmacol Pharm. 2013 Jan 01; 4(1).
23. Yedjou CG, Saeed MA, Hossain MA, Dorsey W, Yu H, Tchounwou PB. Basic apoptotic and necrotic cell death in human liver carcinoma (HepG2 ) cells induced by synthetic azamacrocycle. Environ Toxicol. 2014 Jun; 29(6):605-11.
24. Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ. Heavy metal toxicity and the environment. EXS. 2012; 101:133-64.
25. Yedjou CG, Tchounwou PB. In vitro assessment of oxidative stress and apoptotic mechanisms of garlic extract in the treatment of acute promyelocytic leukemia. J Cancer Sci Ther. 2012 Jan 01; 2012(Suppl 3):6.
26. Wang Y, Aker WG, Hwang HM, Yedjou CG, Yu H, Tchounwou PB. A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ. 2011 Oct 15; 409(22):4753-62.
27. Edwards FL, Yedjou CG, Tchounwou PB. Involvement of oxidative stress in methyl parathion and parathion-induced toxicity and genotoxicity to human liver carcinoma (HepG2) cells. Environ Toxicol. 2013 Jun; 28(6):342-8.
28. Yedjou CG, Byrd R, Allen L, Tchounwou PB. Physiologic Doses of Ascorbic Acid Increase Arsenic Trioxide Toxicity in Human Jurkat -T Lymphoma Cells. Met Ions Biol Med. 2011; 11:236-241.
29. Yedjou CG, Tchounwou PB. Lead-Induced Cell Cycle Arrest in Human Liver Carcinoma (HepG2) Cells: Involvement of oxidative stress, p53 and Cyclin A. Met Ions Biol Med. 2011; 11:242-246.
30. Yedjou C, Tchounwou P, Jenkins J, McMurray R. Basic mechanisms of arsenic trioxide (ATO)-induced apoptosis in human leukemia (HL-60) cells. J Hematol Oncol. 2010 Aug 26; 3:28.
31. Moore PD, Yedjou CG, Tchounwou PB. Malathion-induced oxidative stress, cytotoxicity, and genotoxicity in human liver carcinoma (HepG2) cells. Environ Toxicol. 2010 Jun; 25(3):221-6.
32. Yedjou CG, Milner JN, Howard CB, Tchounwou PB. Basic apoptotic mechanisms of lead toxicity in human leukemia (HL-60) cells. Int J Environ Res Public Health. 2010 05; 7(5):2008-17.
33. Yedjou CG, Tchounwou CK, Haile S, Edwards F, Tchounwou PB. N-acetyl-cysteine protects against DNA damage associated with lead toxicity in HepG2 cells. Ethn Dis. 2010; 20(1 Suppl 1):S1-101-3.
34. Yedjou C, Thuisseu L, Tchounwou C, Gomes M, Howard C, Tchounwou P. Ascorbic Acid Potentiation of Arsenic Trioxide Anticancer Activity Against Acute Promyelocytic Leukemia. Arch Drug Inf. 2009 Dec; 2(4):59-65.
35. Yedjou CG, Tchounwou PB. Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxide. Mol Cell Biochem. 2009 Nov; 331(1-2):207-14.
36. Patlolla AK, Barnes C, Yedjou C, Velma VR, Tchounwou PB. Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats. Environ Toxicol. 2009 Feb; 24(1):66-73.
37. Yedjou C, Izevbigie E, Tchounwou P. Preclinical assessment of vernonia amygdalina leaf extracts as DNA damaging anti-cancer agent in the management of breast cancer. Int J Environ Res Public Health. 2008 Dec; 5(5):337-41.
38. Yedjou CG, Rogers C, Brown E, Tchounwou PB. Differential effect of ascorbic acid and n-acetyl-L-cysteine on arsenic trioxide-mediated oxidative stress in human leukemia (HL-60) cells. J Biochem Mol Toxicol. 2008 Mar-Apr; 22(2):85-92.
39. Brown E, Yedjou CG, Tchounwou PB. Cytotoxicity and oxidative stress in human liver carcinoma cells exposed to arsenic trioxide (HepG(2)). Met Ions Biol Med. 2008; 10:583-587.
40. Yedjou C, Sutton L, Tchounwou P. GENOTOXIC MECHANISMS OF ARSENIC TRIOXIDE IN HUMAN JURKAT T-LYMPHOMA CELLS. Met Ions Biol Med. 2008; 10:495-499.
41. Yedjou CG, Brown E, Rogers C, Tchounwou PB. ASCORBIC ACID - MODULATION OF ARSENIC TRIOXIDE TOXICITY: IMPLICATION FOR THE CLINICAL TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA. Met Ions Biol Med. 2008; 10:413-418.
42. Yedjou CG, Waters D, Tchounwou PB. N-Acetyl-cysteine Protection Against Lead-Induced Oxidative Stress and Genotoxicity in Human Liver Carcinoma (HepG2) Cells. Met Ions Biol Med. 2008; 10:419-424.
43. Yedjou CG, Tchounwou PB. N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int J Environ Res Public Health. 2007 Jun; 4(2):132-7.
44. Yedjou CG, Tchounwou PB. In-vitro cytotoxic and genotoxic effects of arsenic trioxide on human leukemia (HL-60) cells using the MTT and alkaline single cell gel electrophoresis (Comet) assays. Mol Cell Biochem. 2007 Jul; 301(1-2):123-30.
45. Yedjou CG, Moore P, Tchounwou PB. Dose- and time-dependent response of human leukemia (HL-60) cells to arsenic trioxide treatment. Int J Environ Res Public Health. 2006 Jun; 3(2):136-40.
46. Yedjou CG, Tchounwou PB. OXIDATIVE STRESS IN HUMAN LEUKEMIA (HL-60), HUMAN LIVER CARCINOMA (HepG2), AND HUMAN (JURKAT-T) CELLS EXPOSED TO ARSENIC TRIOXIDE. Met Ions Biol Med. 2006; 9:298-303.
47. Tchounwou PB, Yedjou CG, Foxx DN, Ishaque AB, Shen E. Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells. Mol Cell Biochem. 2004 Jan; 255(1-2):161-70.
48. Tchounwou PB, Yedjou CG, Dorsey WC. Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2). Cell Mol Biol (Noisy-le-grand). 2003 Nov; 49(7):1071-9.

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1. Yedjou CG, Sims JN, Njiki S, Tsabang N, Ogungbe IV, Tchounwou PB. Glob J Adv Eng Technol Sci. VERNONIA AMYGDALINA DELILE EXHIBITS A POTENTIAL FOR THE TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA. 2018; 8(5):1-9.

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