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Development of a Novel Agent for Alcohol Dependence


Collapse Biography 

Collapse Overview 
Collapse abstract
Studies are proposed to complete the development of S-methyl N, Ndiethylthiolcarbamate sulfoxide (DETC-MeSO), a novel agents for the treatment of alcohol dependence. Specifically the following studies will be performed.

1. Complete the process chemistry development for DETC-MeSO and its Isomers. (carried out at Thiopharma, Inc)

2. Synthesize sufficient scale UP quantities for preclinical toxicology studies. (carried out at Pharm-Eco Laboratories, Inc)

3. Carry out pharmacokinetic studies in rats to support preclinical toxicology studies. (carried out at The University of Kansas)

4. Preclinical toxicology studies in rats and dogs. (carried out at Battelle).
Collapse sponsor award id
R43AA014566

Collapse Time 
Collapse start date
2003-09-25
Collapse end date
2004-03-31
RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

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