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mahavir Chougule
Title Assistant Professor
Faculty Rank
Degree PhD, M Pharm, B Pharm
Institution University of Hawaii
Department Pharmaceutical Sciences
Clusters Cancer
Address
34 Rainbow Dr.
STE 300
City Hilo
State HI
Postal Code 96720
Telephone 8089814518
Fax 8089814520
Email
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Other Positions icon

Title Member
Institution University of Hawaii Cancer Center
Department Natural Products and Experimental Therapeutics Program

Awards and Honors icon

1999 P. Wadhawani College of Pharmacy, India Gold Medalist- B Pharm
2000 P. Wadhawani College of Pharmacy, India Best Student Award
2004 Lady Tata Memorial Trust, Mumbai, India. Junior Research Fellowship
2005 Indian Council of Medical Research (ICMR), Delhi, India Senior Research Fellowship
2006 Department of Science and Technology, Department of Biotechnology, Govt. of India Travel Award- Respiratory Drug Delivery X Conference, Boca Raton FL, USA
2010 American Association of Pharmaceutical Scientist (AAPS), USA. AAPS Council Travel Award
2012 American Association of Cancer Research , USA AACR Minority-Serving Institution Faculty Scholar in Cancer Research
2013 American Association of Cancer Research (AACR) , USA AACR Minority-Serving Institution Faculty Scholar in Cancer Research

Narrative icon

  Mahavir B. Chougule, Assistant Professor of the Department of Pharmaceutical Sciences, College of Pharmacy, University of Hawaii at Hilo, HI, USA, investigates the use of therapeutic agent, siRNA, proteins and targeted nanotechnology based formulations for treatment of cancer and pulmonary disorders. His research work is focused on targeted delivery using nanocarriers to improve the efficacy and minimize the adverse side effects. Chougule has shown that the inhalation delivery of anticancer drug loaded nanoparticle significantly inhibits tumor growth compared to aerosolized solution. Chougule has also investigated the anticancer activity and molecular mechanism of natural compounds against lung and breast cancer. He also developed the spray dried nano-liposomal dry powder inhalers and topical nanocarrier cream formulation for treatment of skin disorders.

Dr. Chougule has more than 7 years of professional experience in developmental therapeutics and biopharmaceuticals. he has has published 21 research articles, 2 review article, 4 book chapters, and presented work in more than 50 scientific conferences. In addition, he is also an inventor in the 8 patents. He is also serving as member of editorial board on 5 international journals and recipient of several awards including AACR Minority-Serving Institution Faculty Scholar in Cancer Research Awards.

Research Interests: Cancer, asthma, nanotechnology, small compound and gene/protein based drug delivery, Inhalation delivery, topical/transdermal delivery, Molecular biology, cell culture, and animal models.

Publications icon

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1. Alexander A, Agrawal M, Saraf S, Saraf S. Formulation strategies of nano lipid carrier for effective brain targeting of anti-AD drugs. Curr Pharm Des. 2020 Feb 12.
2. Bhatt P, Narvekar P, Lalani R, Chougule MB, Pathak Y, Sutariya V. An in vitro Assessment of Thermo-Reversible Gel Formulation Containing Sunitinib Nanoparticles for Neovascular Age-Related Macular Degeneration. AAPS PharmSciTech. 2019 Aug 09; 20(7):281.
3. Mahaparale PR, Vinjamuri BP, Chavan MS, Chougule MB, Haware RV. Computational Predictability of Microsponge Properties Using Different Multivariate Models. AAPS PharmSciTech. 2019 Apr 23; 20(5):172.
4. Shahin HI, Vinjamuri BP, Mahmoud AA, Shamma RN, Mansour SM, Ammar HO, Ghorab MM, Chougule MB, Chablani L. Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary arterial hypertension. J Control Release. 2019 05 28; 302:126-139.
5. Haware RV, Vinjamuri BP, Gavireddi M, Dave VS, Gupta D, Chougule MB, Stagner WC. Physical properties and solubility studies of Nifedipine-PEG 1450/HPMCAS-HF solid dispersions. Pharm Dev Technol. 2019 Jun; 24(5):550-559.
6. Gandhi NS, Godeshala S, Koomoa-Lange DT, Miryala B, Rege K, Chougule MB. Correction to: Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharm Res. 2018 09 05; 35(11):202.
7. Gandhi NS, Godeshala S, Koomoa-Lange DT, Miryala B, Rege K, Chougule MB. Bioreducible Poly(Amino Ethers) Based mTOR siRNA Delivery for Lung Cancer. Pharm Res. 2018 Aug 13; 35(10):188.
8. Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Chougule MB, Shoyele SA, Alexander A. Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. J Control Release. 2018 07 10; 281:139-177.
9. Agrawal M, Saraf S, Saraf S, Antimisiaris SG, Hamano N, Li SD, Chougule M, Shoyele SA, Gupta U. Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region. Expert Opin Drug Deliv. 2018 06; 15(6):589-617.
10. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Correction to "Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers". Mol Pharm. 2018 03 05; 15(3):1377.
11. Youngren-Ortiz SR, Chougule MB. The Daniel K. Inouye College of Pharmacy Scripts: Targeted Nanocarrier Based Systems for the Treatment of Lung Cancer. Hawaii J Med Public Health. 2017 11; 76(11):318-325.
12. Dave VS, Shahin HI, Youngren-Ortiz SR, Chougule MB, Haware RV. Emerging technologies for the non-invasive characterization of physical-mechanical properties of tablets. Int J Pharm. 2017 Oct 30; 532(1):299-312.
13. Youngren-Ortiz SR, Hill DB, Hoffmann PR, Morris KR, Barrett EG, Forest MG, Chougule MB. Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer. J Aerosol Med Pulm Drug Deliv. 2017 Oct; 30(5):299-321.
14. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB. Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers. Mol Pharm. 2017 01 03; 14(1):252-263.
15. Espana-Serrano L, Chougule MB. Enhanced Anticancer Activity of PF-04691502, a Dual PI3K/mTOR Inhibitor, in Combination With VEGF siRNA Against Non-small-cell Lung Cancer. Mol Ther Nucleic Acids. 2016 Nov 15; 5(11):e384.
16. Youngren-Ortiz SR, Gandhi NS, España-Serrano L, Chougule MB. Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems. Kona. 2017; 34:44-69.
17. Andey T, Patel A, Marepally S, Chougule M, Spencer SD, Rishi AK, Singh M. Formulation, Pharmacokinetic, and Efficacy Studies of Mannosylated Self-Emulsifying Solid Dispersions of Noscapine. PLoS One. 2016; 11(1):e0146804.
18. Glasgow MD, Chougule MB. Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging. J Biomed Nanotechnol. 2015 Nov; 11(11):1859-98.
19. Youngren-Ortiz SR, Gandhi NS, España-Serrano L, Chougule MB. Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems. Kona. 2016 Feb 28; 33:63-85.
20. Aldawsari M, Chougule MB, Babu RJ. Progress in Topical siRNA Delivery Approaches for Skin Disorders. Curr Pharm Des. 2015; 21(31):4594-605.
21. Chougule MB, Tan C. Translational application of nano delivery systems: emerging cancer therapy. AAPS PharmSciTech. 2015 Feb; 16(1):3-4.
22. Tekade RK, Youngren-Ortiz SR, Yang H, Haware R, Chougule MB. Designing hybrid onconase nanocarriers for mesothelioma therapy: a Taguchi orthogonal array and multivariate component driven analysis. Mol Pharm. 2014 Oct 06; 11(10):3671-83.
23. Gandhi NS, Tekade RK, Chougule MB. Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances. J Control Release. 2014 Nov 28; 194:238-56.
24. Patel AR, Chougule M, Singh M. EphA2 targeting pegylated nanocarrier drug delivery system for treatment of lung cancer. Pharm Res. 2014 Oct; 31(10):2796-809.
25. Chougule MB, Patel AR, Patlolla R, Jackson T, Singh M. Epithelial transport of noscapine across cell monolayer and influence of absorption enhancers on in vitro permeation and bioavailability: implications for intestinal absorption. J Drug Target. 2014 Jul; 22(6):498-508.
26. Patel AR, Chougule MB, Lim E, Francis KP, Safe S, Singh M. Theranostic tumor homing nanocarriers for the treatment of lung cancer. Nanomedicine. 2014 Jul; 10(5):1053-63.
27. Youngren SR, Tekade RK, Gustilo B, Hoffmann PR, Chougule MB. STAT6 siRNA matrix-loaded gelatin nanocarriers: formulation, characterization, and ex vivo proof of concept using adenocarcinoma cells. Biomed Res Int. 2013; 2013:858946.
28. Tekade RK, Chougule MB. Formulation development and evaluation of hybrid nanocarrier for cancer therapy: Taguchi orthogonal array based design. Biomed Res Int. 2013; 2013:712678.
29. Youngren SR, Mulik R, Jun B, Hoffmann PR, Morris KR, Chougule MB. Freeze-dried targeted mannosylated selenium-loaded nanoliposomes: development and evaluation. AAPS PharmSciTech. 2013 Sep; 14(3):1012-24.
30. Patel AR, Chougule MB, I T, Patlolla R, Wang G, Singh M. Efficacy of aerosolized celecoxib encapsulated nanostructured lipid carrier in non-small cell lung cancer in combination with docetaxel. Pharm Res. 2013 May; 30(5):1435-46.
31. Patel AR, Spencer SD, Chougule MB, Safe S, Singh M. Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3'' diindolylmethane (DIM). Eur J Pharm Sci. 2012 May 12; 46(1-2):8-16.
32. Chougule MB, Patel A, Sachdeva P, Jackson T, Singh M. Enhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer. PLoS One. 2011; 6(11):e27394.
33. Chougule MB, Patel AR, Jackson T, Singh M. Antitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer. PLoS One. 2011 Mar 15; 6(3):e17733.
34. Ichite N, Chougule M, Patel AR, Jackson T, Safe S, Singh M. Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Mol Cancer Ther. 2010 Nov; 9(11):3003-14.
35. Chougule M, Patel AR, Sachdeva P, Jackson T, Singh M. Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer. Lung Cancer. 2011 Mar; 71(3):271-82.
36. Patlolla RR, Chougule M, Patel AR, Jackson T, Tata PN, Singh M. Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers. J Control Release. 2010 Jun 01; 144(2):233-41.
37. Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clin Cancer Res. 2009 Jan 15; 15(2):543-52.
38. Misra A, Jinturkar K, Patel D, Lalani J, Chougule M. Recent advances in liposomal dry powder formulations: preparation and evaluation. Expert Opin Drug Deliv. 2009 Jan; 6(1):71-89.
39. Padhi BK, Chougule MB, Misra A. Aerosol performance of large respirable particles of amikacin sulfate produced by spray and freeze drying techniques. Curr Drug Deliv. 2009 Jan; 6(1):8-16.
40. Patel G, Chougule M, Singh M, Misra A. Chapter 9 - Nanoliposomal dry powder formulations. Methods Enzymol. 2009; 464:167-91.
41. Jackson T, Chougule MB, Ichite N, Patlolla RR, Singh M. Antitumor activity of noscapine in human non-small cell lung cancer xenograft model. Cancer Chemother Pharmacol. 2008 Dec; 63(1):117-26.
42. Chougule M, Padhi B, Misra A. Development of spray dried liposomal dry powder inhaler of Dapsone. AAPS PharmSciTech. 2008; 9(1):47-53.
43. Chougule MB, Padhi BK, Jinturkar KA, Misra A. Development of dry powder inhalers. Recent Pat Drug Deliv Formul. 2007; 1(1):11-21.
44. Chougule M, Padhi B, Misra A. Nano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokinetics. Int J Nanomedicine. 2007; 2(4):675-88.
45. Chougule MB, Padhi BK, Misra A. Nano-liposomal dry powder inhaler of Amiloride Hydrochloride. J Nanosci Nanotechnol. 2006 Sep-Oct; 6(9-10):3001-9.
46. Padhi BK, Chougule MB, Misra A. Optimization of formulation components and characterization of large respirable powders containing high therapeutic payload. Pharm Dev Technol. 2006; 11(4):465-75.
47. Naik S, Chougule M, Padhi BK, Misra A. Development of novel lyophilized mixed micelle amphotericin B formulation for treatment of systemic fungal infection. Curr Drug Deliv. 2005 Apr; 2(2):177-84.
48. Kalariya M, Padhi BK, Chougule M, Misra A. Clobetasol propionate solid lipid nanoparticles cream for effective treatment of eczema: formulation and clinical implications. Indian J Exp Biol. 2005 Mar; 43(3):233-40.

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Antineoplastic Agents
RNA, Small Interfering
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