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Robert L. Copeland

TitleAssociate Professor
Faculty RankAssociate Professor
InstitutionHoward University
DepartmentPharmacology
AddressHoward University
520 W. Street, N.W.
Washington DC 20059
Phone2028066311
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Daniels MH, Castro J, Lee YT, Gotur D, Knockenhauer KE, Grigoriu S, Lockbaum GJ, Cheong JE, Lu C, Brennan D, Buker SM, Liu J, Yao S, Sparling BA, Sickmier EA, Ribich S, Blakemore SJ, Silver SJ, Boriack-Sjodin PA, Duncan KW, Copeland RA. Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9. J Med Chem. 2025 May 08; 68(9):9537-9554. PMID: 40298172.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Lockbaum GJ, Lynes MM, Shen SA, Liu J, Holt N, Nayak SP, Knockenhauer KE, Yao S, Sickmier EA, Raman A, Wu J, Case A, Shehaj L, Buker SM, Grigoriu S, Ribich S, Blakemore SJ, Sparling BA, Duncan KW, Copeland RA, Silver SJ, Boriack-Sjodin PA. Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor. Commun Biol. 2025 Apr 09; 8(1):589. PMID: 40205031.
      Citations:    
    3. Dasi S, Naab TJ, Kwabi-Addo B, Apprey V, Beyene D, Dewitty RL, Nagel S, Williams R, Bolden K, Hayes-Dixon A, Shokrani B, Stewart DA, Kassim OO, Copeland RL, Kanaan YM. Methylation of ESRa Promoters in Benign Breast Tumors Could Be a Signature for Progression to Breast Cancer in African American Women. Cancer Genomics Proteomics. 2025 Mar-Apr; 22(2):208-230. PMID: 39993808.
      Citations:    Fields:    Translation:HumansCells
    4. Castro J, Daniels MH, Brennan D, Johnston B, Gotur D, Lee YT, Knockenhauer KE, Lu C, Wu J, Nayak S, Collins C, Bansal R, Buker SM, Case A, Liu J, Yao S, Sparling BA, Sickmier EA, Silver SJ, Blakemore SJ, Boriack-Sjodin PA, Duncan KW, Ribich S, Copeland RA. A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair. Cancer Res. 2025 Feb 17; 85(4):758-776. PMID: 39589774.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Owen R, Ashton RE, Bewick T, Copeland RJ, Ferraro FV, Kennerley C, Phillips BE, Maden-Wilkinson T, Parkington T, Skipper L, Thomas C, Arena R, Formenti F, Ozemek C, Veluswamy SK, Gururaj R, Faghy MA. Profiling the persistent and episodic nature of long COVID symptoms and the impact on quality of life and functional status: a cohort observation study. J Glob Health. 2025 Feb 07; 15:04006. PMID: 39913532.
      Citations:    Fields:    Translation:HumansCells
    6. Wang Q, Huang N, Psaltis JB, Gahtani RM, Yan G, Lu D, Cahalan SR, Shi X, Copeland RL, Haddad BR, Martin MB. Activation of estrogen-related receptor ? by calcium and cadmium. Front Endocrinol (Lausanne). 2024; 15:1400022. PMID: 39507056.
      Citations:    Fields:    Translation:HumansCells
    7. Oliveira Santos MJ, Teles-Souza J, de Ara?jo-Calumby RF, Copeland RL, Marcelino HR, Vilas-B?as DS. Advances, limitations and perspectives in the use of celecoxib-loaded nanocarriers in therapeutics of cancer. Discov Nano. 2024 Sep 06; 19(1):142. PMID: 39240502.
      Citations:    
    8. Aloufi A, Aubee J, Vargas KM, Apprey V, Thompson K, Copeland R, Kanaan Y, Ricks-Santi L, Brim H, Abbas M. Vitamin D receptor polymorphisms and associated miRNAs in the development of breast cancer in African American women. Gene. 2024 Nov 15; 927:148695. PMID: 38945313.
      Citations:    Fields:    Translation:HumansCells
    9. Popovici OA, Fallahzadeh M, Saghaei N, Copeland R, Talamas E. A new species-group in Calliscelio Ashmead (Hymenoptera: Scelionidae) takes shape. Zootaxa. 2024 Jun 05; 5463(2):201-214. PMID: 39646219.
      Citations:    Fields:    Translation:Animals
    10. Fleurent-Gr?goire C, Burgess N, McIsaac DI, Chevalier S, Fiore JF, Carli F, Levett D, Moore J, Grocott MP, Copeland R, Edbrooke L, Engel D, Testa GD, Denehy L, Gillis C. Towards a common definition of surgical prehabilitation: a scoping review of randomised trials. Br J Anaesth. 2024 Aug; 133(2):305-315. PMID: 38677949.
      Citations: 15     Fields:    Translation:Humans
    11. Fleurent-Gr?goire C, Burgess N, Denehy L, Edbrooke L, Engel D, Testa GD, Fiore JF, McIsaac DI, Chevalier S, Moore J, Grocott MP, Copeland R, Levett D, Scheede-Bergdahl C, Gillis C. Outcomes reported in randomised trials of surgical prehabilitation: a scoping review. Br J Anaesth. 2024 Jul; 133(1):42-57. PMID: 38570300.
      Citations: 9     Fields:    Translation:Humans
    12. Humphreys L, Myers A, Frith G, Thelwell M, Pickering K, Mills GH, Kerr K, Fisher P, Kidder J, Keen C, Hodson S, Phillips G, Smith R, Evans L, Thornton S, Dale E, Maxwell L, Greenfield DM, Copeland R. The Development of a Multi-Modal Cancer Rehabilitation (Including Prehabilitation) Service in Sheffield, UK: Designing the Active Together Service. Healthcare (Basel). 2024 Mar 29; 12(7). PMID: 38610164.
      Citations:    
    13. Myers AM, Barlow RC, Baldini G, Campbell AM, Carli F, Carr EJ, Collyer T, Danjoux G, Davis JF, Denehy L, Durrand J, Gillis C, Greenfield DM, Griffiths SP, Grocott M, Humphreys L, Jack S, Keen C, Levett DZH, Merchant Z, Moore J, Moug S, Ricketts W, Santa Mina D, Saxton JM, Shaw CE, Tew GA, Thelwell M, West MA, Copeland RJ. International consensus is needed on a core outcome set to advance the evidence of best practice in cancer prehabilitation services and research. Br J Anaesth. 2024 May; 132(5):851-856. PMID: 38522964.
      Citations: 1     Fields:    Translation:Humans
    14. Jones G, Bailey L, Beeken RJ, Brady S, Cooper C, Copeland RJ, Crosland S, Dawson S, Faires M, Gilbody S, Haynes H, Hill A, Hillison E, Horspool M, Lee E, Li J, Machaczek KK, Parrott S, Quirk H, Stubbs B, Tew GA, Traviss-Turner G, Turton E, Walker L, Walters S, Weich S, Wildbore E, Peckham E. Supporting physical activity through co-production in people with severe mental ill health (SPACES): protocol for a randomised controlled feasibility trial. Pilot Feasibility Stud. 2024 Feb 17; 10(1):32. PMID: 38368380.
      Citations:    
    15. Niassy S, Omuse ER, Khang'ati JE, B?chinger I, Kupesa DM, Cheseto X, Mbatha BW, Copeland RS, Mohamed SA, Gama M, Mitti JM, Belayneh Y, Delabays N, Lefort F, Ekesi S, Subramanian S. Validating Indigenous Farmers' Practice in the Management of the Fall Armyworm Spodoptera frugiperda (J. E. Smith) in Maize Cropping Systems in Africa. Life (Basel). 2024 Jan 25; 14(2). PMID: 38398690.
      Citations:    
    16. Cruaud A, Rasplus JY, Zhang J, Burks R, Delvare G, Fusu L, Gumovsky A, Huber JT, Jan?ta P, Mitroiu MD, Noyes JS, van Noort S, Baker A, B?hmov? J, Baur H, Blaimer BB, Brady SG, Buben?kov? K, Chartois M, Copeland RS, Dale-Skey Papilloud N, Dal Molin A, Dominguez C, Gebiola M, Guerrieri E, Kresslein RL, Krogmann L, Lemmon E, Murray EA, Nidelet S, Nieves-Aldrey JL, Perry RK, Peters RS, Polaszek A, Saun? L, Torr?ns J, Triapitsyn S, Tselikh EV, Yoder M, Lemmon AR, Woolley JB, Heraty JM. The Chalcidoidea bush of life: evolutionary history of a massive radiation of minute wasps. Cladistics. 2024 02; 40(1):34-63. PMID: 37919831.
      Citations: 14     Fields:    Translation:Animals
    17. Almohaywi M, Sugita BM, Centa A, Fonseca AS, Antunes VC, Fadda P, Mannion CM, Abijo T, Goldberg SL, Campbell MC, Copeland RL, Kanaan Y, Cavalli LR. Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients. Int J Mol Sci. 2023 Aug 22; 24(17). PMID: 37685851.
      Citations: 4     Fields:    Translation:Humans
    18. L?pez-Fern?ndez J, L?pez-Valenciano A, Pearce G, Copeland RJ, Liguori G, Jim?nez A, Mayo X. Physical Inactivity Levels of European Adolescents in 2002, 2005, 2013, and 2017. Int J Environ Res Public Health. 2023 02 20; 20(4). PMID: 36834451.
      Citations: 2     Fields:    Translation:Humans
    19. Tew GA, Bailey L, Beeken RJ, Cooper C, Copeland R, Brady S, Heron P, Hill A, Lee E, Spanakis P, Stubbs B, Traviss-Turner G, Walker L, Walters S, Gilbody S, Peckham E. Physical Activity in Adults with Schizophrenia and Bipolar Disorder: A Large Cross-Sectional Survey Exploring Patterns, Preferences, Barriers, and Motivating Factors. Int J Environ Res Public Health. 2023 01 31; 20(3). PMID: 36767931.
      Citations: 9     Fields:    Translation:Humans
    20. Beyene D, Naab T, Apprey V, Ricks-Santi L, Esnakula A, Qasim M, George M, Minoza KG, Copeland RL, Broome C, Kanaan Y. Cyclin A2 and Ki-67 proliferation markers could be used to identify tumors with poor prognosis in African American women with breast cancer. J Cancer Biol. 2023; 4(1):3-16. PMID: 37273492.
      Citations:    
    21. Getachew B, Csoka AB, Copeland RL, Manaye KF, Tizabi Y. Dihydromyricetin Protects Against Salsolinol-Induced Toxicity in Dopaminergic Cell Line: Implication for Parkinson's Disease. Neurotox Res. 2023 Apr; 41(2):141-148. PMID: 36585544.
      Citations: 4     Fields:    Translation:HumansCells
    22. Qasim M, Ricks-Santi LJ, Naab TJ, Rajack F, Beyene D, Abbas M, Kassim OO, Copeland RL, Kanaan Y. Inverse Correlation of KISS1 and KISS1R Expression in Triple-negative Breast Carcinomas from African American Women. Cancer Genomics Proteomics. 2022 Nov-Dec; 19(6):673-682. PMID: 36316037.
      Citations: 1     Fields:    Translation:Humans
    23. Winkler IS, Kirk-Spriggs AH, Bayless KM, Soghigian J, Meier R, Pape T, Yeates DK, Carvalho AB, Copeland RS, Wiegmann BM. Phylogenetic resolution of the fly superfamily Ephydroidea-Molecular systematics of the enigmatic and diverse relatives of Drosophilidae. PLoS One. 2022; 17(10):e0274292. PMID: 36197946.
      Citations: 1     Fields:    Translation:Animals
    24. Mitropoulos A, Goodwill S, Copeland R, Klonizakis M. The relationship between physical activity and severity of COVID-19 symptoms in non-hospitalized individuals. Eur J Public Health. 2022 10 03; 32(5):794-798. PMID: 35866626.
      Citations: 4     Fields:    Translation:Humans
    25. Kanaan Y, Copeland RL. The link between vitamin D and prostate cancer. Nat Rev Cancer. 2022 08; 22(8):435. PMID: 35761063.
      Citations: 5     Fields:    Translation:Humans
    26. van Noort S, Shaw SR, Copeland RS. ?Revision of the endemic African genus Dinapsis (Dinapsini, Megalyridae, Hymenoptera) with description of seven new species. Zookeys. 2022; 1112:27-122. PMID: 36760621.
      Citations:    
    27. Copeland RL, Kanaan Y. New targets in triple-negative breast cancer. Nat Rev Cancer. 2021 12; 21(12):744. PMID: 34621048.
      Citations: 5     Fields:    Translation:Humans
    28. Getachew B, Csoka AB, Garden AR, Copeland RL, Tizabi Y. Sodium Butyrate Protects Against Ethanol-Induced Toxicity in SH-SY5Y Cell Line. Neurotox Res. 2021 Dec; 39(6):2186-2193. PMID: 34554410.
      Citations: 11     Fields:    Translation:HumansCells
    29. Turkistani S, Sugita BM, Fadda P, Marchi R, Afsari A, Naab T, Apprey V, Copeland RL, Campbell MC, Cavalli LR, Kanaan Y. A panel of miRNAs as prognostic markers for African-American patients with triple negative breast cancer. BMC Cancer. 2021 Jul 27; 21(1):861. PMID: 34315420.
      Citations: 6     Fields:    Translation:Humans
    30. Faghy MA, Arena R, Stoner L, Haraf RH, Josephson R, Hills AP, Dixit S, Popovic D, Smith A, Myers J, Bacon SL, Niebauer J, Dourado VZ, Babu AS, Maden-Wilkinson TM, Copeland RJ, Gough LA, Bond S, Stuart K, Bewick T, Ashton REM. The need for exercise sciences and an integrated response to COVID-19: A position statement from the international HL-PIVOT network. Prog Cardiovasc Dis. 2021 Jul-Aug; 67:2-10. PMID: 33549590.
      Citations: 23     Fields:    Translation:Humans
    31. Machaczek KK, Allmark P, Pollard N, Goyder E, Shea M, Horspool M, Lee S, de-la-Haye S, Copeland R, Weich S. Integrating physical activity into the treatment of depression in adults: A qualitative enquiry. Health Soc Care Community. 2022 05; 30(3):1006-1017. PMID: 33440023.
      Citations: 5     Fields:    Translation:Humans
    32. Robinson AGJ, Kanaan YM, Copeland RL. Combinatorial Cytotoxic Effects of 2,3-Dichloro-5,8-dimethoxy-1,4-naphthoquinone and 4-hydroxytamoxifen in Triple-negative Breast Cancer Cell Lines. Anticancer Res. 2020 Dec; 40(12):6623-6635. PMID: 33288557.
      Citations: 1     Fields:    Translation:HumansCells
    33. Beyene DA, Daremipouran MR, Apprey V, Naab T, Kassim OO, Copeland RL, Kanaan YM. The Association Between the Genetic VDR SNP c.907+75C>T and Prostate Cancer Risk Is Modified by Tanning Potential. Cancer Genomics Proteomics. 2020 Nov-Dec; 17(6):739-745. PMID: 33099475.
      Citations:    Fields:    Translation:Humans
    34. Quirk H, Hock E, Harrop D, Crank H, Peckham E, Traviss-Turner G, Machaczek K, Stubbs B, Horspool M, Weich S, Copeland R. Understanding the experience of initiating community-based group physical activity by people with serious mental illness: A systematic review using a meta-ethnographic approach. Eur Psychiatry. 2020 Oct 22; 63(1):e95. PMID: 33087211.
      Citations: 9     Fields:    Translation:Humans
    35. Tizabi Y, Getachew B, Copeland RL, Aschner M. Nicotine and the nicotinic cholinergic system in COVID-19. FEBS J. 2020 09; 287(17):3656-3663. PMID: 32790936.
      Citations: 42     Fields:    Translation:HumansCells
    36. Faghy MA, Ashton RE, Maden-Wilkinson TM, Copeland RJ, Bewick T, Smith A, Loosemore M. Integrated sports and respiratory medicine in the aftermath of COVID-19. Lancet Respir Med. 2020 09; 8(9):852. PMID: 32653073.
      Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
    37. Getachew B, Csoka AB, Bhatti A, Copeland RL, Tizabi Y. Butyrate Protects Against Salsolinol-Induced Toxicity in SH-SY5Y Cells: Implication for Parkinson's Disease. Neurotox Res. 2020 Oct; 38(3):596-602. PMID: 32572814.
      Citations: 27     Fields:    Translation:HumansCells
    38. Buker SM, Gurard-Levin ZA, Wheeler BD, Scholle MD, Case AW, Hirsch JL, Ribich S, Copeland RA, Boriack-Sjodin PA. A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity. SLAS Discov. 2020 04; 25(4):361-371. PMID: 31585521.
      Citations: 19     Fields:    Translation:HumansCells
    39. Tizabi Y, Getachew B, Csoka AB, Manaye KF, Copeland RL. Novel targets for parkinsonism-depression comorbidity. Prog Mol Biol Transl Sci. 2019; 167:1-24. PMID: 31601399.
      Citations: 13     Fields:    Translation:Humans
    40. Daremipouran MR, Beyene D, Apprey V, Naab TJ, Kassim OO, Copeland RL, Kanaan YM. The Association of a Novel Identified VDR SNP With Prostate Cancer in African American Men. Cancer Genomics Proteomics. 2019 Jul-Aug; 16(4):245-255. PMID: 31243105.
      Citations: 7     Fields:    Translation:Humans
    41. Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP. Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell. 2019 07 08; 36(1):100-114.e25. PMID: 31257072.
      Citations: 147     Fields:    Translation:HumansCells
    42. Moses-Fynn E, Tang W, Beyene D, Apprey V, Copeland R, Kanaan Y, Kwabi-Addo B. Correlating blood-based DNA methylation markers and prostate cancer risk in African-American men. PLoS One. 2018; 13(9):e0203322. PMID: 30204798.
      Citations: 9     Fields:    Translation:HumansCells
    43. Ren X, Ghassemi P, Kanaan YM, Naab T, Copeland RL, Dewitty RL, Kim I, Strobl JS, Agah M. Kernel-Based Microfluidic Constriction Assay for Tumor Sample Identification. ACS Sens. 2018 08 24; 3(8):1510-1521. PMID: 29979037.
      Citations: 7     Fields:    Translation:HumansCells
    44. Thomenius MJ, Totman J, Harvey D, Mitchell LH, Riera TV, Cosmopoulos K, Grassian AR, Klaus C, Foley M, Admirand EA, Jahic H, Majer C, Wigle T, Jacques SL, Gureasko J, Brach D, Lingaraj T, West K, Smith S, Rioux N, Waters NJ, Tang C, Raimondi A, Munchhof M, Mills JE, Ribich S, Porter Scott M, Kuntz KW, Janzen WP, Moyer M, Smith JJ, Chesworth R, Copeland RA, Boriack-Sjodin PA. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS One. 2018; 13(6):e0197372. PMID: 29856759.
      Citations: 32     Fields:    Translation:HumansCells
    45. Boriack-Sjodin PA, Ribich S, Copeland RA. RNA-modifying proteins as anticancer drug targets. Nat Rev Drug Discov. 2018 06; 17(6):435-453. PMID: 29773918.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    46. Italiano A, Soria JC, Toulmonde M, Michot JM, Lucchesi C, Varga A, Coindre JM, Blakemore SJ, Clawson A, Suttle B, McDonald AA, Woodruff M, Ribich S, Hedrick E, Keilhack H, Thomson B, Owa T, Copeland RA, Ho PTC, Ribrag V. Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study. Lancet Oncol. 2018 05; 19(5):649-659. PMID: 29650362.
      Citations: 339     Fields:    Translation:HumansCTClinical Trials
    47. Drew AE, Moradei O, Jacques SL, Rioux N, Boriack-Sjodin AP, Allain C, Scott MP, Jin L, Raimondi A, Handler JL, Ott HM, Kruger RG, McCabe MT, Sneeringer C, Riera T, Shapiro G, Waters NJ, Mitchell LH, Duncan KW, Moyer MP, Copeland RA, Smith J, Chesworth R, Ribich SA. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep. 2017 12 21; 7(1):17993. PMID: 29269946.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    48. Copeland RL, Beyene D, Apprey V, Daremipouran MR, Naab TJ, Kassim OO, Kanaan YM. DHPLC Elution Patterns of VDR PCR Products Can Predict Prostate Cancer Susceptibility in African American Men. Cancer Genomics Proteomics. 2017 Nov-Dec; 14(6):461-467. PMID: 29109096.
      Citations: 3     Fields:    Translation:Humans
    49. Brach D, Johnston-Blackwell D, Drew A, Lingaraj T, Motwani V, Warholic NM, Feldman I, Plescia C, Smith JJ, Copeland RA, Keilhack H, Chan-Penebre E, Knutson SK, Ribich SA, Raimondi A, Thomenius MJ. EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL. Mol Cancer Ther. 2017 11; 16(11):2586-2597. PMID: 28835384.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    50. Owrang M, Copeland RL, Ricks-Santi LJ, Gaskins M, Beyene D, Dewitty RL, Kanaan YM. Breast Cancer Prognosis for Young Patients. In Vivo. 2017 Jul-Aug; 31(4):661-668. PMID: 28652435.
      Citations: 4     Fields:    Translation:Humans
    51. Campbell CT, Haladyna JN, Drubin DA, Thomson TM, Maria MJ, Yamauchi T, Waters NJ, Olhava EJ, Pollock RM, Smith JJ, Copeland RA, Blakemore SJ, Bernt KM, Daigle SR. Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia. Mol Cancer Ther. 2017 08; 16(8):1669-1679. PMID: 28428443.
      Citations: 31     Fields:    Translation:HumansCells
    52. Kawano S, Grassian AR, Tsuda M, Knutson SK, Warholic NM, Kuznetsov G, Xu S, Xiao Y, Pollock RM, Smith JS, Kuntz KK, Ribich S, Minoshima Y, Matsui J, Copeland RA, Tanaka S, Keilhack H. Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma. PLoS One. 2016; 11(7):e0158888. PMID: 27391784.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    53. Riera TV, Wigle TJ, Copeland RA. Characterization of Inhibitor Binding Through Multiple Inhibitor Analysis: A Novel Local Fitting Method. Methods Mol Biol. 2016; 1439:33-45. PMID: 27316986.
      Citations:    Fields:    Translation:HumansAnimalsCells
    54. Bamji ZD, Washington KN, Akinboye E, Bakare O, Kanaan YM, Copeland RL. Apoptotic Effects of Novel Dithiocarbamate Analogs of Emetine in Prostate Cancer Cell Lines. Anticancer Res. 2015 Sep; 35(9):4723-32. PMID: 26254362.
      Citations: 4     Fields:    Translation:HumansCells
    55. Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, M?ller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundstr?m M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ. The promise and peril of chemical probes. Nat Chem Biol. 2015 Aug; 11(8):536-41. PMID: 26196764.
      Citations: 375     Fields:    Translation:Humans
    56. Akinboye ES, Bamji ZD, Kwabi-Addo B, Ejeh D, Copeland RL, Denmeade SR, Bakare O. Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines. Bioorg Med Chem. 2015 Sep 01; 23(17):5839-45. PMID: 26187015.
      Citations: 7     Fields:    Translation:HumansCells
    57. Winchester D, Ricks-Santi L, Mason T, Abbas M, Copeland RL, Beyene D, Jingwi EY, Dunston GM, Kanaan YM. SPINK1 Promoter Variants Are Associated with Prostate Cancer Predisposing Alterations in Benign Prostatic Hyperplasia Patients. Anticancer Res. 2015 Jul; 35(7):3811-9. PMID: 26124326.
      Citations: 2     Fields:    Translation:HumansCells
    58. Buckley JP, Hedge A, Yates T, Copeland RJ, Loosemore M, Hamer M, Bradley G, Dunstan DW. The sedentary office: an expert statement on the growing case for change towards better health and productivity. Br J Sports Med. 2015 Nov; 49(21):1357-62. PMID: 26034192.
      Citations: 144     Fields:    Translation:Humans
    59. Chan-Penebre E, Kuplast KG, Majer CR, Boriack-Sjodin PA, Wigle TJ, Johnston LD, Rioux N, Munchhof MJ, Jin L, Jacques SL, West KA, Lingaraj T, Stickland K, Ribich SA, Raimondi A, Scott MP, Waters NJ, Pollock RM, Smith JJ, Barbash O, Pappalardi M, Ho TF, Nurse K, Oza KP, Gallagher KT, Kruger R, Moyer MP, Copeland RA, Chesworth R, Duncan KW. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat Chem Biol. 2015 Jun; 11(6):432-7. PMID: 25915199.
      Citations: 274     Fields:    Translation:HumansAnimalsCells
    60. Kassim OO, Copeland RL, Kenguele HM, Nekhai S, Ako-Nai KA, Kanaan YM. Antiproliferative activities of Fagara xanthoxyloides and Pseudocedrela kotschyi against prostate cancer cell lines. Anticancer Res. 2015 Mar; 35(3):1453-8. PMID: 25750297.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    61. Jingwi EY, Abbas M, Ricks-Santi L, Winchester D, Beyene D, Day A, Naab TJ, Kassim OO, Dunston GM, Copeland RL, Kanaan YM. Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men. Anticancer Res. 2015 Mar; 35(3):1549-58. PMID: 25750310.
      Citations: 16     Fields:    Translation:Humans
    62. Knutson SK, Warholic NM, Johnston LD, Klaus CR, Wigle TJ, Iwanowicz D, Littlefield BA, Porter-Scott M, Smith JJ, Moyer MP, Copeland RA, Pollock RM, Kuntz KW, Raimondi A, Keilhack H. Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas. PLoS One. 2014; 9(12):e111840. PMID: 25493630.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    63. Beyene D, Daremipouran M, Apprey V, Williams R, Ricks-Santi L, Kassim OO, Naab TJ, Kanaan YM, Copeland RL. Use of tanning potential as a predictor for prostate cancer risk in African-American men. In Vivo. 2014 Nov-Dec; 28(6):1181-7. PMID: 25398820.
      Citations: 7     Fields:    Translation:Humans
    64. Kanaan YM, Sampey BP, Beyene D, Esnakula AK, Naab TJ, Ricks-Santi LJ, Dasi S, Day A, Blackman KW, Frederick W, Copeland RL, Gabrielson E, Dewitty RL. Metabolic profile of triple-negative breast cancer in African-American women reveals potential biomarkers of aggressive disease. Cancer Genomics Proteomics. 2014 Nov-Dec; 11(6):279-94. PMID: 25422359.
      Citations: 52     Fields:    Translation:HumansCells
    65. Klaus CR, Iwanowicz D, Johnston D, Campbell CA, Smith JJ, Moyer MP, Copeland RA, Olhava EJ, Scott MP, Pollock RM, Daigle SR, Raimondi A. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells. J Pharmacol Exp Ther. 2014 Sep; 350(3):646-56. PMID: 24993360.
      Citations: 68     Fields:    Translation:HumansCells
    66. Mik? I, Copeland RS, Balhoff JP, Yoder MJ, Deans AR. Folding wings like a cockroach: a review of transverse wing folding ensign wasps (Hymenoptera: Evaniidae: Afrevania and Trissevania). PLoS One. 2014; 9(5):e94056. PMID: 24787704.
      Citations: 19     Fields:    Translation:Animals
    67. Knutson SK, Kawano S, Minoshima Y, Warholic NM, Huang KC, Xiao Y, Kadowaki T, Uesugi M, Kuznetsov G, Kumar N, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, Waters NJ, Smith JJ, Porter-Scott M, Chesworth R, Moyer MP, Copeland RA, Richon VM, Uenaka T, Pollock RM, Kuntz KW, Yokoi A, Keilhack H. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther. 2014 Apr; 13(4):842-54. PMID: 24563539.
      Citations: 281     Fields:    Translation:HumansAnimalsCells
    68. Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, Waters NJ, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013 Aug 08; 122(6):1017-25. PMID: 23801631.
      Citations: 369     Fields:    Translation:HumansAnimalsCells
    69. Knutson SK, Warholic NM, Wigle TJ, Klaus CR, Allain CJ, Raimondi A, Porter Scott M, Chesworth R, Moyer MP, Copeland RA, Richon VM, Pollock RM, Kuntz KW, Keilhack H. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):7922-7. PMID: 23620515.
      Citations: 410     Fields:    Translation:HumansAnimalsCells
    70. Basavapathruni A, Jin L, Daigle SR, Majer CR, Therkelsen CA, Wigle TJ, Kuntz KW, Chesworth R, Pollock RM, Scott MP, Moyer MP, Richon VM, Copeland RA, Olhava EJ. Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem Biol Drug Des. 2012 Dec; 80(6):971-80. PMID: 22978415.
      Citations: 59     Fields:    Translation:HumansCells
    71. Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, Sacks JD, Raimondi A, Majer CR, Song J, Scott MP, Jin L, Smith JJ, Olhava EJ, Chesworth R, Moyer MP, Richon VM, Copeland RA, Keilhack H, Pollock RM, Kuntz KW. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov; 8(11):890-6. PMID: 23023262.
      Citations: 409     Fields:    Translation:HumansCells
    72. Kaleem MA, Ramsahai S, Del Fierro K, Rasul S, Onumah C, Lerebours V, Gajjala J, Copeland RA, Jones LS. Ocular findings in human immunodeficiency virus patients in Washington, DC. Int Ophthalmol. 2012 Apr; 32(2):145-51. PMID: 22450559.
      Citations: 4     Fields:    Translation:HumansCells
    73. Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J, Johnston LD, Scott MP, Smith JJ, Xiao Y, Jin L, Kuntz KW, Chesworth R, Moyer MP, Bernt KM, Tseng JC, Kung AL, Armstrong SA, Copeland RA, Richon VM, Pollock RM. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12; 20(1):53-65. PMID: 21741596.
      Citations: 503     Fields:    Translation:HumansAnimalsCells
    74. Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, Lentz KA, Grace JE, Burton CR, Toyn JH, Barten DM, Marcinkeviciene J, Meredith JE, Albright CF, Macor JE. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorg Med Chem Lett. 2011 Nov 15; 21(22):6909-15. PMID: 21974952.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    75. Ferdinand L, Ngakeng V, Copeland RA. Corneal graft rejection in African Americans at Howard University Hospital. Saudi J Ophthalmol. 2011 Jul; 25(3):285-9. PMID: 23960938.
      Citations:    
    76. Brandy Y, Ononiwu I, Adedeji D, Williams V, Mouamba C, Kanaan Y, Copeland RL, Wright DA, Butcher RJ, Denmeade SR, Bakare O. Synthesis and cytotoxic activities of some 2-arylnaphtho[2,3-d]oxazole-4,9-dione derivatives on androgen-dependent (LNCaP) and androgen-independent (PC3) human prostate cancer cell lines. Invest New Drugs. 2012 Aug; 30(4):1709-14. PMID: 21243402.
      Citations: 4     Fields:    Translation:HumansCells
    77. Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM, Copeland RA. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc Natl Acad Sci U S A. 2010 Dec 07; 107(49):20980-5. PMID: 21078963.
      Citations: 343     Fields:    Translation:HumansCells
    78. Kanaan YM, White DF, Das JR, Berhe S, Bakare O, Kenguele H, Beyene D, Zhou Y, Day AA, Copeland RL. Cytotoxic effects of N-(3-chloro-1,4-dioxo 1,4-dihydro-naphthalen-2-yl)-benzamide on androgen-dependent and -independent prostate cancer cell lines. Anticancer Res. 2010 Feb; 30(2):519-27. PMID: 20332464.
      Citations: 1     Fields:    Translation:HumansCells
    79. Kanaan YM, Das JR, Bakare O, Enwerem NM, Berhe S, Beyene D, Williams V, Zhou Y, Copeland RL. Biological evaluation of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone as an anti-breast cancer agent. Anticancer Res. 2009 Jan; 29(1):191-9. PMID: 19331150.
      Citations: 8     Fields:    Translation:HumansCells
    80. Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, Li M, Safonov IG, Takata DT, Venslavsky JW, Yamashita DS, Choudhry AE, Copeland RA, Lai Z, Schaber MD, Tummino PJ, Strum SL, Wood ER, Duckett DR, Eberwein D, Knick VB, Lansing TJ, McConnell RT, Zhang S, Minthorn EA, Concha NO, Warren GL, Kumar R. Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase. J Med Chem. 2008 Sep 25; 51(18):5663-79. PMID: 18800763.
      Citations: 57     Fields:    Translation:Animals
    81. Parrish CA, Adams ND, Auger KR, Burgess JL, Carson JD, Chaudhari AM, Copeland RA, Diamond MA, Donatelli CA, Duffy KJ, Faucette LF, Finer JT, Huffman WF, Hugger ED, Jackson JR, Knight SD, Luo L, Moore ML, Newlander KA, Ridgers LH, Sakowicz R, Shaw AN, Sung CM, Sutton D, Wood KW, Zhang SY, Zimmerman MN, Dhanak D. Novel ATP-competitive kinesin spindle protein inhibitors. J Med Chem. 2007 Oct 04; 50(20):4939-52. PMID: 17725339.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    82. Tizabi Y, Bai L, Copeland RL, Taylor RE. Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell. Alcohol Alcohol. 2007 Sep-Oct; 42(5):413-6. PMID: 17686828.
      Citations: 60     Fields:    Translation:AnimalsCells
    83. Copeland RL, Das JR, Kanaan YM, Taylor RE, Tizabi Y. Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity. Neurotox Res. 2007 Jul; 12(1):61-9. PMID: 17513200.
      Citations: 24     Fields:    Translation:HumansCells
    84. Copeland RL, Das JR, Bakare O, Enwerem NM, Berhe S, Hillaire K, White D, Beyene D, Kassim OO, Kanaan YM. Cytotoxicity of 2,3-dichloro-5,8-dimethoxy-1,4-naphthoquinone in androgen-dependent and -independent prostate cancer cell lines. Anticancer Res. 2007 May-Jun; 27(3B):1537-46. PMID: 17595773.
      Citations: 8     Fields:    Translation:HumansCells
    85. Copeland RL, Leggett YA, Kanaan YM, Taylor RE, Tizabi Y. Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease. Neurotox Res. 2005 Nov; 8(3-4):289-93. PMID: 16371323.
      Citations: 26     Fields:    Translation:HumansCells
    86. Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, Ramamurthy V, Morin PE, Camac DM, King RW, Lasut AL, Ross OH, Hillman MC, Fish B, Shen K, Dowling RL, Kim YB, Graciani NR, Collins D, Combs AP, George H, Thompson LA, Copeland RA. Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme. Arch Biochem Biophys. 2003 Feb 15; 410(2):307-16. PMID: 12573291.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    87. Tizabi Y, Copeland RL, Louis VA, Taylor RE. Effects of combined systemic alcohol and central nicotine administration into ventral tegmental area on dopamine release in the nucleus accumbens. Alcohol Clin Exp Res. 2002 Mar; 26(3):394-9. PMID: 11923594.
      Citations: 80     Fields:    Translation:Animals
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